Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21807-21816

  Olshina, Maya A ^a   Angley, Lauren M ^a   Ramdzan, Yasmin M ^a   Tang, Jinwei ^a   Bailey, Michael F ^a   Hill, Andrew F ^a,b   Hatters, Danny M ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION KINETICS; DENATURING CONDITIONS; HUNTINGTIN; HUNTINGTON DISEASE; IN-CELL; IN-VITRO; INCLUSION BODIES; MAMMALIAN CELLS; MONOMER CONVERSIONS; MUTANT HUNTINGTIN; POLYGLUTAMINE; QUANTITATIVE METHOD; RATE LIMITING; SEDIMENTATION VELOCITIES; TOTAL LOAD;

AGGREGATES; MAMMALS; MONOMERS; OLIGOMERS; PURIFICATION; TOXICITY;

CELLS;

CHAPERONE; HEAT SHOCK COGNATE PROTEIN 70; HUNTINGTIN; MONOMER; MUTANT PROTEIN; OLIGOMER; POLYGLUTAMINE;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; CYTOTOXICITY; HYDRODYNAMICS; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; PROTEIN VARIANT; SEDIMENTATION RATE;

AMYLOID; ANIMALS; BIOPHYSICS; CLONING, MOLECULAR; EXONS; HUMANS; HUNTINGTON DISEASE; KINETICS; MUTAGENESIS; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN DENATURATION; PROTEIN FOLDING; ULTRACENTRIFUGATION;

MAMMALIA;

EID: 77954379810     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.084434     Document Type: Article

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