메뉴 건너뛰기




Volumn 25, Issue 45, 2005, Pages 10510-10519

Peptide YY3-36 inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: Implications for hypothalamic regulation of energy homeostasis

Author keywords

Arcuate; Feeding; Glutamate; Hypothalamus; Peptide YY; Y receptors

Indexed keywords

CALCIUM; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; NEUROPEPTIDE Y; PEPTIDE YY; PEPTIDE YY[3-36]; POTASSIUM CHANNEL; PROOPIOMELANOCORTIN; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 27744527442     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2552-05.2005     Document Type: Article
Times cited : (102)

References (56)
  • 1
    • 1642546623 scopus 로고    scopus 로고
    • Group III metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons
    • Acuna-Goycolea C, Li Y, van den Pol AN (2004) Group III metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons. J Neurosci 24:3013-3022.
    • (2004) J Neurosci , vol.24 , pp. 3013-3022
    • Acuna-Goycolea, C.1    Li, Y.2    Van Den Pol, A.N.3
  • 2
    • 23744470219 scopus 로고    scopus 로고
    • Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus
    • Acuna-Goycolea C, Tamamaki N, Yanagawa Y, Obata K, van den Pol AN (2005) Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus. J Neurosci 25:7406-7419.
    • (2005) J Neurosci , vol.25 , pp. 7406-7419
    • Acuna-Goycolea, C.1    Tamamaki, N.2    Yanagawa, Y.3    Obata, K.4    Van Den Pol, A.N.5
  • 3
    • 0038727630 scopus 로고    scopus 로고
    • The gut hormone peptide YY regulates appetite
    • Batterham RL, Bloom SR (2003) The gut hormone peptide YY regulates appetite. Ann NY Acad Sci 994:162-168.
    • (2003) Ann NY Acad Sci , vol.994 , pp. 162-168
    • Batterham, R.L.1    Bloom, S.R.2
  • 6
    • 0028902849 scopus 로고
    • Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures
    • Bekkers JM, Stevens CF (1995) Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures. J Neurophysiol 73:1145-1156.
    • (1995) J Neurophysiol , vol.73 , pp. 1145-1156
    • Bekkers, J.M.1    Stevens, C.F.2
  • 7
    • 0031002543 scopus 로고    scopus 로고
    • Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus
    • Belousov AB, van den Pol AN (1997) Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus. J Physiol (Lond) 499:747-761.
    • (1997) J Physiol (Lond) , vol.499 , pp. 747-761
    • Belousov, A.B.1    Van Den Pol, A.N.2
  • 8
    • 0030829873 scopus 로고    scopus 로고
    • Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
    • Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66:393-408.
    • (1997) Neuroendocrinology , vol.66 , pp. 393-408
    • Broberger, C.1    Landry, M.2    Wong, H.3    Walsh, J.N.4    Hokfelt, T.5
  • 10
    • 17644428076 scopus 로고    scopus 로고
    • + channels in dendrites of hippocampal CA1 pyramidal neurons
    • + channels in dendrites of hippocampal CA1 pyramidal neurons. J Neurosci 25:3787-3792.
    • (2005) J Neurosci , vol.25 , pp. 3787-3792
    • Chen, X.1    Johnston, D.2
  • 11
    • 0141836834 scopus 로고    scopus 로고
    • Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight
    • Collin M, Backberg M, Ovesjo ML, Fisone G, Edwards RH, Fujiyama F, Meister B (2003) Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur J Neurosci 18:1265-1278.
    • (2003) Eur J Neurosci , vol.18 , pp. 1265-1278
    • Collin, M.1    Backberg, M.2    Ovesjo, M.L.3    Fisone, G.4    Edwards, R.H.5    Fujiyama, F.6    Meister, B.7
  • 16
    • 0344197075 scopus 로고    scopus 로고
    • G protein modulation of voltage-gated calcium channels
    • Dolphin AC (2003) G protein modulation of voltage-gated calcium channels. Pharmacol Rev 55:607-627.
    • (2003) Pharmacol Rev , vol.55 , pp. 607-627
    • Dolphin, A.C.1
  • 19
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist JK, Elias CF, Saper CB (1999) From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221-232.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 20
    • 0001777007 scopus 로고
    • The coexistence of neuropeptide Y with other peptides and amines in the central nervous system
    • (Mutt V, Fuxe K, Hokfelt T, Lundberg J, eds). New York: Raven
    • Everitt BJ, Hokfelt T (1989) The coexistence of neuropeptide Y with other peptides and amines in the central nervous system. In: Neuropeptide Y (Mutt V, Fuxe K, Hokfelt T, Lundberg J, eds), pp 61-72. New York: Raven.
    • (1989) Neuropeptide Y , pp. 61-72
    • Everitt, B.J.1    Hokfelt, T.2
  • 22
    • 5444263310 scopus 로고    scopus 로고
    • Neuropeptide Y inhibits hypocretin/orexin by multiple presynaptic and postsynaptic mechanisms: Tonic depression of the hypothalamic arousal system
