메뉴 건너뛰기




Volumn 660, Issue 1, 2011, Pages 13-20

Physiological roles of the melanocortin MC3 receptor

Author keywords

MSH; Melanocortin; Melanocortin MC3 receptor; Melanocortin 3 receptor; Obesity; Proopiomelanocortin

Indexed keywords

AUTORECEPTOR; GAMMA INTERMEDIN; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN;

EID: 79955930421     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.025     Document Type: Review
Times cited : (49)

References (90)
  • 1
    • 0034733888 scopus 로고    scopus 로고
    • Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3- receptor
    • Abbott, C.R., Rossi, M., Kim, M., AlAhmed, S.H., Taylor, G.M., Ghatei, M.A., Smith, D.M., Bloom, S.R., 2000. Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3- receptor. Brain Res. 869, 203-210.
    • (2000) Brain Res. , vol.869 , pp. 203-210
    • Abbott, C.R.1    Rossi, M.2    Kim, M.3    AlAhmed, S.H.4    Taylor, G.M.5    Ghatei, M.A.6    Smith, D.M.7    Bloom, S.R.8
  • 2
    • 0033567543 scopus 로고    scopus 로고
    • The anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in brain
    • Bagnol, D., Lu, X.Y., Kaelin, C.B., Day, H.E., Ollmann, M., Gantz, I., Akil, H., Barsh, G.S., Watson, S.J., 1999. The anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J. Neurosci. 19, RC26.
    • (1999) J. Neurosci. , vol.19
    • Bagnol, D.1    Lu, X.Y.2    Kaelin, C.B.3    Day, H.E.4    Ollmann, M.5    Gantz, I.6    Akil, H.7    Barsh, G.S.8    Watson, S.J.9
  • 3
    • 0043068115 scopus 로고    scopus 로고
    • Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human melanocortin MC3 receptor and human MC5R
    • Balse-Srinivasan, P., Grieco, P., Cai, M., Trivedi, D., Hruby, V.J., 2003. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human melanocortin MC3 receptor and human MC5R. J. Med. Chem. 46, 3728-3733.
    • (2003) J. Med. Chem. , vol.46 , pp. 3728-3733
    • Balse-Srinivasan, P.1    Grieco, P.2    Cai, M.3    Trivedi, D.4    Hruby, V.J.5
  • 4
    • 70449411697 scopus 로고    scopus 로고
    • The role of melanocortin neuronal pathways in circadian biology: A new homeostatic output involving melanocortin-3 receptors?
    • Begriche, K., Sutton, G.M., Fang, J., Butler, A.A., 2009. The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors? Obes. Rev. 10 (Suppl. 2), 14-24.
    • (2009) Obes. Rev. , vol.10 , Issue.SUPPL. 2 , pp. 14-24
    • Begriche, K.1    Sutton, G.M.2    Fang, J.3    Butler, A.A.4
  • 5
    • 0036046234 scopus 로고    scopus 로고
    • A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence
    • Boucher, N., Lanouette, C.M., Larose, M., Perusse, L., Bouchard, C., Chagnon, Y.C., 2002. A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence. Mol. Med. 8, 158-165.
    • (2002) Mol. Med. , vol.8 , pp. 158-165
    • Boucher, N.1    Lanouette, C.M.2    Larose, M.3    Perusse, L.4    Bouchard, C.5    Chagnon, Y.C.6
  • 6
    • 33845972656 scopus 로고    scopus 로고
    • The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors
    • Breit, A., Wolff, K., Kalwa, H., Jarry, H., Buch, T., Gudermann, T., 2006. The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. J. Biol. Chem. 281, 37447-37456.
    • (2006) J. Biol. Chem. , vol.281 , pp. 37447-37456
    • Breit, A.1    Wolff, K.2    Kalwa, H.3    Jarry, H.4    Buch, T.5    Gudermann, T.6
  • 8
    • 15544377449 scopus 로고    scopus 로고
    • Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and melanocortin MC3 receptor analogues
    • Cai, M., Mayorov, A.V., Cabello, C., Stankova, M., Trivedi, D., Hruby, V.J., 2005. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and melanocortin MC3 receptor analogues. J. Med. Chem. 48, 1839-1848.
