-
1
-
-
25844487226
-
Diseases of unstable repeat expansion: Mechanisms and common principles
-
Gatchel, J.R. and Zoghbi, H.Y. (2005) Diseases of unstable repeat expansion: mechanisms and common principles. Nat. Rev. Genet., 6, 743-755.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 743-755
-
-
Gatchel, J.R.1
Zoghbi, H.Y.2
-
2
-
-
0033134869
-
Aggregates in neurodegenerative disease: Crowds and power?
-
Tran, P.B. and Miller, R.J. (1999) Aggregates in neurodegenerative disease: crowds and power? Trends Neurosci., 22, 194-197.
-
(1999)
Trends Neurosci.
, vol.22
, pp. 194-197
-
-
Tran, P.B.1
Miller, R.J.2
-
3
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito, R.R. (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol., 10, 524-530.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
4
-
-
0031446233
-
Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
-
Ross, C.A. (1997) Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? Neuron, 19, 1147-1150.
-
(1997)
Neuron
, vol.19
, pp. 1147-1150
-
-
Ross, C.A.1
-
5
-
-
18544392423
-
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
-
Warrick, J.M., Paulson, H.L., Gray-Board, G.L., Bui, Q.T., Fischbeck, K.H., Pittman, R.N. and Bonini, N.M. (1998) Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell, 93, 939-949.
-
(1998)
Cell
, vol.93
, pp. 939-949
-
-
Warrick, J.M.1
Paulson, H.L.2
Gray-Board, G.L.3
Bui, Q.T.4
Fischbeck, K.H.5
Pittman, R.N.6
Bonini, N.M.7
-
6
-
-
0037047123
-
Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis
-
Chai, Y., Shao, J., Miller, V.M., Williams, A. and Paulson, H.L. (2002) Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc. Natl Acad. Sci. USA, 99, 9310-9315.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 9310-9315
-
-
Chai, Y.1
Shao, J.2
Miller, V.M.3
Williams, A.4
Paulson, H.L.5
-
7
-
-
0032590053
-
Huntington aggregates may not predict neuronal death in Huntington's disease
-
Kuemmerle, S., Gutekunst, C.A., Klein, A.M., Li, X.J., Li, S.H., Beal, M.F., Hersch, S.M. and Ferrante, R.J. (1999) Huntington aggregates may not predict neuronal death in Huntington's disease. Ann. Neurol., 46, 842-849.
-
(1999)
Ann. Neurol.
, vol.46
, pp. 842-849
-
-
Kuemmerle, S.1
Gutekunst, C.A.2
Klein, A.M.3
Li, X.J.4
Li, S.H.5
Beal, M.F.6
Hersch, S.M.7
Ferrante, R.J.8
-
8
-
-
63149139630
-
Post-translational modifications of expanded polyglutamine proteins: Impact on neurotoxicity
-
Pennuto, M., Palazzolo, I. and Poletti, A. (2009) Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity. Hum. Mol. Genet., 18, R40-R47.
-
(2009)
Hum. Mol. Genet.
, vol.18
-
-
Pennuto, M.1
Palazzolo, I.2
Poletti, A.3
-
9
-
-
34347242503
-
CAG-encoded polyglutamine length polymorphism in the human genome
-
Butland, S.L., Devon, R.S., Huang, Y., Mead, C.L., Meynert, A.M., Neal, S.J., Lee, S.S., Wilkinson, A., Yang, G.S., Yuen, M.M. et al. (2007) CAG-encoded polyglutamine length polymorphism in the human genome. BMC Genomics, 8, 126.
-
(2007)
BMC Genomics
, vol.8
, pp. 126
-
-
Butland, S.L.1
Devon, R.S.2
Huang, Y.3
Mead, C.L.4
Meynert, A.M.5
Neal, S.J.6
Lee, S.S.7
Wilkinson, A.8
Yang, G.S.9
Yuen, M.M.10
-
10
-
-
18344395923
-
The genome of the social amoeba Dictyostelium discoideum
-
Eichinger, L., Pachebat, J.A., Glockner, G., Rajandream, M.A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q. et al. (2005) The genome of the social amoeba Dictyostelium discoideum. Nature, 435, 43-57.
