Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways

Neuroscience

Volumn 156, Issue 1, 2008, Pages 89-98

  Wang, J H ^a   Wang, F ^a,b,c   Yang, M J ^a   Yu, D F ^a   Wu, W N ^a   Liu, J ^a   Ma, L Q ^a   Cai, F ^a   Chen, J G ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

calcium current; leptin; NPY; patch clamp; POMC

Indexed keywords

CALCIUM CHANNEL; JANUS KINASE INHIBITOR; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROPEPTIDE Y; NIFEDIPINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROOPIOMELANOCORTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; APPETITE REGULATION; ARCUATE NUCLEUS; BODY WEIGHT; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; JANUS KINASE 2; LEPTIN; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIALS; NEURONS; NEUROPEPTIDE Y; PATCH-CLAMP TECHNIQUES; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

EID: 51249089235     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.04.079     Document Type: Article

References (48)

1. Baskin D.G., Breininger J.F., and Schwartz M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48 (1999) 828-833
2. Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., Banks A.S., Lavery H.J., Haq A.K., Maratos-Flier E., Neel B.G., Schwartz M.W., and Myers Jr. M.G. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 421 (2003) 856-859
3. Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural network. Science 269 (1995) 546-549
4. Carvalheira J.B., Torsoni M.A., Ueno M., Amaral M.E., Araújo E.P., Velloso L.A., Gontijo J.A., and Saad M.J. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res 13 (2005) 48-57
5. Catterall W.A. Structure and function of voltage-gated ion channels. Annu Rev Biochem 64 (1995) 493-531
6. 2+ channels and their role in neurotransmitter release. Cell Calcium 24 (1998) 307-323
7. Chapman J.C., McClenaghan N.H., Cosgrove K.E., Hashmi M.N., Shepherd R.M., Giesberts A.N., White S.J., Ammälä C., Flatt P.R., and Dunne M.J. ATP-sensitive potassium channels and efaroxan-induced insulin release in electrofusion-derived BRIN-BD 11 β-cell line. Diabetes 48 (1999) 2349-2357
8. 2+ channels constituting a putative positive feedback loop. Free Radic Biol Med 32 (2002) 638-649
9. Clark J.T., Kalra P.S., Crowley W.R., and Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115 (1984) 427-429
10. Cone R.D. The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 20 (1999) 68-100
11. Cowley M.A., Smart J.L., Rubinstein M., Cerdán M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
12. ATP channels knock out. News physiol Sci (1997) 12197-12203
13. Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Bjorbaek C., Flier J.S., Saper C.B., and Elmquist J.K. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23 (1999) 775-786
14. Erickson J.C., Hollopeter G., and Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274 (1996) 1704-1707
15. 2+ channels in adult rat carotid body chemoreceptor type 1 cells. J Physiol 489 (1995) 689-699
16. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., and Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 (1997) 165-168
17. Glaum S.R., Hara M., Bindokas V.P., Lee C.C., Polonsky K.S., Bell G.I., and Miller R.J. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol 50 (1996) 230-235
18. Gomperts B.D., Kramer I.M., and Tatham P.E.R. Signal transduction (2003), Academic Press, San Diego
19. Hahn T.M., Breininger J.F., Baskin D.G., and Schwartz M.W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1 (1998) 271-272
20. Hâkansson M.L., Brown H., Ghilardi N., Skoda R.C., and Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 18 (1998) 559-572
21. Hille B. Ionic channels: molecular pores of excitable membranes. Harvey Lect 82 (1986) 47-69
22. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., and Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 (1997) 131-141
23. ATP channels. Endocrinology 144 (2003) 1331-1340
24. Jo Y.H., Chen Y.J., Chua Jr. S.C., Talmage D.A., and Role L.W. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 48 (2005) 1055-1066
25. King P.J., Widdowson P.S., Doods H.N., and Williams G. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J Neurochem 73 (1999) 641-646
26. 2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52 (2003) 948-956
27. Kohno D., Nakata M., Maekawa F., Fujiwara K., Maejima Y., Kuramochi M., Shimazaki T., Okano H., Onaka T., and Yada T. Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148 (2007) 2251-2263
28. Lin S., Storlien L.H., and Huang X.F. Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res 875 (2000) 89-95
29. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., and Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8 (1996) 733-735
30. 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19 (2004) 1524-1534
31. 2+ channels. J Neurophysiol 78 (1997) 2467-2474
32. Rock F.L., Peterson D., Weig B.C., Kastelein R.A., and Bazan J.F. Binding of leptin to the soluble ectodomain of recombinant leptin receptor. Horm Metab Res 28 (1996) 748-750
33. Saper C.B., Chou T.C., and Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 36 (2002) 199-211
34. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte Jr. D., Woods S.C., Seeley R.J., and Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 (1996) 531-535
35. Schwartz M.W., and Porte Jr. D. Diabetes, obesity, and the brain. Science 307 (2005) 375-379
36. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., and Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98 (1996) 1101-1106
37. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., and Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 (1997) 2119-2123
38. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
39. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., and Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390 (1997) 521-525
40. Spiegelman B.M., and Flier J.S. Obesity and the regulation of energy balance. Cell 104 (2001) 531-543
41. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Wool E.A., Monroe C.A., and Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
42. Tsien R.W., Lipscombe D., Madison D., Bley K., and Fox A. Reflections on calcium channel diversity. Trends Neurosci 18 (1995) 52-54
43. van den Top M., Lee K., Whyment A.D., Blanks A.M., and Spanswick D. Orexin-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7 (2004) 493-494
44. Wilson G.F., Magoski N.S., and Kaczmarek L.K. Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activities. Proc Natl Acad Sci U S A 95 (1998) 10938-10943
45. Xu A.W., Kaelin C.B., Takeda K., Akira S., Schwartz M.W., and Barsh G.S. PI3k integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115 (2005) 951-958
46. 2+ signaling. J Neurosci 21 (2001) 7474-7480
47. Zarjevski N., Cusin I., Vettor R., Rohner-Jeanrenaud F., and Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133 (1993) 1753-1758
48. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432