    • (2005) J. Med. Chem. , vol.48 , pp. 1839-1848
    • Cai, M.1    Mayorov, A.V.2    Cabello, C.3    Stankova, M.4    Trivedi, D.5    Hruby, V.J.6
  • 11
    • 33846698560 scopus 로고    scopus 로고
    • The melanocortin system in leukocyte biology
    • Catania, A., 2007. The melanocortin system in leukocyte biology. J. Leukoc. Biol. 81, 383-392.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 383-392
    • Catania, A.1
  • 12
    • 1542347163 scopus 로고    scopus 로고
    • Targeting melanocortin receptors as a novel strategy to control inflammation
    • Catania, A., Gatti, S., Colombo, G., Lipton, J.M., 2004. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 1-29
    • Catania, A.1    Gatti, S.2    Colombo, G.3    Lipton, J.M.4
  • 13
    • 33846796378 scopus 로고    scopus 로고
    • Melanocortin-3 receptor activates MAP kinase via PI3 kinase
    • Chai, B., Li, J.Y., Zhang, W., Ammori, J.B., Mulholland, M.W., 2007. Melanocortin-3 receptor activates MAP kinase via PI3 kinase. Regul. Pept. 139, 115-121.
    • (2007) Regul. Pept. , vol.139 , pp. 115-121
    • Chai, B.1    Li, J.Y.2    Zhang, W.3    Ammori, J.B.4    Mulholland, M.W.5
  • 14
    • 70149093650 scopus 로고    scopus 로고
    • Role of gamma melanocyte-stimulating hormone-renal melanocortin 3 receptor system in blood pressure regulation in salt-resistant and salt-sensitive rats
    • Chandramohan, G., Durham, N., Sinha, S., Norris, K., Vaziri, N.D., 2009. Role of gamma melanocyte-stimulating hormone-renal melanocortin 3 receptor system in blood pressure regulation in salt-resistant and salt-sensitive rats. Metabolism 58, 1424-1429.
    • (2009) Metabolism , vol.58 , pp. 1424-1429
    • Chandramohan, G.1    Durham, N.2    Sinha, S.3    Norris, K.4    Vaziri, N.D.5
  • 16
    • 31544441358 scopus 로고    scopus 로고
    • Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction
    • DOI 10.1021/bi0521792
    • Chen, M., Aprahamian, C.J., Celik, A., Georgeson, K.E., Garvey, W.T., Harmon, C.M., Yang, Y., 2006. Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction. Biochemistry 45, 1128-1137. (Pubitemid 43167180)
    • (2006) Biochemistry , vol.45 , Issue.4 , pp. 1128-1137
    • Chen, M.1    Aprahamian, C.J.2    Celik, A.3    Georgeson, K.E.4    Garvey, W.T.5    Harmon, C.M.6    Yang, Y.7
  • 17
    • 20444497662 scopus 로고    scopus 로고
    • Role of leptin and melanocortin signaling in uremia-associated cachexia
    • Cheung, W., Yu, P.X., Little, B.M., Cone, R.D., Marks, D.L., Mak, R.H., 2005. Role of leptin and melanocortin signaling in uremia-associated cachexia. J. Clin. Invest. 115, 1659-1665.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1659-1665
    • Cheung, W.1    Yu, P.X.2    Little, B.M.3    Cone, R.D.4    Marks, D.L.5    Mak, R.H.6
  • 18
    • 0029848043 scopus 로고    scopus 로고
    • Distribution of cDNA for melanocortin receptor subtypes in human tissues
    • Chhajlani, V., 1996. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem. Mol. Biol. Int. 38, 73-80.
    • (1996) Biochem. Mol. Biol. Int. , vol.38 , pp. 73-80
    • Chhajlani, V.1
  • 19
    • 0027396787 scopus 로고
    • Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor
    • DOI 10.1016/0140-6736(93)90208-X
    • Clark, A.J., McLoughlin, L., Grossman, A., 1993. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet 341, 461-462. (Pubitemid 23054520)
    • (1993) Lancet , vol.341 , Issue.8843 , pp. 461-462
    • Clark, A.J.L.1    McLoughlin, L.2    Grossman, A.3
  • 20
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • DOI 10.1038/35078085
    • Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J., 2001. Leptin activates anorexigenic proopiomelanocortin neurons through a neural network in the arcuate nucleus. Nature 411, 480-484. (Pubitemid 32494394)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6    Cone, R.D.7    Low, M.J.8
  • 21
    • 0033637383 scopus 로고    scopus 로고
    • Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    • Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., Schibler, U., 2000. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14, 2950-2961.
