메뉴 건너뛰기




Volumn 115, Issue , 2012, Pages 187-227

Active and Passive Anticytokine Immune Therapies: Current Status and Development

Author keywords

AC immune therapies; Cytokines; Novel biotherapies

Indexed keywords

ADALIMUMAB; ALPHA INTERFERON; ANTIFERON; BELIMUMAB; BEVACIZUMAB; CANAKINUMAB; CERTOLIZUMAB PEGOL; CYTOKINE ANTIBODY; D2E7; DENOSUMAB; GAMMA INTERFERON; GOLIMUMAB; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23P19; INTERLEUKIN 5; INTERLEUKIN 6; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 5; OSTEOCLAST DIFFERENTIATION FACTOR; PLACEBO; RANIBIZUMAB; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; USTEKINUMAB; VASCULOTROPIN;

EID: 84861131253     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394299-9.00007-2     Document Type: Chapter
Times cited : (11)

References (181)
  • 2
    • 0036469114 scopus 로고    scopus 로고
    • Autocrine interleukin-6 production in renal cell carcinoma: Evidence for the involvement of p53
    • Angelo L.S., Talpaz M., Kurzrock R. Autocrine interleukin-6 production in renal cell carcinoma: Evidence for the involvement of p53. Cancer Res. 2002, 62:932-940.
    • (2002) Cancer Res. , vol.62 , pp. 932-940
    • Angelo, L.S.1    Talpaz, M.2    Kurzrock, R.3
  • 3
    • 0033766287 scopus 로고    scopus 로고
    • Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: Implication of protein kinase C-dependent pathway
    • Badou A., Bennasser Y., Moreau M., Leclerc C., Benkirane M., Bahraoui E. Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: Implication of protein kinase C-dependent pathway. J. Virol. 2000, 74:10551-10562.
    • (2000) J. Virol. , vol.74 , pp. 10551-10562
    • Badou, A.1    Bennasser, Y.2    Moreau, M.3    Leclerc, C.4    Benkirane, M.5    Bahraoui, E.6
  • 6
    • 84857141296 scopus 로고    scopus 로고
    • Cancer-related inflammation: Common themes and therapeutic opportunities
    • Balkwill F.R., Mantovani A. Cancer-related inflammation: Common themes and therapeutic opportunities. Semin. Cancer Biol. 2012, 22:33-40.
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 33-40
    • Balkwill, F.R.1    Mantovani, A.2
  • 7
    • 0034649199 scopus 로고    scopus 로고
    • Angiogenesis modulators expression in culture cell lines positives for HPV-16 oncoproteins
    • Bequet-Romero M., López-Ocejo O. Angiogenesis modulators expression in culture cell lines positives for HPV-16 oncoproteins. Biochem. Biophys. Res. Commun. 2000, 277:55-61.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 55-61
    • Bequet-Romero, M.1    López-Ocejo, O.2
  • 10
    • 0029300707 scopus 로고
    • " Kinoids": The basis for anticytokine immunisation and their use in HIV infection
    • Bizzini B., Achour A. " Kinoids": The basis for anticytokine immunisation and their use in HIV infection. Cell. Mol. Biol. (Noisy-le-Grand) 1995, 41:351-356.
    • (1995) Cell. Mol. Biol. (Noisy-le-Grand) , vol.41 , pp. 351-356
    • Bizzini, B.1    Achour, A.2
  • 11
    • 0026777352 scopus 로고
    • Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE
    • Bombardier C., Gladman D.D., Urowitz M.B., Caron D., Chang C.H. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992, 35:630-640.
    • (1992) Arthritis Rheum. , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.D.2    Urowitz, M.B.3    Caron, D.4    Chang, C.H.5
  • 12
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T., Sutton A.J., Sweeting M.J., Buchan I., Matteson E.L., Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006, 295:2275-2285.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 13
    • 0030805855 scopus 로고    scopus 로고
    • Clinical relevance of anti-interferon antibodies in the serum of chronic hepatitis C patients treated with interferon-alpha
    • Bonino F., Baldi M., Negro F., Oliveri F., Colombatto P., Bellati G., Brunetto M.R. Clinical relevance of anti-interferon antibodies in the serum of chronic hepatitis C patients treated with interferon-alpha. J. Interferon Cytokine Res. 1997, 17(Suppl. 1):S35-S38.