-
(2005)
Nature
, vol.435
, pp. 43-57
-
-
Eichinger, L.1
Pachebat, J.A.2
Glockner, G.3
Rajandream, M.A.4
Sucgang, R.5
Berriman, M.6
Song, J.7
Olsen, R.8
Szafranski, K.9
Xu, Q.10
-
11
-
-
70449780852
-
PolyQ fibrillation in the cell nucleus: Who's bad?
-
von Mikecz, A. (2009) PolyQ fibrillation in the cell nucleus: who's bad? Trends Cell Biol., 19, 685-691.
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 685-691
-
-
Von Mikecz, A.1
-
12
-
-
0029983147
-
Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development
-
Karlin, S. and Burge, C. (1996) Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development. Proc. Natl Acad. Sci. USA, 93, 1560-1565.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1560-1565
-
-
Karlin, S.1
Burge, C.2
-
13
-
-
0033845697
-
Evolution of simple sequence in proteins
-
Huntley, M. and Golding, G.B. (2000) Evolution of simple sequence in proteins. J. Mol. Evol., 51, 131-140.
-
(2000)
J. Mol. Evol.
, vol.51
, pp. 131-140
-
-
Huntley, M.1
Golding, G.B.2
-
14
-
-
17844383699
-
Functional insights from the distribution and role of homopeptide repeat-containing proteins
-
Faux, N.G., Bottomley, S.P., Lesk, A.M., Irving, J.A., Morrison, J.R., de la Banda, M.G. and Whisstock, J.C. (2005) Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res., 15, 537-551.
-
(2005)
Genome Res.
, vol.15
, pp. 537-551
-
-
Faux, N.G.1
Bottomley, S.P.2
Lesk, A.M.3
Irving, J.A.4
Morrison, J.R.5
De La Banda, M.G.6
Whisstock, J.C.7
-
15
-
-
0024396320
-
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
-
Mitchell, P.J. and Tjian, R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science, 245, 371-378.
-
(1989)
Science
, vol.245
, pp. 371-378
-
-
Mitchell, P.J.1
Tjian, R.2
-
16
-
-
1842717952
-
Comparative analysis of amino acid repeats in rodents and humans
-
Alba, M.M. and Guigo, R. (2004) Comparative analysis of amino acid repeats in rodents and humans. Genome Res., 14, 549-554.
-
(2004)
Genome Res.
, vol.14
, pp. 549-554
-
-
Alba, M.M.1
Guigo, R.2
-
17
-
-
33750345803
-
Exhaustive assignment of compositional bias reveals universally prevalent biased regions: Analysis of functional associations in human and Drosophila
-
Harrison, P.M. (2006) Exhaustive assignment of compositional bias reveals universally prevalent biased regions: analysis of functional associations in human and Drosophila. BMC Bioinformatics, 7, 441.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 441
-
-
Harrison, P.M.1
-
18
-
-
49549096453
-
Polyglutamine gene function and dysfunction in the ageing brain
-
Hands, S., Sinadinos, C. and Wyttenbach, A. (2008) Polyglutamine gene function and dysfunction in the ageing brain. Biochim. Biophys. Acta, 1779, 507-521.