    • Fu L-Y, Acuna-Goycolea C, van den Pol AN (2004) Neuropeptide Y inhibits hypocretin/orexin by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci 24:8741-8751.
    • (2004) J Neurosci , vol.24 , pp. 8741-8751
    • Fu, L.-Y.1    Acuna-Goycolea, C.2    Van Den Pol, A.N.3
  • 23
    • 0033166263 scopus 로고    scopus 로고
    • Neurotrophin-3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat
    • Gao XB, van den Pol AN (1999) Neurotrophin-3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat. J Physiol (Lond) 518:81-95.
    • (1999) J Physiol (Lond) , vol.518 , pp. 81-95
    • Gao, X.B.1    Van Den Pol, A.N.2
  • 24
    • 27744469753 scopus 로고    scopus 로고
    • PYY3-36 inhibits the action potential firing activity of POMC neurons of the arcuate nucleus through postsynaptic Y2 receptors
    • Ghamari-Langroudi M, Colmers WF, Cone RD (2005) PYY3-36 inhibits the action potential firing activity of POMC neurons of the arcuate nucleus through postsynaptic Y2 receptors. Cell Metab 2:191-199.
    • (2005) Cell Metab , vol.2 , pp. 191-199
    • Ghamari-Langroudi, M.1    Colmers, W.F.2    Cone, R.D.3
  • 25
    • 0028173653 scopus 로고
    • Two molecular forms of peptide YY (PYY) are abundant in human blood: Characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36
    • Grandt D, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein VE, Reeve Jr JR (1994) Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul Pept 51:151-159.
    • (1994) Regul Pept , vol.51 , pp. 151-159
    • Grandt, D.1    Schimiczek, M.2    Beglinger, C.3    Layer, P.4    Goebell, H.5    Eysselein, V.E.6    Reeve Jr., J.R.7
  • 26
    • 0036085883 scopus 로고    scopus 로고
    • Y5 receptor mediate neuroprptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus
    • Guo H, Castro PA, Palmiter RD, Baraban SC (2002) Y5 receptor mediate neuroprptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J Neurophysiol 87:558-566.
    • (2002) J Neurophysiol , vol.87 , pp. 558-566
    • Guo, H.1    Castro, P.A.2    Palmiter, R.D.3    Baraban, S.C.4
  • 28
    • 2542444495 scopus 로고    scopus 로고
    • Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism
    • Halatchev IG, Ellacott KL, Fan W, Cone RD (2004) Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145:2585-2590.
    • (2004) Endocrinology , vol.145 , pp. 2585-2590
    • Halatchev, I.G.1    Ellacott, K.L.2    Fan, W.3    Cone, R.D.4
  • 30
    • 0030990363 scopus 로고    scopus 로고
    • Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
    • Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756:283-286.
    • (1997) Brain Res , vol.756 , pp. 283-286
    • Horvath, T.L.1    Bechmann, I.2    Naftolin, F.3    Kalra, S.P.4    Leranth, C.5
  • 31
    • 0033081871 scopus 로고    scopus 로고
    • Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
    • Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19:1072-1087.
    • (1999) J Neurosci , vol.19 , pp. 1072-1087
    • Horvath, T.L.1    Diano, S.2    Van Den Pol, A.N.3
  • 35
    • 18844393687 scopus 로고    scopus 로고
    • Glutamatergic innervation of neuropeptide Y and pro-opiomelanocortin- containing neurons in the hypothalamic arcuate nucleus of the rat
    • Kiss J, Csaba Z, Csaki A, Halasz B (2005) Glutamatergic innervation of neuropeptide Y and pro-opiomelanocortin-containing neurons in the hypothalamic arcuate nucleus of the rat. Eur J Neurosci 21:2111-2119.
    • (2005) Eur J Neurosci , vol.21 , pp. 2111-2119
    • Kiss, J.1    Csaba, Z.2    Csaki, A.3    Halasz, B.4
  • 36
    • 0001312506 scopus 로고
    • Neuropeptide Y actions on reproductive and endocrine functions
    • (Colmers WF, Wahlestedt C, eds). Totowa, NJ: Humana
    • McDonald JK, Koenig JI (1993) Neuropeptide Y actions on reproductive and endocrine functions. In: The biology of neuropeptide Y and related peptides (Colmers WF, Wahlestedt C, eds), pp 419-456. Totowa, NJ: Humana.
    • (1993) The Biology of Neuropeptide Y and Related Peptides , pp. 419-456
    • McDonald, J.K.1    Koenig, J.I.2
  • 37
    • 0034858816 scopus 로고    scopus 로고
    • Identification of potent and selective neuropeptide Y Y(1) receptor agonist with orexigenic activity in vivo
    • Mullins D, Kirby D, Hwa J, Guzzi M, Rivier J, Parker E (2001) Identification of potent and selective neuropeptide Y Y(1) receptor agonist with orexigenic activity in vivo. Mol Pharmacol 60:534-540.
    • (2001) Mol Pharmacol , vol.60 , pp. 534-540
    • Mullins, D.1    Kirby, D.2    Hwa, J.3    Guzzi, M.4    Rivier, J.5    Parker, E.6
  • 39
    • 0025924615 scopus 로고
    • 34neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs
    • 34] neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs. Eur J Pharmacol 193:15-19.
    • (1991) Eur J Pharmacol , vol.193 , pp. 15-19
