Up-regulation of vascular endothelial growth factor-D expression in clear cell renal cell carcinoma by CD74: A critical role in cancer cell tumorigenesis

Journal of Immunology

Volumn 181, Issue 9, 2008, Pages 6584-6594

  Liu, Yu Huei ^a   Lin, Chang Yueh ^a   Lin, Wei Chou ^b   Tang, Sai Wen ^a   Lai, Ming Kuen ^b   Lin, Jung Yaw ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD74 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN D; B LYMPHOCYTE ANTIGEN; HLA ANTIGEN CLASS 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN HEK293; CHROMATIN IMMUNOPRECIPITATION; CLEAR CELL CARCINOMA; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA BINDING; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; KIDNEY CELL; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR PROMOTION; UMBILICAL VEIN; UPREGULATION; WESTERN BLOTTING; XENOGRAFT; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL TRANSFORMATION; COCULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INVARIANT CHAIN; KIDNEY TUMOR; METABOLISM; MOUSE MUTANT; NEOVASCULARIZATION (PATHOLOGY); NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CARCINOMA, RENAL CELL; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COCULTURE TECHNIQUES; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; KIDNEY NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; NEOVASCULARIZATION, PATHOLOGIC; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 58749084336     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.9.6584     Document Type: Article

References (43)

