Herpes simplex virus type 1-based amplicon vectors for fundamental research in neurosciences and gene therapy of neurological diseases

Journal of Physiology Paris

Volumn 106, Issue 1-2, 2012, Pages 2-11

  Jerusalinsky, Diana ^a,b   Baez, María Verónica ^a   Epstein, Alberto Luis ^c,d  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITÉ DE LYON   (France)

Author keywords

Amplicons; Experimental gene therapy; HSV 1 derived vectors; Nervous system; Neurodegenerative disorders

Indexed keywords

AMYLOID BETA PROTEIN; BETA GALACTOSIDASE; DNA FRAGMENT; FRATAXIN; HERPESVIRUS VECTOR; TAU PROTEIN; VIRUS PROTEIN;

ADAPTIVE IMMUNITY; ALZHEIMER DISEASE; AMPLICON; ANXIETY; ARTICLE; ATAXIA TELANGIECTASIA; BEHAVIOR; BRAIN NERVE CELL; BRAIN REGION; CELL CULTURE; CELL FUNCTION; CELL NUCLEUS; DEGENERATIVE DISEASE; EPITHELIUM CELL; EXPERIMENTAL MODEL; FRIEDREICH ATAXIA; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE LOCUS; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; GENE SYNTHESIS; GENE THERAPY; GENETIC DISORDER; GENETIC TRANSDUCTION; GLIA CELL; HERPES SIMPLEX VIRUS 1; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LEARNING; MALIGNANT NEOPLASTIC DISEASE; MEDICAL RESEARCH; MEMORY; MOLECULAR MECHANICS; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROSCIENCE; NONHUMAN; PARKINSON DISEASE; REGULATORY SEQUENCE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL TROPISM; VIRUS GENOME; VIRUS INFECTION; VIRUS PARTICLE;

ANIMALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HUMANS; NERVOUS SYSTEM DISEASES; NEUROSCIENCES;

EID: 84861191461     PISSN: 09284257     EISSN: 17697115     Source Type: Journal    
DOI: 10.1016/j.jphysparis.2011.11.003     Document Type: Article

References (107)

