-
1
-
-
0018234789
-
The ontogeny of feeding and drinking: Effects of early brain damage
-
Almli CR (1978) The ontogeny of feeding and drinking: effects of early brain damage. Neurosci Biobehav Rev 2:281-300
-
(1978)
Neurosci Biobehav Rev
, vol.2
, pp. 281-300
-
-
Almli, C.R.1
-
2
-
-
0019760938
-
Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat
-
Leibowitz SF, Hammer NJ, Chang K (1981) Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Physiol Behav 27:1031-1040
-
(1981)
Physiol Behav
, vol.27
, pp. 1031-1040
-
-
Leibowitz, S.F.1
Hammer, N.J.2
Chang, K.3
-
3
-
-
0014668762
-
Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
-
Olney JW (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164:719-721
-
(1969)
Science
, vol.164
, pp. 719-721
-
-
Olney, J.W.1
-
4
-
-
0022872529
-
Effect of paraventricular nucleus lesions on body weight, food intake and insulin levels
-
Sims JS, Lorden JF (1986) Effect of paraventricular nucleus lesions on body weight, food intake and insulin levels. Behav Brain Res 22:265-281
-
(1986)
Behav Brain Res
, vol.22
, pp. 265-281
-
-
Sims, J.S.1
Lorden, J.F.2
-
5
-
-
0037387207
-
Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels
-
Ibrahim N, Bosch MA, Smart JL, Qiu J, Rubinstein M, Ronnekleiv OK, Low MJ, Kelly MJ (2003) Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 144:1331-1340
-
(2003)
Endocrinology
, vol.144
, pp. 1331-1340
-
-
Ibrahim, N.1
Bosch, M.A.2
Smart, J.L.3
Qiu, J.4
Rubinstein, M.5
Ronnekleiv, O.K.6
Low, M.J.7
Kelly, M.J.8
-
6
-
-
0027436690
-
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system
-
Roselli-Rhefus L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB, Cone RC (1993) Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A 90:8856-8860
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 8856-8860
-
-
Roselli-Rhefus, L.1
Mountjoy, K.G.2
Robbins, L.S.3
Mortrud, M.T.4
Low, M.J.5
Tatro, J.B.6
Entwistle, M.L.7
Simerly, R.B.8
Cone, R.C.9
-
7
-
-
27744469753
-
PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors
-
Ghamari-Langroudi M, Colmers WF, Cone RD (2005) PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors. Cell Metabol 2:191-199
-
(2005)
Cell Metabol
, vol.2
, pp. 191-199
-
-
Ghamari-Langroudi, M.1
Colmers, W.F.2
Cone, R.D.3
-
9
-
-
0020471229
-
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
-
Poulain DA, Wakerley JB (1982) Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin. Neuroscience 7:773-808
-
(1982)
Neuroscience
, vol.7
, pp. 773-808
-
-
Poulain, D.A.1
Wakerley, J.B.2
-
10
-
-
0034662879
-
Silent synapses in the developing hippocampus: Lack of functional AMPA receptors or low probability of glutamate release?
-
Gasparini S, Saviane C, Voronin LL, Cherubini E (2000) Silent synapses in the developing hippocampus: lack of functional AMPA receptors or low probability of glutamate release? Proc Natl Acad Sci U S A 97:9741-9746
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 9741-9746
-
-
Gasparini, S.1
Saviane, C.2
Voronin, L.L.3
Cherubini, E.4
-
11
-
-
0029864416
-
Leptin enters the brain by a saturable system independent of insulin
-
Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311
-
(1996)
Peptides
, vol.17
, pp. 305-311
-
-
Banks, W.A.1
Kastin, A.J.2
Huang, W.3
Jaspan, J.B.4
Maness, L.M.5
-
12
-
-
0035709038
-
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
-
Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ (2001) The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 25(Suppl 5):S63-S67
-
(2001)
Int J Obes Relat Metab Disord
, vol.25
, Issue.SUPPL. 5
-
-
Cone, R.D.1
Cowley, M.A.2
Butler, A.A.3
Fan, W.4
Marks, D.L.5
Low, M.J.6
-
13
-
-
0031054014
-
Leptin activates neurons in ventrobasal hypothalamus and brainstem
-
Elmquist JK, Ahima RS, Maratos Flier E, Flier JS, Saper CB (1997) Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138:839-842
-
(1997)
Endocrinology
, vol.138
, pp. 839-842
-
-
Elmquist, J.K.1
Ahima, R.S.2
Maratos Flier, E.3
Flier, J.S.4
Saper, C.B.5
-
14
-
-
0025612094
-
Localization of insulin receptor mRNA in rat brain by in situ hybridization
-
Marks JL, Porte D Jr, Stahl WL, Baskin DG (1990) Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127:3234-3236
-
(1990)
Endocrinology
, vol.127
, pp. 3234-3236
-
-
Marks, J.L.1
Porte Jr., D.2
Stahl, W.L.3
Baskin, D.G.4
-
15
-
-
0032744366
-
Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
-
Willesen M, Kristensen P, Romer J (1999) Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70:306-316
-
(1999)
Neuroendocrinology
, vol.70
, pp. 306-316
-
-
Willesen, M.1
Kristensen, P.2
Romer, J.3
-
16
-
-
0030062356
-
Expression cloning of a human brain neuropeptide Y Y2 receptor
-
Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (1996) Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol 49:224-228
-
(1996)
Mol Pharmacol
, vol.49
, pp. 224-228
-
-
Gehlert, D.R.1
Beavers, L.S.2
Johnson, D.3
Gackenheimer, S.L.4
Schober, D.A.5
Gadski, R.A.6
-
17
-
-
77249146406
-
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
-
Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, Elias CF, Elmquist JK (2010) Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci 30:2472-2479
-
(2010)
J Neurosci
, vol.30
, pp. 2472-2479
-
-
Williams, K.W.1
Margatho, L.O.2
Lee, C.E.3
Choi, M.4
Lee, S.5
Scott, M.M.6
Elias, C.F.7
Elmquist, J.K.8
-
18
-
-
0032436307
-
Leptin activates hypothalamic CART neurons projecting to the spinal cord
-
Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK (1998) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385
-
(1998)
Neuron
, vol.21
, pp. 1375-1385
-
-
Elias, C.F.1
Lee, C.2
Kelly, J.3
Aschkenasi, C.4
Ahima, R.S.5
Couceyro, P.R.6
Kuhar, M.J.7
Saper, C.B.8
Elmquist, J.K.9
-
19
-
-
1242296867
-
GABA release from proopiomelanocortin neurons
-
Hentges ST, Nishiyama M, Overstreet LS, Stenzel-Poore M, Williams JT, Low MJ (2004) GABA release from proopiomelanocortin neurons. J Neurosci 24:1578-1583
-
(2004)
J Neurosci
, vol.24
, pp. 1578-1583
-
-
Hentges, S.T.1
Nishiyama, M.2
Overstreet, L.S.3
Stenzel-Poore, M.4
