메뉴 건너뛰기




Volumn 30, Issue 1, 2012, Pages 183-208

Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of alzheimer's disease: Protection against and interruption of progression of amyloid and tau pathology and cognitive decline

Author keywords

Aging; Alzheimer's disease; amyloid ; antioxidants; fear conditioning; free radicals; learning; oxidative stress; superoxide dismutase catalase mimetics; tau

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; EUK 207; NUCLEIC ACID; OXIDOREDUCTASE; PRESENILIN 1; SUPEROXIDE CATALASE; SUPEROXIDE DISMUTASE; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 84861516228     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-111298     Document Type: Article
Times cited : (59)

References (71)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81, 741-766. (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0025911018 scopus 로고
    • Advancesin Alzheimer's disease
    • Katzman R, Saitoh T (1991) Advancesin Alzheimer's disease. FASEB J 5, 278-286.
    • (1991) FASEB J , vol.5 , pp. 278-286
    • Katzman, R.1    Saitoh, T.2
  • 4
    • 0030513943 scopus 로고    scopus 로고
    • Structural correlates of cognition in dementia: Quantification and assessment of synapse change
    • DOI 10.1006/neur.1996.0056
    • DeKosky ST, Scheff SW, Styren SD (1996) Structural correlates of cognition in dementia: Quantification and assessment of synapse change. Neurodegeneration 5, 417-421. (Pubitemid 27077903)
    • (1996) Neurodegeneration , vol.5 , Issue.4 , pp. 417-421
    • DeKosky, S.T.1    Scheff, S.W.2    Styren, S.D.3
  • 6
    • 0031938304 scopus 로고    scopus 로고
    • Presenilin mutations in Alzheimer's disease
    • DOI 10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO;2-J
    • Cruts M, Van Broeckhoven C (1998) Presenilin mutations in Alzheimer's disease. Hum Mutat 11, 183-190. (Pubitemid 28132873)
    • (1998) Human Mutation , vol.11 , Issue.3 , pp. 183-190
    • Cruts, M.1    Van Broeckhoven, C.2
  • 7
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 8
    • 33744454404 scopus 로고    scopus 로고
    • Alzheimer's disease pathogenesis: Role of aging
    • DOI 10.1196/annals.1354.065
    • Harman D (2006) Alzheimer's disease pathogenesis: Role of aging. Ann N Y Acad Sci 1067, 454-460. (Pubitemid 43806358)
    • (2006) Annals of the New York Academy of Sciences , vol.1067 , Issue.1 , pp. 454-460
    • Harman, D.1
  • 9
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2003.08.012
    • Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM (2003) Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 24, 1063-1070. (Pubitemid 37487883)
    • (2003) Neurobiology of Aging , vol.24 , Issue.8 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    LaFerla, F.M.5
  • 10
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
    • DOI 10.1016/S0896-6273(03)00434-3
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421. (Pubitemid 36937044)
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 11
    • 0027447286 scopus 로고
    • Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
    • Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993) Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state. J Neurosci 13, 1676-1687. (Pubitemid 23095409)
    • (1993) Journal of Neuroscience , vol.13 , Issue.4 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 12
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to 26 β-protein neurotoxicity
    • DOI 10.1038/nm0798-827
    • Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA (1998) Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 4, 827-831. (Pubitemid 28331025)
    • (1998) Nature Medicine , vol.4 , Issue.7 , pp. 827-831
    • Geula, C.1    Wu, C.-K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 13
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • DOI 10.1016/j.neuron.2005.01.040
    • Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688. (Pubitemid 40320703)
    • (2005) Neuron , vol.45 , Issue.5 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 15
    • 0030921729 scopus 로고    scopus 로고
    • Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: Relevance to Alzheimer's disease
