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Volumn 40, Issue 10, 2012, Pages 4368-4384

Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H4; HYPERTONIC SOLUTION; MAMMALIAN TARGET OF RAPAMYCIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT 5; UNCLASSIFIED DRUG;

EID: 84861563571     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks038     Document Type: Article
Times cited : (40)

References (100)
  • 1
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar, D.C. and Blenis, J. (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene, 23, 3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 4
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D.D., Ali, S.M., Kim, D.H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P. and Sabatini, D.M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol., 14, 1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 5
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • Yang, Q., Inoki, K., Ikenoue, T. and Guan, K.L. (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev., 20, 2820-2832.
    • (2006) Genes Dev. , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.L.4
  • 6
    • 0033539154 scopus 로고    scopus 로고
    • Characterization of S6K2, a novel kinase homologous to S6K1
    • Lee-Fruman, K.K., Kuo, C.J., Lippincott, J., Terada, N. and Blenis, J. (1999) Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene, 18, 5108-5114.
    • (1999) Oncogene , vol.18 , pp. 5108-5114
    • Lee-Fruman, K.K.1    Kuo, C.J.2    Lippincott, J.3    Terada, N.4    Blenis, J.5
  • 8
    • 0036310982 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
    • Peng, T., Golub, T.R. and Sabatini, D.M. (2002) The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell. Biol., 22, 5575-5584.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5575-5584
    • Peng, T.1    Golub, T.R.2    Sabatini, D.M.3
  • 9
    • 0037151120 scopus 로고    scopus 로고
    • Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics
    • Grolleau, A., Bowman, J., Pradet-Balade, B., Puravs, E., Hanash, S., Garcia-Sanz, J.A. and Beretta, L. (2002) Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J. Biol. Chem., 277, 22175-22184.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22175-22184
    • Grolleau, A.1    Bowman, J.2    Pradet-Balade, B.3    Puravs, E.4    Hanash, S.5    Garcia-Sanz, J.A.6    Beretta, L.7
  • 10
    • 1542305503 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase i transcription in response to IGF-1 and nutrients
    • James, M.J. and Zomerdijk, J.C. (2004) Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J. Biol. Chem., 279, 8911-8918.
    • (2004) J. Biol. Chem. , vol.279 , pp. 8911-8918
    • James, M.J.1    Zomerdijk, J.C.2
  • 13
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M.A., Hall, A. and Hall, M.N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol., 6, 1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 14
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, J.D. and Delgoffe, G.M. (2010) The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity, 33, 301-311.
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 15
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates akt phosphorylation and substrate specificity
    • Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J. and Su, B. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates akt phosphorylation and substrate specificity. Cell, 127, 125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 16
    • 78649712949 scopus 로고    scopus 로고
    • MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent akt polypeptide
    • Oh, W.J., Wu, C.C., Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B. and Jacinto, E. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent akt polypeptide. EMBO J., 29, 3939-3951.
    • (2010) EMBO J. , vol.29 , pp. 3939-3951
    • Oh, W.J.1    Wu, C.C.2    Kim, S.J.3    Facchinetti, V.4    Julien, L.A.5    Finlan, M.6    Roux, P.P.7    Su, B.8    Jacinto, E.9
  • 17
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo, A.Y., Yoon, S.O., Kim, S.G., Roux, P.P. and Blenis, J. (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc. Natl Acad. Sci. USA, 105, 17414-17419.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 20
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti, M.N. and Guan, K.L. (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene, 25, 6347-6360.
    • (2006) Oncogene , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.L.2
  • 21
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov, A.V. and Karin, M. (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell, 134, 451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 22
    • 3042818799 scopus 로고    scopus 로고
    • Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
    • Corradetti, M.N., Inoki, K., Bardeesy, N., DePinho, R.A. and Guan, K.L. (2004) Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev., 18, 1533-1538.
    • (2004) Genes Dev. , vol.18 , pp. 1533-1538
    • Corradetti, M.N.1    Inoki, K.2    Bardeesy, N.3    Depinho, R.A.4    Guan, K.L.5
  • 23
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Li, Y., Xu, T. and Guan, K.L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev., 17, 1829-1834.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 24
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T. and Guan, K.L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell, 115, 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 26
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • Choo, A.Y., Kim, S.G., Vander Heiden, M.G., Mahoney, S.J., Vu, H., Yoon, S.O., Cantley, L.C. and Blenis, J. (2010) Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell, 38, 487-499.