-
(2008)
Biochim. Biophys. Acta
, vol.1779
, pp. 507-521
-
-
Hands, S.1
Sinadinos, C.2
Wyttenbach, A.3
-
19
-
-
0037250168
-
The UCSC genome browser database
-
Karolchik, D., Baertsch, R., Diekhans, M., Furey, T.S., Hinrichs, A., Lu, Y.T., Roskin, K.M., Schwartz, M., Sugnet, C.W., Thomas, D.J. et al. (2003) The UCSC Genome Browser Database. Nucleic Acids Res., 31, 51-54.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 51-54
-
-
Karolchik, D.1
Baertsch, R.2
Diekhans, M.3
Furey, T.S.4
Hinrichs, A.5
Lu, Y.T.6
Roskin, K.M.7
Schwartz, M.8
Sugnet, C.W.9
Thomas, D.J.10
-
20
-
-
79960976768
-
UniProt Knowledgebase: A hub of integrated protein data
-
Magrane, M. and Consortium, U. (2011) UniProt Knowledgebase: a hub of integrated protein data. Database, 2011, bar009.
-
(2011)
Database
, vol.2011
-
-
Magrane, M.1
Consortium, U.2
-
21
-
-
0011542799
-
The Pfam protein families database
-
Bateman, A., Birney, E., Cerruti, L., Durbin, R., Etwiller, L., Eddy, S.R., Griffiths-Jones, S., Howe, K.L., Marshall, M. and Sonnhammer, E.L. (2002) The Pfam protein families database. Nucleic Acids Res., 30, 276-280.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 276-280
-
-
Bateman, A.1
Birney, E.2
Cerruti, L.3
Durbin, R.4
Etwiller, L.5
Eddy, S.R.6
Griffiths-Jones, S.7
Howe, K.L.8
Marshall, M.9
Sonnhammer, E.L.10
-
22
-
-
38549163152
-
TreeFam: 2008 update
-
Ruan, J., Li, H., Chen, Z., Coghlan, A., Coin, L.J., Guo, Y., Heriche, J.K., Hu, Y., Kristiansen, K., Li, R. et al. (2008) TreeFam: 2008 Update. Nucleic Acids Res., 36, D735-D740.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Ruan, J.1
Li, H.2
Chen, Z.3
Coghlan, A.4
Coin, L.J.5
Guo, Y.6
Heriche, J.K.7
Hu, Y.8
Kristiansen, K.9
Li, R.10
-
23
-
-
84856918212
-
HIPPIE: Integrating protein interaction networks with experiment based quality scores
-
Schaefer, M.H., Fontaine, J.F., Vinayagam, A., Porras, P., Wanker, E.E. and Andrade-Navarro, M.A. (2012) HIPPIE: integrating protein interaction networks with experiment based quality scores. PLoS One., 7, e31826.
-
(2012)
PLoS One.
, vol.7
-
-
Schaefer, M.H.1
Fontaine, J.F.2
Vinayagam, A.3
Porras, P.4
Wanker, E.E.5
Andrade-Navarro, M.A.6
-
24
-
-
78651328883
-
The BioGRID Interaction Database: 2011 update
-
Stark, C., Breitkreutz, B.J., Chatr-Aryamontri, A., Boucher, L., Oughtred, R., Livstone, M.S., Nixon, J., Van Auken, K., Wang, X., Shi, X. et al. (2011) The BioGRID Interaction Database: 2011 update. Nucleic Acids Res., 39, D698-D704.
-
(2011)
Nucleic Acids Res.
, vol.39
-
-
Stark, C.1
Breitkreutz, B.J.2
Chatr-Aryamontri, A.3
Boucher, L.4
Oughtred, R.5
Livstone, M.S.6
Nixon, J.7
Van Auken, K.8
Wang, X.9
Shi, X.10
-
25
-
-
0038005018
-
DAVID: Database for annotation, visualization, and integrated discovery
-
Dennis, G. Jr, Sherman, B.T., Hosack, D.A., Yang, J., Gao, W., Lane, H.C. and Lempicki, R.A. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol., 4, P3.
-
(2003)
Genome Biol.
, vol.4
-
-
Dennis Jr., G.1
Sherman, B.T.2
Hosack, D.A.3
Yang, J.4
Gao, W.5
Lane, H.C.6
Lempicki, R.A.7
-
26
-
-
0027306173
-
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
-
Strand, M., Prolla, T.A., Liskay, R.M. and Petes, T.D. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature, 365, 274-276.