1. Cordon-Cardo, C., and C. Prives. 1999. At the crossroads of inflammation and tumorigenesis. J. Exp. Med. 190: 1367-1370.
2. Saito, T., M. Kimura, T. Kawasaki, S. Sato, and Y. Tomita. 1997. MHC class II antigen-associated invariant chain on renal cell cancer may contribute to the anti-tumor immune response of the host. Cancer Lett. 115: 121-127. (Pubitemid 27026199)
3. Young, A. N., M. B. Amin, C. S. Moreno, S. D. Lim, C. Cohen, J. A. Petros, F. F. Marshall, and A. S. Neish. 2001. Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am. J. Pathol. 158: 1639-1651.
4. Pehlivan, M., S. Pehlivan, H. Onay, M. Koyuncuoglu, and Z. Kirkali. 2005. Can mycoplasma-mediated oncogenesis be responsible for formation of conventional renal cell carcinoma? Urology 65: 411-414. (Pubitemid 40248052)
5. Erkizan, O., G. Kirkali, K. Yorukoglu, and Z. Kirkali. 2004. Significance of heat shock protein-27 expression in patients with renal cell carcinoma. Urology 64: 474-478. (Pubitemid 39200740)
6. Kopper, L., and J. Timar. 2006. Genomics of renal cell cancer: does it provide breakthrough? Pathol. Oncol. Res. 12: 5-11.
7. Sakamoto, S., A. J. Ryan, and N. Kyprianou. 2008. Targeting vasculature in urologic tumors: mechanistic and therapeutic significance. J. Cell. Biochem. 103: 691-708. (Pubitemid 351240607)
8. Bertolino, P., and C. Rabourdin-Combe. 1996. The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells. Crit. Rev. Immunol. 16: 359-379. (Pubitemid 26419109)
9. Porter, D., J. Lahti-Domenici, A. Keshaviah, Y. K. Bae, P. Argani, J. Marks, A. Richardson, A. Cooper, R. Strausberg, G. J. Riggins, et al. 2003. Molecular markers in ductal carcinoma in situ of the breast. Mol. Cancer Res. 1: 362-375. (Pubitemid 36437922)
10. Burton, J. D., S. Ely, P. K. Reddy, R. Stein, D. V. Gold, T. M. Cardillo, and D. M. Goldenberg. 2004. CD74 is expressed by multiple myeloma and is a promising target for therapy. Clin. Cancer Res. 10: 6606-6611.
11. Tamori, Y., X. Tan, K. Nakagawa, E. Takai, J. Akagi, T. Kageshita, H. Egami, and M. Ogawa. 2005. Clinical significance of MHC class II-associated invariant chain expression in human gastric carcinoma. Oncol. Rep. 14: 873-877.
12. Datta, M. W., A. Shahsafaei, L. M. Nadler, G. J. Freeman, and D. M. Dorfman. 2000. Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms. Appl. Immunohistochem. Mol. Morphol. 8: 210-215.
13. Lazova, R., R. Moynes, D. May, and G. Scott. 1997. LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer 79: 2115-2124. (Pubitemid 27227375)
14. Koide, N., T. Yamada, R. Shibata, T. Mori, M. Fukuma, K. Yamazaki, K. Aiura, M. Shimazu, S. Hirohashi, Y. Nimura, and M. Sakamoto. 2006. Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer. Clin. Cancer Res. 12: 2419-2426.
15. Meyer-Siegler, K. L., E. C. Leifheit, and P. L. Vera. 2004. Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells. BMC Cancer 4: 34.
16. Meyer-Siegler, K. L., K. A. Iczkowski, L. Leng, R. Bucala, and P. L. Vera. 2006. Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells. J. Immunol. 177: 8730-8739.
17. Starlets, D., Y. Gore, I. Binsky, M. Haran, N. Harpaz, L. Shvidel, S. Becker-Herman, A. Berrebi, and I. Shachar. 2006. Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival. Blood 107: 4807-4816. (Pubitemid 43882632)
18. Sanchez, J. C., D. Schaller, F. Ravier, O. Golaz, S. Jaccoud, M. Belet, M. R. Wilkins, R. James, J. Deshusses, and D. Hochstrasser. 1997. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 18: 150-155.
19. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔCT) method. Methods 25: 402-408. (Pubitemid 34164012)
20. Zeng, G., L. Gao, S. Birkle, and R. K. Yu. 2000. Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production. Cancer Res. 60: 6670-6676.
21. Walseng, E., O. Bakke, and P. A. Roche. 2008. Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway. J. Biol. Chem. 283: 14717-14727.
22. Su, J. L., P. C. Yang, J. Y. Shih, C. Y. Yang, L. H. Wei, C. Y. Hsieh, C. H. Chou, Y. M. Jeng, M. Y. Wang, K. J. Chang, et al. 2006. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9: 209-223. (Pubitemid 43357947)
23. Sun, B., J. Nishihira, M. Suzuki, N. Fukushima, T. Ishibashi, M. Kondo, Y. Sato, and S. Todo. 2003. Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis. Int. J. Mol. Med. 12: 633-641. (Pubitemid 36706624)
24. Nishihira, J., T. Ishibashi, T. Fukushima, B. Sun, Y. Sato, and S. Todo. 2003. Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis. Ann. NY Acad. Sci. 995: 171-182. (Pubitemid 36706624)
25. Ren, Y., H. M. Chan, J. Fan, Y. Xie, Y. X. Chen, W. Li, G. P. Jiang, Q. Liu, A. Meinhardt, and P. K. Tam. 2006. Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma. Oncogene 25: 3501-3508. (Pubitemid 43901671)
26. Sun, B., J. Nishihira, T. Yoshiki, M. Kondo, Y. Sato, F. Sasaki, and S. Todo. 2005. Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway. Clin. Cancer Res. 11: 1050-1058. (Pubitemid 40175753)
27. Leng, L., C. N. Metz, Y. Fang, J. Xu, S. Donnelly, J. Baugh, T. Delohery, Y. Chen, R. A. Mitchell, and R. Bucala. 2003. MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197: 1467-1476. (Pubitemid 36686708)
28. Xu, M., G. Qiu, Z. Jiang, E. von Hofe, and R. E. Humphreys. 2000. Genetic modulation of tumor antigen presentation. Trends Biotechnol. 18: 167-172. (Pubitemid 30171335)
29. Vasko, V. V., and M. Saji. 2007. Molecular mechanisms involved in differentiated thyroid cancer invasion and metastasis. Curr. Opin. Oncol. 19: 11-17. (Pubitemid 44885594)
30. Bernhagen, J., R. Krohn, H. Lue, J. L. Gregory, A. Zernecke, R. R. Koenen, M. Dewor, I. Georgiev, A. Schober, L. Leng, et al. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat. Med. 13: 587-596. (Pubitemid 46828480)
31. Mestas, J., M. D. Burdick, K. Reckamp, A. Pantuck, R. A. Figlin, and R. M. Strieter. 2005. The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma. J. Immunol. 175: 5351-5357. (Pubitemid 41456421)
32. Struckmann, K., K. Mertz, S. Steu, M. Storz, P. Staller, W. Krek, P. Schraml, and H. Moch. 2008. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J. Pathol. 214: 464-471. (Pubitemid 351340566)
33. Johrer, K., C. Zelle-Rieser, A. Perathoner, P. Moser, M. Hager, R. Ramoner, H. Gander, L. Holtl, G. Bartsch, R. Greil, and M. Thurnher. 2005. Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma. Clin. Cancer Res. 11: 2459-2465. (Pubitemid 40569440)
34. Lue, H., A. Kapurniotu, G. Fingerle-Rowson, T. Roger, L. Leng, M. Thiele, T. Calandra, R. Bucala, and J. Bernhagen. 2006. Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cell. Signal. 18: 688-703. (Pubitemid 43113299)
35. Lue, H., M. Thiele, J. Franz, E. Dahl, S. Speckgens, L. Leng, G. Fingerle-Rowson, R. Bucala, B. Luscher, and J. Bernhagen. 2007. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene 26: 5046-5059. (Pubitemid 47206949)
36. Shi, X., L. Leng, T. Wang, W. Wang, X. Du, J. Li, C. McDonald, Z. Chen, J. W. Murphy, E. Lolis, et al. 2006. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25: 595-606. (Pubitemid 44529040)
37. Gore, Y., D. Starlets, N. Maharshak, S. Becker-Herman, U. Kaneyuki, L. Leng, R. Bucala, and I. Shachar. 2008. Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J. Biol. Chem. 283: 2784-2792.
38. Tang, S. W., W. H. Chang, Y. W. Chao, C. Y. Lin, H. F. Chen, Y. H. Lai, B. W. Zhan, Y. C. Su, S. W. Jane, Y. C. Chen, et al. 2006. Identification of differentially expressed genes in clear cell renal cell carcinoma by analysis of full-length enriched cDNA library. J. Biomed. Sci. 13: 233-240.
39. Mitchell, R. A. 2004. Mechanisms and effectors of MIF-dependent promotion of tumourigenesis. Cell. Signal. 16: 13-19.
40. Karkkainen, M. J., and T. V. Petrova. 2000. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene 19: 5598-5605.
41. Al-Rawi, M. A., G. Watkins, R. E. Mansel, and W. G. Jiang. 2005. Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo. Br. J. Surg. 92: 305-310. (Pubitemid 40445592)
42. Binsky, I., M. Haran, D. Starlets, Y. Gore, F. Lantner, N. Harpaz, L. Leng, D. M. Goldenberg, L. Shvidel, A. Berrebi, et al. 2007. IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival. Proc. Natl. Acad. Sci. USA 104: 13408-13413. (Pubitemid 47293958)
43. Aggarwal, B. B., S. Shishodia, S. K. Sandur, M. K. Pandey, and G. Sethi. 2006. Inflammation and cancer: how hot is the link? Biochem. Pharmacol. 72: 1605-1621. (Pubitemid 44666739)