    • (2010) Mol. Cell , vol.38 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 27
    • 36549026878 scopus 로고    scopus 로고
    • Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
    • Lee, C.H., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E.P. and Guan, K.L. (2007) Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J., 26, 4812-4823.
    • (2007) EMBO J. , vol.26 , pp. 4812-4823
    • Lee, C.H.1    Inoki, K.2    Karbowniczek, M.3    Petroulakis, E.4    Sonenberg, N.5    Henske, E.P.6    Guan, K.L.7
  • 28
    • 34547134517 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
    • Land, S.C. and Tee, A.R. (2007) Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem., 282, 20534-20543.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20534-20543
    • Land, S.C.1    Tee, A.R.2
  • 29
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    • Toschi, A., Lee, E., Gadir, N., Ohh, M. and Foster, D.A. (2008) Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J. Biol. Chem., 283, 34495-34499.
    • (2008) J. Biol. Chem. , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3    Ohh, M.4    Foster, D.A.5
  • 30
    • 35648982347 scopus 로고    scopus 로고
    • Cellular response to hyperosmotic stresses
    • Burg, M.B., Ferraris, J.D. and Dmitrieva, N.I. (2007) Cellular response to hyperosmotic stresses. Physiol. Rev., 87, 1441-1474.
    • (2007) Physiol. Rev. , vol.87 , pp. 1441-1474
    • Burg, M.B.1    Ferraris, J.D.2    Dmitrieva, N.I.3
  • 31
    • 66749106368 scopus 로고    scopus 로고
    • Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism
    • Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.K., Beck, F.X., Muller, D.N., Derer, W. et al. (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat. Med., 15, 545-552.
    • (2009) Nat. Med. , vol.15 , pp. 545-552
    • MacHnik, A.1    Neuhofer, W.2    Jantsch, J.3    Dahlmann, A.4    Tammela, T.5    MacHura, K.6    Park, J.K.7    Beck, F.X.8    Muller, D.N.9    Derer, W.10
  • 33
    • 77954836528 scopus 로고    scopus 로고
    • Ambient tonicity and intestinal cytochrome CYP3A
    • Chuang, A.I. and Ito, S. (2010) Ambient tonicity and intestinal cytochrome CYP3A. Expert Opin. Drug Metab. Toxicol., 6, 883-893.
    • (2010) Expert Opin. Drug Metab. Toxicol. , vol.6 , pp. 883-893
    • Chuang, A.I.1    Ito, S.2
  • 34
    • 10444280006 scopus 로고    scopus 로고
    • Hypertonic stress response
    • Dmitrieva, N.I. and Burg, M.B. (2005) Hypertonic stress response. Mutat. Res., 569, 65-74.
    • (2005) Mutat. Res. , vol.569 , pp. 65-74
    • Dmitrieva, N.I.1    Burg, M.B.2
  • 37
    • 33646482382 scopus 로고    scopus 로고
    • Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation
    • McDill, B.W., Li, S.Z., Kovach, P.A., Ding, L. and Chen, F. (2006) Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc. Natl Acad. Sci. USA, 103, 6952-6957.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6952-6957
    • McDill, B.W.1    Li, S.Z.2    Kovach, P.A.3    Ding, L.4    Chen, F.5
  • 38
    • 0032549031 scopus 로고    scopus 로고
    • Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
    • Ma, T., Yang, B., Gillespie, A., Carlson, E.J., Epstein, C.J. and Verkman, A.S. (1998) Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J. Biol. Chem., 273, 4296-4299.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4296-4299
    • Ma, T.1    Yang, B.2    Gillespie, A.3    Carlson, E.J.4    Epstein, C.J.5    Verkman, A.S.6
  • 39
    • 0442307916 scopus 로고    scopus 로고
    • Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain
    • Loyher, M.L., Mutin, M., Woo, S.K., Kwon, H.M. and Tappaz, M.L. (2004) Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neuroscience, 124, 89-104.
    • (2004) Neuroscience , vol.124 , pp. 89-104
    • Loyher, M.L.1    Mutin, M.2    Woo, S.K.3    Kwon, H.M.4    Tappaz, M.L.5
  • 40
    • 78650642981 scopus 로고    scopus 로고
    • NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia
    • Berga-Bolanos, R., Drews-Elger, K., Aramburu, J. and Lopez-Rodriguez, C. (2010) NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia. J. Immunol., 185, 6624-6635.