-
(1993)
Nature
, vol.365
, pp. 274-276
-
-
Strand, M.1
Prolla, T.A.2
Liskay, R.M.3
Petes, T.D.4
-
27
-
-
77954965070
-
Trinucleotide repeats in human genome and exome
-
Kozlowski, P., de Mezer, M. and Krzyzosiak, W.J. (2010) Trinucleotide repeats in human genome and exome. Nucleic Acids Res., 38, 4027-4039.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 4027-4039
-
-
Kozlowski, P.1
De Mezer, M.2
Krzyzosiak, W.J.3
-
28
-
-
0035503214
-
SCA12: An unusual mutation leads to an unusual spinocerebellar ataxia
-
Holmes, S.E., Hearn, E.O., Ross, C.A. and Margolis, R.L. (2001) SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia. Brain Res. Bull., 56, 397-403.
-
(2001)
Brain Res. Bull.
, vol.56
, pp. 397-403
-
-
Holmes, S.E.1
Hearn, E.O.2
Ross, C.A.3
Margolis, R.L.4
-
29
-
-
58149189877
-
GtRNAdb: A database of transfer RNA genes detected in genomic sequence
-
Chan, P.P. and Lowe, T.M. (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res., 37, D93-D97.
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Chan, P.P.1
Lowe, T.M.2
-
30
-
-
0034282958
-
Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy
-
Miller, J.W., Urbinati, C.R., Teng-Umnuay, P., Stenberg, M.G., Byrne, B.J., Thornton, C.A. and Swanson, M.S. (2000) Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO J., 19, 4439-4448.
-
(2000)
EMBO J.
, vol.19
, pp. 4439-4448
-
-
Miller, J.W.1
Urbinati, C.R.2
Teng-Umnuay, P.3
Stenberg, M.G.4
Byrne, B.J.5
Thornton, C.A.6
Swanson, M.S.7
-
31
-
-
78651061861
-
Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats
-
Reddy, K., Tam, M., Bowater, R.P., Barber, M., Tomlinson, M., Nichol Edamura, K., Wang, Y.H. and Pearson, C.E. (2010) Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Res., 39, 1749-1762.
-
(2010)
Nucleic Acids Res.
, vol.39
, pp. 1749-1762
-
-
Reddy, K.1
Tam, M.2
Bowater, R.P.3
Barber, M.4
Tomlinson, M.5
Nichol Edamura, K.6
Wang, Y.H.7
Pearson, C.E.8
-
32
-
-
76249098186
-
R loops stimulate genetic instability of CTG.CAG repeats
-
Lin, Y., Dent, S.Y., Wilson, J.H., Wells, R.D. and Napierala, M. (2010) R loops stimulate genetic instability of CTG.CAG repeats. Proc. Natl Acad. Sci. USA, 107, 692-697.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 692-697
-
-
Lin, Y.1
Dent, S.Y.2
Wilson, J.H.3
Wells, R.D.4
Napierala, M.5
-
33
-
-
75549090603
-
The Pfam protein families database
-
Finn, R.D., Mistry, J., Tate, J., Coggill, P., Heger, A., Pollington, J.E., Gavin, O.L., Gunasekaran, P., Ceric, G., Forslund, K. et al. (2010) The Pfam protein families database. Nucleic Acids Res., 38, D211-D222.
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Finn, R.D.1
Mistry, J.2
Tate, J.3
Coggill, P.4
Heger, A.5
Pollington, J.E.6
Gavin, O.L.7
Gunasekaran, P.8
Ceric, G.9
Forslund, K.10
-
34
-
-
0037138361
-
The phosphatidylinositol 3-phosphate-binding FYVE finger
-
Stenmark, H., Aasland, R. and Driscoll, P.C. (2002) The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett., 513, 77-84.
-
(2002)
FEBS Lett.
