Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia

Atherosclerosis

Volumn 214, Issue 1, 2011, Pages 81-85

  Luo, Wei ^a   Bodary, Peter F ^a   Shen, Yuechun ^a   Wickenheiser, Kevin J ^a   Öhman, Miina K ^a   Guo, Chiao ^a   Bahrou, Kristina L ^a   Myers, Martin G ^a   Eitzman, Daniel T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Hyperlipidemia; Leptin; Murine model; Obesity

Indexed keywords

APOLIPOPROTEIN E; FATTY ACID BINDING PROTEIN 4; LEPTIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT3 PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DISEASE SEVERITY; GENE MUTATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; MACROPHAGE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; FEMALE; HETEROZYGOTE; HYPERLIPIDEMIAS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 78650836336     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.10.009     Document Type: Article

References (28)

1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
2. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006, 393:7-20.
3. Uotani S., Abe T., Yamaguchi Y. Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway. Biochem Biophys Res Commun 2006, 351:171-175.
4. Rahmouni K., Morgan D.A., Morgan G.M., Mark A.L., Haynes W.G. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 2005, 54:2012-2018.
5. Bodary P.F., Gu S., Shen Y., Hasty A.H., Buckler J.M., Eitzman D.T. Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2005, 25:e119-122.
6. Hasty A.H., Shimano H., Osuga J., et al. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 2001, 276:37402-37408.
7. Wu K.K., Wu T.J., Chin J., et al. Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor. Atherosclerosis 2005, 181:251-259.
8. Bates S.H., Kulkarni R.N., Seifert M., Myers M.G. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 2005, 1:169-178.
9. Bates S.H., Stearns W.H., Dundon T.A., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
10. Bodary P.F., Shen Y., Ohman M., et al. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 2007, 27:70-76.
11. Ohman M.K., Shen Y., Obimba C.I., et al. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008, 117:798-805.
12. Bodary P.F., Westrick R.J., Wickenheiser K.J., Shen Y., Eitzman D.T. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 2002, 287:1706-1709.
13. Hubert H.B., Feinleib M., McNamara P.M., Castelli W.P. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983, 67:968-977.
14. Pearson T.A., Mensah G.A., Alexander R.W., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003, 107:499-511.
15. Maruyama I., Nakata M., Yamaji K. Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis. Ann NY Acad Sci 2000, 902:315-319.
16. Martin-Romero C., Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000, 199:15-24.
17. Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999, 194:6-11.
18. Korda M., Kubant R., Patton S., Malinski T. Leptin-induced endothelial dysfunction in obesity. Am J Physiol Heart Circ Physiol 2008, 295:H1514-1521.
19. Taleb S., Herbin O., Ait-Oufella H., et al. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:2691-2698.
20. Bouloumie A., Drexler H.C., Lafontan M., Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998, 83:1059-1066.
21. Caro J.F., Kolaczynski J.W., Nyce M.R., et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996, 348:159-161.
22. Konstantinides S., Schafer K., Koschnick S., Loskutoff D.J. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001, 108:1533-1540.
23. Oral E.A., Simha V., Ruiz E., et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002, 346:570-578.
24. Funato H., Tsai A.L., Willie J.T., et al. Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab 2009, 9:64-76.
25. Wellen K.E., Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003, 112:1785-1788.
26. Ohman M.K., Wright A.P., Wickenheiser K.J., Luo W., Russo H.M., Eitzman D.T. Monocyte chemoattractant protein-1 deficiency protects against visceral fat-induced atherosclerosis. Arterioscler Thromb Vasc Biol 2010, 30:1151-1158.
27. Furuhashi M., Tuncman G., Gorgun C.Z., et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 2007, 447:959-965.
28. Boord J.B., Maeda K., Makowski L., et al. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 2004, 110:1492-1498.