Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Li, Xiaosong ^a   Wu, Xhiping ^a   Camacho, Raul ^a   Schwartz, Gary J ^a   LeRoith, Derek ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENERGY BALANCE; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID OXIDATION; LOCOMOTION; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; TRIACYLGLYCEROL BLOOD LEVEL; VAGOTOMY; VAGUS REFLEX; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HOMEOSTASIS; INNERVATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VAGUS NERVE;

MUS;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EVALUATION, PRECLINICAL; GLUCOSE; HOMEOSTASIS; INFUSIONS, INTRAVENTRICULAR; LEPTIN; LIVER; MALE; MICE; MICE, KNOCKOUT; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; THINNESS; VAGUS NERVE;

EID: 79951877179     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017058     Document Type: Article

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