    • (2010) J. Immunol. , vol.185 , pp. 6624-6635
    • Berga-Bolanos, R.1    Drews-Elger, K.2    Aramburu, J.3    Lopez-Rodriguez, C.4
  • 41
    • 0034793579 scopus 로고    scopus 로고
    • Maintenance of genomic integrity in mammalian kidney cells exposed to hyperosmotic stress
    • Kultz, D. and Chakravarty, D. (2001) Maintenance of genomic integrity in mammalian kidney cells exposed to hyperosmotic stress. Comp. Biochem. Physiol. A. Mol. Integr. Physiol., 130, 421-428.
    • (2001) Comp. Biochem. Physiol. A. Mol. Integr. Physiol. , vol.130 , pp. 421-428
    • Kultz, D.1    Chakravarty, D.2
  • 42
    • 0039594736 scopus 로고    scopus 로고
    • Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation
    • Dmitrieva, N., Kultz, D., Michea, L., Ferraris, J. and Burg, M. (2000) Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation. J. Biol. Chem., 275, 18243-18247.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18243-18247
    • Dmitrieva, N.1    Kultz, D.2    Michea, L.3    Ferraris, J.4    Burg, M.5
  • 44
    • 65349121222 scopus 로고    scopus 로고
    • The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress
    • Drews-Elger, K., Ortells, M.C., Rao, A., Lopez-Rodriguez, C. and Aramburu, J. (2009) The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One, 4, e5245.
    • (2009) PLoS One , vol.4
    • Drews-Elger, K.1    Ortells, M.C.2    Rao, A.3    Lopez-Rodriguez, C.4    Aramburu, J.5
  • 47
    • 3242674944 scopus 로고    scopus 로고
    • NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment
    • Go, W.Y., Liu, X., Roti, M.A., Liu, F. and Ho, S.N. (2004) NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc. Natl Acad. Sci. USA, 101, 10673-10678.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 10673-10678
    • Go, W.Y.1    Liu, X.2    Roti, M.A.3    Liu, F.4    Ho, S.N.5
  • 48
    • 79954480118 scopus 로고    scopus 로고
    • TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and-independent pathways
    • Lee, S.D., Choi, S.Y., Lim, S.W., Lamitina, S.T., Ho, S.N., Go, W.Y. and Kwon, H.M. (2011) TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and-independent pathways. Am. J. Physiol. Renal Physiol., 300, F707-F715.
    • (2011) Am. J. Physiol. Renal Physiol. , vol.300
    • Lee, S.D.1    Choi, S.Y.2    Lim, S.W.3    Lamitina, S.T.4    Ho, S.N.5    Go, W.Y.6    Kwon, H.M.7
  • 49
    • 13044250453 scopus 로고    scopus 로고
    • Tonicity-responsive enhancer binding protein a rel-like protein that stimulates transcription in response to hypertonicity
    • Miyakawa, H., Woo, S.K., Dahl, S.C., Handler, J.S. and Kwon, H.M. (1999) Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc. Natl Acad. Sci. USA, 96, 2538-2542.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2538-2542
    • Miyakawa, H.1    Woo, S.K.2    Dahl, S.C.3    Handler, J.S.4    Kwon, H.M.5
  • 50
    • 0033594887 scopus 로고    scopus 로고
    • NFAT5 a constitutively nuclear NFAT protein that does not cooperate with fos and jun
    • Lopez-Rodriguez, C., Aramburu, J., Rakeman, A.S. and Rao, A. (1999) NFAT5, a constitutively nuclear NFAT protein that does not cooperate with fos and jun. Proc. Natl Acad. Sci. USA, 96, 7214-7219.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7214-7219
    • Lopez-Rodriguez, C.1    Aramburu, J.2    Rakeman, A.S.3    Rao, A.4
  • 51
    • 0034907525 scopus 로고    scopus 로고
    • Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress
    • Lopez-Rodriguez, C., Aramburu, J., Jin, L., Rakeman, A.S., Michino, M. and Rao, A. (2001) Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity, 15, 47-58.
    • (2001) Immunity , vol.15 , pp. 47-58
    • Lopez-Rodriguez, C.1    Aramburu, J.2    Jin, L.3    Rakeman, A.S.4    Michino, M.5    Rao, A.6
  • 52
    • 0036318568 scopus 로고    scopus 로고
    • TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity
    • Woo, S.K., Lee, S.D., Na, K.Y., Park, W.K. and Kwon, H.M. (2002) TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity. Mol. Cell. Biol., 22, 5753-5760.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5753-5760
    • Woo, S.K.1    Lee, S.D.2    Na, K.Y.3    Park, W.K.4    Kwon, H.M.5
  • 53
    • 3042779657 scopus 로고    scopus 로고
    • Regulation of expression of the stress response gene Osp94: Identification of the tonicity response element and intracellular signalling pathways
    • Kojima, R., Randall, J.D., Ito, E., Manshio, H., Suzuki, Y. and Gullans, S.R. (2004) Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathways. Biochem. J., 380, 783-794.