, vol.513
, pp. 77-84
-
-
Stenmark, H.1
Aasland, R.2
Driscoll, P.C.3
-
35
-
-
58149194624
-
SMART 6: Recent updates and new developments
-
Letunic, I., Doerks, T. and Bork, P. (2009) SMART 6: recent updates and new developments. Nucleic Acids Res., 37, D229-D232.
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Letunic, I.1
Doerks, T.2
Bork, P.3
-
36
-
-
38549163153
-
CORUM: The comprehensive resource of mammalian protein complexes
-
Ruepp, A., Brauner, B., Dunger-Kaltenbach, I., Frishman, G., Montrone, C., Stransky, M., Waegele, B., Schmidt, T., Doudieu, O.N., Stumpflen, V. et al. (2008) CORUM: the comprehensive resource of mammalian protein complexes. Nucleic Acids Res., 36, D646-D650.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Ruepp, A.1
Brauner, B.2
Dunger-Kaltenbach, I.3
Frishman, G.4
Montrone, C.5
Stransky, M.6
Waegele, B.7
Schmidt, T.8
Doudieu, O.N.9
Stumpflen, V.10
-
37
-
-
33748313080
-
Membrane and juxtamembrane targeting by PH and PTB domains
-
DiNitto, J.P. and Lambright, D.G. (2006) Membrane and juxtamembrane targeting by PH and PTB domains. Biochim. Biophys. Acta, 1761, 850-867.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 850-867
-
-
Dinitto, J.P.1
Lambright, D.G.2
-
38
-
-
0038062668
-
ENTH/ANTH domains expand to the Golgi
-
Duncan, M.C. and Payne, G.S. (2003) ENTH/ANTH domains expand to the Golgi. Trends Cell Biol., 13, 211-215.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 211-215
-
-
Duncan, M.C.1
Payne, G.S.2
-
39
-
-
0033519641
-
Structure and ligand of a histone acetyltransferase bromodomain
-
Dhalluin, C., Carlson, J.E., Zeng, L., He, C., Aggarwal, A.K. and Zhou, M.M. (1999) Structure and ligand of a histone acetyltransferase bromodomain. Nature, 399, 491-496.
-
(1999)
Nature
, vol.399
, pp. 491-496
-
-
Dhalluin, C.1
Carlson, J.E.2
Zeng, L.3
He, C.4
Aggarwal, A.K.5
Zhou, M.M.6
-
40
-
-
78650441363
-
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins
-
Fiumara, F., Fioriti, L., Kandel, E.R. and Hendrickson, W.A. (2010) Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins. Cell, 143, 1121-1135.
-
(2010)
Cell
, vol.143
, pp. 1121-1135
-
-
Fiumara, F.1
Fioriti, L.2
Kandel, E.R.3
Hendrickson, W.A.4
-
41
-
-
0026356891
-
Predicting coiled coils from protein sequences
-
Lupas, A., Van Dyke, M. and Stock, J. (1991) Predicting coiled coils from protein sequences. Science, 252, 1162-1164.
-
(1991)
Science
, vol.252
, pp. 1162-1164
-
-
Lupas, A.1
Van Dyke, M.2
Stock, J.3
-
42
-
-
28944446477
-
Oligoproline effects on polyglutamine conformation and aggregation
-
Bhattacharyya, A., Thakur, A.K., Chellgren, V.M., Thiagarajan, G., Williams, A.D., Chellgren, B.W., Creamer, T.P. and Wetzel, R. (2006) Oligoproline effects on polyglutamine conformation and aggregation. J. Mol. Biol., 355, 524-535.
-
(2006)
J. Mol. Biol.
, vol.355
, pp. 524-535
-
-
Bhattacharyya, A.1
Thakur, A.K.2
Chellgren, V.M.3
Thiagarajan, G.4
Williams, A.D.5
Chellgren, B.W.6
Creamer, T.P.7
Wetzel, R.8
-
43
-
-
0038245117
-
An electronic effect on protein structure
-
Hinderaker, M.P. and Raines, R.T. (2003) An electronic effect on protein structure. Protein Sci., 12, 1188-1194.