    • Butterfield DA, Hensley K, Cole P, Subramaniam R, Aksenov M, Aksenova M, Bummer PM, Haley BE, Carney JM (1997) Oxidatively induced structural alteration of glutamine syn-thetase assessed by analysis of spin label incorporation kinetics: Relevance to Alzheimer's disease. J Neurochem 68, 2451-2457. (Pubitemid 27218166)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.6 , pp. 2451-2457
    • Butterfield, D.A.1    Hensley, K.2    Cole, P.3    Subramaniam, R.4    Aksenov, M.5    Aksenova, M.6    Bummer, P.M.7    Haley, B.E.8    Carney, J.M.9
  • 17
  • 18
    • 0035194145 scopus 로고    scopus 로고
    • Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid β-peptide
    • DOI 10.1016/S1471-4914(01)02173-6, PII S1471491401021736
    • Butterfield DA, Drake J, Pocernich C, Castegna A (2001) Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid beta-peptide. Trends Mol Med 7, 548-554. (Pubitemid 33127140)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.12 , pp. 548-554
    • Butterfield, D.A.1    Drake, J.2    Pocernich, C.3    Castegna, A.4
  • 19
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • DOI 10.1016/S0197-4580(01)00340-2, PII S0197458001003402
    • Butterfield DA, Castegna A, Lauderback CM, Drake J (2002) Evidence that amyloid beta-peptide-induced lipid peroxida-tion and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 23, 655-664. (Pubitemid 35217687)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 655-664
    • Allan Butterfield, D.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 20
    • 0031754202 scopus 로고    scopus 로고
    • Increased nuclear DNA oxidation in the brain in Alzheimer' s disease
    • Gabbita SP, Lovell MA, Markesbery WR (1998) Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 71, 2034-2040. (Pubitemid 28491559)
    • (1998) Journal of Neurochemistry , vol.71 , Issue.5 , pp. 2034-2040
    • Gabbita, S.P.1    Lovell, M.A.2    Markesbery, W.R.3
  • 22
    • 0035105715 scopus 로고    scopus 로고
    • Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid
    • Lovell MA, Markesbery WR (2001) Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol 58, 392-396. (Pubitemid 32217455)
    • (2001) Archives of Neurology , vol.58 , Issue.3 , pp. 392-396
    • Lovell, M.A.1    Markesbery, W.R.2
  • 23
    • 64849090408 scopus 로고    scopus 로고
    • Microglia-aging: Roles of microglial lysosome-and mitochondria-derived reactive oxygen species in brain aging
    • Nakanishi H, Wu Z (2009) Microglia-aging: Roles of microglial lysosome-and mitochondria-derived reactive oxygen species in brain aging. Behav Brain Res 201, 1-7.
    • (2009) Behav Brain Res , vol.201 , pp. 1-7
    • Nakanishi, H.1    Wu, Z.2
  • 25
    • 0033133579 scopus 로고    scopus 로고
    • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42)
    • DOI 10.1016/S0197-4580(99)00056-1, PII S0197458099000561
    • Yatin SM, Varadarajan S, Link CD, Butterfield DA (1999) In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42). Neurobiol Aging 20, 325-330; discussion 339-342. (Pubitemid 29525418)
    • (1999) Neurobiology of Aging , vol.20 , Issue.3 , pp. 325-330
    • Yatin, S.M.1    Varadarajan, S.2    Link, C.D.3    Butterfield, D.A.4
  • 27
    • 0033860372 scopus 로고    scopus 로고
    • Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
    • Varadarajan S, Yatin S, Aksenova M, Butterfield DA (2000) Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130, 184-208.
    • (2000) J Struct Biol , vol.130 , pp. 184-208
    • Varadarajan, S.1    Yatin, S.2    Aksenova, M.3    Butterfield, D.A.4
  • 30
    • 0033769804 scopus 로고    scopus 로고
    • Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons
    • de la Monte SM, Neely TR, Cannon J, Wands JR (2000) Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons. Cell Mol Life Sci 57, 1471-1481.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1471-1481
    • De La Monte, S.M.1    Neely, T.R.2    Cannon, J.3    Wands, J.R.4
  • 32
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106, 14670-14675.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 33
    • 79955764600 scopus 로고    scopus 로고
    • Amyloid beta-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide
    • Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E (2011) Amyloid beta-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci 31, 5589-5595.