Williams, J.T.5
Low, M.J.6
-
20
-
-
70350528730
-
Proopiomelanocortin expression in both GABA and glutamate neurons
-
Hentges ST, Otero-Corchon V, Pennock RL, King CM, Low MJ (2009) Proopiomelanocortin expression in both GABA and glutamate neurons. J Neurosci 29:13684-13690
-
(2009)
J Neurosci
, vol.29
, pp. 13684-13690
-
-
Hentges, S.T.1
Otero-Corchon, V.2
Pennock, R.L.3
King, C.M.4
Low, M.J.5
-
21
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB (2008) Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11:998-1000
-
(2008)
Nat Neurosci
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
Ye, C.P.2
Jones, J.E.3
Elmquist, J.K.4
Lowell, B.B.5
-
22
-
-
32444449631
-
Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
-
Smart JL, Tolle V, Low MJ (2006) Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J Clin Invest 116:495-505
-
(2006)
J Clin Invest
, vol.116
, pp. 495-505
-
-
Smart, J.L.1
Tolle, V.2
Low, M.J.3
-
23
-
-
26444540359
-
Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
-
Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA, Bloom SR (2005) Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J 19:1680-1682
-
(2005)
FASEB J
, vol.19
, pp. 1680-1682
-
-
Bewick, G.A.1
Gardiner, J.V.2
Dhillo, W.S.3
Kent, A.S.4
White, N.E.5
Webster, Z.6
Ghatei, M.A.7
Bloom, S.R.8
-
24
-
-
0037173035
-
Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice
-
Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Furtinger S, Jenkins A, Cox HM, Sperk G, Hokfelt T, Herzog H (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci U S A 99:8938-8943
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8938-8943
-
-
Sainsbury, A.1
Schwarzer, C.2
Couzens, M.3
Fetissov, S.4
Furtinger, S.5
Jenkins, A.6
Cox, H.M.7
Sperk, G.8
Hokfelt, T.9
Herzog, H.10
-
25
-
-
67549112681
-
Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
-
Wu Q, Boyle MP, Palmiter RD (2009) Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137:1225-1234
-
(2009)
Cell
, vol.137
, pp. 1225-1234
-
-
Wu, Q.1
Boyle, M.P.2
Palmiter, R.D.3
-
26
-
-
79951992387
-
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
-
Aponte Y, Atasoy D, Sternson SM (2011) AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci 14:351-355
-
(2011)
Nat Neurosci
, vol.14
, pp. 351-355
-
-
Aponte, Y.1
Atasoy, D.2
Sternson, S.M.3
-
27
-
-
79953307878
-
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
-
Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB (2011) Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Investig 121:1424-1428
-
(2011)
J Clin Investig
, vol.121
, pp. 1424-1428
-
-
Krashes, M.J.1
Koda, S.2
Ye, C.3
Rogan, S.C.4
Adams, A.C.5
Cusher, D.S.6
Maratos-Flier, E.7
Roth, B.L.8
Lowell, B.B.9
-
28
-
-
38449087113
-
In vivo evidence for inverse agonism of agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice
-
Tolle V, Low MJ (2008) In vivo evidence for inverse agonism of agouti-related peptide in the central nervous system of proopiomelanocortin- deficient mice. Diabetes 57:86-94
-
(2008)
Diabetes
, vol.57
, pp. 86-94
-
-
Tolle, V.1
Low, M.J.2
-
29
-
-
17844401704
-
Anatomy and regulation of the central melanocortin system
-
Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578
-
(2005)
Nat Neurosci
, vol.8
, pp. 571-578
-
-
Cone, R.D.1
-
30
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
31
-
-
84857418715
-
Defining POMC neurons using transgenic reagents: Impact of transient POMC expression in diverse immature neuronal populations
-
Padilla SL, Reef D, Zeltser LM (2012) Defining POMC neurons using transgenic reagents: impact of transient POMC expression in diverse immature neuronal populations. Endocrinology 153(2)
-
(2012)
Endocrinology
, vol.153
, Issue.2
-
-
Padilla, S.L.1
Reef, D.2
Zeltser, L.M.3
-
32
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D Jr (1996) Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2:589-593
-
(1996)
Nat Med
, vol.2
, pp. 589-593
-
-
Schwartz, M.W.1
Peskind, E.2
Raskind, M.3
Boyko, E.J.4
Porte Jr., D.5
-
33
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB (1998) Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395:535-547
-
(1998)
J Comp Neurol
, vol.395
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
34
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
Cheung CC, Clifton DK, Steiner RA (1997) Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinol 138:4489-4492
-
(1997)
Endocrinol
, vol.138
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
35
-
-
0029762615
-
Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
-
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P (1996) Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8:733-735
-
(1996)
J Neuroendocrinol
, vol.8
, pp. 733-735
-
-
Mercer, J.G.1
Hoggard, N.2
Williams, L.M.3
Lawrence, C.B.4
Hannah, L.T.5
Morgan, P.J.6
Trayhurn, P.7
-
36
-
-
66149141484
-
-
Wiley Subscription Services, New York
-
Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK (2009) Leptin targets in the mouse brain. Wiley Subscription Services, New York, pp 518-532
-
(2009)
Leptin Targets in the Mouse Brain
, pp. 518-532
-
-
Scott, M.M.1
Lachey, J.L.2
Sternson, S.M.3
Lee, C.E.4
Elias, C.F.5
Friedman, J.M.6
Elmquist, J.K.7
-
37
-
-
79960190012
-
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
-
Vong L, Ye C, Yang Z, Choi B, Chua S Jr, Lowell Bradford B (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71:142-154
-
(2011)
Neuron
, vol.71
, pp. 142-154
-
-
Vong, L.1
Ye, C.2
Yang, Z.3
Choi, B.4
Chua Jr., S.5
Lowell Bradford, B.6
-
38
-
-
33644665508
-
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
-
Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW (2005) Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 289:E1051-E1057
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Morrison, C.D.1
Morton, G.J.2
Niswender, K.D.3
Gelling, R.W.4
Schwartz, M.W.5
-
39
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
40
-
-
72649103549
-
Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
-
Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ (2010) Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metabol 11:77-83
-
(2010)
Cell Metabol
, vol.11
, pp. 77-83
-
-
Hayes, M.R.1
Skibicka, K.P.2
Leichner, T.M.3
Guarnieri, D.J.4
DiLeone, R.J.5
Bence, K.K.6
Grill, H.J.7
-
41
-
-
43049116846
-
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
-
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK (2008) Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Investig 118:1796-1805
-
(2008)
J Clin Investig
, vol.118
, pp. 1796-1805
-
-
Hill, J.W.1
Williams, K.W.2
Ye, C.3
Luo, J.4
Balthasar, N.5
Coppari, R.6
Cowley, M.A.7
Cantley, L.C.8
Lowell, B.B.9
Elmquist, J.K.10
-
42
-
-
75349092316
-
Leptin excites proopiomelanocortin neurons via activation of TRPC channels
-
Qiu J, Fang Y, Ronnekleiv OK, Kelly MJ (2010) Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci 30:1560-1565
-
(2010)
J Neurosci
, vol.30
, pp. 1560-1565
-
-
Qiu, J.1
Fang, Y.2
Ronnekleiv, O.K.3
Kelly, M.J.4
-
43
-
-
51249089235
-
Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways
-
Wang JH, Wang F, Yang MJ, Yu DF, Wu WN, Liu J, Ma LQ, Cai F, Chen JG (2008) Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways. Neuroscience 156:89-98
-
(2008)
Neuroscience
, vol.156
, pp. 89-98
-
-
Wang, J.H.1
Wang, F.2
Yang, M.J.3
Yu, D.F.4
Wu, W.N.5
Liu, J.6
Ma, L.Q.7
Cai, F.8
Chen, J.G.9
-
44
-
-
2142758640
-
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
-
van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D (2004) Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7:493-494
-
(2004)
Nat Neurosci
, vol.7
, pp. 493-494
-
-
Van Den Top, M.1
Lee, K.2
Whyment, A.D.3
Blanks, A.M.4
Spanswick, D.5
-
45
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
-
Choudhury AI, Heffron H et al (2005) The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
-
46
-
-
33745819212
-
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
-
Plum L, Ma X et al (2006) Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest 116(7):1886-1901
-
(2006)
J Clin Invest
, vol.116
, Issue.7
, pp. 1886-1901
-
-
Plum, L.1
Ma, X.2
-
47
-
-
34249651956
-
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC (2007) Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabol 5:438-449
-
(2007)
Cell Metabol
, vol.5
, pp. 438-449
-
-
Könner, A.C.1
Janoschek, R.2
Plum, L.3
Jordan, S.D.4
Rother, E.5
Ma, X.6
Xu, C.7
Enriori, P.8
Hampel, B.9
Barsh, G.S.10
Kahn, C.R.11
Cowley, M.A.12
Ashcroft, F.M.13
Brüning, J.C.14
-
48
-
-
17844379717
-
Hypothalamic KATP channels control hepatic glucose production
-
Pocai A, Lam TKT, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L (2005) Hypothalamic KATP channels control hepatic glucose production. Nature 434:1026-1031
-
(2005)
Nature
, vol.434
, pp. 1026-1031
-
-
Pocai, A.1
Lam, T.K.T.2
Gutierrez-Juarez, R.3
Obici, S.4
Schwartz, G.J.5
Bryan, J.6
Aguilar-Bryan, L.7
Rossetti, L.8
-
49
-
-
70350389400
-
Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
-
Al-Qassab H, Smith MA et al (2009) Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons. Cell Metabolism 10 (5):343-354
-
(2009)
Cell Metabolism
, vol.10
, Issue.5
, pp. 343-354
-
-
Al-Qassab, H.1
Smith, M.A.2
-
50
-
-
0033944152
-
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
-
Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML (2000) Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3:757-758
-
(2000)
Nat Neurosci
, vol.3
, pp. 757-758
-
-
Spanswick, D.1
Smith, M.A.2
Mirshamsi, S.3
Routh, V.H.4
Ashford, M.L.5
-
51
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
-
(2003)
Neuron
, vol.37
, pp. 649-661
-
-
Cowley, M.A.1
Smith, R.G.2
Diano, S.3
Tschop, M.4
Pronchuk, N.5
Grove, K.L.6
Strasburger, C.J.7
Bidlingmaier, M.8
Esterman, M.9
Heiman, M.L.10
Garcia-Segura, L.M.11
Nillni, E.A.12
Mendez, P.13
Low, M.J.14
Sotonyi, P.15
Friedman, J.M.16
Liu, H.17
Pinto, S.18
Colmers, W.F.19
Cone, R.D.20
Horvath, T.L.21
more..
-
52
-
-
33748560432
-
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
-
Abizaid A, Liu Z-W, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao X-B, Horvath TL (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Investig 116:3229-3239
-
(2006)
J Clin Investig
, vol.116
, pp. 3229-3239
-
-
Abizaid, A.1
Liu, Z.-W.2
Andrews, Z.B.3
Shanabrough, M.4
Borok, E.5
Elsworth, J.D.6
Roth, R.H.7
Sleeman, M.W.8
Picciotto, M.R.9
Tschöp, M.H.10
Gao, X.-B.11
Horvath, T.L.12
-
53
-
-
0037382853
-
Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
-
Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T (2003) Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52:948-956
-
(2003)
Diabetes
, vol.52
, pp. 948-956
-
-
Kohno, D.1
Gao, H.Z.2
Muroya, S.3
Kikuyama, S.4
Yada, T.5
-
54
-
-
37449021674
-
Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons
-
Kohno D, Sone H, Minokoshi Y, Yada T (2008) Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem Biophys Res Commun 366:388-392
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 388-392
-
-
Kohno, D.1
Sone, H.2
Minokoshi, Y.3
Yada, T.4
-
55
-
-
0033784980
-
Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats
-
Hewson AK, Dickson SL (2000) Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12:1047-1049
-
(2000)
J Neuroendocrinol
, vol.12
, pp. 1047-1049
-
-
Hewson, A.K.1
Dickson, S.L.2
-
56
-
-
0035513696
-
Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats
-
Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I (2001) Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50:2438-2443
-
(2001)
Diabetes
, vol.50
, pp. 2438-2443
-
-
Kamegai, J.1
Tamura, H.2
Shimizu, T.3
Ishii, S.4
Sugihara, H.5
Wakabayashi, I.6
-
57
-
-
0035843183
-
A role for ghrelin in the central regulation of feeding
-
Nakazato M, Murakami N et al (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194-198
-
(2001)
Nature
, vol.409
, pp. 194-198
-
-
Nakazato, M.1
Murakami, N.2
-
58
-
-
33751214825
-
Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures
-
Goto M, Arima H et al (2006) Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology 147 (11):5102-9
-
(2006)
Endocrinology
