Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide

Vascular Pharmacology

Volumn 51, Issue 2-3, 2009, Pages 198-204

  Mascareno, Eduardo ^a   Beckles, Daniel ^b   Dhar Mascareno, Manya ^c   Siddiqui, M A Q ^a  

^a SUNY Downstate Medical Center   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Atrial natriuretic peptide; Leptin; ob ob mice; Pressure overload hypertrophy

Indexed keywords

ATRIAL NATRIURETIC FACTOR; LEPTIN; MOLECULAR MARKER; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DNA BINDING; ECHOCARDIOGRAPHY; EVALUATION; FEMALE; GENE EXPRESSION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE WALL; HEART MUSCLE CELL; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THICKNESS; TRANSCRIPTION INITIATION;

ANALYSIS OF VARIANCE; ANIMALS; AORTA; ATRIAL NATRIURETIC FACTOR; CALCINEURIN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONSTRICTION, PATHOLOGIC; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC MARKERS; HEART VENTRICLES; HYPERTROPHY, LEFT VENTRICULAR; IMMUNOHISTOCHEMISTRY; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; OBESITY; PROMOTER REGIONS, GENETIC; PROTEIN TRANSPORT; RATS; TIME FACTORS; VENTRICULAR REMODELING;

EID: 68049126126     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2009.06.005     Document Type: Article

References (36)