    • (1997) J. Interferon Cytokine Res. , vol.17 , Issue.SUPPL. 1
    • Bonino, F.1    Baldi, M.2    Negro, F.3    Oliveri, F.4    Colombatto, P.5    Bellati, G.6    Brunetto, M.R.7
  • 16
    • 0021713342 scopus 로고
    • Production of functional chimaeric mouse/human antibody
    • Boulianne G.L., Hozumi N., Shulman M.J. Production of functional chimaeric mouse/human antibody. Nature 1984, 312:643-646.
    • (1984) Nature , vol.312 , pp. 643-646
    • Boulianne, G.L.1    Hozumi, N.2    Shulman, M.J.3
  • 17
    • 0029617952 scopus 로고
    • Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist
    • Butler D.M., Maini R.N., Feldmann M., Brennan F.M. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytokine Netw. 1995, 6:225-230.
    • (1995) Eur. Cytokine Netw. , vol.6 , pp. 225-230
    • Butler, D.M.1    Maini, R.N.2    Feldmann, M.3    Brennan, F.M.4
  • 20
    • 0030764538 scopus 로고    scopus 로고
    • Natural antibodies to interferon-gamma
    • Caruso A., Turano A. Natural antibodies to interferon-gamma. Biotherapy 1997, 10:29-37.
    • (1997) Biotherapy , vol.10 , pp. 29-37
    • Caruso, A.1    Turano, A.2
  • 21
    • 0034898470 scopus 로고    scopus 로고
    • Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies
    • Chackerian B., Lowy D.R., Schiller J.T. Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J. Clin. Invest. 2001, 108:415-423.
    • (2001) J. Clin. Invest. , vol.108 , pp. 415-423
    • Chackerian, B.1    Lowy, D.R.2    Schiller, J.T.3
  • 22
  • 23
    • 0031875403 scopus 로고    scopus 로고
    • Experimental vaccine strategies for cancer immunotherapy
    • Review
    • Chen C.H., Wu T.C. Experimental vaccine strategies for cancer immunotherapy. J. Biomed. Sci. 1998, 5:231-252. Review.
    • (1998) J. Biomed. Sci. , vol.5 , pp. 231-252
    • Chen, C.H.1    Wu, T.C.2
  • 25
    • 0025972506 scopus 로고
    • In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects
    • Chensue S.W., Terebuh P.D., Remick D.G., Scales W.E., Kunkel S.L. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am. J. Pathol. 1991, 138:395-402.
    • (1991) Am. J. Pathol. , vol.138 , pp. 395-402
    • Chensue, S.W.1    Terebuh, P.D.2    Remick, D.G.3    Scales, W.E.4    Kunkel, S.L.5
  • 26
    • 0026523212 scopus 로고
    • IL-12 receptor (1992). I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
    • Chizzonite R., Truitt T., Desai B.B., Nunes P., Podlaski F.J., Stern A.S., Gately M.K. IL-12 receptor (1992). I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol. 1992, 148:3117-3124.
    • (1992) J. Immunol. , vol.148 , pp. 3117-3124
    • Chizzonite, R.1    Truitt, T.2    Desai, B.B.3    Nunes, P.4    Podlaski, F.J.5    Stern, A.S.6    Gately, M.K.7
  • 31
    • 77950355734 scopus 로고    scopus 로고
    • Anti-inflammatory agents: Present and future
    • Dinarello C.A. Anti-inflammatory agents: Present and future. Cell 2010, 140:935-950.
    • (2010) Cell , vol.140 , pp. 935-950
    • Dinarello, C.A.1
  • 36
    • 0024637649 scopus 로고
    • NIH conference. Development and evaluation of a vaccine for human immunodeficiency virus (HIV) infection
    • Fauci A.S., Gallo R.C., Koenig S., Salk J., Purcell R.H. NIH conference. Development and evaluation of a vaccine for human immunodeficiency virus (HIV) infection. Ann. Intern. Med. 1989, 110:373-385.
    • (1989) Ann. Intern. Med. , vol.110 , pp. 373-385
    • Fauci, A.S.1    Gallo, R.C.2    Koenig, S.3    Salk, J.4    Purcell, R.H.5
  • 39
    • 77957764473 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy
    • Ferrara N. Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy. Nat. Med. 2010, 16:1107-1111.
    • (2010) Nat. Med. , vol.16 , pp. 1107-1111
    • Ferrara, N.1
  • 40
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: Therapeutic implications. N. Engl. J. Med. 1971, 285:1182-1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 41
    • 0026846928 scopus 로고
    • The role of angiogenesis in tumor growth
    • Folkman J. The role of angiogenesis in tumor growth. Semin. Cancer Biol. 1992, 3:65-71.