, vol.147
, Issue.11
, pp. 5102-5109
-
-
Goto, M.1
Arima, H.2
-
59
-
-
0037043704
-
Gut hormone PYY(3-36) physiologically inhibits food intake
-
Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654
-
(2002)
Nature
, vol.418
, pp. 650-654
-
-
Batterham, R.L.1
Cowley, M.A.2
Small, C.J.3
Herzog, H.4
Cohen, M.A.5
Dakin, C.L.6
Wren, A.M.7
Brynes, A.E.8
Low, M.J.9
Ghatei, M.A.10
Cone, R.D.11
Bloom, S.R.12
-
60
-
-
27744527442
-
Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: Implications for hypothalamic regulation of energy homeostasis
-
Acuna-Goycolea C, van den Pol AN (2005) Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis. J Neurosci 25:10510-10519
-
(2005)
J Neurosci
, vol.25
, pp. 10510-10519
-
-
Acuna-Goycolea, C.1
Van Den Pol, A.N.2
-
61
-
-
33847105586
-
Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin
-
Ma X, Zubcevic L, Bruning JC, Ashcroft FM, Burdakov D (2007) Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci 27:1529-1533
-
(2007)
J Neurosci
, vol.27
, pp. 1529-1533
-
-
Ma, X.1
Zubcevic, L.2
Bruning, J.C.3
Ashcroft, F.M.4
Burdakov, D.5
-
62
-
-
12144288387
-
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus
-
Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T (2004) Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19:1524-1534
-
(2004)
Eur J Neurosci
, vol.19
, pp. 1524-1534
-
-
Muroya, S.1
Funahashi, H.2
Yamanaka, A.3
Kohno, D.4
Uramura, K.5
Nambu, T.6
Shibahara, M.7
Kuramochi, M.8
Takigawa, M.9
Yanagisawa, M.10
Sakurai, T.11
Shioda, S.12
Yada, T.13
-
63
-
-
59649114144
-
Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin
-
Acuna-Goycolea C, van den Pol AN (2009) Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin. J Neurosci 29:1503-1513
-
(2009)
J Neurosci
, vol.29
, pp. 1503-1513
-
-
Acuna-Goycolea, C.1
Van Den Pol, A.N.2
-
64
-
-
0035809304
-
Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus
-
Guan JL, Saotome T, Wang QP, Funahashi H, Hori T, Tanaka S, Shioda S (2001) Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus. Neuroreport 12:547-551
-
(2001)
Neuroreport
, vol.12
, pp. 547-551
-
-
Guan, J.L.1
Saotome, T.2
Wang, Q.P.3
Funahashi, H.4
Hori, T.5
Tanaka, S.6
Shioda, S.7
-
65
-
-
0037775991
-
Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger
-
Burdakov D, Liss B, Ashcroft FM (2003) Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J Neurosci 23:4951-4957
-
(2003)
J Neurosci
, vol.23
, pp. 4951-4957
-
-
Burdakov, D.1
Liss, B.2
Ashcroft, F.M.3
-
67
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB (2004) Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42:983-991
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
68
-
-
41549111593
-
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
-
van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr (2008) Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149:1773-1785
-
(2008)
Endocrinology
, vol.149
, pp. 1773-1785
-
-
Van De Wall, E.1
Leshan, R.2
Xu, A.W.3
Balthasar, N.4
Coppari, R.5
Liu, S.M.6
Jo, Y.H.7
MacKenzie, R.G.8
Allison, D.B.9
Dun, N.J.10
Elmquist, J.11
Lowell, B.B.12
Barsh, G.S.13
De Luca, C.14
Myers Jr., M.G.15
Schwartz, G.J.16
Chua Jr., S.C.17
-
69
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, Lowell BB (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49:191-203
-
(2006)
Neuron
, vol.49
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
Coppari, R.11
Balthasar, N.12
Cowley, M.A.13
Chua, S.14
Elmquist, J.K.15
Lowell, B.B.16
-
70
-
-
78651063747
-
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
-
Ghamari-Langroudi M, Srisai D, Cone RD (2011) Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin. Proc Natl Acad Sci 108:355-360
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 355-360
-
-
Ghamari-Langroudi, M.1
Srisai, D.2
Cone, R.D.3
-
71
-
-
78649413249
-
Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity
-
Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD (2010) Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol 24:2366-2381
-
(2010)
Mol Endocrinol
, vol.24
, pp. 2366-2381
-
-
Ghamari-Langroudi, M.1
Vella, K.R.2
Srisai, D.3
Sugrue, M.L.4
Hollenberg, A.N.5
Cone, R.D.6
-
72
-
-
0021271479
-
Reduction of food intake and body weight by chronic intraventricular insulin infusion
-
Brief DJ, Davis JD (1984) Reduction of food intake and body weight by chronic intraventricular insulin infusion. Brain Res Bull 12:571-575
-
(1984)
Brain Res Bull
, vol.12
, pp. 571-575
-
-
Brief, D.J.1
Davis, J.D.2
-
73
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
Woods SC, Lotter EC, McKay LD, Porte D Jr (1979) Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282:503-505
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr., D.4
-
74
-
-
0027361094
-
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
-
Baura GD, Foster DM, Porte D Jr, Kahn SE, Bergman RN, Cobelli C, Schwartz MW (1993) Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest 92:1824-1830
-
(1993)
J Clin Invest
, vol.92
, pp. 1824-1830
-
-
Baura, G.D.1
Foster, D.M.2
Porte Jr., D.3
Kahn, S.E.4
Bergman, R.N.5
Cobelli, C.6
Schwartz, M.W.7
-
75
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
Havrankova J, Fau-Roth J, Roth J, Fau-Brownstein M, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272:827-829
-
(1978)
Nature
, vol.272
, pp. 827-829
-
-
Havrankova, J.1
Fau-Roth, J.2
Roth, J.3
Fau-Brownstein, M.4
Brownstein, M.5
-
76
-
-
45749158925
-
Central insulin action regulates peripheral glucose and fat metabolism in mice
-
Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC (2008) Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Investig 118:2132-2147
-
(2008)
J Clin Investig
, vol.118
, pp. 2132-2147
-
-
Koch, L.1
Wunderlich, F.T.2
Seibler, J.3
Könner, A.C.4
Hampel, B.5
Irlenbusch, S.6
Brabant, G.7
Kahn, C.R.8
Schwenk, F.9
Brüning, J.C.10
-
77
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L (2002) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376-1382
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
78
-
-
0036267472
-
