Nicastrin is dispensable for γ-secretase protease activity in the presence of specific presenilin mutations

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 13013-13022

  Futai, Eugene ^a,b   Yagishita, Sosuke ^a   Ishiura, Shoichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; ENDOPROTEOLYSIS; GALACTOSIDASE; INTRACELLULAR DOMAIN; LOOP REGIONS; MAMMALIAN CELLS; MEMBRANE PROTEIN COMPLEX; MEMBRANE-BOUND; MULTISUBUNIT; NICASTRIN; PRESENILIN; PROTEASE ACTIVITIES; REPORTER GENE; SECRETASE; TRANS-MEMBRANE DOMAINS; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL ACTIVATORS; TRANSMEMBRANE; WILD TYPES;

ACTIVATION ANALYSIS; AMINES; CHEMICAL ACTIVATION; GLYCOPROTEINS; MAMMALS; PROTEINS; SUBSTRATES; YEAST;

CELL MEMBRANES;

ADENINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA GALACTOSIDASE; GAMMA SECRETASE; HISTIDINE; MUTANT PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN; PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENE MUTATION; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; REPORTER GENE; TRANSCRIPTION INITIATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; IMMUNOBLOTTING; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MUTATION; PRESENILINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SACCHAROMYCES CEREVISIAE;

MAMMALIA;

EID: 66349111071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807653200     Document Type: Article

References (45)

1. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766
2. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488
3. Laudon, H., Hansson, E. M., Melén, K., Bergman, A., Farmery, M. R., Winblad, B., Lendahl, U., von Heijne, G., and Näslund, J. (2005) J. Biol. Chem. 280, 35352-35360
4. Oh, Y. S., and Turner, R. J. (2005) Biochemistry 44, 11821-11828
5. Spasic, D., Tolia, A., Dillen, K., Baert, V., De Strooper, B., Vrijens, S., and Annaert, W. (2006) J. Biol. Chem. 281, 26569-26577
6. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
7. Shen, J., and Kelleher, R. J., III (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 403-409
8. Shah, S., Lee, S. F., Tabuchi, K., Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., 3rd, Südhof, T., and Yu, G. (2005) Cell 122, 435-447
9. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-441
10. Niimura, M., Isoo, N., Takasugi, N., Tsuruoka, M., Ui-Tei, K., Saigo, K., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2005) J. Biol. Chem. 280, 12967-12975
11. Kaether, C., Capell, A., Edbauer, D., Winkler, E., Novak, B., Steiner, H., and Haass, C. (2004) EMBO J. 23, 4738-4748
12. slund, J. (2004) J. Biol. Chem. 279, 45564-45572
13. Wang, J., Beher, D., Nyborg, A. C., Shearman, M. S., Golde, T. E., and Goate, A. (2006) J. Neurochem. 96, 218-227
14. Kim, S. H., and Sisodia, S. S. (2005) J. Biol. Chem. 280, 41953-41966
15. Watanabe, N., Tomita, T., Sato, C., Kitamura, T., Morohashi, Y., and Iwatsubo, T. (2005) J. Biol. Chem. 280, 41967-41967
16. Kornilova, A. Y., Bihel, F., Das, C., and Wolfe, M. S. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3230-3235
17. Annaert, W. G., Esselens, C., Baert, V., Boeve, C., Snellings, G., Cupers, P., Craessaerts, K., and De Strooper, B. (2001) Neuron 32, 579-589
18. Tolia, A., Cha'vez-Gutie'rrez, L., and De Strooper, B. (2006) J. Biol. Chem. 281, 27633-27642
19. Sato, C., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2006) J. Neurosci. 26, 12081-12088
20. Tolia, A., Horre', K., and De Strooper, B. (2008) J. Biol. Chem. 283, 19793-19803
21. Sato, C., Takagi, S., Tomita, T., and Iwatsubo, T. (2008) J. Neurosci. 28, 6264-6271
22. Kopan, R., and Ilagan, M. X. (2004) Nat. Rev. Mol. Cell Biol. 5, 499-504
23. Weihofen, A., Binns, K., Lemberg, M. K., Ashman, K., and Martoglio, B. (2002) Science 296, 2215-2218
24. Martin, L., Fluhrer, R., Reiss, K., Kremmer, E., Saftig, P., and Haass, C. (2008) J. Biol. Chem. 283, 1644-1652
25. Sato, T., Nyborg, A. C., Iwata, N., Diehl, T. S., Saido, T. C., Golde, T. E., and Wolfe, M. S. (2006) Biochemistry 45, 8649-8656
26. Iben, L. G., Olson, R. E., Balanda, L. A., Jayachandra, S., Robertson, B. J., Hay, V., Corradi, J., Prasad, C. V., Zaczek, R., Albright, C. F., and Toyn, J. H. (2007) J. Biol. Chem. 282, 36829-36836
27. Narayanan, S., Sato, T., and Wolfe, M. S. (2007) J. Biol. Chem. 282, 20172-20179
28. Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., Baekelandt, V., Dressel, R., Cupers, P., Huylebroeck, D., Zwijsen, A., Van Leuven, F., and De Strooper, B. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11872-11877
29. Herreman, A., Serneels, L., Annaert, W., Collen, D., Schoonjans, L., and De Strooper, B. (2000) Nat. Cell Biol. 2, 461-462
30. Li, T., Ma, G., Cai, H., Price, D. L., and Wong, P. C. (2003) J. Neurosci. 23, 3272-3277
31. Zhang, Y., Luo, W., Wang, H., Lin, P., Vetrivel, K. S., Liao, F., Li, F., Wong, P. C., Farquhar, M. G., Thinakaran, G., and Xu, H. (2005) J. Biol. Chem. 280, 17020-17026
32. Miller, C. A., III, Martinat, M. A., and Hyman, L. E. (1998) Nucleic Acids Res. 26, 3577-3583
33. Mumberg, D.,Müller, R., and Funk, M. (1995) Gene (Amst.) 156, 119-122
34. James, P., Halladay, J., and Craig, E. A. (1996) Genetics 144, 1425-1436
35. Clontech (2001) Yeast Protocols Handbook, Clontech, Mountain View, CA
36. Ono, Y., Torii, F., Ojima, K., Doi, N., Yoshioka, K., Kawabata, Y., Labeit, D., Labeit, S., Suzuki, K., Abe, K., Maeda, T., and Sorimachi, H. (2006) J. Biol. Chem. 281, 18519-18531
37. Wuestehube, L. J., and Schekman, R. W. (1992) Methods Enzymol. 219, 124-136
38. Yagishita, S., Futai, E., and Ishiura, S. (2008) Biochem. Biophys. Res. Commun. 377, 141-145
39. Yagishita, S., Morishima-Kawashima, M., Ishiura, S., and Ihara, Y. (2008) J. Biol. Chem. 283, 733-738
40. Yagishita, S., Morishima-Kawashima, M., Tanimura, Y., Ishiura, S., and Ihara, Y. (2006) Biochemistry 45, 3952-3960
41. Schroeter, E. H., Kisslinger, J. A., and Kopan, R. (1998) Nature 393, 382-386
42. Takasugi, N., Takahashi, Y., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2002) J. Biol. Chem. 277, 50198-50205
43. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2025-2030
44. Consler, T. G., Tsolas, O., and Kaback, H. R. (1991) Biochemistry 30, 1291-1298
45. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kang, D. E., Marquez-Sterling, N., Golde, T. E., and Koo, E. H. (2001) Nature 414, 212-216