Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 11, 2006, Pages 4246-4251

  Bodner, Ruth A ^a   Outeiro, Tiago Fleming ^b   Altmann, Stephen ^b   Maxwell, Michele M ^b   Cho, Stephanie H ^a   Hyman, Bradley T ^b   McLean, Pamela J ^b   Young, Anne B ^b   Housman, David E ^a   Kazantsev, Aleksey G ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Misfolded proteins; Neurodegenerative disease

Indexed keywords

5 [4 (2 FLUOROBENZOYL) 1 PIPERAZINYL] 8 NITROQUINOLINE; 5 [4 (4 CHLOROBENZOYL) 1 PIPERAZINYL] 8 NITROQUINOLINE; 8 [4 (2 FLUOROBENZOYL) 1 PIPERAZINYL] 5 NITROQUINOLINE; ALPHA SYNUCLEIN; ETHYL 2 [[(4 METHOXYPHENYL)ACETYL]AMINO] 5 [[(2 METHOXYPHENYL)AMINO]CARBONYL] 4 METHYL 3 THIOPHENECARBOXYLATE; HUNTINGTIN; NITROQUINOLINE DERIVATIVE; PROTEASOME; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CYTOPATHOLOGY; CYTOTOXICITY; DEGENERATIVE DISEASE; DRUG SCREENING; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NONHUMAN; PARKINSON DISEASE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; DNA, RECOMBINANT; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; HUNTINGTON DISEASE; INCLUSION BODIES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PARKINSON DISEASE; PIPERAZINES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; QUINOLINES; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 33645235438     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0511256103     Document Type: Article

References (23)

1. Frydman, J. (2001) Annu. Rev. Biochem. 70, 603-647.
2. Glickman, M. H. & Ciechanover, A. (2002) Physiol. Rev. 82, 373-428.
3. Ross, C. A. & Pickart, C. M. (2004) Trends Cell Biol. 14, 703-711.
4. Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R. & Finkbeiner, S. (2004) Nature 431, 805-810.
5. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M. & Stefani, M. (2002) Nature 416, 507-511.
6. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W. & Glabe, C. G. (2003) Science 300, 486-489.
7. Taylor, J. P., Tanaka, F., Robitschek, J., Sandoval, C. M., Taye, A., Markovic-Plese, S. & Fischbeck, K. H. (2003) Hum. Mol. Genet. 12, 749-757.
8. Apostol, B. L., Kazantsev, A., Raffioni, S., Illes, K., Pallos, J., Bodai, L., Slepko, N., Bear, J. E., Gertler, F. B., Hersch, S., et al. (2003)Proc. Natl. Acad. Sci. USA 100, 5950-5955.
9. Bence, N. F., Sampat, R. M. & Kopito, R. R. (2001) Science 292, 1552-1555.
10. Bennett, E. J., Bence, N. F., Jayakumar, R. & Kopito, R. R. (2005) Mol. Cell 17, 351-365.
11. Holmberg, C. I., Staniszewski, K. E., Mensah, K. N., Matouschek, A. & Morimoto, R. I. (2004) EMBO J. 23, 4307-4318.
12. Jana, N. R., Zemskov, E. A., Wang, G. & Nukina, N. (2001) Hum. Mol. Genet. 10, 1049-1059.
13. Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N. & Goldberg, A. L. (2004) Mol. Cell 14, 95-104.
14. Verhoef, L. G., Lindsten, K., Masucci, M. G. & Dantuma, N. P. (2002) Hum. Mol. Genet. 11, 2689-2700.
15. Gilon, T., Chomsky, O. & Kulka, R. G. (1998) EMBO J. 17, 2759-2766.
16. McLean, P. J., Kawamata, H. & Hyman, B. T. (2001) Neuroscience 104, 901-912.
17. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) Science 276, 2045-2047.
18. Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Outra, A., Nussbaum, R., et al. (2003) Science 302, 841.
19. Klucken, J., Shin, Y., Masliah, E., Hyman, B. T. & McLean, P. J. (2004) J. Biol. Chem. 279, 25497-25502.
20. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E. & Neckers, L. M. (1994) Proc. Natl. Acad. Sci. USA 91, 8324-8328.
21. Thulasiraman, V. & Matts, R. L. (1996) Biochemistry 35, 13443-13450.
22. McLean, P. J., Kawamata, H., Shariff, S., Hewett, J., Sharma, N., Ueda, K., Breakefield, X. O. & Hyman, B. T. (2002) J. Neurochem. 83, 846-854.
23. Schumacher, R. J., Hansen, W. J., Freeman, B. C., Alnemri, E., Litwack, G. & Toft, D. O. (1996) Biochemistry 35, 14889-14898.