Mre11-Rad50-Nbs1 complex is activated by hypertonicity

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 5, 2006, Pages

  Mee, Rie Sheen ^a   Seung, Whan Kim ^a   Jung, Ju Young ^b   Joon, Young Ahn ^c   Rhee, Juong G ^a   Kwon, H Moo ^a,d   Seung, Kyoon Woo ^a,d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Chungnam National University   (South Korea)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d Bressler Research Laboratories 11 019   (United States)

Author keywords

ATM; Cell cycle checkpoint; Chk2; DNA repair; Double strand DNA breaks; Histone H2AX; Renal medulla

Indexed keywords

ATR PROTEIN; BLEOMYCIN; HYPERTONIC SOLUTION; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; ABC TRANSPORTER; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; DNA BINDING PROTEIN; H2AX PROTEIN, MOUSE; HISTONE; MRE11A PROTEIN, HUMAN; MRE11A PROTEIN, MOUSE; NBS1 PROTEIN, HUMAN; NIJMEGEN BREAKAGE SYNDROME 1 PROTEIN, MOUSE; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN SERINE THREONINE KINASE; RAD50 PROTEIN, HUMAN; RAD50 PROTEIN, MOUSE; SODIUM CHLORIDE;

ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL CYCLE; CELL FUNCTION; DNA REPAIR; DOWNSTREAM PROCESSING; HELA CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; KIDNEY MEDULLA; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL LINE; CELL NUCLEUS; CELL STRAIN COS1; CERCOPITHECUS; CYTOLOGY; CYTOPLASM; ELECTROLYTE BALANCE; FIBROBLAST; HUMAN; KIDNEY; METABOLISM; MOUSE; OSMOTIC PRESSURE; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FIBROBLASTS; HELA CELLS; HISTONES; HUMANS; KIDNEY; MICE; NUCLEAR PROTEINS; OSMOTIC PRESSURE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SALINE SOLUTION, HYPERTONIC; SIGNAL TRANSDUCTION; WATER-ELECTROLYTE BALANCE;

EID: 33750931298     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00153.2006     Document Type: Article

References (30)

1. Bakkenist CJ and Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506, 2003.
2. Bakkenist CJ and Kastan MB. Initiating cellular stress responses. Cell 118: 9-17, 2004.
3. Beck FX, Burger-Kentischer A, and Muller E. Cellular response to osmotic stress in the renal medulla. Pflügers Arch 436: 814-827, 1998.
4. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, and Petrini JH. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-486, 1998.
5. Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, and Concannon P. Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation. Mutagenesis 15: 281-286, 2000.
6. Dahl SC, Handler JS, and Kwon HM. Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP. Am J Physiol Cell Physiol 280: C248-C253, 2001.
7. Dmitrieva NI and Burg MB. Living with DNA breaks is an everyday reality for cells adapted to high NaCl. Cell Cycle 3: 561-563, 2004.
8. Dmitrieva NI and Burg MB. Hypertonic stress response. Mutat Res 569: 65-74, 2005.
9. Dmitrieva NI, Bulavin DV, and Burg MB. High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair. Am J Physiol Renal Physiol 285: F266-F274, 2003.
10. Dmitrieva NI, Cai Q, and Burg MB. Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo. Proc Natl Acad Sci USA 101: 2317-2322, 2004.
11. Dmitrieva N, Kultz D, Michea L, Ferraris J, and Burg M. Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation. J Biol Chem 275: 18243-18247, 2000.
12. Dmitrieva N, Michea L, and Burg M. p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication. Am J Physiol Renal Physiol 281: F522-F530, 2001.
13. Falck J, Coates J, and Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434: 605-611, 2005.
14. Irarrazabal CE, Liu JC, Burg MB, and Ferraris JD. ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci USA 101: 8809-8814, 2004.
15. Jamison RL and Hall DA. Collecting duct function and sodium balance. Annu Rev Med 33: 241-254, 1982.
16. Kastan MB and Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1: 179-186, 2000.
17. Kitagawa R, Bakkenist CJ, McKinnon PJ, and Kastan MB. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18: 1423-1438, 2004.
18. Kultz D and Chakravarty D. Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells. Proc Natl Acad Sci USA 98: 1999-2004, 2001.
19. Kultz D, Madhany S, and Burg MB. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2. J Biol Chem 273: 13645-13651, 1998.
20. Levenson V and Hamlin JL. A general protocol for evaluating the specific effects of DNA replication inhibitors. Nucleic Acids Res 21: 3997-4004, 1993.
21. Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, and Kastan MB. ATM phosphorylates p95/Nbs1 in an S-phase checkpoint pathway. Nature 404: 613-617, 2000.
22. Lisby M and Rothstein R. DNA damage checkpoint and repair centers. Curr Opin Cell Biol 16: 328-334, 2004.
23. Mirzoeva OK and Petrini JH. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol 21: 281-288, 2001.
24. Miyakawa H, Woo SK, Dahl SC, Handler JS, and Kwon HM. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci USA 96: 2538-2542, 1999.
25. Nunes SL and Calderwood SK. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem Biophys Res Commun 213: 1-6, 1995.
26. Ordoukhanian P and Taylor JS. Caged single and double strand breaks. Bioconjug Chem 11: 94-103, 2000.
27. Petrini JH. The Mre11 complex and ATM: collaborating to navigate S phase. Curr Opin Cell Biol 12: 293-296, 2000.
28. Rantala I, Maki M, Laasonen A, and Visakorpi JK. Periodate-lysine- paraformaldehyde as fixative for the study of duodenal mucosa. Morphologic and immunohistochemical results at light and electron microscopic levels. Acta Pathol Microbiol Immunol Scand 93: 165-173, 1985.
29. Rauchman MI, Nigam SK, Delpire E, and Gullans SR. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol Renal Fluid Electrolyte Physiol 265: F416-F424, 1993.
30. Zhang Z, Dmitrieva NI, Park JH, Levine RL, and Burg MB. High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA. Proc Natl Acad Sci USA 101: 9491-9496, 2004.