Amyloid β peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

Journal of Neurochemistry

Volumn 67, Issue 1, 1996, Pages 277-286

  Harris, Marni E ^a,c   Wang, Yaning ^a,b   Pedigo Jr , Norman W ^a,b   Hensley, Kenneth ^a   Butterfield, D Allan ^a   Carney, John M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Astrocytes; Free radicals; Glutamate transport

Indexed keywords

AMYLOID BETA PROTEIN; GLUTAMIC ACID; SODIUM ION; TROLOX C;

ALZHEIMER DISEASE; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; FETUS; HIPPOCAMPUS; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029889640     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67010277.x     Document Type: Article

References (76)

1. Araujo D. M. and Cotman C. W. (1992) β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 569, 141-145.
2. Bass D. W., Parce J. W., DeChatelet R., Szejda P., Seeds M. C., and Thomas M. (1983) Flow cytometric studies of oxidative product formation by neutrophils: a graded response. J. Immunol. 130, 944-950.
3. Baughman R. W. and Gilbert C. D. (1981) Aspartate and glutamate as possible neurotransmitters in the visual cortex. J. Neurosci. 1, 427-439.
4. Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130.
5. Behl C., Davis J., Cole G. M., and Schubert D. (1992) Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem. Biophys. Res. Commun. 186, 944-950.
6. Behl C., Davis J. B., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 817-827.
7. Butterfield D. A., Hensley K., Harris M., Mattson M., and Carney J. (1994) β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence specific fashion: implications to Alzheimer's disease. Biochem. Biophys. Res. Commun. 200, 710-715.
8. Cheng B. and Mattson M. P. (1991) NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron 7, 1031-1041.
9. Clark R. M. and Collins G. G. S. (1976) The release of endogenous amino acids from rat visual cortex. J. Physiol. (Lond.) 262, 384-400.
10. Cleland W. W. (1964) Dithiothreitol, a new protective reagent for SH groups. Biochemistry 3, 480-482.
11. del Rio-Hortega P. (1932) Microglia, in Cytology and Cellular Pathology of the Nervous System, 2nd edit. (Penfield W., ed), pp. 483-534. Hoeber, New York.
12. Derouiche A. and Frotscher M. (1991) Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: evidence for transmitter degradation. Brain Res. 552, 346-350.
13. Dickson D. W., Farlo J., Davies P., Crystal H., Fuld P., and Yen S.-H. C. (1988) Alzheimer's disease: a doublelabeling immunohistochemical study of senile plaques. Am. J. Pathol. 132, 86-101.
14. Diedrich J. F., Minnigan H., Carp R. I., Whitaker J. N., Race R., Frey W., and Haase A. (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J. Virol. 65, 4759-4768.
15. Dunlop J., Grieve A., and Griffiths R. (1993) L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-transPDC) has properties consistent with that of a competitive substrate for the plasma membrane glutamate transporter. Biochem. Soc. Trans. 21, 111S.
16. Esiri M. M., Pearson R. C. A., and Powell T. P. S. (1986) The cortex of the primary auditory area in Alzheimer's disease. Brain Res. 366, 385-387.
17. Esterbauer H. and Zollner H. (1989) Methods for determination of aldehydic lipid peroxidation products. Free Radic. Biol. Med. 7, 197-203.
18. Fagg G. E. (1985) L-Glutamate, excitatory amino acid receptors and brain function. Trends Neurosci. 8, 207-210.
19. Fagg G. E. and Foster A. C. (1983) Amino acid neurotransmitters and their pathways in the mammalian central nervous system. Neuroscience 9, 701-709.
20. Fernaud-Espinosa I., Nieto-Sampedro M., and Bovolenta P. (1993) Differential activation of microglia and astrocytes in aniso- and isomorphic gliotic tissue. Glia 8, 277-291.
21. Fiske C. H. and Subbarow Y. (1925) The colorimetric determination of phosphorous. J. Biol. Chem. 66, 375-400.
22. Flott B. and Seifert W. (1991) Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain. Glia 4, 293-304.
23. Floyd R. A. and Carney J. M. (1993) The role of metal ions in oxidative processes and aging. Toxicol. Ind. Health 9, 197-214.