    • (2011) J Neurosci , vol.31 , pp. 5589-5595
    • Ma, T.1    Hoeffer, C.A.2    Wong, H.3    Massaad, C.A.4    Zhou, P.5    Iadecola, C.6    Murphy, M.P.7    Pautler, R.G.8    Klann, E.9
  • 34
    • 69449096141 scopus 로고    scopus 로고
    • Overexpression of SOD-2 reduces hippocampal superox-ide and prevents memory deficits in a mouse model of Alzheimer's disease
    • Massaad CA, Washington TM, Pautler RG, Klann E (2009) Overexpression of SOD-2 reduces hippocampal superox-ide and prevents memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106, 13576-13581.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13576-13581
    • Massaad, C.A.1    Washington, T.M.2    Pautler, R.G.3    Klann, E.4
  • 37
    • 79958790879 scopus 로고    scopus 로고
    • Further evidence on mitochondrial targeting of beta-amyloid and specificity of beta-amyloid-induced mitotoxicity in neurons
    • Tillement L, Lecanu L, Papadopoulos V (2011) Further evidence on mitochondrial targeting of beta-amyloid and specificity of beta-amyloid-induced mitotoxicity in neurons. Neurodegener Dis 8, 331-344.
    • (2011) Neurodegener Dis , vol.8 , pp. 331-344
    • Tillement, L.1    Lecanu, L.2    Papadopoulos, V.3
  • 38
    • 77955857970 scopus 로고    scopus 로고
    • Clinical features and pathogenesis of Alzheimer's disease: Involvement of mitochondria and mitochondrial DNA
    • Mancuso M, Orsucci D, LoGerfo A, Calsolaro V, Siciliano G (2010) Clinical features and pathogenesis of Alzheimer's disease: Involvement of mitochondria and mitochondrial DNA. Adv Exp Med Biol 685, 34-44.
    • (2010) Adv Exp Med Biol , vol.685 , pp. 34-44
    • Mancuso, M.1    Orsucci, D.2    Logerfo, A.3    Calsolaro, V.4    Siciliano, G.5
  • 39
    • 77955089623 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: Common final pathway in brain aging and Alzheimer's disease-therapeutic aspects
    • Muller WE, Eckert A, Kurz C, Eckert GP, Leuner K (2010) Mitochondrial dysfunction: Common final pathway in brain aging and Alzheimer's disease-therapeutic aspects. Mol Neurobiol 41, 159-171.
    • (2010) Mol Neurobiol , vol.41 , pp. 159-171
    • Muller, W.E.1    Eckert, A.2    Kurz, C.3    Eckert, G.P.4    Leuner, K.5
  • 42
    • 70350534700 scopus 로고    scopus 로고
    • Ferulic acid inhibits oxidative stress and cell death induced by Afj oligomers: Improved delivery by solid lipid nanoparticles
    • Picone P, Bondi ML, Montana G, Bruno A, Pitarresi G, Giammona G, Di Carlo M (2009) Ferulic acid inhibits oxidative stress and cell death induced by Afj oligomers: Improved delivery by solid lipid nanoparticles. Free Radic Res 43, 1133-1145.
    • (2009) Free Radic Res , vol.43 , pp. 1133-1145
    • Picone, P.1    Bondi, M.L.2    Montana, G.3    Bruno, A.4    Pitarresi, G.5    Giammona, G.6    Di Carlo, M.7
  • 43
    • 77957885219 scopus 로고    scopus 로고
    • Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure
    • Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A (2010) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PLoS One 5, e12359.
    • (2010) PLoS One , vol.5
    • Rhein, V.1    Giese, M.2    Baysang, G.3    Meier, F.4    Rao, S.5    Schulz, K.L.6    Hamburger, M.7    Eckert, A.8
  • 47
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM (2008) Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci 28, 6388-6392.
