The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema

Physiology and Behavior

Volumn 87, Issue 2, 2006, Pages 353-359

  Gilg, S ^a   Lutz, T A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Area postrema; Food intake; Ghrelin; Vagus nerve

Indexed keywords

APPETITE STIMULANT; GHRELIN;

ANIMAL EXPERIMENT; AREA POSTREMA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; LIGHT DARK CYCLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHOMBENCEPHALON;

EID: 31944442281     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2005.10.015     Document Type: Article

References (34)

1. M. Kojima, H. Hosoda, H. Matsuo, and K. Kangawa Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor Trends Endocrinol Metab 12 2001 118 122
2. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a GH-releasing acylated peptide from stomach Nature 402 1999 656 660
3. Y. Date, N. Murakami, M. Kojima, T. Kuroiwa, S. Matsukura, and K. Kangawa Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats Biochem Biophys Res Commun 275 2000 477 480
4. A. Inui Ghrelin: an orexigenic and somatotrophic signal from the stomach Nat Rev 2 2001 551 561
5. A.M. Wren, C.J. Small, H.L. Ward, K.G. Murphy, C.L. Dakin, and S. Taheri The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion Endocrinology 141 2000 4325 4328
6. D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
7. M. Tschöp, D.L. Smiley, and M.L. Heimann Ghrelin induces adiposity in rodents Nature 407 2000 908 913
8. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
9. T.L. Horvath, S. Diano, P. Sotonyi, M. Heiman, and M. Tschöp Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective Endocrinology 142 2001 4163 4169
10. A. Asakawa, A.A. Inui, T. Kaga, H. Yuzuriha, T. Nagata, and N. Ueno Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin Gastroenterology 120 2001 337 345
11. Y. Masuda, T. Tanaka, N. Inomata, N. Ohnuma, S. Tanaka, and Z. Itoh Ghrelin stimulates gastric acid secretion and motility in rats Biochem Biophys Res Commun 276 2000 905 908
12. Y. Date, M. Nakazato, N. Murakami, M. Kojima, K. Kangawa, and S. Matsukura Ghrelin acts in the central nervous system to stimulate gastric acid secretion Biochem Biophys Res Commun 280 2001 904 907
13. M. Arnold, A. Mura, N. Geary, and W. Langhans Subdiaphragmatic vagal afferents are not necessary for the feeding-stimulatory effect of intraperitoneally administered ghrelin Abstr Soc Neurosci 34 2004 194.8
14. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Brain Res Mol Brain Res 48 1997 23 29
15. G.S. Tannenbaum, M. Lapointe, A. Beaudet, and A.D. Howard Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus Endocrinology 139 1998 4420 4423
16. M.G. Willesen, P. Kristensen, and J. Romer Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat Neuroendocrinology 70 1999 306 316
17. J.K. Elmqvist, C. Bjorbaek, R.S. Ahima, J.S. Flier, and C.B. Saper Distributions of leptin receptor mRNA isoforms in the rat brain J Comp Neurol 395 1998 535 547
18. M. Träbert, T. Riediger, S. Whitebread, E. Scharrer, and H.A. Schmid Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus J Neuroendocrinol 14 2002 580 586
19. T. Riediger, M. Traebert, H.A. Schmid, C. Scheel, T.A. Lutz, and E. Scharrer Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus Neurosci Lett 341 2003 151 155
20. T.A. Lutz, N. Geary, M.M. Szabady, E. Del Prete, and E. Scharrer Amylin decreases meal size in rats Physiol Behav 58 1995 1197 1202
21. J.J. McGlone, S. Ritter, and K.W. Kelley The antiaggressive effect of lithium is abolished by area postrema lesion Physiol Behav 24 1980 1095 1100
22. T.A. Lutz, M. Senn, J. Althaus, E. Del Prete, F. Ehrensperger, and E. Scharrer Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats Peptides 19 1998 309 317
23. A.M. Wren, C.J. Small, C.R. Abbott, W.S. Dhillo, L.J. Seal, and M.A. Cohen Ghrelin causes hyperphagia and obesity in rats Diabetes 50 2001 2540 2547
24. T. Shiiya, M. Nakazato, M. Mizuta, Y. Date, M.S. Mondal, and M. Tanaka Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion J Clin Endocrinol Metab 87 2002 240 244
25. K. Toshinai, M.S. Mondal, M. Nakazato, Y. Date, N. Murakami, and M. Kojima Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration Biochem Biophys Res Commun 281 2001 1220 1225
26. Y. Date, N. Murakami, K. Toshinai, S. Matsukura, A. Niijima, and H. Matsuo The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats Gastroenterology 123 2002 1120 1128
27. I. Depoortere, B. De Winter, T. Thijs, J. De Man, P. Pelckmans, and T. Peeters Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro Eur J Pharmacol 515 2005 160 168
28. R.G. Smith, L. Betancourt, and Y. Sun Molecular endocrinology and physiology of the aging central nervous system Endocr Rev 26 2005 203 250
29. M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, and K. Takaya Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 50 2001 227 232
30. A.K. Hewson, and S.L. Dickson Systemic administration of ghrelin induces fos and egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J Neuroendocrinol 12 2000 1047 1049
31. L.F. Faulconbridge, D.E. Cummings, J.M. Kaplan, and H.J. Grill Hyperphagic effects of brainstem ghrelin administration Diabetes 52 2003 2260 2265
32. L.F. Faulconbridge, H.J. Grill, and J.M. Kaplan Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia Diabetes 54 2005 1985 1993
33. C.B. Lawrence, A.C. Snape, F.M. Baudoin, and S.M. Luckman Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers Endocrinology 143 2002 155 162
34. R. Yokote, M. Sato, S. Matsubara, H. Ohye, M. Niimi, and K. Murao Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues Peptides 19 1998 15 50