    • (2000) Genes Dev. , vol.14 , pp. 2950-2961
    • Damiola, F.1    Le Minh, N.2    Preitner, N.3    Kornmann, B.4    Fleury-Olela, F.5    Schibler, U.6
  • 22
    • 36348946386 scopus 로고    scopus 로고
    • Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling
    • DOI 10.1210/en.2007-0699
    • Ellacott, K.L., Murphy, J.G., Marks, D.L., Cone, R.D., 2007. Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. Endocrinology 148, 6186-6194. (Pubitemid 350146148)
    • (2007) Endocrinology , vol.148 , Issue.12 , pp. 6186-6194
    • Ellacott, K.L.J.1    Murphy, J.G.2    Marks, D.L.3    Cone, R.D.4
  • 24
    • 24144443764 scopus 로고    scopus 로고
    • Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity
    • DOI 10.2337/diabetes.54.9.2663
    • Feng, N., Young, S.F., Aguilera, G., Puricelli, E., Adler-Wailes, D.C., Sebring, N.G., Yanovski, J.A., 2005. Co-occurrence of two partially inactivating polymorphisms of melanocortin MC3 receptor is associated with pediatric-onset obesity. Diabetes 54, 2663-2667. (Pubitemid 41233588)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2663-2667
    • Feng, N.1    Young, S.F.2    Aguillera, G.3    Puricelli, E.4    Adler-Wailes, D.C.5    Sebring, N.G.6    Yanovski, J.A.7
  • 27
    • 0034888386 scopus 로고    scopus 로고
    • Arthritic diseases: Melanocortin type 3 receptor agonists as potential therapeutics
    • Getting, S.J., Perretti, M., 2001. Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Curr. Opin. Investig. Drugs 2, 1064-1069.
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 1064-1069
    • Getting, S.J.1    Perretti, M.2
  • 28
    • 0033397801 scopus 로고    scopus 로고
    • Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx
    • Getting, S.J., Flower, R.J., Perretti, M., 1999a. Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx. Inflamm. Res. 48 (Suppl. 2), S140-S141.
    • (1999) Inflamm. Res. , vol.48 , Issue.SUPPL. 2
    • Getting, S.J.1    Flower, R.J.2    Perretti, M.3
  • 29
    • 0033564575 scopus 로고    scopus 로고
    • POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
    • Getting, S.J., Gibbs, L., Clark, A.J., Flower, R.J., Perretti, M., 1999b. Proopiomelanocortin gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. 162, 7446-7453. (Pubitemid 29277724)
    • (1999) Journal of Immunology , vol.162 , Issue.12 , pp. 7446-7453
    • Getting, S.J.1    Gibbs, L.2    Clark, A.J.L.3    Flower, R.J.4    Perretti, M.5
  • 30
    • 0347927272 scopus 로고    scopus 로고
    • Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor
    • Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N., Flower, R.J., Schioth, H.B., Perretti, M., 2003. Redundancy of a functional melanocortin 1 receptor in the antiinflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J. Immunol. 170, 3323-3330. (Pubitemid 36302211)
    • (2003) Journal of Immunology , vol.170 , Issue.6 , pp. 3323-3330
    • Getting, S.J.1    Christian, H.C.2    Lam, C.W.3    Gavins, F.N.E.4    Flower, R.J.5    Schioth, H.B.6    Perretti, M.7
  • 31
    • 33845664425 scopus 로고    scopus 로고
    • Melanocortin 3 receptors control crystal-induced inflammation
    • DOI 10.1096/fj.06-6339com
    • Getting, S.J., Lam, C.W., Chen, A.S., Grieco, P., Perretti, M., 2006a. Melanocortin 3 receptors control crystal-induced inflammation. FASEB J. 20, 2234-2241. (Pubitemid 44953853)
    • (2006) FASEB Journal , vol.20 , Issue.13 , pp. 2234-2241
    • Getting, S.J.1    Lam, C.W.2    Chen, A.S.3    Grieco, P.4    Perretti, M.5
  • 32
    • 33751080408 scopus 로고    scopus 로고
    • 8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)
    • DOI 10.1124/mol.106.028878
    • Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N., Grieco, P., Perretti, M., 2006b. [D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol. Pharmacol. 70, 1850-1855. (Pubitemid 44771900)
    • (2006) Molecular Pharmacology , vol.70 , Issue.6 , pp. 1850-1855
    • Getting, S.J.1    Lam, C.W.2    Leoni, G.3    Gavins, F.N.E.4    Grieco, P.5    Perretti, M.6
  • 34
    • 0034727855 scopus 로고    scopus 로고
    • D-amino acid scan of gamma-melanocyte-stimulating hormone: Importance of Trp(8) on human MC3 receptor selectivity
    • Grieco, P., Balse, P.M., Weinberg, D., MacNeil, T., Hruby, V.J., 2000. D-amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J. Med. Chem. 43, 4998-5002.