1. Adrover M.F., Guyot-Revol V., Cheli V.T., Blanco C., Vidal R., Alche L., Kornisiuk E., Epstein A.L., Jerusalinsky D. Hippocampal infection with HSV-1-derived vectors expressing an NMDAR1 antisense modifies behavior. Genes Brain Behav. 2003, 2:103-113.
2. Antonawich F.J., Federoff H.J., Davis J.N. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp. Neurol. 1999, 156:130-137.
3. Arvanian V.L., Bowers W.J., Anderson A., Horner P.J., Federoff H.J., Mendell L.M. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Exp. Neurol. 2006, 197:347-352.
4. Balducci C., Tonini R., Zianni E., Nazzaro C., Fiordaliso F., Salio M., Vismara L., Gardoni F., Di Luca M., Carli M., Forloni G. Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice. J. Alzheimers Dis. 2010, 21:1367-1381.
5. Bakowska J.C., Di Maria M.V., Camp S.M., Wang Y., Allen P.D., Breakefield X.O. Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector. Gene Ther. 2003, 10:1691-1702.
6. Barrot M., Wallace D.L., Bolanos C.A., Graham D.L., Perrotti L.I., Neve R.L., Chambliss H., Yin J.C., Nestler E.J. Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens. PNAS 2005, 102:8357-8362.
7. Boutell C., Canning M., Orr A., Everett R.D. Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. J. Virol. 2005, 79:12342-12354.
8. Bowers W.J., Chen X., Guo H., Frisina D.R., Federoff H.J., Frisina R.D. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol. Ther. 2002, 6:12-18.
9. Bowers W.J., Mastrangelo M.A., Howard D.F., Southerland H.A., Maguire-Zeiss K.A., Federoff H.J. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol. Ther. 2006, 13:580-588.
10. Bowers W.J., Mastrangelo M.A., Stanley H.A., Casey A.E., Milo L.J., Federoff H.J. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol. Aging 2005, 26:393-407.
11. Brightwell J.J., Smith C.A., Countryman R.A., Neve R.L., Colombo P.J. Hippocampal overexpression of mutant creb blocks long-term, but not short-term memory for a socially transmitted food preference. Learn. Memory 2005, 12:12-17.
12. Brightwell J.J., Smith C.A., Neve R.L., Colombo P.J. Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning. Neurobiol. Learn. Mem. 2008, 89:27-35.
13. Cao H., Zhang G.R., Wang X., Kong L., Geller A.I. Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles. BMC Neurosci. 2008, 9:37.
14. Cheli V., Adrover M., Blanco C., Ferrari C., Cornea A., Pitossi F., Epstein A.L., Jerusalinsky D. Knocking-down the NMDAR1 subunit in a limited amount of neurons in the rat hippocampus impairs learning. J. Neurochem. 2006, 97(Suppl. 1):68-73.
15. Cheli V.T., Adrover M.F., Blanco C., Rial Verde E., Guyot-Revol V., Vidal R., Martin E., Alche L., Sanchez G., Acerbo M., Epstein A.L., Jerusalinsky D. Gene transfer of NMDAR1 subunit sequences to the rat CNS using herpes simplex virus vectors interfered with habituation. Cell Mol. Neurobiol. 2002, 22:303-314.
16. Chen X., Frisina R.D., Bowers W.J., Frisina D.R., Federoff H.J. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol. Ther. 2001, 3:958-963.
17. Corona J.C., Gimenez-Cassina A., Lim F., Díaz-Nido J. Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease. J. Neurosci. Res. 2010, 88:1943-1950.
18. Corso T.D., Torres G., Goulah C., Roy I., Gambino A.S., Nayda J., Buckley T., Stachowiak E.K., Bergey E.J., Pudavar H., Dutta P., Bloom D.C., Bowers W.J., Stachowiak M.K. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain Res. Mol. Brain Res. 2005, 139:361-366.
19. Cortes M.L., Bakkenist C.J., Di Maria M.V., Kastan M.B., Breakefield X.O. HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Gene Ther. 2003, 10:1321-1327.
20. Cortes M.L., Oehmig A., Perry K.F., Sanford J.D., Breakefield X.O. Expression of human ATM cDNA in Atm-deficient mouse brain mediated by HSV-1 amplicon vector. Neuroscience 2006, 141:1247-1256.
21. Cortes M.L., Oehmig A., Saydam O., Sanford J.D., Perry K.F., Fraefel C., Breakefield X.O. Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector. Mol Ther. 2008, 16:81-88.
22. Cousins S.L., Hoey S.E., Anne Stephenson F., Perkinton M.S. Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery. J. Neurochem. 2009, 111:1501-1513.
23. Cuchet D., Ferrera R., Lomonte P., Epstein A.L. Characterization of antiproliferative and cytotoxic properties of the HSV-1 immediate-early ICP0 protein. J. Gene Med. 2005, 7:1187-1199.
24. Cuchet D., Potel C., Thomas J., Epstein A.L. HSV-1 amplicon vectors: a promising and versatile tool for gene delivery. Expert. Opin. Biol. Ther. 2007, 7:975-995.
25. De Felice F.G., Velasco P.T., Lambert M.P., Viola K., Fernandez S.J., Ferreira S.T., Klein W.L. Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. JBC 2007, 282:11590-11601.