    • (1992) Semin. Cancer Biol. , vol.3 , pp. 65-71
    • Folkman, J.1
  • 42
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: An organizing principle for drug discovery?. Nat. Rev. Drug Discov. 2007, 6:273-286.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 273-286
    • Folkman, J.1
  • 43
    • 0029653368 scopus 로고
    • Kinetic and affinity limits on antibodies produced during immune responses
    • Foote J., Eisen H.N. Kinetic and affinity limits on antibodies produced during immune responses. Proc. Natl. Acad. Sci. USA 1995, 92:1254-1256.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1254-1256
    • Foote, J.1    Eisen, H.N.2
  • 44
    • 0026534643 scopus 로고
    • Interferons in the persistence, pathogenesis, and treatment of HIV infection
    • Review
    • Francis M.L., Meltzer M.S., Gendelman H.E. Interferons in the persistence, pathogenesis, and treatment of HIV infection. AIDS Res. Hum. Retroviruses 1992, 8:199-207. Review.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 199-207
    • Francis, M.L.1    Meltzer, M.S.2    Gendelman, H.E.3
  • 45
    • 0021964141 scopus 로고
    • Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay
    • Friguet B., Chaffotte A.F., Djavadi-Ohaniance L., Goldberg M.E. Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J. Immunol. Methods 1985, 77:305-319.
    • (1985) J. Immunol. Methods , vol.77 , pp. 305-319
    • Friguet, B.1    Chaffotte, A.F.2    Djavadi-Ohaniance, L.3    Goldberg, M.E.4
  • 47
    • 0033587718 scopus 로고    scopus 로고
    • Tat as one key to HIV-induced immune pathogenesis and Tat toxoid as an important component of a vaccine
    • Gallo R.C. Tat as one key to HIV-induced immune pathogenesis and Tat toxoid as an important component of a vaccine. Proc. Natl. Acad. Sci. USA 1999, 96:8324-8326.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8324-8326
    • Gallo, R.C.1
  • 49
    • 0037280306 scopus 로고    scopus 로고
    • The role of VEGF in normal and neoplastic hematopoiesis
    • Gerber H.P., Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J. Mol. Med. (Berl.) 2003, 81:20-31.
    • (2003) J. Mol. Med. (Berl.) , vol.81 , pp. 20-31
    • Gerber, H.P.1    Ferrara, N.2
  • 50
    • 0027970730 scopus 로고
    • Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially up-regulates IL-6 and TGF-beta 1 mRNA expression and protein synthesis in peripheral blood monocytes
    • Gibellini D., Zauli G., Re M.C., Milani D., Furlini G., Caramelli E., Capitani S., La Placa M. Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially up-regulates IL-6 and TGF-beta 1 mRNA expression and protein synthesis in peripheral blood monocytes. Br. J. Haematol. 1994, 88:261-267.
    • (1994) Br. J. Haematol. , vol.88 , pp. 261-267
    • Gibellini, D.1    Zauli, G.2    Re, M.C.3    Milani, D.4    Furlini, G.5    Caramelli, E.6    Capitani, S.7    La Placa, M.8
  • 52
    • 0031882913 scopus 로고    scopus 로고
    • The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
    • Grell M., Wajant H., Zimmermann G., Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. USA 1998, 95:570-575.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 570-575
    • Grell, M.1    Wajant, H.2    Zimmermann, G.3    Scheurich, P.4
  • 56
    • 0033402030 scopus 로고    scopus 로고
    • Favorable treatment outcome with neutralizing anti transforming growth factor beta antibodies in experimental diabetic kidney disease
    • Han D.C., Ziyadeh F.N. Favorable treatment outcome with neutralizing anti transforming growth factor beta antibodies in experimental diabetic kidney disease. Perit. Dial. Int. 1999, 19(Suppl. 2):S234-S237.
    • (1999) Perit. Dial. Int. , vol.19 , Issue.SUPPL. 2
    • Han, D.C.1    Ziyadeh, F.N.2
  • 57
    • 77953658260 scopus 로고    scopus 로고
    • The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions
    • Harding F.A., Stickler M.M., Razo J., DuBridge R.B. The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions. MAbs 2010, 2:256-265.