    • (2000) J. Med. Chem. , vol.43 , pp. 4998-5002
    • Grieco, P.1    Balse, P.M.2    Weinberg, D.3    MacNeil, T.4    Hruby, V.J.5
  • 35
    • 70149087276 scopus 로고    scopus 로고
    • Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action
    • Gruber, K.A., Fan, W., Akerberg, H., Larhammar, D., Chee, M.J., Colmers, W.F., Cone, R.D., 2009. Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action. Endocrine 35, 312-324.
    • (2009) Endocrine , vol.35 , pp. 312-324
    • Gruber, K.A.1    Fan, W.2    Akerberg, H.3    Larhammar, D.4    Chee, M.J.5    Colmers, W.F.6    Cone, R.D.7
  • 36
    • 33845354765 scopus 로고    scopus 로고
    • Cardiovascular and renal actions of melanocyte-stimulating hormone actions
    • Humphreys, M.H., 2007. Cardiovascular and renal actions of melanocyte-stimulating hormone actions. Curr. Opin. Nephrol. Hypertens. 16, 32-38.
    • (2007) Curr. Opin. Nephrol. Hypertens , vol.16 , pp. 32-38
    • Humphreys, M.H.1
  • 38
    • 17344381056 scopus 로고    scopus 로고
    • Differential effects of melanocortin peptides on ingestive behaviour in rats: Evidence against the i involvement of MC(3) receptor in the regulation of food intake
    • Kask, A., Rago, L., Wikberg, J.E., Schioth, H.B., 2000. Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the i involvement of MC(3) receptor in the regulation of food intake. Neurosci. Lett. 283, 1-4.
    • (2000) Neurosci. Lett. , vol.283 , pp. 1-4
    • Kask, A.1    Rago, L.2    Wikberg, J.E.3    Schioth, H.B.4
  • 39
    • 0037030692 scopus 로고    scopus 로고
    • Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors
    • Kavarana, M.J., Trivedi, D., Cai, M., Ying, J., Hammer, M., Cabello, C., Grieco, P., Han, G., Hruby, V.J., 2002. Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J. Med. Chem. 45, 2644-2650.
    • (2002) J. Med. Chem. , vol.45 , pp. 2644-2650
    • Kavarana, M.J.1    Trivedi, D.2    Cai, M.3    Ying, J.4    Hammer, M.5    Cabello, C.6    Grieco, P.7    Han, G.8    Hruby, V.J.9
  • 40
    • 0021260924 scopus 로고
    • The distribution and projection of gamma-melanocyte stimulating hormone in the rat brain: An immunohistochemical analysis
    • DOI 10.1016/0006-8993(84)90539-0
    • Kawai, Y., Inagaki, S., Shiosaka, S., Shibasaki, T., Ling, N., Tohyama, M., Shiotani, Y., 1984. The distribution and projection of gamma-melanocyte- stimulating hormone in the rat brain: an immunohistochemical analysis. Brain Res. 297, 21-32. (Pubitemid 14131924)
    • (1984) Brain Research , vol.297 , Issue.1 , pp. 21-32
    • Kawai, Y.1    Inagaki, S.2    Shiosaka, S.3
  • 41
    • 0037200005 scopus 로고    scopus 로고
    • Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors
    • Kim, C.S., Lee, S.H., Kim, R.Y., Kim, B.J., Li, S.Z., Lee, I.H., Lee, E.J., Lim, S.K., Bae, Y.S., Lee, W., Baik, J.H., 2002a. Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors. J. Biol. Chem. 277, 31310-31317.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31310-31317
    • Kim, C.S.1    Lee, S.H.2    Kim, R.Y.3    Kim, B.J.4    Li, S.Z.5    Lee, I.H.6    Lee, E.J.7    Lim, S.K.8    Bae, Y.S.9    Lee, W.10    Baik, J.H.11
  • 42
    • 0035996843 scopus 로고    scopus 로고
    • Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor
    • DOI 10.1016/S0196-9781(02)00039-6, PII S0196978102000396
    • Kim, M.S., Rossi, M., Abbott, C.R., AlAhmed, S.H., Smith, D.M., Bloom, S.R., 2002b. Sustained orexigenic effect of agouti related protein may be not mediated by the melanocortin 4 receptor. Peptides 23, 1069-1076. (Pubitemid 34786295)
    • (2002) Peptides , vol.23 , Issue.6 , pp. 1069-1076
    • Kim, M.-S.1    Rossi, M.2    Abbott, C.R.3    AlAhmed, S.H.4    Smith, D.M.5    Bloom, S.R.6