    • (2004) Biochem. J. , vol.380 , pp. 783-794
    • Kojima, R.1    Randall, J.D.2    Ito, E.3    Manshio, H.4    Suzuki, Y.5    Gullans, S.R.6
  • 54
    • 4344581099 scopus 로고    scopus 로고
    • Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells
    • Ito, T., Fujio, Y., Hirata, M., Takatani, T., Matsuda, T., Muraoka, S., Takahashi, K. and Azuma, J. (2004) Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells. Biochem. J., 382, 177-182.
    • (2004) Biochem. J. , vol.382 , pp. 177-182
    • Ito, T.1    Fujio, Y.2    Hirata, M.3    Takatani, T.4    Matsuda, T.5    Muraoka, S.6    Takahashi, K.7    Azuma, J.8
  • 55
    • 0034623952 scopus 로고    scopus 로고
    • The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression
    • Nakayama, Y., Peng, T., Sands, J.M. and Bagnasco, S.M. (2000) The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. J. Biol. Chem., 275, 38275-38280.
    • (2000) J. Biol. Chem. , vol.275 , pp. 38275-38280
    • Nakayama, Y.1    Peng, T.2    Sands, J.M.3    Bagnasco, S.M.4
  • 56
    • 33847753121 scopus 로고    scopus 로고
    • Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes
    • Ito, T., Fujio, Y., Takahashi, K. and Azuma, J. (2007) Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J. Biol. Chem., 282, 1152-1160.
    • (2007) J. Biol. Chem. , vol.282 , pp. 1152-1160
    • Ito, T.1    Fujio, Y.2    Takahashi, K.3    Azuma, J.4
  • 57
    • 0033609834 scopus 로고    scopus 로고
    • Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase
    • Parrott, L.A. and Templeton, D.J. (1999) Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase. J. Biol. Chem., 274, 24731-24736.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24731-24736
    • Parrott, L.A.1    Templeton, D.J.2
  • 58
    • 0033056079 scopus 로고    scopus 로고
    • Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state
    • Chen, D., Fucini, R.V., Olson, A.L., Hemmings, B.A. and Pessin, J.E. (1999) Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state. Mol. Cell. Biol., 19, 4684-4694.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4684-4694
    • Chen, D.1    Fucini, R.V.2    Olson, A.L.3    Hemmings, B.A.4    Pessin, J.E.5
  • 59
    • 8544278060 scopus 로고    scopus 로고
    • Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress
    • Naegele, S. and Morley, S.J. (2004) Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. J. Biol. Chem., 279, 46023-46034.
    • (2004) J. Biol. Chem. , vol.279 , pp. 46023-46034
    • Naegele, S.1    Morley, S.J.2
  • 60
    • 0033544956 scopus 로고    scopus 로고
    • Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
    • Van der Kaay, J., Beck, M., Gray, A. and Downes, C.P. (1999) Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses. J. Biol. Chem., 274, 35963-35968.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35963-35968
    • Van Der Kaay, J.1    Beck, M.2    Gray, A.3    Downes, C.P.4
  • 63
    • 33745035164 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
    • Irarrazabal, C.E., Burg, M.B., Ward, S.G. and Ferraris, J.D. (2006) Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: role in osmoprotective transcriptional regulation. Proc. Natl Acad. Sci. USA, 103, 8882-8887.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 8882-8887
    • Irarrazabal, C.E.1    Burg, M.B.2    Ward, S.G.3    Ferraris, J.D.4
  • 64
    • 40449099957 scopus 로고    scopus 로고
    • Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice
    • Morancho, B., Minguillon, J., Molkentin, J.D., Lopez-Rodriguez, C. and Aramburu, J. (2008) Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol. Biol., 9, 13.