    • (2010) MAbs , vol.2 , pp. 256-265
    • Harding, F.A.1    Stickler, M.M.2    Razo, J.3    DuBridge, R.B.4
  • 59
    • 0033924551 scopus 로고    scopus 로고
    • Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice
    • Hondowicz B.D., Park A.Y., Elloso M.M., Scott P. Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice. Eur. J. Immunol. 2000, 30:2007-2014.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2007-2014
    • Hondowicz, B.D.1    Park, A.Y.2    Elloso, M.M.3    Scott, P.4
  • 60
    • 84861135030 scopus 로고    scopus 로고
    • Active Immunization Against IFNa with IFN-Kinoid in SLE Patients Is Safe, Immunogenic and Induces Down-Regulation of IFN Mediated Genes. Arthritis & Rheumatism 63 (S10) Abstract 2470 - The American College of Rheumatology/Association of Rheumatology Health Professionals
    • Chicago, Illinois
    • Houssiau F.A., Rashkov R., Hachulla E., Lazaro E., Jorgensen C., Spertini F., Mariette X., Grouard-Vogel G., Fanget B., Dhellin O., Lauwerys B., Vandepapeliere P. Active Immunization Against IFNa with IFN-Kinoid in SLE Patients Is Safe, Immunogenic and Induces Down-Regulation of IFN Mediated Genes. Arthritis & Rheumatism 63 (S10) Abstract 2470 - The American College of Rheumatology/Association of Rheumatology Health Professionals. Annual Scientific Meeting 2011, Chicago, Illinois.
    • (2011) Annual Scientific Meeting
    • Houssiau, F.A.1    Rashkov, R.2    Hachulla, E.3    Lazaro, E.4    Jorgensen, C.5    Spertini, F.6    Mariette, X.7    Grouard-Vogel, G.8    Fanget, B.9    Dhellin, O.10    Lauwerys, B.11    Vandepapeliere, P.12
  • 61
    • 0034689206 scopus 로고    scopus 로고
    • Tumor-induced immunosuppression: A barrier to immunotherapy of large tumors by cytokine-secreting tumor vaccine
    • Hsieh C.L., Chen D.S., Hwang L.H. Tumor-induced immunosuppression: A barrier to immunotherapy of large tumors by cytokine-secreting tumor vaccine. Hum. Gene Ther. 2000, 11:681-692.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 681-692
    • Hsieh, C.L.1    Chen, D.S.2    Hwang, L.H.3
  • 63
    • 0028081880 scopus 로고
    • Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice
    • Ishida H., Muchamuel T., Sakaguchi S., Andrade S., Menon S., Howard M. Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J. Exp. Med. 1994, 179:305-310.
    • (1994) J. Exp. Med. , vol.179 , pp. 305-310
    • Ishida, H.1    Muchamuel, T.2    Sakaguchi, S.3    Andrade, S.4    Menon, S.5    Howard, M.6
  • 64
    • 84861175377 scopus 로고    scopus 로고
    • Human Press Inc., Totowa, NJ. (Eng), J.M. Jacobson (Ed.)
    • Immunotherapy for Infectious Diseases 2002, Human Press Inc., Totowa, NJ, 331pp. (Eng). J.M. Jacobson (Ed.).
    • (2002) Immunotherapy for Infectious Diseases , pp. 331
  • 65
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • Jakowlew S.B. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006, 25:435-457.
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 435-457
    • Jakowlew, S.B.1
  • 66
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones P.T., Dear P.H., Foote J., Neuberger M.S., Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 1986, 321:522-525.
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 70
    • 0032585977 scopus 로고    scopus 로고
    • Cytokine expression of transforming growth factor-beta2 and interleukin-10 in squamous cell carcinomas of the head and neck. Comparison of tissue expression and serum levels
    • Karcher J., Reisser C., Daniel V., Herold-Mende C. Cytokine expression of transforming growth factor-beta2 and interleukin-10 in squamous cell carcinomas of the head and neck. Comparison of tissue expression and serum levels. HNO 1999, 47:879-884.
    • (1999) HNO , vol.47 , pp. 879-884
    • Karcher, J.1    Reisser, C.2    Daniel, V.3    Herold-Mende, C.4
  • 71
    • 67349145653 scopus 로고    scopus 로고
    • Erythropoietin
    • Elsevier, London, A.W. Thomson, M.T. Lotze (Eds.)
    • Kasper C. Erythropoietin. The cytokine handbook 2003, 149-166. Elsevier, London, vol I. 4th edn. A.W. Thomson, M.T. Lotze (Eds.).
    • (2003) The cytokine handbook , vol.1 , pp. 149-166
    • Kasper, C.1
  • 72
    • 63749093322 scopus 로고    scopus 로고
    • Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor
    • Kaymakcalan Z., Sakorafas P., Bose S., Scesney S., Xiong L., Hanzatian D.K., Salfeld J., Sasso E.H. Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. Clin. Immunol. 2009, 131:308-316.