-
(2003)
Protein Sci.
, vol.12
, pp. 1188-1194
-
-
Hinderaker, M.P.1
Raines, R.T.2
-
44
-
-
32144456009
-
Paircoil2: Improved prediction of coiled coils from sequence
-
McDonnell, A.V., Jiang, T., Keating, A.E. and Berger, B. (2006) Paircoil2: improved prediction of coiled coils from sequence. Bioinformatics, 22, 356-358.
-
(2006)
Bioinformatics
, vol.22
, pp. 356-358
-
-
McDonnell, A.V.1
Jiang, T.2
Keating, A.E.3
Berger, B.4
-
45
-
-
38049100631
-
Features of trinucleotide repeat instability in vivo
-
Kovtun, I.V. and McMurray, C.T. (2008) Features of trinucleotide repeat instability in vivo. Cell Res., 18, 198-213.
-
(2008)
Cell Res.
, vol.18
, pp. 198-213
-
-
Kovtun, I.V.1
McMurray, C.T.2
-
46
-
-
0035020731
-
The comparative genomics of polyglutamine repeats: Extreme differences in the codon organization of repeat-encoding regions between mammals and Drosophila
-
Alba, M.M., Santibanez-Koref, M.F. and Hancock, J.M. (2001) The comparative genomics of polyglutamine repeats: extreme differences in the codon organization of repeat-encoding regions between mammals and Drosophila. J. Mol. Evol., 52, 249-259.
-
(2001)
J. Mol. Evol.
, vol.52
, pp. 249-259
-
-
Alba, M.M.1
Santibanez-Koref, M.F.2
Hancock, J.M.3
-
47
-
-
0029597867
-
The contribution of slippage-like processes to genome evolution
-
Hancock, J.M. (1995) The contribution of slippage-like processes to genome evolution. J. Mol. Evol., 41, 1038-1047.
-
(1995)
J. Mol. Evol.
, vol.41
, pp. 1038-1047
-
-
Hancock, J.M.1
-
48
-
-
0037039436
-
Amino acid runs in eukaryotic proteomes and disease associations
-
Karlin, S., Brocchieri, L., Bergman, A., Mrazek, J. and Gentles, A.J. (2002) Amino acid runs in eukaryotic proteomes and disease associations. Proc. Natl Acad. Sci. USA, 99, 333-338.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 333-338
-
-
Karlin, S.1
Brocchieri, L.2
Bergman, A.3
Mrazek, J.4
Gentles, A.J.5
-
49
-
-
0035897405
-
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
-
Suhr, S.T., Senut, M.C., Whitelegge, J.P., Faull, K.F., Cuizon, D.B. and Gage, F.H. (2001) Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J. Cell. Biol., 153, 283-294.
-
(2001)
J. Cell. Biol.
, vol.153
, pp. 283-294
-
-
Suhr, S.T.1
Senut, M.C.2
Whitelegge, J.P.3
Faull, K.F.4
Cuizon, D.B.5
Gage, F.H.6
-
50
-
-
77950903972
-
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
-
Filimonenko, M., Isakson, P., Finley, K.D., Anderson, M., Jeong, H., Melia, T.J., Bartlett, B.J., Myers, K.M., Birkeland, H.C., Lamark, T. et al. (2010) The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol. Cell, 38, 265-279.
-
(2010)
Mol. Cell
, vol.38
, pp. 265-279
-
-
Filimonenko, M.1
Isakson, P.2
Finley, K.D.3
Anderson, M.4
Jeong, H.5
Melia, T.J.6
Bartlett, B.J.7
Myers, K.M.8
Birkeland, H.C.9
Lamark, T.10
-
51
-
-
33751193268
-
Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus
-
Gissi, C., Pesole, G., Cattaneo, E. and Tartari, M. (2006) Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus. BMC Genomics, 7, 288.