    • (2008) J Neurosci , vol.28 , pp. 6388-6392
    • Wang, J.1    Ho, L.2    Zhao, W.3    Ono, K.4    Rosensweig, C.5    Chen, L.6    Humala, N.7    Teplow, D.B.8    Pasinetti, G.M.9
  • 48
    • 74149083183 scopus 로고    scopus 로고
    • Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice
    • Clausen A, Doctrow S, Baudry M (2010) Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. Neurobiol Aging 31, 425-433.
    • (2010) Neurobiol Aging , vol.31 , pp. 425-433
    • Clausen, A.1    Doctrow, S.2    Baudry, M.3
  • 49
    • 74149083183 scopus 로고    scopus 로고
    • Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice
    • Clausen A, Doctrow S, Baudry M (2010) Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. Neurobiol Aging 31, 425-433.
    • (2010) Neurobiol Aging , vol.31 , pp. 425-433
    • Clausen, A.1    Doctrow, S.2    Baudry, M.3
  • 50
    • 0035503501 scopus 로고    scopus 로고
    • Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    • Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B (2001) Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci 21, 8348-8353. (Pubitemid 33051432)
    • (2001) Journal of Neuroscience , vol.21 , Issue.21 , pp. 8348-8353
    • Melov, S.1    Doctrow, S.R.2    Schneider, J.A.3    Haberson, J.4    Patel, M.5    Coskun, P.E.6    Huffman, K.7    Wallace, D.C.8    Malfroy, B.9
  • 51
    • 33645648795 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: Attenuation via antioxidant treatment
    • DOI 10.1074/jbc.M509261200
    • Morten KJ, Ackrell BA, Melov S (2006) Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: Aattenuation via antioxidant treatment. J Biol Chem 281, 3354-3359. (Pubitemid 43845949)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.6 , pp. 3354-3359
    • Morten, K.J.1    Ackrell, B.A.C.2    Melov, S.3
  • 53
    • 0028917654 scopus 로고
    • Oxygen free radicals in rat limbic structures after kainate-induced seizures
    • Bruce AJ, Baudry M (1995) Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic Biol Med 18, 993-1002.
    • (1995) Free Radic Biol Med , vol.18 , pp. 993-1002
    • Bruce, A.J.1    Baudry, M.2
  • 55
    • 0026635574 scopus 로고
    • Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
    • Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106, 274-285.
    • (1992) Behav Neurosci , vol.106 , pp. 274-285
    • Phillips, R.G.1    Ledoux, J.E.2
  • 56
    • 0026514823 scopus 로고
    • Modality-specific retrograde amnesia of fear
    • Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256, 675-677.
    • (1992) Science , vol.256 , pp. 675-677
    • Kim, J.J.1    Fanselow, M.S.2
  • 57
    • 0030699445 scopus 로고    scopus 로고
    • Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
    • DOI 10.1016/S0166-4328(97)00088-0, PII S0166432897000880
    • Maren S, Aharonov G, Fanselow MS (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88, 261-274. (Pubitemid 27496322)
    • (1997) Behavioural Brain Research , vol.88 , Issue.2 , pp. 261-274
    • Maren, S.1    Aharonov, G.2    Fanselow, M.S.3
  • 58
    • 0030853016 scopus 로고    scopus 로고
    • Nucleus accumbens lesions impair context, but not cue, conditioning in rats
    • Riedel G, Harrington NR, Hall G, Macphail EM (1997) Nucleus accumbens lesions impair context, but not cue, conditioning in rats. Neuroreport 8, 2477-2481. (Pubitemid 27308446)
    • (1997) NeuroReport , vol.8 , Issue.11 , pp. 2477-2481
    • Riedel, G.1    Harrington, N.R.2    Hall, G.3    Macphail, E.M.4
  • 60
    • 1442314722 scopus 로고    scopus 로고
    • Early vitamin e supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease
    • Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Pratico D (2004) Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. FASEB J 18, 323-325.