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
-
Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L (2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566-572
-
(2002)
Nat Neurosci
, vol.5
, pp. 566-572
-
-
Obici, S.1
Feng, Z.2
Karkanias, G.3
Baskin, D.G.4
Rossetti, L.5
-
79
-
-
33645071314
-
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
-
Gelling RW, Morton GJ, Morrison CD, Niswender KD, Myers MG Jr, Rhodes CJ, Schwartz MW (2006) Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metabol 3:67-73
-
(2006)
Cell Metabol
, vol.3
, pp. 67-73
-
-
Gelling, R.W.1
Morton, G.J.2
Morrison, C.D.3
Niswender, K.D.4
Myers Jr., M.G.5
Rhodes, C.J.6
Schwartz, M.W.7
-
80
-
-
77449144768
-
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
-
Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D (2010) Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59:337-346
-
(2010)
Diabetes
, vol.59
, pp. 337-346
-
-
Lin, H.V.1
Plum, L.2
Ono, H.3
Gutiérrez-Juárez, R.4
Shanabrough, M.5
Borok, E.6
Horvath, T.L.7
Rossetti, L.8
Accili, D.9
-
81
-
-
52449086180
-
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
-
van den Hoek AM, van Heijningen C, Schrö-van der Elst JP, Ouwens DM, Havekes LM, Romijn JA, Kalsbeek A, Pijl H (2008) Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation. Diabetes 57:2304-2310
-
(2008)
Diabetes
, vol.57
, pp. 2304-2310
-
-
Van Den Hoek, A.M.1
Van Heijningen, C.2
Schrö-van Der Elst, J.P.3
Ouwens, D.M.4
Havekes, L.M.5
Romijn, J.A.6
Kalsbeek, A.7
Pijl, H.8
-
82
-
-
20644434143
-
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus
-
Carvalheira JB, Torsoni MA, Ueno M, Amaral ME, Araujo EP, Velloso LA, Gontijo JA, Saad MJ (2005) Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res 13:48-57
-
(2005)
Obes Res
, vol.13
, pp. 48-57
-
-
Carvalheira, J.B.1
Torsoni, M.A.2
Ueno, M.3
Amaral, M.E.4
Araujo, E.P.5
Velloso, L.A.6
Gontijo, J.A.7
Saad, M.J.8
-
83
-
-
30044447631
-
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
-
Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metabol 2:411-420
-
(2005)
Cell Metabol
, vol.2
, pp. 411-420
-
-
Morton, G.J.1
Gelling, R.W.2
Niswender, K.D.3
Morrison, C.D.4
Rhodes, C.J.5
Schwartz, M.W.6
-
84
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW (2003) Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231
-
(2003)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
Olson, R.4
Baskin, D.G.5
Myers Jr., M.G.6
Seeley, R.J.7
Schwartz, M.W.8
-
85
-
-
0035950093
-
Intracellular signaling: Key enzyme in leptin-induced anorexia
-
Niswender K, Morton G, Stearns W, Rhodes C, Myers M, Schwartz M (2001) Intracellular signaling: key enzyme in leptin-induced anorexia. Nature 413:794-795
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.1
Morton, G.2
Stearns, W.3
Rhodes, C.4
Myers, M.5
Schwartz, M.6
-
86
-
-
72449192299
-
Ghrelin in the regulation of body weight and metabolism
-
Castañeda TR, Tong J, Datta R, Culler M, Tschöp MH (2010) Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol 31:44-60
-
(2010)
Front Neuroendocrinol
, vol.31
, pp. 44-60
-
-
Castañeda, T.R.1
Tong, J.2
Datta, R.3
Culler, M.4
Tschöp, M.H.5
-
87
-
-
9444246501
-
A receptor in pituitary and hypothalamus that functions in growth hormone release
-
Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Van der Ploeg LH et al (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
-
(1996)
Science
, vol.273
, pp. 974-977
-
-
Howard, A.D.1
Feighner, S.D.2
Cully, D.F.3
Arena, J.P.4
Liberator, P.A.5
Rosenblum, C.I.6
Hamelin, M.7
Hreniuk, D.L.8
Palyha, O.C.9
Anderson, J.10
Paress, P.S.11
Diaz, C.12
Chou, M.13
Liu, K.K.14
McKee, K.K.15
Pong, S.S.16
Chaung, L.Y.17
Elbrecht, A.18
Dashkevicz, M.19
Heavens, R.20
Rigby, M.21
Sirinathsinghji, D.J.22
Dean, D.C.23
Melillo, D.G.24
Van Der Ploeg, L.H.25
more..
-
88
-
-
0034676324
-
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
-
Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV (2000) Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 43:4370-4376
-
(2000)
J Med Chem
, vol.43
, pp. 4370-4376
-
-
Bednarek, M.A.1
Feighner, S.D.2
Pong, S.S.3
McKee, K.K.4
Hreniuk, D.L.5
Silva, M.V.6
Warren, V.A.7
Howard, A.D.8
Van Der Ploeg, L.H.9
Heck, J.V.10
-
89
-
-
33746739498
-
Ghrelin and the short- and long-term regulation of appetite and body weight
-
Cummings DE (2006) Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol Behav 89:71-84
-
(2006)
Physiol Behav
, vol.89
, pp. 71-84
-
-
Cummings, D.E.1
-
90
-
-
0034970034
-
Post-prandial decrease of circulating human ghrelin levels
-
Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C (2001) Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Investig 24:RC19-RC21
-
(2001)
J Endocrinol Investig
, vol.24
-
-
Tschop, M.1
Wawarta, R.2
Riepl, R.L.3
Friedrich, S.4
Bidlingmaier, M.5
Landgraf, R.6
Folwaczny, C.7
-
91
-
-
0038031634
-
Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
-
Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T (2003) Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett 342:183-186
-
(2003)
Neurosci Lett
, vol.342
, pp. 183-186
-
-
Sakata, I.1
Yamazaki, M.2
Inoue, K.3
Hayashi, Y.4
Kangawa, K.5
Sakai, T.6
-
92
-
-
29044434688
-
Expression of ghrelin receptor mRNA in the rat and the mouse brain
-
Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK (2006) Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528-548
-
(2006)
J Comp Neurol
, vol.494
, pp. 528-548
-
-
Zigman, J.M.1
Jones, J.E.2
Lee, C.E.3
Saper, C.B.4
Elmquist, J.K.5
-
93
-
-
0034816726
-
Ghrelin acts in the central nervous system to stimulate gastric acid secretion
-
Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S (2001) Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280:904-907
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 904-907
-
-
Date, Y.1
Nakazato, M.2
Murakami, N.3
Kojima, M.4
Kangawa, K.5
Matsukura, S.6
-
95
-
-
0036787457
-
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
-
Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
-
(2002)
Gastroenterology
, vol.123
, pp. 1120-1128
-
-
Date, Y.1