26. Decker H., Jurgensen S., Adrover M.F., Brito-Moreira J., Bomfim T.R., Klein W.L., Epstein A.L., De Felice F.G., Jerusalinsky D., Ferreira S.T. N-methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-beta peptide oligomers. J. Neurochem. 2010, 115:1520-1529.
27. During M.J., Naegele J.R., O'Malley K.L., Geller A.I. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 1994, 266:1399-1403.
28. Frazer M.E., Hughes J.E., Mastrangelo M.A., Tibbens J.L., Federoff H.J., Bowers W.J. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol. Ther. 2008, 16:845-853.
29. Gao Q., Sun M., Wang X., Geller A.I. Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system. Brain Res. 2007, 1130:1-16.
30. Garrido J.J., Alonso M.T., Lim F., Carnicero E., Giraldez F., Schimmang T. Defining responsiveness of avian cochlear neurons to brain-derived neurotrophic factor and nerve growth factor by HSV-1-mediated gene transfer. J. Neurochem. 1998, 70:2336-2346.
31. Geschwind M.D., Hartnick C.J., Liu W., Amat J., Van De Water T.R., Federoff H.J. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Hum. Gene Ther. 1996, 7:173-182.
32. Gimenez-Cassina A., Lim F., Cerrato T., Palomo G.M., Diaz-Nido J. Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J. Biol. Chem. 2009, 284:3001-3011.
33. Gimenez-Cassina, A., Wade-Martins, R., Gomez-Sebastian, S., Corona, J.C., Lim, F., Diaz-Nido, J., 2011. Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector. Gene Ther Apr 14. [Epub ahead of print].
34. Gomez-Sebastian S., Gimenez-Cassina A., Diaz-Nido J., Lim F., Wade-Martins R. Infectious delivery and expression of a 135kb Human FRDA genomic DNA Locus Complements Friedreich's Ataxia Deficiency in Human Cells. Mol. Ther. 2007, 15:248-254.
35. Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. 2007, 8:101-112.
36. Han J.H., Kushner S.A., Yiu A.P., Cole C.J., Matynia A., Brown R.A., Neve R.L., Guzowski J.F., Silva A.J., Josselyn S.A. Neuronal competition and selection during memory formation. Science 2007, 316:457-460.
37. Han J.H., Yiu A.P., Cole C.J., Hsiang H.L., Neve R.L., Josselyn S.A. Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear. Learn. Mem. 2008, 15:443-453.
38. Harvey B.K., Chang C.F., Chiang Y.H., Bowers W.J., Morales M., Hoffer B.J., Wang Y., Federoff H.J. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Exp. Neurol. 2003, 183:47-55.
39. Heister T., Heid I., Ackermann M., Fraefel C. Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19. J. Virol. 2002, 76:7163-7173.
40. Ho D.Y., Mocarski E.S., Sapolsky R.M. Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene. PNAS 1993, 90:3655-3659.
41. Ho D.Y., Saydam T.C., Fink S.L., Lawrence M.S., Sapolsky R.M. Defective herpes simplex virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults. J. Neurochem. 1995, 65:842-850.
42. Ho I.A., Hui K.M., Lam P.Y. Glioma-specific and cell cycle-regulated herpes simplex virus type 1 amplicon viral vector. Hum. Gene Ther. 2004, 15:495-508.
43. Ho I.A., Hui K.M., Lam P.Y. Targeting proliferating tumor cells via the transcriptional control of therapeutic genes. Cancer Gene Ther. 2006, 13:44-52.
44. Ho I.A., Ng W.H., Lam P.Y. FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors. Mol. Cancer 2010, 9:270.
45. Hoehn B., Ringer T.M., Xu L., Giffard R.G., Sapolsky R.M., Steinberg G.K., Yenari M.A. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J. Cereb. Blood Flow Metab. 2001, 21:1303-1309.
46. Hoey S.E., Williams R.J., Perkinton M.S. Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. J. Neurosci. 2009, 29:4442-4460.
47. Hoshi M., Harada A., Kawase T., Uyemura K., Yazaki T. Antitumoral effects of defective herpes simplex virus-mediated transfer of tissue inhibitor of metalloproteinases-2 gene in malignant glioma U87 in vitro: consequences for anti-cancer gene therapy. Cancer Gene Ther. 2000, 7:799-805.
48. Jacobs A.H., Winkeler A., Hartung M., Slack M., Dittmar C., Kummer C., Knoess C., Galldiks N., Vollmar S., Wienhard K., Heiss W.D. Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes. Hum. Gene Ther. 2003, 14:277-297.
49. Jerusalinsky D., Epstein A.L. Amplicon vectors as outstanding tools to study and modify cognitive functions. Curr. Gene Ther. 2006, 6:351-360.
50. Kelly S., Zhanf Z.J., Zhao H., Xu L., Giffard R.G., Sapolsky R.M., Yenari M.A., Steinberg G.K. Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2. Ann. Neurol. 2002, 52:160-167.
51. Klein W.L. Synaptic targeting by Abeta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimers Dement 2006, 2:43-55.
52. Lamigeon C., Prod'Hon C., De Frias V., Michoudet C., Jacquemont B. Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector. Exp. Neuro. 2003, 184:381-392.
53. Lawrence M.S., Ho D.Y., Dash R., Sapolsky R.M. Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss. PNAS 1995, 92:7247-7251.
