Caloric restriction in leptin deficiency does not correct myocardial steatosis: Failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling

Physiological Genomics

Volumn 43, Issue 12, 2011, Pages 726-738

  Eduardo Rame, J ^a   Barouch, Lili A ^a   Sack, Michael N ^c   Lynn, Edward G ^c   Abu Asab, Mones ^d   Tsokos, Maria ^d   Kern, Steven J ^e   Barb, Jennifer J ^f   Munson, Peter J ^f   Halushka, Marc K ^g   Miller, Karen L ^b   Fox Talbot, Karen ^g   Zhang, Jianhua ^e   Hare, Joshua M ^h   Solomon, Michael A ^c,e   Danner, Robert L ^e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c National Heart   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e CLINICAL CENTER   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac metabolism; Glycerolipid free fatty acid metabolism; Leptin; Lipotoxicity; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor coactivator

Indexed keywords

FATTY ACID; GLYCEROLIPID; LEPTIN; LIPID; OIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CELL DEATH; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; FEEDING; HEART LEFT VENTRICLE WALL; HEART VENTRICLE; HEART WEIGHT; HORMONE DEFICIENCY; LIPID METABOLISM; LIPID STORAGE; MITOCHONDRION; MOUSE; MYOCARDIAL DISEASE; MYOCARDIAL STEATOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; STAINING; THERMOGENESIS; UPREGULATION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BODY WEIGHT; CALORIC RESTRICTION; ECHOCARDIOGRAPHY; GENE EXPRESSION PROFILING; HYPERTROPHY, LEFT VENTRICULAR; LEPTIN; LIPIDS; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROARRAY ANALYSIS; MICROSCOPY, ELECTRON; MYOCARDIUM; OXIDATIVE STRESS; PPAR ALPHA;

ANIMALIA; MUS;

EID: 79959842990     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00088.2010     Document Type: Article

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