    • (2008) BMC Mol. Biol. , vol.9 , pp. 13
    • Morancho, B.1    Minguillon, J.2    Molkentin, J.D.3    Lopez-Rodriguez, C.4    Aramburu, J.5
  • 65
    • 0035860714 scopus 로고    scopus 로고
    • The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in saccharomyces cerevisiae
    • Crespo, J.L., Daicho, K., Ushimaru, T. and Hall, M.N. (2001) The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in saccharomyces cerevisiae. J. Biol. Chem., 276, 34441-34444.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34441-34444
    • Crespo, J.L.1    Daicho, K.2    Ushimaru, T.3    Hall, M.N.4
  • 66
    • 0035831446 scopus 로고    scopus 로고
    • The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
    • Weisman, R. and Choder, M. (2001) The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem., 276, 7027-7032.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7027-7032
    • Weisman, R.1    Choder, M.2
  • 69
    • 76749139887 scopus 로고    scopus 로고
    • Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways
    • Bjorklund, M.A., Vaahtomeri, K., Peltonen, K., Viollet, B., Makela, T.P., Band, A.M. and Laiho, M. (2010) Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways. Exp. Cell Res., 316, 762-774.
    • (2010) Exp. Cell Res. , vol.316 , pp. 762-774
    • Bjorklund, M.A.1    Vaahtomeri, K.2    Peltonen, K.3    Viollet, B.4    Makela, T.P.5    Band, A.M.6    Laiho, M.7
  • 71
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article 3
    • Smyth, G.K. (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 3, Article 3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 73
    • 0030048284 scopus 로고    scopus 로고
    • The role of cellular hydration in the regulation of cell function
    • Haussinger, D. (1996) The role of cellular hydration in the regulation of cell function. Biochem. J., 313, 697-710.
    • (1996) Biochem. J. , vol.313 , pp. 697-710
    • Haussinger, D.1
  • 74
    • 15444362044 scopus 로고    scopus 로고
    • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
    • Corradetti, M.N., Inoki, K. and Guan, K.L. (2005) The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J. Biol. Chem., 280, 9769-9772.
    • (2005) J. Biol. Chem. , vol.280 , pp. 9769-9772
    • Corradetti, M.N.1    Inoki, K.2    Guan, K.L.3
  • 77
    • 0036163891 scopus 로고    scopus 로고
    • Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development
    • Nishimura, K., Nakatsu, F., Kashiwagi, K., Ohno, H., Saito, T. and Igarashi, K. (2002) Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells, 7, 41-47.
    • (2002) Genes Cells , vol.7 , pp. 41-47
    • Nishimura, K.1    Nakatsu, F.2    Kashiwagi, K.3    Ohno, H.4    Saito, T.5    Igarashi, K.6
  • 78
    • 58749084336 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor-D expression in clear cell renal cell carcinoma by CD74: A critical role in cancer cell tumorigenesis
    • Liu, Y.H., Lin, C.Y., Lin, W.C., Tang, S.W., Lai, M.K. and Lin, J.Y. (2008) Up-regulation of vascular endothelial growth factor-D expression in clear cell renal cell carcinoma by CD74: a critical role in cancer cell tumorigenesis. J. Immunol., 181, 6584-6594.
    • (2008) J. Immunol. , vol.181 , pp. 6584-6594
    • Liu, Y.H.1    Lin, C.Y.2    Lin, W.C.3    Tang, S.W.4    Lai, M.K.5    Lin, J.Y.6
  • 79
    • 77956671612 scopus 로고    scopus 로고
    • Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
    • Cubas, R., Zhang, S., Li, M., Chen, C. and Yao, Q. (2010) Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol. Cancer., 9, 253.
    • (2010) Mol. Cancer. , vol.9 , pp. 253
    • Cubas, R.1    Zhang, S.2    Li, M.3    Chen, C.4    Yao, Q.5
  • 82
    • 0034282947 scopus 로고    scopus 로고
    • Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues
    • Wu, P., Blair, P.V., Sato, J., Jaskiewicz, J., Popov, K.M. and Harris, R.A. (2000) Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch. Biochem. Biophys., 381, 1-7.
    • (2000) Arch. Biochem. Biophys. , vol.381 , pp. 1-7
    • Wu, P.1    Blair, P.V.2    Sato, J.3    Jaskiewicz, J.4    Popov, K.M.5    Harris, R.A.6
  • 83
    • 13244278180 scopus 로고    scopus 로고
    • The pim kinases control rapamycin-resistant T cell survival and activation
    • Fox, C.J., Hammerman, P.S. and Thompson, C.B. (2005) The pim kinases control rapamycin-resistant T cell survival and activation. J. Exp. Med., 201, 259-266.