-
(2006)
BMC Genomics
, vol.7
, pp. 288
-
-
Gissi, C.1
Pesole, G.2
Cattaneo, E.3
Tartari, M.4
-
52
-
-
36448930958
-
Polyglutamine domain modulates the TBP-TFIIB interaction: Implications for its normal function and neurodegeneration
-
Friedman, M.J., Shah, A.G., Fang, Z.H., Ward, E.G., Warren, S.T., Li, S. and Li, X.J. (2007) Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat. Neurosci., 10, 1519-1528.
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 1519-1528
-
-
Friedman, M.J.1
Shah, A.G.2
Fang, Z.H.3
Ward, E.G.4
Warren, S.T.5
Li, S.6
Li, X.J.7
-
53
-
-
0027406964
-
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
-
Hoey, T., Weinzierl, R.O., Gill, G., Chen, J.L., Dynlacht, B.D. and Tjian, R. (1993) Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell, 72, 247-260.
-
(1993)
Cell
, vol.72
, pp. 247-260
-
-
Hoey, T.1
Weinzierl, R.O.2
Gill, G.3
Chen, J.L.4
Dynlacht, B.D.5
Tjian, R.6
-
54
-
-
29244462838
-
In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
-
Zhai, W., Jeong, H., Cui, L., Krainc, D. and Tjian, R. (2005) In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell, 123, 1241-1253.
-
(2005)
Cell
, vol.123
, pp. 1241-1253
-
-
Zhai, W.1
Jeong, H.2
Cui, L.3
Krainc, D.4
Tjian, R.5
-
55
-
-
78549278120
-
Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes
-
Whan, V., Hobbs, M., McWilliam, S., Lynn, D.J., Lutzow, Y.S., Khatkar, M., Barendse, W., Raadsma, H. and Tellam, R.L. (2010) Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes. BMC Genomics, 11, 654.
-
(2010)
BMC Genomics
, vol.11
, pp. 654
-
-
Whan, V.1
Hobbs, M.2
McWilliam, S.3
Lynn, D.J.4
Lutzow, Y.S.5
Khatkar, M.6
Barendse, W.7
Raadsma, H.8
Tellam, R.L.9
-
56
-
-
69849086690
-
Secondary structure of Huntingtin amino-terminal region
-
Kim, M.W., Chelliah, Y., Kim, S.W., Otwinowski, Z. and Bezprozvanny, I. (2009) Secondary structure of Huntingtin amino-terminal region. Structure, 17, 1205-1212.
-
(2009)
Structure
, vol.17
, pp. 1205-1212
-
-
Kim, M.W.1
Chelliah, Y.2
Kim, S.W.3
Otwinowski, Z.4
Bezprozvanny, I.5
-
57
-
-
33846025461
-
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast
-
Dehay, B. and Bertolotti, A. (2006) Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast. J. Biol. Chem., 281, 35608-35615.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35608-35615
-
-
Dehay, B.1
Bertolotti, A.2
-
58
-
-
0030470459
-
Glutamine repeats and inherited neurodegenerative diseases: Molecular aspects
-
Perutz, M.F. (1996) Glutamine repeats and inherited neurodegenerative diseases: molecular aspects. C Opin. Struct. Biol., 6, 848-858.
-
(1996)
C Opin. Struct. Biol.
, vol.6
, pp. 848-858
-
-
Perutz, M.F.1
-
59
-
-
33744952750
-
Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein
-
Ignatova, Z. and Gierasch, L.M. (2006) Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein. J. Biol. Chem., 281, 12959-12967.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12959-12967
-
-
Ignatova, Z.1
Gierasch, L.M.2
-
60
-
-
67650868984
-
Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins
-
Simon, M. and Hancock, J.M. (2009) Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins. Genome Biol., 10, R59.
-
(2009)
Genome Biol.
, vol.10
-
-
Simon, M.1
Hancock, J.M.2
-
61
-
-
20744437001
-
RONN: The bio-basis function neural network technique applied to the detection of natively disordered regions in proteins
-
Yang, Z.R., Thomson, R., McNeil, P. and Esnouf, R.M. (2005) RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins. Bioinformatics, 21, 3369-3376.