54. Lawrence M.S., Ho D.Y., Sun G.H., Steinberg G.K., Sapolsky R.M. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci. 1996, 16:486-496.
55. Lawrence M.S., McLaughlin J.R., Sun G.H., Ho D.Y., McIntosh L., Kunis D.M., Sapolsky R.M., Steinberg G.K. Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke. J. Cereb. Blood Flow Metab. 1997, 17:740-744.
56. Lesne S., Koh M.T., Kotilinek L., Kayed R., Glabe C.G., Yang A., Gallagher M., Ashe K.H. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440:352-357.
57. Lim F., Palomo G.M., Mauritz C., Gimenez-Cassina A., Illana B., Wandosell F., Diaz-Nido J. Functional recovery in a Friedreich's ataxia mouse model by frataxin gene transfer using an HSV-1 amplicon vector. Mol. Ther. 2007, 15:1072-1078.
58. Lim M.C., Brooke S.M., Sapolsky R.M. Gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. Brain Res. Bull. 2003, 61:183-188.
59. Linnik M.D., Zahos P., Geschwind M.D., Federoff H.J. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 1995, 26:1670-1674. (discussion 1675).
60. Liu J., Chang L., Roselli F., Almeida O.F., Gao X., Wang X., Yew D.T., Wu Y. Amyloid-beta induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. J. Alzheimers Dis. 2010, 22:541-556.
61. Liu J., Yang A.R., Kelly T., Puche A., Esoga C., June H.L., Elnabawi A., Merchenthaler I., Sieghart W., June H.L., Aurelian L. Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. PNAS 2011, 108:4465-4470.
62. Liu M., Thankachan S., Kaur S., Begum S., Blanco-Centurion C., Sakurai T., Yanagisawa M., Neve R., Shiromani P.J. Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. Eur. J. Neurosci. 2008, 28:1382-1393.
63. Lomonte P., Sullivan K.F., Everett R.D. Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. J. Biol. Chem. 2001, 276:5829-5835.
64. Lufino M.M., Manservigi R., Wade-Martins R. An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency. NAR 2007, 35:e98.
65. Marconi P., Manservigi R., Epstein A.L. HSV-1-derived helper-independent defective vectors, replicating vectors and amplicon vectors, for the treatment of brain diseases. Curr. Opin. Drug Discov. Dev. 2010, 13:169-183.
66. Meier T.J., Ho D.Y., Park T.S., Sapolsky R.M. Gene transfer of calbindin D28k cDNA via herpes simplex virus amplicon vector decreases cytoplasmic calcium ion response and enhances neuronal survival following glutamatergic challenge but not following cyanide. J. Neurochem. 1998, 71:1013-1023.
67. Moralli D., Simpson K.M., Wade-Martins R., Monaco Z.L. A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors. EMBO Rep. 2006, 7:911-918.
68. Neill J.C., Sarkisian M.R., Wang Y., Liu Z., Yu L., Tandon P., Zhang G., Holmes G.L., Geller A.I. Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. Brain Res. Mol. Brain Res. 2001, 93:127-136.
69. Olschowka J.A., Bowers W.J., Hurley S.D., Mastrangelo M.A., Federoff H.J. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol. Ther. 2003, 7:218-227.
70. Paoletti P. Molecular basis of NMDA receptor functional diversity. Eur. J. Neurosci. 2011, 33:1351-1365.
71. Peruzzi P.P., Lawler S.E., Senior S.L., Dmitrieva N., Edser P.A., Gianni D., Chiocca E.A., Wade-Martins R. Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons. Mol. Ther. 2009, 17:1517-1526.
72. Phillips R.G., Meier T.J., Giuli L.C., McLaughlin J.R., Ho D.Y., Sapolsky R.M. Calbindin D28K gene transfer via herpes simplex virus amplicon vector decreases hippocampal damage in vivo following neurotoxic insults. J. Neurochem. 1999, 73:1200-1205.
73. Picciotto M.R., Wickman K. Using knockout and transgenic mice to study neurophysiology and behavior. Physiol. Rev. 1998, 78:1131-1163.
74. Prabhakar S., Brenner G.J., Sung B., Messerli S.M., Mao J., Sena-Esteves M., Stemmer-Rachamimov A., Tannous B., Breakefield X.O. Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther. 2010, 17:266-274.
75. Rainov N.G., Sena-Esteves M., Fraefel C., Dobberstein K.U., Chiocca E.A., Breakefield X.O. A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. Adv. Exp. Med. Biol. 1998, 451:393-403.
76. Roselli F., Tirard M., Lu J., Hutzler P., Lamberti P., Livrea P., Morabito M., Almeida O.F. Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J. Neurosci. 2005, 25:11061-11070.
77. Rumpel S., LeDoux J., Zador A., Malinow R. Postsynaptic receptor trafficking underlying a form of associative learning. Science 2005, 308:83-88.
78. Saeki Y., Fraefel C., Ichikawa T., Breakefield X.O., Chiocca E.A. Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. Mol. Ther. 2001, 3:591-601.
79. Saydam O., Glauser D.L., Heid I., Turkeri G., Hilbe M., Jacobs A.H., Ackermann M., Fraefel C. Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Mol. Ther. 2005, 12:803-812.