24. Fonnum F., Soreide A., Kvale I., Walker J., and Walaas I. (1981) Glutamate in cortical fibers. Adv. Biochem. Psychopharmacol. 27, 29-41.
25. Friguet B., Stadtman E. R., and Szweda L. I. (1994) Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. J. Biol. Chem. 269, 21639-21643.
26. Ginsberg L., Atack J. R., Rapoport S. I., and Gershfeld N. L. (1993) Evidence for a membrane lipid defect in Alzheimer disease. Mol. Chem. Neuropathol. 19, 37-46.
27. Gollin P, A., Kalaria R. N., Eikelenboom P., Rozemuller A., and Perry G. (1992) α1-antitrypsin and α1-antichymotrypsin are in the lesions of Alzheimer's disease. Neuroreport 3, 201-203.
28. Goodman Y. and Mattson M. P. (1994) Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury. Exp. Neurol. 128, 1-12.
29. Greenamyre J. T. and Young A. B. (1989) Excitatory amino acids and Alzheimer's disease. Neurobiol. Aging 10, 593-602.
30. Griffin W. S. T., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White C. L. III, and Araoz C. (1989) Brain interleukin-1 and S100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 86, 7611-7615.
31. Grynkiewicz G., Poenie M., and Tsien R. Y. (1985) A new generation of calcium indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
32. Gunnersen D. and Haley B. (1992) Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA 89, 11949-11953.
33. Harris M. E., Carney J. M., Hua D. H., and Leedle R. A. (1994) Detection of oxidation products in individual neurons by fluorescence microscopy. Exp. Neurol. 129, 95-102.
34. Harris M. E., Carney J. M., Cole P. M., Hensley K., Howard B. J., Martin L., Bummer P., Wang Y., Pedigo N. W. Jr., and Butterfield D. A. (1995a) β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport 6, 1875-1879.
35. Harris M. E., Hensley K., Butterfield D. A., Leedle R. A., and Carney J. M. (1995b) Direct evidence of oxidative injury produced by the Alzheimer's amyloid beta protein (1-40) in cultured hippocampal neurons. Exp. Neurol. 132, 1-10.
36. Hensley K., Carney J. M., Mattson M. P., Aksenova M., Harris M., Wu J. F., Floyd R. A., and Butterfield D. A. (1994) A model of β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 3270-3274.
37. Hensley K., Aksenova M., Carney J. M., Harris M., and Butterfield D. A. (1995a) Amyloid β-peptide spin trapping I: peptide enzyme toxicity is related to free radical spin trap reactivity. Neuroreport 6, 493-496.
38. Hensley K., Aksenova M., Carney J. M., Harris M., and Butterfield D. A. (1995b) Amyloid β-peptide spin trapping II: evidence for decomposition of the PBN spin adduct. Neuroreport 6, 489-492.
39. Hertz L. and Schousboe A. (1986) Role of astrocytes in compartmentation of amino acids and energy metabolism, in Astrocytes, 2nd edit. (Fedoroff S. and Vernadakis A., eds), pp. 179-208. Academic Press, Orlando, Florida.
40. Hertz L. and Schousboe A. (1988) Metabolism of glutamate and glutamine in neurons and astrocytes in primary cultures, in Glutamine and Glutamate in Mammals, 2nd edit. (Kvamme E., ed), pp. 39-55. CRC Press, Boca Raton, Florida.
41. Hertz L., Schousboe A., Boechler N., Mukerji S., and Fedoroff S. (1978) Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures. Neurochem. Res. 3, 1-14.
42. Hicks T. P. and Geddes R. C. A. (1981) Synaptic transmission in suprasylvian visual cortex is reduced by excitatory amino acid antagonists. Can. J. Physiol. Pharmacol. 59, 893-896.
43. Hosli E., Schousboe A., and Hoslie L. (1986) Amino acid uptake, in Astrocytes, 2nd edit. (Fedoroff S. and Vernadakis A., eds), pp. 133-153. Academic Press, Orlando, Florida.
44. Koh J.-Y., Yang L. L., and Cotman C. W. (1990) β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533, 315-320.
45. Kontos H. A. (1989) Oxygen radicals in CNS damage. Chem. Biol. Interact. 72, 229-255.
46. Lebel C. P., Ischiropoulos H., and Bondy S. C. (1992) Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5, 227-231.
47. +] coupled L-glutamate transporter purified from rat brain confirms glial cell localization. FEBS Lett. 317, 79-84.
48. Mattson M. P., Cheng B., Davis D., Bryant K., Lieberburg I., and Rydel R. E. (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376-389.
49. 3H]-glutamate in rat brain tissue. Brain Res. 115, 139-144.