  • 43
    • 0031884124 scopus 로고    scopus 로고
    • Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA, predominance of Mc4 in fetal rat nervous system
    • DOI 10.1046/j.1365-2826.1998.00180.x
    • Kistler-Heer, V., Lauber, M.E., Lichtensteiger, W., 1998. Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of MC4 in fetal rat nervous system. J. Neuroendocrinol. 10, 133-146. (Pubitemid 28098528)
    • (1998) Journal of Neuroendocrinology , vol.10 , Issue.2 , pp. 133-146
    • Kistler-Heer, V.1    Lauber, M.E.2    Lichtensteiger, W.3
  • 44
    • 0028233234 scopus 로고
    • Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor
    • Konda, Y., Gantz, I., DelValle, J., Shimoto, Y., Miwa, H., Yamada, T., 1994. Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor. J. Biol. Chem. 269, 13162-13166.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13162-13166
    • Konda, Y.1    Gantz, I.2    DelValle, J.3    Shimoto, Y.4    Miwa, H.5    Yamada, T.6
  • 45
    • 0031012096 scopus 로고    scopus 로고
    • Identification of common polymorphisms in the coding sequence of the human MSH receptor (MCIR) with possible biological effects
    • Koppula, S.V., Robbins, L.S., Lu, D., Baack, E., White Jr., C.R., Swanson, N.A., Cone, R.D., 1997. Identification of common polymorphisms in the coding sequence of the human MSH receptor (MCIR) with possible biological effects. Hum. Mutat. 9, 30-36.
    • (1997) Hum. Mutat. , vol.9 , pp. 30-36
    • Koppula, S.V.1    Robbins, L.S.2    Lu, D.3    Baack, E.4    White Jr., C.R.5    Swanson, N.A.6    Cone, R.D.7
  • 46
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by proopiomelanocortin mutations in humans
    • Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Gruters, A., 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by proopiomelanocortin mutations in humans. Nat. Genet. 19, 155-157.
    • (1998) Nat. Genet. , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 47
    • 0036963510 scopus 로고    scopus 로고
    • A novel melanocortin 3 receptor gene (melanocortin MC3 receptor) mutation associated with severe obesity
    • Lee, Y.S., Poh, L.K., Loke, K.Y., 2002. A novel melanocortin 3 receptor gene (melanocortin MC3 receptor) mutation associated with severe obesity. J. Clin. Endocrinol. Metab. 87, 1423-1426.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1423-1426
    • Lee, Y.S.1    Poh, L.K.2    Loke, K.Y.3
  • 48
    • 84991847410 scopus 로고    scopus 로고
    • The role of melanocortin 3 receptor gene in childhood obesity
    • DOI 10.2337/db07-0225
    • Lee, Y.S., Poh, L.K., Kek, B.L., Loke, K.Y., 2007. The role of melanocortin 3 receptor gene in childhood obesity. Diabetes 56, 2622-2630. (Pubitemid 47523271)
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2622-2630
    • Yung, S.L.1    Poh, L.K.S.2    Kek, B.L.K.3    Kah, Y.L.4
  • 49
    • 39649094099 scopus 로고    scopus 로고
    • Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic proopiomelanocortin expression
    • Lee, M., Kim, A., Conwell, I.M., Hruby, V., Mayorov, A., Cai, M., Wardlaw, S.L., 2008. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic proopiomelanocortin expression. Peptides 29, 440-447.
    • (2008) Peptides , vol.29 , pp. 440-447
    • Lee, M.1    Kim, A.2    Conwell, I.M.3    Hruby, V.4    Mayorov, A.5    Cai, M.6    Wardlaw, S.L.7
  • 51
    • 57349184220 scopus 로고    scopus 로고
    • Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
    • Leoni, G., Patel, H.B., Sampaio, A.L., Gavins, F.N., Murray, J.F., Grieco, P., Getting, S.J., Perretti, M., 2008. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB J. 22, 4228-4238.