    • Potter, E.K.1    Fuhlendorff, J.2    Schwartz, T.W.3
  • 40
    • 0030900211 scopus 로고    scopus 로고
    • Regulation of neurotransmission in the arcute nucleus of the rat by different neuropeptide Y receptors
    • Rhim H, Kinney GA, Emmerson PJ, Miller RJ (1997) Regulation of neurotransmission in the arcute nucleus of the rat by different neuropeptide Y receptors. J Neurosci 17:2980-2989.
    • (1997) J Neurosci , vol.17 , pp. 2980-2989
    • Rhim, H.1    Kinney, G.A.2    Emmerson, P.J.3    Miller, R.J.4
  • 41
    • 1542358816 scopus 로고    scopus 로고
    • Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice
    • Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM (2004) Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41:711-722.
    • (2004) Neuron , vol.41 , pp. 711-722
    • Roseberry, A.G.1    Liu, H.2    Jackson, A.C.3    Cai, X.4    Friedman, J.M.5
  • 42
    • 0037057802 scopus 로고    scopus 로고
    • The need to feed: Homeostatic and hedonic control of eating
    • Saper CB, Chou TC, Elmquist JK (2002) The need to feed: homeostatic and hedonic control of eating. Neuron 36:199-211.
    • (2002) Neuron , vol.36 , pp. 199-211
    • Saper, C.B.1    Chou, T.C.2    Elmquist, J.K.3
  • 43
    • 0037043534 scopus 로고    scopus 로고
    • Obesity: Keeping hunger at bay
    • Schwartz MW, Morton GJ (2002) Obesity: keeping hunger at bay. Nature 418:595-597.
    • (2002) Nature , vol.418 , pp. 595-597
    • Schwartz, M.W.1    Morton, G.J.2
  • 45
    • 0242363255 scopus 로고    scopus 로고
    • Monitoring of stored and available fuel by the CNS: Implications for obesity
    • Seeley RJ, Woods SC (2003) Monitoring of stored and available fuel by the CNS: implications for obesity. Nat Rev Neurosci 4:901-909.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 901-909
    • Seeley, R.J.1    Woods, S.C.2
  • 46
    • 0029662055 scopus 로고    scopus 로고
    • B receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons
    • B receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci 16:6374-6385.
    • (1996) J Neurosci , vol.16 , pp. 6374-6385
    • Sodickson, D.L.1    Bean, B.P.2
  • 47
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104:531-543.
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 48
    • 0000555383 scopus 로고
    • Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
    • Stanley BG, Leibowitz SF (1985) Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 82:3940-3943.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 3940-3943
    • Stanley, B.G.1    Leibowitz, S.F.2
  • 49
    • 1942487860 scopus 로고    scopus 로고
    • Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide
    • Stanley S, Wynne K, Bloom S (2004) Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am J Physiol Gastrointest Liver Physiol 286:693-697.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286 , pp. 693-697
    • Stanley, S.1    Wynne, K.2    Bloom, S.3
  • 50
    • 0032976846 scopus 로고    scopus 로고
    • 2+ channels in acutely isolated neurons from the rat arcuate nucleus
    • 2+ channels in acutely isolated neurons from the rat arcuate nucleus. J Neurophysiol 81:1391-1403.
    • (1999) J Neurophysiol , vol.81 , pp. 1391-1403
    • Sun, L.1    Miller, R.2
  • 52
    • 0025635709 scopus 로고
    • Glutamate, the dominant excitatory transmitter in neuroendocrine regulation
    • van den Pol AN, Wuarin JP, Dudek FE (1990) Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science 250:1276-1278.
    • (1990) Science , vol.250 , pp. 1276-1278
    • Van Den Pol, A.N.1    Wuarin, J.P.2    Dudek, F.E.3
  • 53
    • 0347993676 scopus 로고    scopus 로고
    • Weighing the role of hypothalamic feeding neurotransmitters
    • van den Pol AN (2003) Weighing the role of hypothalamic feeding neurotransmitters. Neuron 40:1059-1061.
    • (2003) Neuron , vol.40 , pp. 1059-1061
    • Van Den Pol, A.N.1
  • 54
    • 2442538044 scopus 로고    scopus 로고
    • Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    • van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635-652.
    • (2004) Neuron , vol.42 , pp. 635-652
    • Van Den Pol, A.N.1    Acuna-Goycolea, C.2    Clark, K.R.3    Ghosh, P.K.4
  • 55
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D (2004) Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7:493-494.
    • (2004) Nat Neurosci , vol.7 , pp. 493-494
    • Van Den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 56
    • 0035883810 scopus 로고    scopus 로고
    • Role of melanocortins in control of obesity
    • Wisse BE, Schwartz MW (2001) Role of melanocortins in control of obesity. Lancet 358:857-859.
    • (2001) Lancet , vol.358 , pp. 857-859
    • Wisse, B.E.1    Schwartz, M.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.