    • (2009) Clin. Immunol. , vol.131 , pp. 308-316
    • Kaymakcalan, Z.1    Sakorafas, P.2    Bose, S.3    Scesney, S.4    Xiong, L.5    Hanzatian, D.K.6    Salfeld, J.7    Sasso, E.H.8
  • 73
    • 0036136882 scopus 로고    scopus 로고
    • IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    • Keir M.E., Stoddart C.A., Linquist-Stepps V., Moreno M.E., McCune J.M. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J. Immunol. 2002, 168:325-331.
    • (2002) J. Immunol. , vol.168 , pp. 325-331
    • Keir, M.E.1    Stoddart, C.A.2    Linquist-Stepps, V.3    Moreno, M.E.4    McCune, J.M.5
  • 74
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel R.S., Kamen B.A. The anti-angiogenic basis of metronomic chemotherapy. Nat. Rev. Cancer 2004, 4:423-436.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 75
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim K.J., Li B., Winer J., Armanini M., Gillett N., Phillips H.S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 77
    • 0027534985 scopus 로고
    • Up-regulation of IL-6-receptors by IL-3 on a plasma cell leukaemia cell line which proliferates dependently on both IL-3 and IL-6
    • Kobayashi M., Tanaka J., Imamura M., Maeda S., Iwasaki H., Tanaka M., Tsudu Y., Sakurada K., Miyazaki T. Up-regulation of IL-6-receptors by IL-3 on a plasma cell leukaemia cell line which proliferates dependently on both IL-3 and IL-6. Br. J. Haematol. 1993, 83:535-538.
    • (1993) Br. J. Haematol. , vol.83 , pp. 535-538
    • Kobayashi, M.1    Tanaka, J.2    Imamura, M.3    Maeda, S.4    Iwasaki, H.5    Tanaka, M.6    Tsudu, Y.7    Sakurada, K.8    Miyazaki, T.9
  • 78
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975, 256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 79
    • 0031015257 scopus 로고    scopus 로고
    • Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice
    • Kojouharoff G., Hans W., Obermeier F., Männel D.N., Andus T., Schölmerich J., Gross V., Falk W. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice. Clin. Exp. Immunol. 1997, 107:353-358.
    • (1997) Clin. Exp. Immunol. , vol.107 , pp. 353-358
    • Kojouharoff, G.1    Hans, W.2    Obermeier, F.3    Männel, D.N.4    Andus, T.5    Schölmerich, J.6    Gross, V.7    Falk, W.8
  • 80
    • 77956326466 scopus 로고    scopus 로고
    • Averting inflammation by targeting the cytokine environment
    • Kopf M., Bachmann M.F., Marsland B.J. Averting inflammation by targeting the cytokine environment. Nat. Rev. Drug Discov. 2010, 9:703-718.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 703-718
    • Kopf, M.1    Bachmann, M.F.2    Marsland, B.J.3
  • 81
    • 79958772395 scopus 로고    scopus 로고
    • Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody
    • Kostenuik P.J., Smith S.Y., Jolette J., Schroeder J., Pyrah I., Ominsky M.S. Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody. Bone 2011, 49:151-161.
    • (2011) Bone , vol.49 , pp. 151-161
    • Kostenuik, P.J.1    Smith, S.Y.2    Jolette, J.3    Schroeder, J.4    Pyrah, I.5    Ominsky, M.S.6
  • 83
    • 37549055446 scopus 로고    scopus 로고
    • Human monoclonal antibodies by immortalization of memory B cells
    • Lanzavecchia A., Corti D., Sallusto F. Human monoclonal antibodies by immortalization of memory B cells. Curr. Opin. Biotechnol. 2007, 18:523-528.
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 523-528
    • Lanzavecchia, A.1    Corti, D.2    Sallusto, F.3
  • 86
    • 33845879373 scopus 로고    scopus 로고
    • TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation
    • Le Buanec H., Delavallée L., Bessis N., Paturance S., Bizzini B., Gallo R., Zagury D., Boissier M.C. TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation. Proc. Natl. Acad. Sci. USA 2006, 103:19442-19447.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 19442-19447
    • Le Buanec, H.1    Delavallée, L.2    Bessis, N.3    Paturance, S.4    Bizzini, B.5    Gallo, R.6    Zagury, D.7    Boissier, M.C.8
  • 89
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard J.P., Waldburger K.E., Goldman S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 1995, 181:381-386.