    • (2008) FASEB J. , vol.22 , pp. 4228-4238
    • Leoni, G.1    Patel, H.B.2    Sampaio, A.L.3    Gavins, F.N.4    Murray, J.F.5    Grieco, P.6    Getting, S.J.7    Perretti, M.8
  • 53
    • 0023157141 scopus 로고
    • Prevention of reflex natiuresis after acute unilateral nephrectomy byneonatal administration of MSG
    • Lin, S.-Y., Wiedemann, E., Deschepper, C.F., Alper, R.H., Humpreys, M.H., 1987. Prevention of reflex natiuresis after acute unilateral nephrectomy byneonatal administration of MSG. Am. Physiol. Soc. F276-F282.
    • (1987) Am. Physiol. Soc.
    • Lin, S.-Y.1    Wiedemann, E.2    Deschepper, C.F.3    Alper, R.H.4    Humpreys, M.H.5
  • 54
    • 0021894747 scopus 로고
    • Gamma-2 MSH is natriuretic in the rat
    • Lymangrover, J.R., Buckalew, V.M., Harris, J., Klein, M.C., Gruber, K.A., 1985. Gamma-2 MSH is natriuretic in the rat. Endocrinology 116, 1227-1229. (Pubitemid 15136990)
    • (1985) Endocrinology , vol.116 , Issue.3 , pp. 1227-1229
    • Lymangrover, J.R.1    Buckalew, V.M.2    Harris, J.3
  • 55
    • 0035866377 scopus 로고    scopus 로고
    • Role of the central melanocortin system in cachexia
    • Marks, D.L., Ling, N., Cone, R.D., 2001. Role of the central melanocortin system in cachexia. Cancer Res. 61, 1432-1438. (Pubitemid 34292569)
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1432-1438
    • Marks, D.L.1    Ling, N.2    Cone, R.D.3
  • 56
    • 31544453062 scopus 로고    scopus 로고
    • The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
    • DOI 10.1016/j.peptides.2005.01.025, PII S0196978105004377, The Melanocortin Pathway 2005 Part II
    • Marks, D.L., Hruby, V., Brookhart, G., Cone, R.D., 2006. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (melanocortin MC3 receptor). Peptides 27, 259-264. (Pubitemid 43162897)
    • (2006) Peptides , vol.27 , Issue.2 , pp. 259-264
    • Marks, D.L.1    Hruby, V.2    Brookhart, G.3    Cone, R.D.4
  • 57
    • 0037387355 scopus 로고    scopus 로고
    • Differential role of melanocortin receptor subtypes in cachexia
    • DOI 10.1210/en.2002-221099
    • Marks, D.L., Butler, A.A., Turner, R., Brookhart, G., Cone, R.D., 2003. Differential role of melanocortin receptor subtypes in cachexia. Endocrinology 144, 1513-1523. (Pubitemid 36428494)
    • (2003) Endocrinology , vol.144 , Issue.4 , pp. 1513-1523
    • Marks, D.L.1    Butler, A.A.2    Turner, R.3    Brookhart, G.4    Cone, R.D.5
  • 58
    • 0029785717 scopus 로고    scopus 로고
    • Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance
    • Mayan, H., Ling, K.T., Lee, E.Y., Wiedemann, E., Kalinyak, J.E., Humphreys, M.H., 1996. Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance. Hypertension 28, 244-249. (Pubitemid 26322797)
    • (1996) Hypertension , vol.28 , Issue.2 , pp. 244-249
    • Mayan, H.1    Ling, K.-T.2    Lee, E.Y.3    Wiedemann, E.4    Kalinyak, J.E.5    Humphreys, M.H.6
  • 61
    • 33646500989 scopus 로고    scopus 로고
    • Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus
    • Mounien, L., Bizet, P., Boutelet, I., Vaudry, H., Jegou, S., 2005. Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology 82, 164-170.
