A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors

Molecular Brain Research

Volumn 84, Issue 1-2, 2000, Pages 17-31

  Zhang, Guo rong ^a   Wang, Xiaodan ^a   Yang, Tianzhong ^a   Sun, Mei ^a   Zhang, Wei ^a   Wang, Yaming ^a   Geller, Alfred I ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Gene transfer; Herpes simplex virus vector; Long term expression; Neurofilament promoter; Tyrosine hydroxylase promoter

Indexed keywords

BACTERIOPHAGE DNA; BETA GLOBIN; CHIMERIC PROTEIN; NEUROFILAMENT PROTEIN; PROTEIN SUBUNIT; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIOPHAGE LAMBDA; CONTROLLED STUDY; CORPUS STRIATUM; CYTOMEGALOVIRUS; EXPRESSION VECTOR; FOREBRAIN; GENE EXPRESSION REGULATION; GENE INSERTION; GENE TARGETING; GENE TRANSFER; GLOBIN GENE; HELPER VIRUS; HERPES SIMPLEX VIRUS 1; HIPPOCAMPUS; IMMEDIATE EARLY GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SACCHAROMYCES CEREVISIAE;

ANIMALS; CELL LINE; CRICETINAE; CYTOMEGALOVIRUS; DNA, RECOMBINANT; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; GENES, REPORTER; GENETIC VECTORS; HELPER VIRUSES; HERPESVIRUS 1, HUMAN; HIPPOCAMPUS; MALE; MICROINJECTIONS; NEOSTRIATUM; NEUROFILAMENT PROTEINS; NEURONS; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; BACTERIOPHAGE LAMBDA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; EUKARYOTA; GALLUS GALLUS; HERPES; HUMAN HERPESVIRUS 1; SACCHAROMYCES CEREVISIAE;

EID: 0034624216     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00197-2     Document Type: Article

References (45)

1. Gene transfer into mammalian central nervous system using herpes virus vectors: Extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter
2. 5' Flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice
3. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice
4. Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus
5. Organization and evolution of the rat tyrosine hydroxylase gene
6. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
7. A 5'element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
8. A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons
9. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
10. The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum
11. Gene transfer to neurons using herpes simplex virus-based vectors
12. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells
13. Intracellular distribution of transgenic bacterial beta-galactosidase in central nervous system neurons and neuroglia
14. Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice
15. Genetic analysis of the role of protein kinase C signaling pathways in behaviors by direct gene transfer with HSV-1 vectors
16. A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons
17. Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene
18. Classical Transmitters in the CNS, Part I. Distribution maps of tyrosine hydroxylase immunoreactive neurons in the rat brain
19. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector
20. Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector
21. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
22. Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system
23. An adenovirus vector for gene transfer into neurons and glia in the brain
24. Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells
25. Identification of cell type-specific promoter elements associated with the rat tyrosine hydroxylase gene using transgenic founder analysis
26. A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription
27. 5' Upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice
28. 3.6 kb of the 5' flanking DNA activates the mouse tyrosine hydroxylase gene promoter without catecholaminergic-specific expression
29. NeuN, a neuronal specific nuclear protein in vertebrates
30. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
31. Nucleotide sequence of bacteriophage lambda DNA
32. The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
33. Identification of potential target genes for the neuron-restrictive silencer factor
34. Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro
35. Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression
36. Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons
37. An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain
38. Molecular and cellular biology of intermediate filaments
39. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons
40. Improved titers for helper virus-free herpes simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of noninfectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packaging procedure
41. Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice
42. Fifty-one kilobase HSV-1 plasmid vector can be packaged using a helper virus-free system and supports expression in the rat brain
43. Diverse stabilities of expression in the rat brain from different cellular promoters in a helper virus-free herpes simplex virus type 1 vector system
44. Enhanced gene transfer and long-term expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of mutations in specific HSV-1 proteins that affect the virion