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 90
    • 60549088318 scopus 로고    scopus 로고
    • A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone
    • Li X., Loberg R., Liao J., Ying C., Snyder L.A., Pienta K.J., McCauley L.K. A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone. Cancer Res. 2009, 69:1685-1692.
    • (2009) Cancer Res. , vol.69 , pp. 1685-1692
    • Li, X.1    Loberg, R.2    Liao, J.3    Ying, C.4    Snyder, L.A.5    Pienta, K.J.6    McCauley, L.K.7
  • 93
    • 0028814315 scopus 로고
    • Human antibodies from transgenic mice
    • Lonberg N., Huszar D. Human antibodies from transgenic mice. Int. Rev. Immunol. 1995, 13(1):65-93.
    • (1995) Int. Rev. Immunol. , vol.13 , Issue.1 , pp. 65-93
    • Lonberg, N.1    Huszar, D.2
  • 94
    • 70350381008 scopus 로고    scopus 로고
    • Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    • Lu X., Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J. Biol. Chem. 2009, 284:29087-29096.
    • (2009) J. Biol. Chem. , vol.284 , pp. 29087-29096
    • Lu, X.1    Kang, Y.2
  • 95
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen- induced arthritis reduces joint inflammation, cartilage destructionand bone erosion
    • Lubberts E., Koenders M.I., Oppers-Walgreen B., Van den Bersselaar L., Coenen-de Roo C.J.J., Joosten L.A.B., van den Berg W.B. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen- induced arthritis reduces joint inflammation, cartilage destructionand bone erosion. Arthritis Rheum. 2004, 50:650-659.
    • (2004) Arthritis Rheum. , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    Van den Bersselaar, L.4    Coenen-de Roo, C.J.J.5    Joosten, L.A.B.6    van den Berg, W.B.7
  • 96
    • 34548437104 scopus 로고    scopus 로고
    • Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice
    • Ma Y., Hayglass K.T., Becker A.B. Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice. Am. J. Resp. Crit. Care Med. 2007, 176:439-445.
    • (2007) Am. J. Resp. Crit. Care Med. , vol.176 , pp. 439-445
    • Ma, Y.1    Hayglass, K.T.2    Becker, A.B.3
  • 98
    • 0028846008 scopus 로고
    • VEGF-mediated tumour angiogenesis: A new target for cancer therapy
    • Martiny-Baron G., Marmé D. VEGF-mediated tumour angiogenesis: A new target for cancer therapy. Curr. Opin. Biotechnol. 1995, 6:675-680.
    • (1995) Curr. Opin. Biotechnol. , vol.6 , pp. 675-680
    • Martiny-Baron, G.1    Marmé, D.2
  • 99
    • 79955863984 scopus 로고    scopus 로고
    • Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus
    • Mathian A., Amoura Z., Adam E., Colaone F., Hoekman M.F., Dhellin O., Vandepapelière P., Haroche J., Piette J.C., Lebon P., Grouard-Vogel G. Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus. Ann. Rheum. Dis. 2011, 70:1138-1143.
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1138-1143
    • Mathian, A.1    Amoura, Z.2    Adam, E.3    Colaone, F.4    Hoekman, M.F.5    Dhellin, O.6    Vandepapelière, P.7    Haroche, J.8    Piette, J.C.9    Lebon, P.10    Grouard-Vogel, G.11
  • 100
    • 0031826252 scopus 로고    scopus 로고
    • Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice
    • Matthys P., Vermeire K., Mitera T., Heremans H., Huang S., Billiau A. Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice. Eur. J. Immunol. 1998, 28:2143-2151.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2143-2151
    • Matthys, P.1    Vermeire, K.2    Mitera, T.3    Heremans, H.4    Huang, S.5    Billiau, A.6
  • 102
    • 0025226085 scopus 로고
    • Phage antibodies:filamentous phage displaying antibody variable domains
    • McCafferty J., Griffiths A.D., Winter G., Chiswell D.J. Phage antibodies:filamentous phage displaying antibody variable domains. Nature 1990, 348:552-554.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 103
    • 0032848409 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model
    • Melnyk O., Zimmerman M., Kim K.J., Shuman M. Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model. J. Urol. 1999, 161:960-963.
    • (1999) J. Urol. , vol.161 , pp. 960-963
    • Melnyk, O.1    Zimmerman, M.2    Kim, K.J.3    Shuman, M.4
  • 105
    • 0024507353 scopus 로고
    • Ligand-dependent selection of the receptor gene: Segregation of IL-2 binding activity and anti-Tac reactivity by a single amino acid alteration in the Tac antigen (p55)
    • Minamoto S., Itoh S., Kono T., Doi T., Hatakeyama M. Ligand-dependent selection of the receptor gene: Segregation of IL-2 binding activity and anti-Tac reactivity by a single amino acid alteration in the Tac antigen (p55). Immunol. Lett. 1989, 20:139-147.
