Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

Journal of Neuroscience

Volumn 16, Issue 2, 1996, Pages 486-496

  Lawrence, Matthew S ^a   Ho, Dora Y ^a   Sun, Guo Hua ^a   Steinberg, Gary K ^a   Sapolsky, Robert M ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

adriamycin; Bcl 2; gene transfer; glutamate; herpes simplex virus; hypoglycemia; hypoxia ischemia

Indexed keywords

CALCIUM IONOPHORE; DOXORUBICIN; FLUORESCEIN DERIVATIVE; GLUTAMIC ACID; GROWTH FACTOR; LIPID; OXYGEN RADICAL; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FETUS; GENE EXPRESSION; GENE TRANSFER; HERPES SIMPLEX VIRUS; HYPOGLYCEMIA; IMMUNOFLUORESCENCE; LIPID PEROXIDATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RAT;

EID: 0030025668     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-02-00486.1996     Document Type: Article

References (51)

1. Allsopp TE, Wyatt S, Paterson HF, Davies AM (1993) The protooncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73:295-307.
2. Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, Epstein AL, Korsmeyer SJ (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:889-906.
3. Behl C, Hovey L, Krajewski S, Schubert D, Reed JC (1993) Bcl-2 prevents killing of neuronal cells by glutamate but not by amyloid β protein. Biochem Biophys Res Commun 197:949-956.
4. Coyle J, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695.
5. Dash R, Lawrence M, Ho D, Sapolsky R (1995) A herpes simplex virus vector overexpressing the glucose transporter gene protects the rat dentate gyms from an antimetabolite toxin. Exp Neurol, in press.
6. DeLuca NA, McCarthy AM, Schaffer PA (1985) Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene incoding immediate-early regulatory protein ICP4. J Virol 56:558-570.
7. Dubois-Dauphin M, Frankowski H, Tsujimoto Y, Huarte J, Martinou JC (1994) Neonatal motor neurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc Natl Acad Sci USA 91:3309-3313.
8. Dumuis A, Sebben M, Haynes H, Pin JP, Bockaert J (1988) NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature 336:68-72.
9. During MJ, Naegele JR, O'Malley KL, Geller AI (1994) Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266:1399-1403.
10. Garcia I, Martinou I, Tsujimoto Y, Martinou JC (1992) Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science 258:302-304.
11. Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine. New York: Oxford UP.
12. Ho DY, Mocarski ES, Sapolsky RM (1993) Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene. Proc Natl Acad Sci USA 90:3655-3659.
13. Ho, DY (1994) Amplicon-based herpes simplex virus vectors. Methods Cell Biol 43:191-210.
14. Ho DY, Saydem TC, Fink SL, Lawrence MS, Sapolsky RM (1995) Defective herpes simplex virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults. J Neurochem 65:842-848.
15. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an innermitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336.
16. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
17. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965.
18. Jacobson MD, Raff MC (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374:814-816.
19. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262:1274-1277.
20. Lafon-Cazal M, Pietre S, Culasi M, Bockaert J (1993) NMDA-dependent Superoxide production and neurotoxicity. Nature 364:535-537.
21. Lawrence MS, Dash R, Ho DY, Sapolsky RM (1995a) Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss. Proc Natl Acad Sci USA 92:7247-7251.
22. Lawrence MS, Sun GH, Kunis DM, Saydem TC, Dash R, Ho DY, Sapolsky RM, Steinberg GK (1995b) Overexpression of the glucose transporter gene with a herpes simplex viral vector protects striatal neurons against stroke. J Cereb Blood Flow Metab, in press.
23. Lebel CP, Ali SF, McKee M, Bondy SC (1990) Organometal-induced increase in oxygen reactive species: the potential of dichlorofluorescein diacitate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:17-25.
24. Levy DI, Lipton SA (1990) Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology 40:852-855.
25. Linnik MD, Zahos P, Geschwind MD, Federoff HJ (1994) Expression of Bcl-2 from a defective herpes simplex virus limits neuronal death in stroke. Soc Neurosci Abstr 609:8.
26. Lithgow T, van Driel R, Bertram JF, Strasser A (1994) The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ 5:411-417.
27. Liu TH, Beckman JS, Freeman BA, Hogan EL, Hsu CY (1989) Polyethylene glycoconjugated Superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol 256:H589-H593.
28. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91.
29. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE (1993) The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem 60:1183-1186.
30. Martinou, JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, Huarte J (1994) Overexpression of Bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030.
31. Memezawa H, Minamisawa H, Smith ML, Siesjo BK (1992) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78.
32. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ (1994) Bcl-2 protein expression is widepread in the developing nervous system and retained in the adult PNS. Development 120:301-311.
33. Murphy TH, Schnaar RL, Coyle JT (1990) Immature cotical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J 3:1624-1633.
34. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 144:3602-3610.
35. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6.
36. Rosenkranz AR, Schmaldienst S, Stuhlmeier KM, Chen W, Knapp W, Zlabinger GJ (1992) A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescein-diacetate. J Immunol Methods 156:39-45.
37. Saez J, Kessler J, Bennett M, Spray D (1987) Superoxide dismutase protects cultured neurons against death by starvation. Proc Natl Acad Sci USA 84:3056-3060.
38. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991) Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888.
39. Shimazaki K, Ishida X, Kawai N (1994) Increase in Bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci Res 20:95-99.
40. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811-813.
41. Strasser A, Harris AW, Cory S (1991) Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889-899.
42. Tombaugh G, Yang S, Swanson R, Sapolsky R (1992) Glucocorticoids exacerbate hypoxic and hypoglycemic hippocampal injury in vitro: biochemical correlates and a role for astrocytes. J Neurochem 59:137-146.
43. Tsujimoto Y, Gorham J, Cossam J, Jaffe E, Croce C (1985) The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229:1300-1303.
44. Vaux DL (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442.
45. Vaux DL, Weissman IL, Kim SK (1992) Prevention of programmed cell death in Ceanorhabditis elegans by human bcl-2. Science 258:1955-1957.
46. Wood KA, Youle RJ (1994) Apoptosis and free radicals. In: The neurobiology of NO- and -OH (Chiueh CC, Gilbert DL, Colton, CA, eds), pp 400-407. New York: New York Academy of Sciences.
47. Yoon EJ, Steinberg GK (1994) Mild intraischemic hypothermia protects against focal cerebral ischemia. Soc Neurosci Abstr 19:225.
48. Yoshida S, Inoh S, Asano T (1980) Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain: lipid peroxidation as a possible cause of post ischemic injury. J Neurosurg 53:323-331.
49. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652.
50. Zhong LT, Kane DJ, Bredesen DE (1993a) Bcl-2 blocks glutamate toxicity in neuronal cell lines. Mol Brain Res 19:353-355.
51. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE (1993b) Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 90:4533-4537.