Murakami, N.2
Toshinai, K.3
Matsukura, S.4
Niijima, A.5
Matsuo, H.6
Kangawa, K.7
Nakazato, M.8
-
96
-
-
33748946416
-
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus
-
Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, Miyazato M, Kokame K, Ishizuka Y, Ishida Y, Kageyama H, Shioda S, Kangawa K, Nakazato M (2006) Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metabol 4:323-331
-
(2006)
Cell Metabol
, vol.4
, pp. 323-331
-
-
Date, Y.1
Shimbara, T.2
Koda, S.3
Toshinai, K.4
Ida, T.5
Murakami, N.6
Miyazato, M.7
Kokame, K.8
Ishizuka, Y.9
Ishida, Y.10
Kageyama, H.11
Shioda, S.12
Kangawa, K.13
Nakazato, M.14
-
97
-
-
33751120393
-
Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
-
Arnold M, Mura A, Langhans W, Geary N (2006) Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 26:11052-11060
-
(2006)
J Neurosci
, vol.26
, pp. 11052-11060
-
-
Arnold, M.1
Mura, A.2
Langhans, W.3
Geary, N.4
-
98
-
-
0035143816
-
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
-
Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K (2001) Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227-232
-
(2001)
Diabetes
, vol.50
, pp. 227-232
-
-
Shintani, M.1
Ogawa, Y.2
Ebihara, K.3
Aizawa-Abe, M.4
Miyanaga, F.5
Takaya, K.6
Hayashi, T.7
Inoue, G.8
Hosoda, K.9
Kojima, M.10
Kangawa, K.11
Nakao, K.12
-
99
-
-
25144473425
-
Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice
-
Shaw AM, Irani BG, Moore MC, Haskell-Luevano C, Millard WJ (2005) Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Peptides 26:1720-1727
-
(2005)
Peptides
, vol.26
, pp. 1720-1727
-
-
Shaw, A.M.1
Irani, B.G.2
Moore, M.C.3
Haskell-Luevano, C.4
Millard, W.J.5
-
100
-
-
45549092924
-
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system
-
Kola B, Farkas I, Christ-Crain M, Wittmann G, Lolli F, Amin F, Harvey-White J, Liposits Z, Kunos G, Grossman AB, Fekete C, Korbonits M (2008) The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 3:e1797
-
(2008)
PLoS One
, vol.3
-
-
Kola, B.1
Farkas, I.2
Christ-Crain, M.3
Wittmann, G.4
Lolli, F.5
Amin, F.6
Harvey-White, J.7
Liposits, Z.8
Kunos, G.9
Grossman, A.B.10
Fekete, C.11
Korbonits, M.12
-
101
-
-
34249829624
-
Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
-
Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T (2007) Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148:2251-2263
-
(2007)
Endocrinology
, vol.148
, pp. 2251-2263
-
-
Kohno, D.1
Nakata, M.2
Maekawa, F.3
Fujiwara, K.4
Maejima, Y.5
Kuramochi, M.6
Shimazaki, T.7
Okano, H.8
Onaka, T.9
Yada, T.10
-
102
-
-
34249293852
-
Synaptic plasticity in energy balance regulation
-
Horvath TL (2006) Synaptic plasticity in energy balance regulation. Obesity 14:228S-233S
-
(2006)
Obesity
, vol.14
-
-
Horvath, T.L.1
-
103
-
-
79952267286
-
Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus
-
Cui RJ, Li X, Appleyard SM (2011) Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus. J Neurosci 31:3484-3492
-
(2011)
J Neurosci
, vol.31
, pp. 3484-3492
-
-
Cui, R.J.1
Li, X.2
Appleyard, S.M.3
-
105
-
-
31944442281
-
The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema
-
Gilg S, Lutz TA (2006) The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema. Physiol Behav 87:353-359
-
(2006)
Physiol Behav
, vol.87
, pp. 353-359
-
-
Gilg, S.1
Lutz, T.A.2
-
106
-
-
0022398837
-
Human distribution and release of a putative new gut hormone, peptide YY
-
Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR (1985) Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89:1070-1077
-
(1985)
Gastroenterology
, vol.89
, pp. 1070-1077
-
-
Adrian, T.E.1
Ferri, G.L.2
Bacarese-Hamilton, A.J.3
Fuessl, H.S.4
Polak, J.M.5
Bloom, S.R.6
-
107
-
-
0036163841
-
Peptide YY: A key mediator of orexigenic behavior
-
Hagan MM (2002) Peptide YY: a key mediator of orexigenic behavior. Peptides 23:377-382
-
(2002)
Peptides
, vol.23
, pp. 377-382
-
-
Hagan, M.M.1
-
108
-
-
0022392297
-
Peptide YY (PYY), a potent orexigenic agent
-
Morley JE, Levine AS, Grace M, Kneip J (1985) Peptide YY (PYY), a potent orexigenic agent. Brain Res 341:200-203
-
(1985)
Brain Res
, vol.341
, pp. 200-203
-
-
Morley, J.E.1
Levine, A.S.2
Grace, M.3
Kneip, J.4
-
109
-
-
0030829873
-
Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide Ycontaining neurons of the rat hypothalamic arcuate nucleus
-
Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide Ycontaining neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66:393-408
-
(1997)
Neuroendocrinology
, vol.66
, pp. 393-408
-
-
Broberger, C.1
Landry, M.2
Wong, H.3
Walsh, J.N.4
Hokfelt, T.5
-
110
-
-
2542444495
-
Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism
-
Halatchev IG, Ellacott KL, Fan W, Cone RD (2004) Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145:2585-2590
-
(2004)
Endocrinology
, vol.145
, pp. 2585-2590
-
-
Halatchev, I.G.1
Ellacott, K.L.2
Fan, W.3
Cone, R.D.4
-
111
-
-
12144291698
-
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
-
Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S (2004) Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci U S A 101:4695-4700
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4695-4700
-
-
Challis, B.G.1
Coll, A.P.2
Yeo, G.S.3
Pinnock, S.B.4
Dickson, S.L.5
Thresher, R.R.6
Dixon, J.7
Zahn, D.8
Rochford, J.J.9
White, A.10
Oliver, R.L.11
Millington, G.12
Aparicio, S.A.13
Colledge, W.H.14
Russ, A.P.15
Carlton, M.B.16
O'Rahilly, S.17
-
112
-
-
3442879939
-
Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin
-
Martin NM, Small CJ, Sajedi A, Patterson M, Ghatei MA, Bloom SR (2004) Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin. Int J Obes Relat Metab Disord 28:886-893
-
(2004)
Int J Obes Relat Metab Disord
, vol.28
, pp. 886-893
-
-
Martin, N.M.1
Small, C.J.2
Sajedi, A.3
Patterson, M.4
Ghatei, M.A.5
Bloom, S.R.6
-
113
-
-
20244380014
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
Arch, J.R.11
Buckingham, R.E.12
Haynes, A.C.13
Carr, S.A.14
Annan, R.S.15
McNulty, D.E.16
Liu, W.S.17
Terrett, J.A.18
Elshourbagy, N.A.19
Bergsma, D.J.20
Yanagisawa, M.21
more..