    • (1989) Immunol. Lett. , vol.20 , pp. 139-147
    • Minamoto, S.1    Itoh, S.2    Kono, T.3    Doi, T.4    Hatakeyama, M.5
  • 106
    • 0023868764 scopus 로고
    • B-cell activation in HIV infection: Relationship of spontaneous immunoglobulin secretion to various immunological parameters
    • Mizuma H., Litwin S., Zolla-Pazner S. B-cell activation in HIV infection: Relationship of spontaneous immunoglobulin secretion to various immunological parameters. Clin. Exp. Immunol. 1988, 71:410-416.
    • (1988) Clin. Exp. Immunol. , vol.71 , pp. 410-416
    • Mizuma, H.1    Litwin, S.2    Zolla-Pazner, S.3
  • 107
    • 0023835294 scopus 로고
    • Lipopolysaccharide as a tool to reveal autoreactive B cells
    • Möller G. Lipopolysaccharide as a tool to reveal autoreactive B cells. APMIS 1988, 96:93-100.
    • (1988) APMIS , vol.96 , pp. 93-100
    • Möller, G.1
  • 108
    • 0021716682 scopus 로고
    • Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
    • Morrison S.L., Johnson M.J., Herzenberg L.A., Oi V.T. Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA 1984, 81:6851-6855.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 6851-6855
    • Morrison, S.L.1    Johnson, M.J.2    Herzenberg, L.A.3    Oi, V.T.4
  • 109
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath M.F., Fuss I., Kelsall B.L., Stüber E., Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995, 182:1281-1290.
    • (1995) J. Exp. Med. , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stüber, E.4    Strober, W.5
  • 110
    • 79959355853 scopus 로고    scopus 로고
    • Immune modulation for treatment of allergic disease
    • Nguyen T.H., Casale T.B. Immune modulation for treatment of allergic disease. Immunol. Rev. 2011, 242:258-271.
    • (2011) Immunol. Rev. , vol.242 , pp. 258-271
    • Nguyen, T.H.1    Casale, T.B.2
  • 111
    • 0031023298 scopus 로고    scopus 로고
    • Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-gamma antibody
    • Nicoletti F., Zaccone P., Di Marco R., Lunetta M., Magro G., Grasso S., Meroni P., Garotta G. Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-gamma antibody. Endocrinology 1997, 13:281-288.
    • (1997) Endocrinology , vol.13 , pp. 281-288
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Lunetta, M.4    Magro, G.5    Grasso, S.6    Meroni, P.7    Garotta, G.8
  • 112
    • 0028321590 scopus 로고
    • Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells
    • Obiri N.I., Siegel J.P., Varricchio F., Puri R.K. Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells. Clin. Exp. Immunol. 1994, 95:148-155.
    • (1994) Clin. Exp. Immunol. , vol.95 , pp. 148-155
    • Obiri, N.I.1    Siegel, J.P.2    Varricchio, F.3    Puri, R.K.4
  • 113
    • 85047692430 scopus 로고    scopus 로고
    • IL-10-producing and naturallyoccurring CD4+ Tregs: Limiting collateral damage
    • O'Garra A., Vieira P.L., Vieira P., Goldfeld A.E. IL-10-producing and naturallyoccurring CD4+ Tregs: Limiting collateral damage. J. Clin. Invest. 2004, 114:1372-1378.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1372-1378
    • O'Garra, A.1    Vieira, P.L.2    Vieira, P.3    Goldfeld, A.E.4
  • 114
  • 117
    • 81255182827 scopus 로고    scopus 로고
    • Springer, NewYork, NY, Inc, S.A. Plotkin (Ed.)
    • History of Vaccine Development 2011, Springer, NewYork, NY, Inc. S.A. Plotkin (Ed.).
    • (2011) History of Vaccine Development
  • 118
    • 0026677361 scopus 로고
    • Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor
    • Piguet P.F., Grau G.E., Vesin C., Loetscher H., Gentz R., Lesslauer W. Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology 1992, 77:510-514.
    • (1992) Immunology , vol.77 , pp. 510-514
    • Piguet, P.F.1    Grau, G.E.2    Vesin, C.3    Loetscher, H.4    Gentz, R.5    Lesslauer, W.6
  • 123
  • 124
    • 80054814059 scopus 로고    scopus 로고
    • Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients
    • Rodriguez P.C., Neninger E., García B., Popa X., Viada C., Luaces P., González G., Lage A., Montero E., Crombet T. Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients. J. Immune Based Ther. Vaccines 2011, 9:7.