80. Shah K., Tang Y., Breakefield X.O., Weissleder R. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene 2003, 22:6865-6872.
81. Shah K., Tung C.H., Breakefield X.O., Weissleder R. In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. Mol. Ther. 2005, 11:926-931.
82. Shah K., Breakefield X.O. HSV amplicon vectors for cancer therapy. Curr. Gene Ther. 2006, 6:361-370.
83. Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., Sabatini B.L. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 2007, 27:2866-2875.
84. Shankar G.M., Li S., Mehta T.H., Garcia-Munoz A., Shepardson N.E., Smith I., Brett F.M., Farrell M.A., Rowan M.J., Lemere C.A., Regan C.M., Walsh D.M., Sabatini B.L., Selkoe D.J. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 2008, 14:837-842.
85. Simonato M., Manservigi R., Marconi P., Glorioso J. Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors. Trends Neurosci. 2000, 23:183-190.
86. Sortwell C.E., Bowers W.J., Counts S.E., Pitzer M.R., Fleming M.F., McGuire S.O., Maguire-Zeiss K.A., Federoff H.J., Collier T.J. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Res. 2007, 1134:33-44.
87. Spaete R.R., Frenkel N. The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector. Cell 1982, 30:295-304.
88. Staecker H., Gabaizadeh R., Federoff H., Van De Water T.R. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 1998, 119:7-13.
89. Sun M., Zhang G.R., Kong L., Holmes C., Wang X., Zhang W., Goldstein D.S., Geller A.I. Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector. Hum. Gene Ther. 2003, 14:415-424.
90. Sun M., Kong L., Wang X., Holmes C., Gao Q., Zhang G.R., Pfeilschifter J., Goldstein D.S., Geller A.I. Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. Hum. Gene Ther. 2004, 15:1177-1196.
91. Sun M., Kong L., Wang X., Lu X.G., Gao Q., Geller A.I. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. Brain Res. 2005, 2005(1052):119-129.
92. Suzuki M., Kasai K., Saeki Y. Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin. J. Virol. 2006, 80:3293-3300.
93. Suzuki M., Chiocca E.A., Saeki Y. Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene. Mol. Ther. 2007, 15:2017-2026.
94. Suzuki M., Chiocca E.A., Saeki Y. Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals. Mol. Ther. 2008, 16:1727-1736.
95. Thinakaran G., Koo E.H. Amyloid precursor protein trafficking, processing, and function. JBC 2008, 283:29615-29619.
96. Tsitoura E., Thomas J., Cuchet D., Thoinet K., Mavromara P., Epstein A.L. Infection with herpes simplex type 1-based amplicon vectors results in an IRF3/7-dependent, TRL-independent activation of the innate antiviral response in primary human fibroblasts. J. Gen. Virol. 2009, 90:2209-2220.
97. Wade-Martins R., Smith E.R., Tyminski E., Chiocca E.A., Saeki Y. An infectious transfer and expression system for genomic DNA loci in human and mouse cells. Nat. Biotechnol. 2001, 19:1067-1070.
98. Wade-Martins R., Saeki Y., Chiocca E.A. Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Mol. Ther. 2003, 7:604-612.
99. Wang H., Cheng E., Brooke S., Chang P., Sapolsky R. Over-expression of antioxidant enzymes protects cultured hippocampal and cortical neurons from necrotic insults. J. Neurochem. 2003, 87:1527-1534.
100. Wang Y., Camp S.M., Niwano M., Shen X., Bakowska J.C., Breakefield X.O., Allen P.D. Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration. J. Virol. 2002, 76:7150-7162.
101. Wang S., Vos J.M. A hybrid herpesvirus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo. J. Virol. 1996, 70:8422-8430.
102. Zaupa C., Revol-Guyot V., Epstein A.L. Improved packaging system for generation of high-level noncytotoxic HSV-1 amplicon vectors using Cre-loxP site-specific recombination to delete the packaging signals of defective helper genomes. Hum. Gene Ther. 2003, 14:1049-1063.
103. Zemlyak I., Nimon V., Brooke S., Moore T., McLaughlin J., Sapolsky R. Gene therapy in the nervous system with superoxide dismutase. Brain Res. 2006, 9(1088):12-18.
104. Zhang G.R., Wang X., Yang T., Sun M., Zhang W., Wang Y., Geller A.I. A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors. Brain Res. Mol. Brain Res. 2000, 84:17-31.
105. Zhang G.R., Geller A.I. A helper virus-free HSV-1 vector containing the vesicular glutamate transporter-1 promoter supports expression preferentially in VGLUT1-containing glutamatergic neurons. Brain Res. 2010, 1331:12-19.
106. Zhang G.R., Zhao H., Li X., Awasthi S., Geller A.I. A 16bp upstream sequence from the rat tyrosine hydroxylase promoter supports long-term expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system. Brain Res. 2011, (Epub ahead of print).
107. Zhao H., Yenari M.A., Cheng D., Barreto-Chang O.L., Sapolsky R.M., Steinberg G.K. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J. Cereb. Blood Flow Metab. 2004, 24:681-692.