-
(2005)
Bioinformatics
, vol.21
, pp. 3369-3376
-
-
Yang, Z.R.1
Thomson, R.2
McNeil, P.3
Esnouf, R.M.4
-
62
-
-
35348980793
-
Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease
-
Truant, R., Atwal, R.S. and Burtnik, A. (2007) Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease. Prog. Neurobiol., 83, 211-227.
-
(2007)
Prog. Neurobiol.
, vol.83
, pp. 211-227
-
-
Truant, R.1
Atwal, R.S.2
Burtnik, A.3
-
63
-
-
45749147456
-
RNA toxicity is a component of ataxin-3 degeneration in Drosophila
-
Li, L.B., Yu, Z., Teng, X. and Bonini, N.M. (2008) RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature, 453, 1107-1111.
-
(2008)
Nature
, vol.453
, pp. 1107-1111
-
-
Li, L.B.1
Yu, Z.2
Teng, X.3
Bonini, N.M.4
-
64
-
-
0033030565
-
Evidence for proteasome involvement in polyglutamine disease: Localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro
-
Chai, Y., Koppenhafer, S.L., Shoesmith, S.J., Perez, M.K. and Paulson, H.L. (1999) Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro. Hum. Mol. Genet., 8, 673-682.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 673-682
-
-
Chai, Y.1
Koppenhafer, S.L.2
Shoesmith, S.J.3
Perez, M.K.4
Paulson, H.L.5
-
65
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N.F., Sampat, R.M. and Kopito, R.R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science, 292, 1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
66
-
-
0034754875
-
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
-
Waelter, S., Boeddrich, A., Lurz, R., Scherzinger, E., Lueder, G., Lehrach, H. and Wanker, E.E. (2001) Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol. Biol. Cell, 12, 1393-1407.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1393-1407
-
-
Waelter, S.1
Boeddrich, A.2
Lurz, R.3
Scherzinger, E.4
Lueder, G.5
Lehrach, H.6
Wanker, E.E.7
-
67
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin, M.T. and Beal, M.F. (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 443, 787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
68
-
-
14044264256
-
Disturbed Ca2+signaling and apoptosis of medium spiny neurons in Huntington's disease
-
Tang, T.S., Slow, E., Lupu, V., Stavrovskaya, I.G., Sugimori, M., Llinas, R., Kristal, B.S., Hayden, M.R. and Bezprozvanny, I. (2005) Disturbed Ca2+signaling and apoptosis of medium spiny neurons in Huntington's disease. Proc. Natl Acad. Sci. USA, 102, 2602-2607.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2602-2607
-
-
Tang, T.S.1
Slow, E.2
Lupu, V.3
Stavrovskaya, I.G.4
Sugimori, M.5
Llinas, R.6
Kristal, B.S.7
Hayden, M.R.8
Bezprozvanny, I.9
-
69
-
-
77956795163
-
Widespread protein aggregation as an inherent part of aging in C
-
David, D.C., Ollikainen, N., Trinidad, J.C., Cary, M.P., Burlingame, A.L. and Kenyon, C. (2010) Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol., 8, e1000450.
-
(2010)
Elegans. PLoS Biol.
, vol.8
-
-
David, D.C.1
Ollikainen, N.2
Trinidad, J.C.3
Cary, M.P.4
Burlingame, A.L.5
Kenyon, C.6
-
70
-
-
79952168998
-
Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration
-
Jafar-Nejad, P., Ward, C.S., Richman, R., Orr, H.T. and Zoghbi, H.Y. (2011) Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration. Proc. Natl Acad. Sci. USA, 108, 2142-2147.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 2142-2147
-
-
Jafar-Nejad, P.1
Ward, C.S.2
Richman, R.3
Orr, H.T.4
Zoghbi, H.Y.5
|