-
114
-
-
0033081871
-
Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
-
Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19:1072-1087
-
(1999)
J Neurosci
, vol.19
, pp. 1072-1087
-
-
Horvath, T.L.1
Diano, S.2
Van Den Pol, A.N.3
-
115
-
-
0036460171
-
Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: Focus on orexin targets involved in control of food and water intake
-
Backberg M, Hervieu G, Wilson S, Meister B (2002) Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci 15:315-328
-
(2002)
Eur J Neurosci
, vol.15
, pp. 315-328
-
-
Backberg, M.1
Hervieu, G.2
Wilson, S.3
Meister, B.4
-
116
-
-
0037199670
-
Ultrastructural localization of orexin-1 receptor in pre- and post-synaptic neurons in the rat arcuate nucleus
-
Guan JL, Suzuki R, Funahashi H, Wang QP, Kageyama H, Uehara K, Yamada S, Tsurugano S, Shioda S (2002) Ultrastructural localization of orexin-1 receptor in pre- and post-synaptic neurons in the rat arcuate nucleus. Neurosci Lett 329:209-212
-
(2002)
Neurosci Lett
, vol.329
, pp. 209-212
-
-
Guan, J.L.1
Suzuki, R.2
Funahashi, H.3
Wang, Q.P.4
Kageyama, H.5
Uehara, K.6
Yamada, S.7
Tsurugano, S.8
Shioda, S.9
-
117
-
-
0033811876
-
Orexin A activates leptin-responsive neurons in the arcuate nucleus
-
Rauch M, Riediger T, Schmid HA, Simon E (2000) Orexin A activates leptin-responsive neurons in the arcuate nucleus. Pflugers Archiv 440:699-703
-
(2000)
Pflugers Archiv
, vol.440
, pp. 699-703
-
-
Rauch, M.1
Riediger, T.2
Schmid, H.A.3
Simon, E.4
-
118
-
-
3242721424
-
Autocrine feedback inhibition of plateau potentials terminates phasic bursts in magnocellular neurosecretory cells of the rat supraoptic nucleus
-
Brown CH, Bourque CW (2004) Autocrine feedback inhibition of plateau potentials terminates phasic bursts in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol 557:949-960
-
(2004)
J Physiol
, vol.557
, pp. 949-960
-
-
Brown, C.H.1
Bourque, C.W.2
-
119
-
-
0342804352
-
Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus
-
Jegou S, Boutelet I, Vaudry H (2000) Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus. J Neuroendocrinol 12:501-505
-
(2000)
J Neuroendocrinol
, vol.12
, pp. 501-505
-
-
Jegou, S.1
Boutelet, I.2
Vaudry, H.3
-
120
-
-
0034727855
-
D-Amino acid scan of gamma-melanocyte-stimulating hormone: Importance of Trp(8) on human MC3 receptor selectivity
-
Grieco P, Balse PM, Weinberg D, MacNeil T, Hruby VJ (2000) D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J Med Chem 43:4998-5002
-
(2000)
J Med Chem
, vol.43
, pp. 4998-5002
-
-
Grieco, P.1
Balse, P.M.2
Weinberg, D.3
MacNeil, T.4
Hruby, V.J.5
-
121
-
-
31544453062
-
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
-
Marks DL, Hruby V, Brookhart G, Cone RD (2006) The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides 27:259-264
-
(2006)
Peptides
, vol.27
, pp. 259-264
-
-
Marks, D.L.1
Hruby, V.2
Brookhart, G.3
Cone, R.D.4
-
122
-
-
33846191084
-
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
-
Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford ML (2007) Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. J Physiol 578:425-438
-
(2007)
J Physiol
, vol.578
, pp. 425-438
-
-
Smith, M.A.1
Hisadome, K.2
Al-Qassab, H.3
Heffron, H.4
Withers, D.J.5
Ashford, M.L.6
-
123
-
-
79955930421
-
Physiological roles of the melanocortin MC3 receptor
-
Renquist BJ, Lippert RN, Sebag JA, Ellacott KLJ, Cone RD (2011) Physiological roles of the melanocortin MC3 receptor. Eur J Pharmacol 660:13-20
-
(2011)
Eur J Pharmacol
, vol.660
, pp. 13-20
-
-
Renquist, B.J.1
Lippert, R.N.2
Sebag, J.A.3
Ellacott, K.L.J.4
Cone, R.D.5
-
124
-
-
0026652339
-
Effect of opioid receptor antagonism on proopiomelanocortin peptide levels and gene expression in the hypothalamus
-
Markowitz CE, Berkowitz KM, Jaffe SB, Wardlaw SL (1992) Effect of opioid receptor antagonism on proopiomelanocortin peptide levels and gene expression in the hypothalamus. Mol Cell Neurosci 3:184-190
-
(1992)
Mol Cell Neurosci
, vol.3
, pp. 184-190
-
-
Markowitz, C.E.1
Berkowitz, K.M.2
Jaffe, S.B.3
Wardlaw, S.L.4
-
125
-
-
0028222432
-
Effect of opioid antagonism on [beta]-endorphin processing and proopiomelanocortinpeptide release in the hypothalamus
-
Jaffe SB, Sobieszczyk S, Wardlaw SL (1994) Effect of opioid antagonism on [beta]-endorphin processing and proopiomelanocortinpeptide release in the hypothalamus. Brain Res 648:24-31
-
(1994)
Brain Res
, vol.648
, pp. 24-31
-
-
Jaffe, S.B.1
Sobieszczyk, S.2
Wardlaw, S.L.3
-
126
-
-
0025108381
-
Opioids hyperpolarize beta-endorphin neurons via mu-receptor activation of a potassium conductance
-
Kelly MJ, Loose MD, Ronnekleiv OK (1990) Opioids hyperpolarize beta-endorphin neurons via mu-receptor activation of a potassium conductance. Neuroendocrinology 52:268-275
-
(1990)
Neuroendocrinology
, vol.52
, pp. 268-275
-
-
Kelly, M.J.1
Loose, M.D.2
Ronnekleiv, O.K.3
-
127
-
-
0033064348
-
[mu]-Opioid receptor mRNA expression in proopiomelanocortin neurons of the rat arcuate nucleus
-
Bouret S, Prevot V, Croix D, Jégou S, Vaudry H, Stefano GB, Beauvillain J-C, Mitchell V (1999) [mu]-Opioid receptor mRNA expression in proopiomelanocortin neurons of the rat arcuate nucleus. Mol Brain Res 70:155-158
-
(1999)
Mol Brain Res
, vol.70
, pp. 155-158
-
-
Bouret, S.1
Prevot, V.2
Croix, D.3
Jégou, S.4
Vaudry, H.5
Stefano, G.B.6
Beauvillain, J.-C.7
Mitchell, V.8
-
128
-
