Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats

Behavioural Brain Research

Volumn 88, Issue 2, 1997, Pages 261-274

  Maren, Stephen ^a   Aharonov, Gal ^b   Fanselow, Michael S ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amnesia; Anterograde; Context; Fear conditioning; Freezing; Hippocampal formation; Lesion; Locomotor activity; Rat; Retrograde

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; FEAR; HIPPOCAMPUS; IMMOBILIZATION; LEARNING; LOCOMOTION; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK;

ANIMALS; CONDITIONING, CLASSICAL; EXPLORATORY BEHAVIOR; FEAR; HIPPOCAMPUS; MALE; N-METHYLASPARTATE; NEURONS; RATS;

EID: 0030699445     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)00088-0     Document Type: Article

References (42)

1. Alvarez P., Zola-Morgan S., Squire L.R., Damage L.R. limited to the hippocampal region produces long-lasting memory impairment in monkeys. J. Neurosci. 15:1995;3796-3807.
2. Bellgowan P.S.F., Helmstetter F.J. Effects of muscimol applied to the dorsal hippocampus on the acquisition and expression of cued versus contextual fear conditioning. Soc. Neurosci. Abstr. 21:1995;534.
3. Burns L.H., Annett L., Kelley A.E., Everitt B.J., Robbins T.W. Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex and nucleus accumbens on the reaction to novelty: Implication for limbic-striatal interactions. Behav. Neurosci. 110:1996;60-73.
4. Campeau S., Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J. Neurosci. 15:1995;2301-2311.
5. Canteras N.S., Swanson L.W. Projections of the ventral subiculum to the amygdala, septum and hypothalamus: A PHAL anterograde tract-tracing study in the rat. J. Comp. Neurol. 324:1992;180-194.
6. Cho Y.H., Beracochea D., Jaffard R. Extended temporal gradient for retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice. J. Neurosci. 13:1993;1759-1766.
7. Cho Y.H., Kesner R.P. Involvement of entorhinal cortex or parietal cortex in long-term spatial discrimination memory in rats - retrograde-amnesia. Behav. Neurosci. 110:1996;436-442.
8. Fanselow M.S. Associative vs. topographical accounts of the immediate shock freezing deficit in rats: Implications for the response selection rules governing species specific defensive reactions. Learning Motivation. 17:1986;16-39.
9. Jarrard J.E. What does the hippocampus really do? Behav. Brain Res. 71:1995;1-10.
10. Jarrard L.E., Meldrum B.S. Selective excitotoxic pathology in the rat hippocampus. Neuropath. Appl. Neurobiol. 19:1993;381-389.
11. Kiernan M.J., Bailey G., Sims J., Lukes D., Cranney J. Accumbal lesions attenuate contextual fear conditioning in the rat. Soc. Neurosci. Abstr. 22:1996;1381.
12. Kim J.J., Clark R.E., Thompson R.F. Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. Behav. Neurosci. 109:1995;195-203.
13. Kim J.J., Fanselow M.S. Modality-specific retrograde amnesia of fear. Science. 256:1992;675-677.
14. Kim J.J., Rison R.A., Fanselow M.S. Effects of amygdala, hippocampus and periaqueductal gray lesions on short- and long-term contextual fear. Behav. Neurosci. 107:1993;1093-1098.
15. LeDoux J.E., Cicchetti P., Xagoraris A., Romanski L.M. The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. J. Neurosci. 10:1990;1062-1069.
16. Maren S., Aharonov G., Fanselow M.S. Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: Absence of a temporal gradient. Behav. Neurosci. 110:1996;717-718.
17. Maren S., Fanselow M.S. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J. Neurosci. 15:1995;7548-7564.
18. Maren S., Fanselow M.S. The amygdala and fear conditioning: Has the nut been cracked? Neuron. 16:1996;237-240.
19. Maren S., Fanselow M.S. Electrolytic lesions of the dorsal hippocampus, fimbria/fornix, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiol. Learn. Mem. 67:1997;142-149.
20. G.J. Mogenson, Limbic-motor integration, in: A.N. Epstein, A.R. Morrison (Eds.), Progress in Psychobiology and Physiological Psychology, vol. 12, Academic, London, 1987, pp. 117-170.
21. Moser M.-B., Moser E.I., Forrest E., Andersen P., Morris R.G.M. Spatial learning with a minislab in the dorsal hippocampus. Proc. Natl. Acad. Sci. USA. 92:1995;9697-9701.
22. Moser E., Moser M.-B., Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 13:1993;3916-3925.
23. Murray E.A., Mishkin M. 40-min visual recognition memory in rhesus monkeys with hippocampal lesions. Soc. Neurosci. Abstr. 22:1996;281.
24. J. O'Keefe, L. Nadel, The Hippocampus as a Cognitive Map, Clarendon, Oxford, 1978.
25. Phillips R.G., LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106:1992;274-285.
26. Phillips R.G., LeDoux J.E. Lesions of the dorsal hippocampal formation interfere with background by not foreground contextual fear conditioning. Learn. Mem. 1:1994;34-44.
27. Phillips R.G., LeDoux J.E. Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning. J. Neurosci. 15:1995;5308-5315.
28. Rempel-Clower N.L., Zola S.M., Squire L.R., Amaral D.G. Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation. J. Neurosci. 16:1996;5233-5255.
29. Rudy J.W., Pugh C.R. A comparison of contextual and generalized auditory-cue fear conditioning: Evidence for similar memory processes. Behav. Neurosci. 110:1996;1299-1308.
30. Rudy J.W., Sutherland R.J. Configural association theory and the hippocampal formation: An appraisal and reconfiguration. Hippocampus. 5:1995;375-389.
31. Selden N.R., Everitt B.J., Jarrard L.E., Robbins T.W. Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience. 42:1991;335-350.
32. Squire L.R., Alvarez P. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr. Opin. Neurobiol. 5:1995;169-177.
33. N.S. Sutherland, N.J. Mackintosh, Mechanisms of Animal Discrimination Learning, Academic, New York, 1971.
34. Sutherland R.J., Rudy J.W. Configural association theory: The role of the hippocampal formation in learning, memory and amnesia. Psychobiology. 17:1989;129-144.
35. L.W. Swanson, Brain maps: Structure of the Rat Brain, Elsevier, New York, 1992.
36. Whishaw I.Q., Cassel J.-C., Majchrzak M., Cassel S., Will B. 'Short-stops' in rats with fimbria-fornix lesions: Evidence for a change in the mobility gradient. Hippocampus. 4:1994;577-582.
37. Whishaw I.Q., Jarrard L.E. Similarities vs. differences in place learning and circadian activity in rats after fimbria-fornix section or ibotenate removal of hippocampal cells. Hippocampus. 5:1995;595-604.
38. Wiig K.A., Cooper L.N., Bear M.F. Temporally graded retrograde-amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat. Learn. Mem. 3:1996;313-325.
39. Winocur G. Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions. Behav. Brain Res. 38:1990;145-154.
40. Young S.L., Bohenek D., Fanselow M.S. NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: Immunization against amnesia by context preexposure. Behav. Neurosci. 108:1994;19-29.
41. Zola-Morgan S., Squire L.R. The primate hippocampal formation: Evidence for a time-limited role in memory storage. Science. 250:1990;288-290.
42. Zola-Morgan S., Squire L.R., Ramus S.J. Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system. Hippocampus. 4:1994;1-13.