    • (2011) J. Immune Based Ther. Vaccines , vol.9 , pp. 7
    • Rodriguez, P.C.1    Neninger, E.2    García, B.3    Popa, X.4    Viada, C.5    Luaces, P.6    González, G.7    Lage, A.8    Montero, E.9    Crombet, T.10
  • 126
    • 0035423557 scopus 로고    scopus 로고
    • An etiopathogenic role for the type I IFN system in SLE
    • Rönnblom L., Alm G.V. An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 2001, 22:427-431.
    • (2001) Trends Immunol. , vol.22 , pp. 427-431
    • Rönnblom, L.1    Alm, G.V.2
  • 127
    • 77953555514 scopus 로고    scopus 로고
    • Cytokines as therapeutic targets in SLE
    • Review
    • Rönnblom L., Elkon K.B. Cytokines as therapeutic targets in SLE. Nat. Rev. Rheumatol. 2010, 6:339-347. Review.
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 339-347
    • Rönnblom, L.1    Elkon, K.B.2
  • 128
    • 0025049877 scopus 로고
    • Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors
    • Ross C., Hansen M.B., Schyberg T., Berg K. Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors. Clin. Exp. Immunol. 1990, 82:57-62.
    • (1990) Clin. Exp. Immunol. , vol.82 , pp. 57-62
    • Ross, C.1    Hansen, M.B.2    Schyberg, T.3    Berg, K.4
  • 129
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi S., Sakaguchi N., Shimizu J., Yamazaki S., Sakihama T., Itoh M., Kuniyasu Y., Nomura T., Toda M., Takahashi T. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001, 182:18-32.
    • (2001) Immunol. Rev. , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3    Yamazaki, S.4    Sakihama, T.5    Itoh, M.6    Kuniyasu, Y.7    Nomura, T.8    Toda, M.9    Takahashi, T.10
  • 130
    • 0030008658 scopus 로고    scopus 로고
    • Differential effects of high-dose gamma irradiation on the production of transforming growth factor-beta in fresh and established human ovarian cancer
    • Santin A.D., Hiserodt J.C., DiSaia P.J., Pećorelli S., Granger G.A. Differential effects of high-dose gamma irradiation on the production of transforming growth factor-beta in fresh and established human ovarian cancer. Gynecol. Oncol. 1996, 61:403-408.
    • (1996) Gynecol. Oncol. , vol.61 , pp. 403-408
    • Santin, A.D.1    Hiserodt, J.C.2    DiSaia, P.J.3    Pećorelli, S.4    Granger, G.A.5
  • 132
  • 133
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
    • Selmaj K., Raine C.S., Cross A.H. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 1991, 30:694-700.
    • (1991) Ann. Neurol. , vol.30 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 134
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K., Jin Y., Guo J., Ziyadeh F.N. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996, 45:522-530.
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 135
    • 0031604598 scopus 로고    scopus 로고
    • Cell hybridization, hybridomas, and human hybridomas
    • Shirahata S., Katakura Y., Teruya K. Cell hybridization, hybridomas, and human hybridomas. Methods Cell Biol. 1998, 57:111-145.
    • (1998) Methods Cell Biol. , vol.57 , pp. 111-145
    • Shirahata, S.1    Katakura, Y.2    Teruya, K.3
  • 136
    • 0028964310 scopus 로고
    • The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo
    • Siegel S.A., Shealy D.J., Nakada M.T., Le J., Woulfe D.S., Probert L., Kollias G., Ghrayeb J., Vilcek J., Daddona P.E. The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo. Cytokine 1995, 7:15-25.
    • (1995) Cytokine , vol.7 , pp. 15-25
    • Siegel, S.A.1    Shealy, D.J.2    Nakada, M.T.3    Le, J.4    Woulfe, D.S.5    Probert, L.6    Kollias, G.7    Ghrayeb, J.8    Vilcek, J.9    Daddona, P.E.10
  • 137
    • 44049085950 scopus 로고    scopus 로고
    • A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis
    • Smitten A.L., Simon T.A., Hochberg M.C., Suissa S. A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res. Ther. 2008, 10:R45.
    • (2008) Arthritis Res. Ther. , vol.10
    • Smitten, A.L.1    Simon, T.A.2    Hochberg, M.C.3    Suissa, S.4
  • 141
    • 43649107676 scopus 로고    scopus 로고
    • