Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Estrada Gelonch, Anaïs ^a   Aramburu, Jose ^a   López Rodríguez, Cristina ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT5; UNCLASSIFIED DRUG; DNA; NFAT5 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CHROMATIN; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DNA BINDING; GENE DELETION; GENE MUTATION; GENE REPRESSION; HUMAN; HUMAN CELL; INTERPHASE; MITOSIS; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; CELL NUCLEUS; GENETIC TRANSCRIPTION; HELA CELL; METABOLISM; METHODOLOGY; MOUSE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CELL NUCLEUS; CHROMATIN; CYTOPLASM; DNA; HELA CELLS; HUMANS; INTERPHASE; MICE; MICROSCOPY, CONFOCAL; MITOSIS; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 70349202714     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007036     Document Type: Article

References (42)

1. Hogan PG, Chen L, Nardone J, Rao A (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17: 2205-2232.
2. Aramburu J, Drews-Elger K, Estrada-Gelonch A, Minguillon J, Morancho B, et al. (2006) Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochem Pharmacol 72: 1597-1604.
3. Lopez-Rodriguez C, Aramburu J, Rakeman AS, Rao A (1999) NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci U S A 96: 7214-7219.
4. Lopez-Rodriguez C, Aramburu J, Rakeman AS, Copeland NG, Gilbert DJ, et al. (1999) NF-AT5: The NF-AT family of transcription factors expands in a new direction. Cold Spring Harb Symp Quant Biol 64: 517-526.
5. Lopez-Rodriguez C, Aramburu J, Jin L, Rakeman AS, Michino M, et al. (2001) Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity 15: 47-58.
6. Stroud JC, Lopez-Rodriguez C, Rao A, Chen L (2002) Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nat Struct Biol 9: 90-94.
7. Jeon US, Kim JA, Sheen MR, Kwon HM (2006) How tonicity regulates genes: Story of TonEBP transcriptional activator. Acta Physiol (Oxf) 187: 241-247.
8. Burg MB, Ferraris JD (2008) Intracellular organic osmolytes: Function and regulation. J Biol Chem 283: 7309-7313.
9. Lopez-Rodriguez C, Antos CL, Shelton JM, Richardson JA, Lin F, et al. (2004) Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A 101: 2392-2397.
10. Go WY, Liu X, Roti MA, Liu F, Ho SN (2004) NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A 101: 10673-10678.
11. Trama J, Go WY, Ho SN (2002) The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol 169: 5477-5488.
12. Drews-Elger K, Ortells MC, Rao A, Lopez-Rodriguez C, Aramburu J (2009) The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS ONE 4: e5245.
13. Ranjbar S, Tsytsykova AV, Lee SK, Rajsbaum R, Falvo JV, et al. (2006) NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog 2: e130.
14. Jauliac S, Lopez-Rodriguez C, Shaw LM, Brown LF, Rao A, et al. (2002) The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol 4: 540-544.
15. O'Connor RS, Mills ST, Jones KA, Ho SN, Pavlath GK (2007) A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis. J Cell Sci 120: 149-159.
16. Chen M, Sinha M, Luxon BA, Bresnick AR, O'Connor KL (2009) Integrin α6β4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/Metastasin. J Biol Chem 284: 1484-1494.
17. Burg MB, Ferraris JD, Dmitrieva NI (2007) Cellular response to hyperosmotic stresses. Physiol Rev 87: 1441-1474.
18. Lee SD, Colla E, Sheen MR, Na KY, Kwon HM (2003) Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity. J Biol Chem 278: 47571-47577.
19. Miyakawa H, Rim JS, Handler JS, Kwon HM (1999) Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene. Biochim Biophys Acta 1446: 359-364.
20. Tong EH, Guo JJ, Huang AL, Liu H, Hu CD, et al. (2006) Regulation of nucleocytoplasmic trafficking of transcription factor OREBP/TonEBP/ NFAT5. J Biol Chem 281: 23870-23879.
21. Xu S, Wong CC, Tong EH, Chung SS, Yates JR 3rd, et al. (2008) Phosphorylation by casein kinase 1 regulates tonicity-induced osmotic response element-binding protein/tonicity enhancer-binding protein nucleocytoplasmic trafficking. J Biol Chem 283: 17624-17634.
22. Kwon MS, Lee SD, Kim JA, Colla E, Choi YJ, et al. (2008) Novel nuclear localization signal regulated by ambient tonicity in vertebrates. J Biol Chem 283: 22400-22409.
23. Prescott DM, Bender MA (1962) Synthesis of RNA and protein during mitosis in mammalian tissue culture cells. Exp Cell Res 26: 260-268.
24. Gottesfeld JM, Forbes DJ (1997) Mitotic repression of the transcriptional machinery. Trends Biochem Sci 22: 197-202.
25. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, et al. (2002) A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev 16: 2985-2990.
26. Martinez-Balbas MA, Dey A, Rabindran SK, Ozato K, Wu C (1995) Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 83: 29-38.
27. Caelles C, Hennemann H, Karin M (1995) M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Mol Cell Biol 15: 6694-6701.
28. Batonnet-Pichon S, Tintignac LJ, Castro A, Sirri V, Leibovitch MP, et al. (2006) MyoD undergoes a distinct G2/M-specific regulation in muscle cells. Exp Cell Res 312: 3999-4010.
29. Sarge KD, Park-Sarge OK (2005) Gene bookmarking: Keeping the pages open. Trends Biochem Sci 30: 605-610.
30. Michelotti EF, Sanford S, Levens D (1997) Marking of active genes on mitotic chromosomes. Nature 388: 895-899.
31. Lee AY, Chung SK, Chung SS (1995) Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci U S A 92: 2780-2784.
32. -dependent myo-inositol transporter gene in mouse lens led to congenital cataract. Invest Ophthalmol Vis Sci 41: 1467-1472.
33. Vikramadithyan RK, Hu Y, Noh HL, Liang CP, Hallam K, et al. (2005) Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J Clin Invest 115: 2434-2443.
34. Morancho B, Minguillon J, Molkentin JD, Lopez-Rodriguez C, Aramburu J (2008) Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol Biol 9: 13.
35. Fan CM, Maniatis T (1991) Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature 354: 395-398.
36. Rice NR, MacKichan ML, Israel A (1992) The precursor of NF-kappa B p50 has I kappa B-like functions. Cell 71: 243-253.
37. Liou HC, Nolan GP, Ghosh S, Fujita T, Baltimore D (1992) The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50. EMBO J 11: 3003-3009.
38. Mercurio F, DiDonato JA, Rosette C, Karin M (1993) p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev 7: 705-718.
39. Rodriguez A, Flemington EK (1999) Transfection-mediated cell-cycle signaling: Considerations for transient transfection-based cell-cycle studies. Anal Biochem 272: 171-181.
40. Mendez J, Stillman B (2000) Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis. Mol Cell Biol 20: 8602-8612.
41. Huang X, Darzynkiewicz Z (2006) Cytometric assessment of histone H2AX phosphorylation: A reporter of DNA damage. Methods Mol Biol 314: 73-80.
42. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, et al. (1998) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res 5: 355-364.