    • (2004) FASEB J , vol.18 , pp. 323-325
    • Sung, S.1    Yao, Y.2    Uryu, K.3    Yang, H.4    Lee, V.M.5    Trojanowski, J.Q.6    Pratico, D.7
  • 61
    • 0025081477 scopus 로고
    • 3H]PK 11195 binding autoradiography
    • Altar CA, Baudry M (1990) Systemic injection of kainic acid: Gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography. Exp Neurol 109, 333-341. (Pubitemid 20348964)
    • (1990) Experimental Neurology , vol.109 , Issue.3 , pp. 333-341
    • Altar, C.A.1    Baudry, M.2
  • 62
    • 77956228961 scopus 로고    scopus 로고
    • Braga MF Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala tosoman-induced neuropathology
    • Apland JP, Figueiredo TH, Qashu F, Aroniadou-Anderjaska V, Souza AP, Braga MF Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala tosoman-induced neuropathology. Neurotoxicology 31, 485-492.
    • Neurotoxicology , vol.31 , pp. 485-492
    • Apland, J.P.1    Figueiredo, T.H.2    Qashu, F.3    Aroniadou-Anderjaska, V.4    Souza, A.P.5
  • 63
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • DOI 10.1038/ng0996-55
    • Miyata M, Smith JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxida-tive insults and beta-amyloid peptides. Nat Genet 14, 55-61. (Pubitemid 26301547)
    • (1996) Nature Genetics , vol.14 , Issue.1 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 64
    • 0037171066 scopus 로고    scopus 로고
    • Oxidative protein damage in cells engaged in β-amyloidosis is related to apoE genotype
    • Mazur-Kolecka B, Frackowiak J, Kowal D, Krzeslowska J, Dickson D (2002) Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype. Neuroreport 13, 465-468. (Pubitemid 34293191)
    • (2002) NeuroReport , vol.13 , Issue.4 , pp. 465-468
    • Mazur-Kolecka, B.1    Frackowiak, J.2    Kowal, D.3    Krzeslowska, J.4    Dickson, D.5
  • 67
    • 0037103792 scopus 로고    scopus 로고
    • Oxidation of nitric oxide by oxomanganese-salen complexes: A new mechanism for cellular protection by superoxide dismutase/catalase mimetics
    • DOI 10.1042/BJ20020154
    • Sharpe MA, Ollosson R, Stewart VC, Clark JB (2002) Oxidation of nitric oxide by oxomanganese-salen complexes: A new mechanism for cellular protection by superoxide dismu-tase/catalase mimetics. Biochem J 366, 97-107. (Pubitemid 34971808)
    • (2002) Biochemical Journal , vol.366 , Issue.1 , pp. 97-107
    • Sharpe, M.A.1    Ollosson, R.2    Stewart, V.C.3    Clark, J.B.4
  • 68
    • 0942298545 scopus 로고    scopus 로고
    • Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice
    • DOI 10.1046/j.1471-4159.2003.02195.x
    • Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doc-trow SR, Harry J, Melov S (2004) Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem 88, 657-667. (Pubitemid 38140210)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.3 , pp. 657-667
    • Hinerfeld, D.1    Traini, M.D.2    Weinberger, R.P.3    Cochran, B.4    Doctrow, S.R.5    Harry, J.6    Melov, S.7
  • 69
    • 0036829434 scopus 로고    scopus 로고
    • Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain
    • DOI 10.1016/S0891-5849(02)01021-3, PII S0891584902010213
    • Smith MA, Casadesus G, Joseph JA, Perry G (2002) Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 33, 1194-1199. (Pubitemid 35246587)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.9 , pp. 1194-1199
    • Smith, M.A.1    Casadesus, G.2    Joseph, J.A.3    Perry, G.4
  • 71
    • 20444441575 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and Alzheimer's disease: Role of amyloid-β peptide alcohol dehydrogenase (ABAD)
    • DOI 10.1111/j.0959-9673.2005.00427.x
    • Yan SD, Stern DM (2005) Mitochondrial dysfunction and Alzheimer's disease: Role of amyloid-beta peptide alcohol dehydrogenase (ABAD). Int J Exp Pathol 86, 161-171. (Pubitemid 40813912)
    • (2005) International Journal of Experimental Pathology , vol.86 , Issue.3 , pp. 161-171
    • Yan, S.D.1    Stern, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.