    • (2005) Neuroendocrinology , vol.82 , pp. 164-170
    • Mounien, L.1    Bizet, P.2    Boutelet, I.3    Vaudry, H.4    Jegou, S.5
  • 62
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy, K.G., Mortrud, M.T., Low, M.J., Simerly, R.B., Cone, R.D., 1994. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8, 1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 63
    • 0347137958 scopus 로고    scopus 로고
    • Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells
    • Mountjoy, K.G., Kong, P.L., Taylor, J.A., Willard, D.H., Wilkison, W.O., 2001. Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells. Physiol. Genomics 5, 11-19. (Pubitemid 33675198)
    • (2001) Physiological Genomics , vol.2001 , Issue.5 , pp. 11-19
    • Mountjoy, K.G.1    Kong, P.L.2    Taylor, J.A.3    Willard, D.H.4    Wilkison, W.O.5
  • 65
    • 0037397005 scopus 로고    scopus 로고
    • Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse
    • Ni, X.P., Pearce, D., Butler, A.A., Cone, R.D., Humphreys, M.H., 2003. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J. Clin. Invest. 111, 1251-1258.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1251-1258
    • Ni, X.P.1    Pearce, D.2    Butler, A.A.3    Cone, R.D.4    Humphreys, M.H.5
  • 66
    • 33645421796 scopus 로고    scopus 로고
    • Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney
    • Ni, X.P., Bhargava, A., Pearce, D., Humphreys, M.H., 2006a. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R560-R567.
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.290
    • Ni, X.P.1    Bhargava, A.2    Pearce, D.3    Humphreys, M.H.4
  • 67
    • 33750235776 scopus 로고    scopus 로고
    • Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones
    • DOI 10.1097/01.hjh.0000249702.49854.fa, PII 0000487220061100000019
    • Ni, X.P., Butler, A.A., Cone, R.D., Humphreys, M.H., 2006b. Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones. J. Hypertens. 24, 2239-2246. (Pubitemid 44611033)
    • (2006) Journal of Hypertension , vol.24 , Issue.11 , pp. 2239-2246
    • Ni, X.-P.1    Butler, A.A.2    Cone, R.D.3    Humphreys, M.H.4
  • 68
    • 0035130843 scopus 로고    scopus 로고
    • AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
    • Nijenhuis, W.A., Oosterom, J., Adan, R.A., 2001. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol. Endocrinol. 15, 164-171.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 164-171
    • Nijenhuis, W.A.1    Oosterom, J.2    Adan, R.A.3
  • 69
    • 44649104515 scopus 로고    scopus 로고
    • Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB
    • Nyan, D.C., Anbazhagan, R., Hughes-Darden, C.A., Wachira, S.J., 2008. Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB. Neuropeptides 42, 355-366.
    • (2008) Neuropeptides , vol.42 , pp. 355-366
    • Nyan, D.C.1    Anbazhagan, R.2    Hughes-Darden, C.A.3    Wachira, S.J.4
  • 70
    • 77953810909 scopus 로고    scopus 로고
    • Melanocortin-3 receptor gene variants: Association with childhood obesity and eating behavior in Chilean families
    • Obregon, A.M., Amador, P., Valladares, M., Weisstaub, G., Burrows, R., Santos, J.L., 2010. Melanocortin-3 receptor gene variants: association with childhood obesity and eating behavior in Chilean families. Nutrition 26, 760-765.
    • (2010) Nutrition , vol.26 , pp. 760-765
    • Obregon, A.M.1    Amador, P.2    Valladares, M.3    Weisstaub, G.4    Burrows, R.5    Santos, J.L.6
  • 71
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann, M.M., Wilson, B.D., Yang, Y.-K., Kerns, J.A., Chen, Y., Gantz, I., Barsh, G.S., 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-137.
    • (1997) Science , vol.278 , pp. 135-137
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 72
    • 3242795783 scopus 로고    scopus 로고
    • Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity
    • Rached, M., Buronfosse, A., Begeot, M., Penhoat, A., 2004. Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. Biochim. Biophys. Acta 1689, 229-234.
    • (2004) Biochim. Biophys. Acta , vol.1689 , pp. 229-234
    • Rached, M.1    Buronfosse, A.2    Begeot, M.3    Penhoat, A.4
  • 75
    • 33947533651 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
    • Rutanen, J., Pihlajamaki, J., Vanttinen, M., Salmenniemi, U., Ruotsalainen, E., Kuulasmaa, T., Kainulainen, S., Laakso, M., 2007. Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects. J. Clin. Endocrinol. Metab. 92, 1112-1117.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1112-1117
    • Rutanen, J.1    Pihlajamaki, J.2    Vanttinen, M.3    Salmenniemi, U.4    Ruotsalainen, E.5    Kuulasmaa, T.6    Kainulainen, S.7    Laakso, M.8
  • 77
    • 77953845379 scopus 로고    scopus 로고
    • Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure
    • Scarlett, J.M., Bowe, D.D., Zhu, X., Batra, A.K., Grant, W.F., Marks, D.L., 2010. Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure. J Endocrinol 206, 121-130.
