Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice

Neurobiology of Aging

Volumn 31, Issue 3, 2010, Pages 425-433

  Clausen, Aaron ^a   Doctrow, Susan ^b   Baudry, Michel ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Proteome Systems   (United States)

Author keywords

Aging; Antioxidants; Fear conditioning; Free radicals; Learning; Oxidative stress; Superoxide dismutase catalase mimetics

Indexed keywords

ANTIOXIDANT; EUK 189; EUK 207; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; FEAR; LIPID PEROXIDATION; MALE; MENTAL PERFORMANCE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIMARY PREVENTION; PRIORITY JOURNAL;

AGING; ANIMALS; BRAIN; CATALASE; COGNITION DISORDERS; CONDITIONING, CLASSICAL; FREE RADICALS; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MOLECULAR MIMICRY; NOOTROPIC AGENTS; NUCLEIC ACIDS; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SALICYLATES; SUPEROXIDE DISMUTASE;

EID: 74149083183     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.05.009     Document Type: Article

References (32)

1. Barnes C.A., Markowska A.L., Ingram D.K., Kametani H., Spangler E.L., Lemken V.J., and Olton D.S. Acetyl-1-carnitine. 2: effects on learning and memory performance of aged rats in simple and complex mazes. Neurobiol. Aging 11 (1990) 499-506
2. Boveris A., and Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134 (1973) 707-716
3. Bruce A.J., and Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic. Biol. Med. 18 (1995) 993-1002
4. Butterfield D.A., Reed T., Perluigi M., De Marco C., Coccia R., Cini C., and Sultana R. Elevated protein-bound levels of the lipid peroxidation product 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. Neurosci. Lett. 397 (2006) 170-173
5. Calabrese V., Scapagnini G., Ravagna A., Colombrita C., Spadaro F., Butterfield D.A., and Giuffrida Stella A.M. Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech. Ageing Dev. 125 (2004) 325-335
6. Carney J.M., Starke-Reed P.E., Oliver C.N., Landum R.W., Cheng M.S., Wu J.F., and Floyd R.A. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin trapping compound N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 3633-3636
7. Cini M., and Moretti A. Studies on lipid peroxidation and protein oxidation in the aging brain. Neurobiol. Aging 16 (1995) 53-57
8. Davis H.P., Small S.A., Stern Y., Mayeux R., Feldstein S.N., and Keller F.R. Acquisition, recall and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individuals. Cortex 39 (2003) 1063-1091
9. Doctrow S.R., Huffman K., Marcus C.B., Tocco G., Malfroy E., Adinolfi C.A., Kruk H., Baker K., Lazarowych N., Mascarenhas J., and Malfroy B. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J. Med. Chem. 45 (2002) 4549-4558
10. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247
11. Forster M.J., Dubey A., Dawson K.M., Stutts W.A., Lal H., and Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 4765-4769
12. Fukui K., Onodera K., Shinkai T., Suzuki S., and Urano S. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidant defense mechanisms. Ann. N. Y. Acad. Sci. 928 (2001) 168-175
13. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59 (1992) 1609-1623
14. Hamilton M.L., Van Remmen H., Drake J.A., Yang H., Guo Z.M., Kewitt K., Walter C.A., and Richardson A. Does oxidative damage to DNA increase with age?. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10469-10474
15. Liu R., Liu I.Y., Bi X., Thompson R.F., Doctrow S.R., Malfroy B., and Baudry M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8526-8531
16. Malfroy-Camine, B., Doctrow, S.R., 2003. Cyclic salen metal complexes: reactive oxygen species scavengers useful as antioxidants for treatment and prevention of disease. U.S. Patent 6,589,948.
17. Maren S., Aharonov G., and Fanselow M.S. Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav. Brain Res. 88 (1997) 261-274
18. Melov S., Doctrow S.R., Schneider J.A., Haberson J., Patel M., Coskun P.E., Huffman K., Wallace D.C., and Malfroy B. Life extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nulliygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21 (2001) 8348-8353
19. Melov S., Wolf N., Strozyk D., Doctrow S.R., and Bush A.I. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic. Biol. Med. 38 (2005) 258-261
20. Nicolle M.M., Gonzalez J., Sugaya K., Baskerville K.A., Bryan D., Lund K., Gallagher M., and McKinney M. Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents. Neuroscience 107 (2001) 415-431
21. O'Donnell E., and Lynch M.A. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol. Aging 19 (1998) 461-467
22. O'Donnell E., Vereker E., and Lynch M.A. Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms. Eur. J. Neurosci. 12 (2000) 345-352
23. Petersen R.C., Doody R., Kurz A., Mohs R.C., Morris J.C., Rabins P.V., Ritchie K., Rossor M., Thal L., and Winblad B. Current concepts in mild cognitive impairment. Arch. Neurol. 59 (2001) 1985-1992
24. Phillips R.G., and LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106 (1992) 274-285
25. Quick K.L., Ali S.S., Arch R., Xiong C., Wozniak D., and Dugan L.L. A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiol. Aging 29 (2008) 117-128
26. Raghavendra V., and Kulkarni S.K. Possible antioxidant mechanisms in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. Free Radic. Biol. Med. 30 (2001) 595-602
27. Rao G., Xia E., and Richardson A. Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats. Mech. Ageing Dev. 53 (1990) 49-60
28. Sawada M., and Carlson J.C. Changes in superoxide radical and lipid peroxide formation in the brain, heart, and liver during the lifetime of the rat. Mech. Ageing Dev. 41 (1987) 125-137
29. Sharpe M.A., Ollosson R., Stewart V.C., and Clark J.B. Oxidation of nitric oxide by oxomanganese salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem. J. 366 Pt 1 (2002) 97-107
30. Siqueira R.I., Fochesatto C., Da Silva Torres I.L., Dalmaz C., and Netto C.A. Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats. Life Sci. 78 (2005) 271-278
31. Sohal R.S., Ku H.H., Agarwal S., Forster M.J., and Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74 (1994) 121-133
32. Stoll S., Rostock A., Bartsch R., Korn E., Meichelbock A., and Muller W.E. The potent free radical scavenger alpha-lipoic acid improves cognition in rodents. Ann. N. Y. Acad. Sci. 717 (1994) 122-128