50. Meldrum B. (1985) Excitatory amino acids and anoxia/ischemic brain. Trends Neurosci. 8, 47-48.
51. Nieto-Sampedro M. and Mora F. (1994) Active microglia, sick astroglia and Alzheimer type dementias. Neuroreport 5, 375-380.
52. Oliver C. N., Levine R. L., and Stadtman E. R. (1987) A role of mixed-function oxidation reactions in the accumulation of altered enzyme forms during aging. J. Am. Geriatr. Soc. 35, 947-956.
53. 2+ in toxic cell killing. Trends Pharmacol. Sci. 10, 281-284.
54. Pearson R. C. A., Esiri M. M., Hiorns R. W., Wilcock G. K., and Powell T. P. S. (1985) Anatomical correlates of the pathological changes in the neocortex in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 82, 4531-4534.
55. Pines G., Danbolt N. C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., and Kanner B. I. (1992) Cloning and expression of a rat brain L-glutamate transporter. Nature 360, 464-467.
56. Pomara N., Singh R., Deptula D., Chou J. C.-Y., Schwartz M. B., and LeWitt P. A. (1992) Glutamate and other CSF amino acids in Alzheimer's disease. Am. J. Psychiatry 149, 251-254.
57. Potter H. (1992) The involvement of astrocytes and an acute phase response in the amyloid deposition of Alzheimer's disease, in Progress in Brain Research, 94th edit. (Yu A. C. H., Hertz L., Norenberg M. D., Sykova E., and Waxman S. G., eds), pp. 447-458. Elsevier Science Publishers B.V., Amsterdam.
58. Raess B. U. and Vincenzi F. F. (1980) A semi-automated method for the determination of multiple membrane ATPase activities. Methods Enzymol. 52, 302-310.
59. Richardson J. S., Subbarao K. V., and Ang L. C. (1995) On the possible role of iron-induced free radical peroxidation in neural degeneration in Alzheimer's disease. Ann. NY Acad. Sci. 648, 326-327.
60. Rogers J. and Morrison J. H. (1985) Quantitative morphology and regional laminar distributions of senile plaques in Alzheimer's disease. J. Neurosci. 5, 2801-2808.
61. Rohn T. T., Hinds T. R., and Vincenzi F. F. (1993) Ion transport ATPases as targets for free radical damage. Biochem. Pharmacol. 46, 525-534.
62. Rosenberg P. A. (1991) Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine. Glia 4, 91-100.
63. Rosenberg P. A., Amin S., and Leitner M. (1992) Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture. J. Neurosci. 12, 56-61.
64. Rowe W. B., Remzio R. A., Wellner V. P., and Meister A. (1970) Glutamine synthetase. Methods Enzymol. 17, 900-910.
65. Shao Y., Enkvist K., and McCarthy K. (1993) Astroglial adrenergic receptors, in Astrocytes (Murphy S., ed), Academic Press, San Diego.
66. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A., and Markesberry W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Sci. USA 88, 10540-10543.
67. Stadtman E. R. (1990) Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic. Biol. Med. 9, 315-325.
68. Storm-Mathisen J. (1977) Glutamic acid and excitatory nerve endings: reductions of glutamic acid uptake after axotomy. Brain Res. 120, 379-386.
69. Strittmatter W. J., Saunders A. M., Schmechel D., PericakVance M., Enghild J., Salvesen G. S., and Roses A. D. (1993) Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 1977-1981.
70. Subbarao K. V., Richardson J. S., and Ang L. C. (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J. Neurochem. 55, 342-345.
71. Sugiyama K., Brunori A., and Mayer M. L. (1989) Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus. Neuroscience 32, 779-791.
72. Thomas C. E. and Reed D. J. (1990) Radical-induced inactivation of kidney Na+,K+-ATPase: sensitivity to membrane lipid peroxidation and the protective effect of vitamin E. Arch. Biochem. Biophys. 281, 96-105.
73. Volterra A., Trotti D., Tromba C., Floridi S., and Racagni G. (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14, 2924-2932.
74. White W. F., Nadler J. V., Hamberger A., Cotman C. W., and Cummins J. T. (1977) Glutamate as a transmitter of the hippocampal perforant path. Nature 270, 356-367.
75. Zhang Y., Tatsuno T., Carney J. M., and Mattson M. P. (1993) Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J. Cereb. Blood Flow Metab. 13, 378-388.
76. +)-coupled glutamate transporter from rat brain. J. Biol. Chem. 269, 19573-19577.