-
0026463547
-
Neuropeptide Y innervation of b-endorphin-containing cells in the rat mediobasal hypothalamus. A light and electron microscopic double-immunostaining study
-
Horvath T, Naftolin F, Kalra S, Leranth C (1992) Neuropeptide Y innervation of b-endorphin-containing cells in the rat mediobasal hypothalamus. A light and electron microscopic double-immunostaining study. Endo 131:2461-2467
-
(1992)
Endo
, vol.131
, pp. 2461-2467
-
-
Horvath, T.1
Naftolin, F.2
Kalra, S.3
Leranth, C.4
-
129
-
-
33845582594
-
A central thermogenic-like mechanism in feeding regulation: An interplay between arcuate nucleus T3 and UCP2
-
Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S (2007) A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabol 5:21-33
-
(2007)
Cell Metabol
, vol.5
, pp. 21-33
-
-
Coppola, A.1
Liu, Z.W.2
Andrews, Z.B.3
Paradis, E.4
Roy, M.C.5
Friedman, J.M.6
Ricquier, D.7
Richard, D.8
Horvath, T.L.9
Gao, X.B.10
Diano, S.11
-
130
-
-
0033567543
-
The anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in brain
-
Bagnol T, Lu XY, Kaelin CB, Day HE, Ollmann M, Gantz I, Akil H, Barsh GS, Watson SJ (1999) The anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J Neurosci 19:RC26
-
(1999)
J Neurosci
, vol.19
-
-
Bagnol, T.1
Lu, X.Y.2
Kaelin, C.B.3
Day, H.E.4
Ollmann, M.5
Gantz, I.6
Akil, H.7
Barsh, G.S.8
Watson, S.J.9
-
131
-
-
33846435768
-
Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety
-
Singru PS, Sanchez E, Fekete C, Lechan RM (2007) Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety. Endocrinology 148:638-646
-
(2007)
Endocrinology
, vol.148
, pp. 638-646
-
-
Singru, P.S.1
Sanchez, E.2
Fekete, C.3
Lechan, R.M.4
-
132
-
-
33644861253
-
Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus
-
Menyhert J, Wittmann G, Hrabovszky E, Keller E, Liposits Z, Fekete C (2006) Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus. Brain Res 1076:101-105
-
(2006)
Brain Res
, vol.1076
, pp. 101-105
-
-
Menyhert, J.1
Wittmann, G.2
Hrabovszky, E.3
Keller, E.4
Liposits, Z.5
Fekete, C.6
-
133
-
-
0036627597
-
Multiple neural systems controlling food intake and body weight
-
Berthoud H-R (2002) Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 26:393-428
-
(2002)
Neurosci Biobehav Rev
, vol.26
, pp. 393-428
-
-
Berthoud, H.-R.1
-
134
-
-
27744457512
-
Topographic mapping of VMH [rarr] arcuate nucleus microcircuits and their reorganization by fasting
-
Sternson SM, Shepherd GMG, Friedman JM (2005) Topographic mapping of VMH [rarr] arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci 8:1356-1363
-
(2005)
Nat Neurosci
, vol.8
, pp. 1356-1363
-
-
Sternson, S.M.1
Shepherd, G.M.G.2
Friedman, J.M.3
-
135
-
-
79956308808
-
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis
-
Louis GW, Greenwald-Yarnell M, Phillips R, Coolen LM, Lehman MN, Myers MG (2011) Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology 152:2302-2310
-
(2011)
Endocrinology
, vol.152
, pp. 2302-2310
-
-
Louis, G.W.1
Greenwald-Yarnell, M.2
Phillips, R.3
Coolen, L.M.4
Lehman, M.N.5
Myers, M.G.6
-
136
-
-
78049297525
-
Outstanding scientific achievement award lecture 2010: Deconstructing leptin: From signals to circuits
-
Myers MG (2010) Outstanding scientific achievement award lecture 2010: deconstructing leptin: from signals to circuits. Diabetes 59:2708-2714
-
(2010)
Diabetes
, vol.59
, pp. 2708-2714
-
-
Myers, M.G.1
-
137
-
-
0033038418
-
Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
-
Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100
-
(1999)
Endocr Rev
, vol.20
, pp. 68-100
-
-
Kalra, S.P.1
Dube, M.G.2
Pu, S.3
Xu, B.4
Horvath, T.L.5
Kalra, P.S.6
-
138
-
-
33846046623
-
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
-
Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao X-B, Mobbs C, Shulman GI, Diano S, Horvath TL (2007) Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med 13:89-94
-
(2007)
Nat Med
, vol.13
, pp. 89-94
-
-
Gao, Q.1
Mezei, G.2
Nie, Y.3
Rao, Y.4
Choi, C.S.5
Bechmann, I.6
Leranth, C.7
Toran-Allerand, D.8
Priest, C.A.9
Roberts, J.L.10
Gao, X.-B.11
Mobbs, C.12
Shulman, G.I.13
Diano, S.14
Horvath, T.L.15
-
139
-
-
78049525571
-
Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice
-
Gyengesi E, Liu Z-W, D'Agostino G, Gan G, Horvath TL, Gao X-B, Diano S (2010) Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice. Endocrinology 151:5395-5402
-
(2010)
Endocrinology
, vol.151
, pp. 5395-5402
-
-
Gyengesi, E.1
Liu, Z.-W.2
D'Agostino, G.3
Gan, G.4
Horvath, T.L.5
Gao, X.-B.6
Diano, S.7
-
140
-
-
1842529267
-
Rapid rewiring of arcuate nucleus feeding circuits by leptin
-
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304:110-115
-
(2004)
Science
, vol.304
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
141
-
-
14244254196
-
Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/agouti-related protein neurons
-
Takahashi KA, Cone RD (2005) Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/agouti-related protein neurons. Endocrinology 146:1043-1047
-
(2005)
Endocrinology
, vol.146
, pp. 1043-1047
-
-
Takahashi, K.A.1
Cone, R.D.2
-
142
-
-
33745178513
-
The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus
-
Perello M, Stuart RC, Nillni EA (2006) The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 147:3296-3306
-
(2006)
Endocrinology
, vol.147
, pp. 3296-3306
-
-
Perello, M.1
Stuart, R.C.2
Nillni, E.A.3
|