    • (2010) J Endocrinol , vol.206 , pp. 121-130
    • Scarlett, J.M.1    Bowe, D.D.2    Zhu, X.3    Batra, A.K.4    Grant, W.F.5    Marks, D.L.6
  • 79
    • 33645839593 scopus 로고    scopus 로고
    • Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors
    • Sutton, G.M., Trevaskis, J.L., Hulver, M.W., McMillan, R.P., Markward, N.J., Babin, M.J., Meyer, E.A., Butler, A.A., 2006. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147, 2183-2196.
    • (2006) Endocrinology , vol.147 , pp. 2183-2196
    • Sutton, G.M.1    Trevaskis, J.L.2    Hulver, M.W.3    McMillan, R.P.4    Markward, N.J.5    Babin, M.J.6    Meyer, E.A.7    Butler, A.A.8
  • 81
    • 77952307945 scopus 로고    scopus 로고
    • Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle
    • Sutton, G.M., Begriche, K., Kumar, K.G., Gimble, J.M., Perez-Tilve, D., Nogueiras, R., McMillan, R.P., Hulver, M.W., Tschop, M.H., Butler, A.A., 2010. Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J. 24, 862-872.
    • (2010) FASEB J. , vol.24 , pp. 862-872
    • Sutton, G.M.1    Begriche, K.2    Kumar, K.G.3    Gimble, J.M.4    Perez-Tilve, D.5    Nogueiras, R.6    McMillan, R.P.7    Hulver, M.W.8    Tschop, M.H.9    Butler, A.A.10
  • 82
    • 4043093705 scopus 로고    scopus 로고
    • Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
    • Tao, Y.X., Segaloff, D.L., 2004. Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J. Clin. Endocrinol. Metab. 89, 3936-3942.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3936-3942
    • Tao, Y.X.1    Segaloff, D.L.2
  • 83
  • 84
    • 0027423948 scopus 로고
    • Hereditary isolated glucocorticoid-deficiency is associated with abnormalities of the adrenocorticotropin receptor gene
    • Tsigos, C., Arai, K., Hung, W., Chrousos, G.P., 1993. Hereditary isolated glucocorticoid-deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. J. Clin. Invest. 92, 2458-2461.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2458-2461
    • Tsigos, C.1    Arai, K.2    Hung, W.3    Chrousos, G.P.4
  • 86
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., Froguel, P., 2000. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106, 253-262.
    • (2000) J. Clin. Invest. , vol.106 , pp. 253-262
    • Vaisse, C.1    Clement, K.2    Durand, E.3    Hercberg, S.4    Guy-Grand, B.5    Froguel, P.6
  • 87
    • 0028786945 scopus 로고
    • Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans
    • Valverde, P., Healy, E., J., I., J.L., R., Thody, A.J., 1995. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat. Genet. 11, 328-330.
    • (1995) Nat. Genet. , vol.11 , pp. 328-330
    • Valverde, P.1    Healy, E.2    J, I.3    JL, R.4    Thody, A.J.5
  • 89
    • 0030980505 scopus 로고    scopus 로고
    • Postnatal expression of melanocortin-3 receptor in rat diencephalon and mesencephalon
    • DOI 10.1016/S0028-3908(96)00151-7, PII S0028390896001517
    • Xia, Y., Wikberg, J.E.S., 1997. Postnatal expression of melanocortin-3 receptor in ratdiencephalon and mesencephalon. Neuropharmacology 36, 217-224. (Pubitemid 27149510)
    • (1997) Neuropharmacology , vol.36 , Issue.2 , pp. 217-224
    • Xia, Y.1    Wikberg, J.E.S.2
  • 90
    • 0037036419 scopus 로고    scopus 로고
    • Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity
    • Yang, Y., Chen, M., Lai, Y., Gantz, I., Georgeson, K.E., Harmon, C.M., 2002. Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity. J. Biol. Chem. 277, 20328-20335.
    • (2002) J. Biol. Chem. , vol.277 , pp. 20328-20335
    • Yang, Y.1    Chen, M.2    Lai, Y.3    Gantz, I.4    Georgeson, K.E.5    Harmon, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.