Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes

Circulation

Volumn 110, Issue 10, 2004, Pages 1269-1275

  Xu, Fang Ping ^a,d   Chen, Min Sheng ^a   Wang, Yan Zhen ^b   Yi, Quan ^a   Lin, Shu Bing ^a   Chen, Alex F ^c   Luo, Jian Dong ^a,c  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Endothelin; Hypertrophy; Leptin; Stress

Indexed keywords

ANTIOXIDANT; ATRASENTAN; CATALASE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; LEPTIN; REACTIVE OXYGEN METABOLITE; RNA;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR DISEASE; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; NEWBORN; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RISK FACTOR;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ATRIAL NATRIURETIC FACTOR; CARDIOMEGALY; CATALASE; CELL SIZE; CELLS, CULTURED; ENDOTHELIN-1; GENE EXPRESSION REGULATION; LEPTIN; MYOCYTES, CARDIAC; OBESITY; OXIDATIVE STRESS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, ENDOTHELIN A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 4444303576     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000140766.52771.6D     Document Type: Article

References (43)

1. Williams CL, Hayman LL, Daniels SR, et al. Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2002;106:143-160.
2. Keaney JF Jr, Larson MG, Vasan RS, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 2003;23:434-439.
3. Tartaglia LA. The leptin receptor. J Biol Chem. 1997;272:6093-6096.
4. Murad A, Nath AK, Cha ST, et al. Leptin is an autocrine/paracrine regulator of wound healing. FASEB J. 2003;17:1895-1897.
5. Barba G, Russo O, Siani A, et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obesity Res. 2003;11:160-166.
6. Narkiewicz K, Somers VK, Mos L, et al. An independent relationship between plasma leptin and heart rate in untreated patients with essential hypertension. J Hypertens. 1999;17:245-249.
7. Singhal A, Farooqi IS, Cole TJ, et al. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation. 2002;106:1919-1924.
8. Correia ML, Morgan DA, Sivitz WI, et al. Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension. 2001;37:936-942.
9. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation. 2001;104:3052-3056.
10. Paolisso G, Tagliamonte MR, Galderisi M, et al. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension. 1999;34:1047-1052.
11. Toth MJ, Gottlieb SS, Fisher ML, et al. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism. 1997;46: 450-453.
12. Rajapurohitam V, Gan XT, Kirshenbaum LA, et al. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res. 2003;93:277-279.
13. Sawyer DB, Siwik DA, Xiao L, et al. Role of oxidative stress in myocardial hypertrophy and failure. J Mol Cell Cardiol 2002;34:379-388.
14. Nakamura K, Fushimi K, Kouchi H, et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II. Circulation. 1998;98:794-799.
15. Takemoto M, Node K, Nakagami H, et al. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest. 2001;108: 1429-1437.
16. Luo JD, Xie F, Zhang WW, et al. Simvastatin inhibits noradrenaline- induced hypertrophy of cultured neonatal rat cardiomyocytes. Br J Pharmacol. 2001;132:159-164.
17. Hirotani S, Otsu K, Nishida K, et al. Involvement of nuclear factor-κB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation. 2002;105: 509-515.
18. Bouloumie A, Marumo T, Lafontan M, et al. Leptin induces oxidative stress in human endothelial cells. FASEB J. 1999;13:1231-1238.
19. Yamagishi SI, Edelstein D, Du XL, et al. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001;276:25096-25100.
20. Quehenberger P, Exner M, Sunder-Plassmann R, et al. Leptin induces endothelin-1 in endothelial cells in vitro. Circ Res. 2002;90:711-718.
21. 1-adrenergic receptor interaction: evidence for independent regulation of growth and beating. Circ Res. 1985;56:884-894.
22. Zhu H, Bannenberg GL, Moldeus P, et al. Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescein. Arch Toxicol. 1994;68: 582-587.
23. Frankfurt OS. Flow cytometric analysis of double-stranded RNA content distributions. J Histochem Cytochem. 1980;28:663-669.
24. Loennechen JP, Stoylen A, Beisvag V, et al. Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart. Am J Physiol. 2001;280:H2902-H2910.
25. Li L, Fink GD, Watts SW, et al. Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension. Circulation. 2003;107:1053-1058.
26. Barouch LA, Berkowitz DE, Harrison RW, et al. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation. 2003;108:754-759.
27. A Receptor Blockade Trial (HEAT). Circulation. 2002;106: 2666-2672.
28. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol. 2003;65:45-79.
29. Sugden PH. An overview of endothelin signaling in the cardiac myocyte. J Mol Cell Cardiol. 2003;35:871-886.
30. Mather KJ, Mirzamohammadi B, Lteif A, et al. Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes. Diabetes. 2002;51:3517-3523.
31. Ferri C, Bellini C, Desideri G, et al. Plasma endothelin-1 levels in obese hypertensive and normotensive men. Diabetes. 1995;44:431-436.
32. Pieske B, Beyermann B, Breu V, et al. Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and fairing myocardium. Circulation. 1999;99:1802-1809.
33. Yamazaki T, Komuro I, Kudoh S, et al. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem. 1996;271:3221-3228.
34. Illiano G, Naviglio S, Pagano M, et al. Leptin affects adenylate cyclase activity in H9c2 cardiac cell line: effects of short- and long-term exposure. Am J Hypertens. 2002;15:638-643.
35. Unger RH. Lipotoxic diseases. Annu Rev Med. 2002;53:319-336.
36. Lee Y, Yu X, Gonzales F, et al. PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A. 2002;99:11848-11853.
37. Finck BN, Lehman JJ, Leone TC, et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002;109:121-130.
38. Kodama H, Fukuda K, Pan J, et al. Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes. Circ Res. 1998;82: 244-250.
39. Wold LE, Relling DP, Duan J, et al. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension. 2002;39:69-74.
40. Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002;105: 804-809.
41. Nakamura K, Kusano K, Nakamura Y, et al. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation. 2002;105:2867-2871.
42. Landmesser U, Spiekermann S, Dikalov S, et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation. 2002;106:3073-3078.
43. Farquharson CA, Butler R, Hill A, et al. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation. 2002;106:221-226.