Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 26136-26145

  Beam, Monica ^a,c   Silva, M Catarina ^a,b   Morimoto, Richard I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF LISBON   (Portugal)

^c Northwestern University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE FORMATION; BIOPHYSICAL STATE; CAENORHABDITIS ELEGANS; CELLULAR ENVIRONMENT; COMPLEX PATTERN; CONFORMATIONAL STATE; DYNAMIC IMAGING; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HETEROGENEOUS DISTRIBUTIONS; IMAGING METHOD; IN-VIVO; INTERMEDIATE SPECIE; METABOLIC DISEASE; MULTIPLE ORDERS; NEURODEGENERATION; OLIGOMERIC STATE; POLYGLUTAMINE; POLYGLUTAMINE (POLYQ); PROTEIN CONFORMATION; PROTEIN MISFOLDING; REVERSIBLE TRANSITIONS; SINGLE MOLECULE;

CONFORMATIONS; FLUORESCENCE MICROSCOPY; FLUORESCENCE SPECTROSCOPY; MONOMERS; NEURODEGENERATIVE DISEASES; OLIGOMERS; PHOTOBLEACHING; PROTEINS; TOXICITY;

AGGREGATES;

OLIGOMER; POLYGLUTAMINE;

ARTICLE; BRIGHTNESS; CAENORHABDITIS ELEGANS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE IMAGING; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENETIC ASSOCIATION; HYDRODYNAMICS; IN VIVO STUDY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; RNA INTERFERENCE;

ANIMALS; BACTERIAL PROTEINS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE KNOCKDOWN TECHNIQUES; LUMINESCENT PROTEINS; PEPTIDES; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SPECTROMETRY, FLUORESCENCE;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 84864378845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.362764     Document Type: Article

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