    • (2005) J. Exp. Med. , vol.201 , pp. 259-266
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 87
    • 5444225805 scopus 로고    scopus 로고
    • Elongation by RNA polymerase II: The short and long of it
    • Sims, R.J. 3rd, Belotserkovskaya, R. and Reinberg, D. (2004) Elongation by RNA polymerase II: the short and long of it. Genes Dev., 18, 2437-2468.
    • (2004) Genes Dev. , vol.18 , pp. 2437-2468
    • Sims III, R.J.1    Belotserkovskaya, R.2    Reinberg, D.3
  • 88
    • 57649088471 scopus 로고    scopus 로고
    • Fifteen years of clinical studies and clinical practice in renal transplantation: Reviewing outcomes with de novo use of sirolimus in combination with cyclosporine
    • Kahan, B.D. (2008) Fifteen years of clinical studies and clinical practice in renal transplantation: reviewing outcomes with de novo use of sirolimus in combination with cyclosporine. Transplant. Proc., 40, S17-S20.
    • (2008) Transplant. Proc. , vol.40
    • Kahan, B.D.1
  • 90
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Leontieva, O.V. and Blagosklonny, M.V. (2010) DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging, 2, 924-935.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 91
  • 92
    • 22344443038 scopus 로고    scopus 로고
    • Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP
    • Zhou, X., Ferraris, J.D., Cai, Q., Agarwal, A. and Burg, M.B. (2005) Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP. Am. J. Physiol. Renal Physiol., 289, F377-F385.
    • (2005) Am. J. Physiol. Renal Physiol. , vol.289
    • Zhou, X.1    Ferraris, J.D.2    Cai, Q.3    Agarwal, A.4    Burg, M.B.5
  • 94
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • Hargreaves, D.C., Horng, T. and Medzhitov, R. (2009) Control of inducible gene expression by signal-dependent transcriptional elongation. Cell, 138, 129-145.
    • (2009) Cell , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 95
    • 77954413330 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    • Sun, Y., Ge, Y., Drnevich, J., Zhao, Y., Band, M. and Chen, J. (2010) Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis. J. Cell Biol., 189, 1157-1169.
    • (2010) J. Cell Biol. , vol.189 , pp. 1157-1169
    • Sun, Y.1    Ge, Y.2    Drnevich, J.3    Zhao, Y.4    Band, M.5    Chen, J.6
  • 96
    • 0345305803 scopus 로고    scopus 로고
    • Chromatin-mediated regulation of nucleolar structure and RNA pol i localization by TOR
    • Tsang, C.K., Bertram, P.G., Ai, W., Drenan, R. and Zheng, X.F. (2003) Chromatin-mediated regulation of nucleolar structure and RNA pol I localization by TOR. EMBO J., 22, 6045-6056.
    • (2003) EMBO J. , vol.22 , pp. 6045-6056
    • Tsang, C.K.1    Bertram, P.G.2    Ai, W.3    Drenan, R.4    Zheng, X.F.5
  • 97
    • 79952355184 scopus 로고    scopus 로고
    • Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in saccharomyces cerevisiae
    • Ha, C.W. and Huh, W.K. (2010) Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in saccharomyces cerevisiae. Nucleic Acids Res., 39, 1336-1350.
    • (2010) Nucleic Acids Res. , vol.39 , pp. 1336-1350
    • Ha, C.W.1    Huh, W.K.2
  • 98
    • 0037223438 scopus 로고    scopus 로고
    • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation
    • Rohde, J.R. and Cardenas, M.E. (2003) The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol. Cell. Biol., 23, 629-635.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 629-635
    • Rohde, J.R.1    Cardenas, M.E.2
  • 99
    • 0033179817 scopus 로고    scopus 로고
    • Transfection-mediated cell-cycle signaling: Considerations for transient transfection-based cell-cycle studies
    • Rodriguez, A. and Flemington, E.K. (1999) Transfection-mediated cell-cycle signaling: considerations for transient transfection-based cell-cycle studies. Anal. Biochem., 272, 171-181.
    • (1999) Anal. Biochem. , vol.272 , pp. 171-181
    • Rodriguez, A.1    Flemington, E.K.2
  • 100
    • 70349202714 scopus 로고    scopus 로고
    • Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase
    • Estrada-Gelonch, A., Aramburu, J. and Lopez-Rodriguez, C. (2009) Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase. PLoS One, 4, e7036.
    • (2009) PLoS One , vol.4
    • Estrada-Gelonch, A.1    Aramburu, J.2    Lopez-Rodriguez, C.3


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