1. Abe Y., Ono K., Kawamura T., Wada H., Kita T., Shimatsu A., and Hasegawa K. Leptin induces elongation of cardiac myocytes and causes left ventricular dilation with compensation. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H2387-H2396
2. Barouch L.A., Berkowitz D.E., Harrison R.W., O'Donnell C.P., and Hare J.M. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108 (2003) 754-759
3. Beckles D.L., Mascareno E., and Siddiqui M.A.Q. Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy. Vascul. Pharmacol. 45 (2006) 350-357
4. Christoffersen C., Bollano E., Lindegaard M.L., Bartels E.D., Goetze J.P., Andersen C.B., and Nielsen L.B. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology 144 (2003) 3483-3490
5. Clerk A., Cullingford T.E., Fuller S.J., Giraldo A., Markou T., Pikkarainen S., and Sugden P.H. Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. J. Cell. Physiol. 212 (2007) 311-322
6. de Simone G. Morbid obesity and left ventricular geometry. Hypertension 49 (2007) 7-9
7. Feng J.A., Perry G., Mori T., Hayashi T., Oparil S., and Chen Y.F. Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient mice. Clin. Exp. Pharmacol. Physiol. 30 (2003) 343-349
8. Franco V., Chen F., Oparil S., Feng J.A., Wang D., Hage F., and Perry G. Atrial natriuretic peptide dose-dependently inhibits pressure overload-induced cardiac remodeling. Hypertension 44 (2004) 746-750
9. Gardner D.G., Chen S., Glenn D.J., and Grisby C.L. Molecular biology of natriuretic peptide system: implication for physiology and hypertension. Hypertension. 49 (2007) 419-426
10. Houweling A.C., van Borren M.M., Moorman A.F., and Christoffels V.M. Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease. Cardiovasc. Res. 67 (2005) 583-593
11. John S.W., Krege J.H., Oliver P.M., Hagaman J.R., Hodgin J.B., Pang S.C., Flynn T.G., and Smithies O. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science. 267 (1995) 679-681
12. Knowles J.W., Esposito G., Mao L., Hagaman J.R., Fox J.E., Smithies O., Rockman H.A., and Maeda N. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J. Clin. Invest. 107 (2001) 975-984
13. London B. Natriuretic peptides and cardiac hypertrophy. J. Am. Coll. Cardiol. 48 (2006) 506-507
14. Mascareno E., Dhar M., and Siddiqui M.A.Q. Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5590-5594
15. Mascareno E., Beckles D., and Siddiqui M.A. Janus Kinase-2 signaling mediates apoptosis in rat cardiomyocytes. Vascul. Pharmacol. 43 (2005) 327-335
16. McGaffin K.R., Sun C.K., Rager J.J., Romano L., Zou B., Mathier M.A., Doherthy R.M., McTiernan C.F., and O'Donnell C.P. Leptin signaling reduces the severity of cardiac dysfunction and remodeling after chronic ischaemic injury. Cardiovasc. Res. 77 (2008) 54-63
17. Minhas K.M., Khan S.A., Raju S.V., Phan A.C., Gonzalez D.R., Skaf M.W., Lee K., Tejani A.D., Saliaris A.P., Barouch L.A., O ' Donnell C.P., Emala C.W., Berkowitz D.E., and Hare J.M. Leptin repletion restores depressed β-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. J. Physiol. 565 (2005) 463-474
18. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., and Olson E.N. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93 (1998) 215-228
19. Nishikimi T., Maeda N., and Matsuoka H. The role of natriuretic peptides in cardioprotection. Cardiovasc. Res. 69 (2006) 318-328
20. Oliver P.M., Fox J.E., Kim R., Rockman H.A., Kim H.S., Reddick R.L., Pandey K.N., Milgram S.L., Smithies O., and Maeda N. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 14730-14735
21. Paolisso G., Tagliamonte M.R., Galderisi M., Zito G.A., Petrocelli A., Carella C., de Divitiis O., and Varricchio M. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension 34 (1999) 1047-1052
22. Perego L., Pizzocri P., Corradi D., Maisano F., Paganelli M., Fiorina P., Barbieri M., Morabito A., Paolisso G., Folli F., and Pontiroli A.E. Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J. Clin. Endocrinol. Metab. 90 (2005) 4087-4093
23. Pladevall M., Williams K., Guyer H., Sadurni J., Falces C., Ribes A., Pare C., Brotons C., Gabriel R., Serrano-Rios M., and Haffner S. The association between leptin and left ventricular hypertrophy: a population-based cross-sectional study. J. Hypertens. 21 (2003) 1467-1473
24. Rajapurohitam V., Gan X.T., Kirshenbaum L.A., and Karmazyn M. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ. Res. 93 (2003) 277-279
25. Ritter O., and Neyses L. The molecular basis of myocardial hypertrophy and heart failure. Trends. Mol. Med. 9 (2003) 313-321
26. Seidman C.E., Wong D.W., Jarcho J.A., Bloch K.D., and Seidman J.G. Cis-acting sequences that modulate atrial natriuretic factor gene expression. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 4104-4108
27. Swynghedauw B. Phenotypic plasticity of adult myocardium: molecular mechanisms. J. Exp. Biol. 209 (2006) 2320-2327
28. Temsah R., and Nemer M. GATA factors and transcriptional regulation of cardiac natriuretic peptide genes. Regul. Pept. 128 (2005) 177-185
29. Trivedi P., Yang R., and Barouch L.A. Decreased p110 catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell Cycle 7 (2008) 560-565
30. Wang D., Oparil S., Feng J.A., Li P., Perry G., Chen L.B., Dai M., John S.W., and Chen Y.F. Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouse. Hypertension 42 (2003) 88-95
31. Wilkins B., De Windt L., Bueno O., Braz J., Glascock B., Kimball T.R., and Molkentin J.D. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophy growth. Mol. Cell. Biol. 22 (2002) 7603-7613
32. Wilkins B.J., Dai Y.S., Bueno O.F., Parsons S.A., Xu J., Plank D.M., Jones F., Kimball T.R., and Molkentin J.D. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ. Res. 94 (2004) 110-118
33. Xu F.P., Chen M.S., Wang Y.Z., Yi Q., Lin S.B., Chen A.F., and Luo J.D. Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation 110 (2004) 1269-1275
34. Yang R., and Barouch L.A. Leptin signaling in obesity: cardiovascular consequences. Circ. Res. 101 (2007) 545-559
35. Zang M.X., Li Y., Xue L.X., Jia H.T., and Jing H. Cooperative activation of atrial natriuretic peptide promoter by dHAND and MEF2C. J. Cell. Biochem. 93 (2004) 1255-1266
36. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432