Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety

Endocrinology

Volumn 148, Issue 2, 2007, Pages 638-646

  Singru, Praful S ^a   Sánchez, Edith ^a   Fekete, Csaba ^a,b   Lechan, Ronald M ^a,c  

^a TUFTS MEDICAL CENTER   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; PROTEIN C FOS;

ANOREXIA; ARTICLE; CONTROLLED STUDY; FEEDING; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY; THALAMUS MIDLINE NUCLEUS;

ALPHA-MSH; ANIMAL FEED; ANIMALS; ARCUATE NUCLEUS; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; EATING; FASTING; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; MALE; NERVE FIBERS; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SATIETY RESPONSE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 33846435768     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1233     Document Type: Article

References (59)

1. Cone RD 2005 Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578
2. Hillebrand JJ, Kas MJ, Adan RA 2006 To eat or not to eat: regulation by the melanocortin system. Physiol Behav 89:97-102
3. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
4. Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, Palmiter RD 2000 A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci USA 97:12339-12344
5. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157
6. Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S 2000 Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279
7. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262
8. Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC, O'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303-306
9. Ahima RS, Saper CB, Flier JS, Elmquist JK 2000 Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263-307
10. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
11. Dube D, Lissitzky JC, Leclerc R, Pelletier G 1978 Localization of α-melanocyte-stimulating hormone in rat brain and pituitary. Endocrinology 102:1283-1291
12. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457:213-235
13. Adan RA, Gispen WH 2000 Melanocortins and the brain: from effects via receptors to drug targets. Eur J Pharmacol 405:13-24
14. Wirth MM, Olszewski PK, Yu C, Levine AS, Giraudo SQ 2001 Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects. Peptides 22:129-134
15. Kask A, Schioth HB 2000 Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat. Brain Res 887:460-464
16. Giraudo SQ, Billington CJ, Levine AS 1998 Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Res 809:302-306
17. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505
18. Timofeeva E, Picard F, Duclos M, Deshaies Y, Richard D 2002 Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding. Eur J Neurosci 15:1013-1029
19. Timofeeva E, Baraboi ED, Richard D 2005 Contribution of the vagus nerve and lamina terminalis to brain activation induced by refeeding. Eur J Neurosci 22:1489-1501
20. Sarkar S, Legradi G, Lechan RM 2002 Intracerebroventricular administration of α-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus. Brain Res 945:50-59
21. Lu XY, Barsh GS, Akil H, Watson SJ 2003 Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 23:7863-7872
22. Martin NM, Smith KL, Bloom SR, Small CJ 2006 Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis. Peptides 27:333-339
23. Paxinos G, Watson C 1998 The rat brain in stereotaxic coordinates. 4th ed. New York: Academic Press
24. Ji H, Friedman MI 1999 Compensatory hyperphagia after fasting tracks recovery of liver energy status. Physiol Behav 68:181-186
25. Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y 2005 Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J Neurosci 25:8657-8664
26. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94:10455-10460
27. Singru PS, Fekete C, Lechan RM 2005 Neuroanatomical evidence for participation of the hypothalamic dorsomedial nucleus (DMN) in regulation of the hypothalamic paraventricular nucleus (PVN) by α-melanocyte stimulating hormone. Brain Res 1064:42-51
28. Evans SA, Messina MM, Knight WD, Parsons AD, Overton JM 2005 Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction. Am J Physiol Regul Integr Comp Physiol 288:R1468-R1476
29. Dulloo AG, Jacquet J 2001 An adipose-specific control of thermogenesis in body weight regulation. Int J Obes Relat Metab Disord 25(Suppl 5):S22-S29
30. Rothwell NJ, Saville ME, Stock MJ 1983 Role of insulin in thermogenic responses to refeeding in 3-day-fasted rats. Am J Physiol 245:E160-E165
31. Rothwell NJ, Saville ME, Stock MJ 1983 Metabolic responses to fasting and refeeding in lean and genetically obese rats. Am J Physiol 244:R615-R620
32. Lechan RM 1987 Neuroendocrinology of pituitary hormone regulation. Endocrinol Metab Clin North Am 16:475-501
33. Sawchenko PE, Li HY, Ericsson A 2000 Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms. Prog Brain Res 122:61-78
34. McKinley MJ, Cairns MJ, Denton DA, Egan G, Mathai ML, Uschakov A, Wade JD, Weisinger RS, Oldfield BJ 2004 Physiological and pathophysiological influences on thirst. Physiol Behav 81:795-803
35. Cherel Y, Le Maho Y 1991 Refeeding after the late increase in nitrogen excretion during prolonged fasting in the rat. Physiol Behav 50:345-349
36. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD 1992 The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251
37. Lechan RM, Fekete C 2004 Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome. J Endocrinol Invest 27:105-119
38. Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, Emerson CH, Lechan RM 2000 α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci 20:1550-1558
39. Legradi G, Lechan RM 1999 Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 140:3643-3652
40. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T 1998 The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95:15043-15048
41. Swart I, Jahng JW, Overton JM, Houpt TA 2002 Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice. Am J Physiol Regul Integr Comp Physiol 283:R1020-R1026
42. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-163
43. Bellinger LL, Bernardis LL 2002 The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol Behav 76:431-442
44. Bellinger LL 1987 Ingestive behavior of rats with ibotenic acid lesions of the dorsomedial hypothalamus. Am J Physiol 252:R938-R946
45. Bellinger LL, Mendel VE, Bernardis LL, Castonguay TW 1986 Meal patterns of rats with dorsomedial hypothalamic nuclei lesions or sham operations. Physiol Behav 36:693-698
46. Bellinger LL, Bernardis LL 1999 Effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior. Am J Physiol 276:R1772-R1779
47. Bernardis LL, Bellinger LL 1998 The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med 218:284-306
48. Iritani N, Sugimoto T, Fukuda H 2000 Gene expressions of leptin, insulin receptors and lipogenic enzymes are coordinately regulated by insulin and dietary fat in rats. J Nutr 130:1183-1188
49. Hollopeter G, Erickson JC, Seeley RJ, Marsh DJ, Palmiter RD 1998 Response of neuropeptide Y-deficient mice to feeding effectors. Regul Pept 75-76:383-389
50. Wang L, Martinez V, Barrachina MD, Tache Y 1998 Fos expression in the brain induced by peripheral injection of CCK or leptin plus CCK in fasted lean mice. Brain Res 791:157-166
51. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM 2006 Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 147:520-529
52. Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, Seeley RJ, Woods SC 2002 The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci 22:9048-9052
53. Porte Jr D, Baskin DG, Schwartz MW 2002 Leptin and insulin action in the central nervous system. Nutr Rev 60:S20-S29; discussion S68-S87
54. Benoit SC, Clegg DJ, Seeley RJ, Woods SC 2004 Insulin and leptin as adiposity signals. Recent Prog Horm Res 59:267-285
55. Halatchev IG, Ellacott KL, Fan W, Cone RD 2004 Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145:2585-2590
56. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR 2002 Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654
57. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
58. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK 1998 Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385
59. Edwards CM, Abbott CR, Sunter D, Kim M, Dakin CL, Murphy KG, Abusnana S, Taheri S, Rossi M, Bloom SR 2000 Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat. Brain Res 866:128-134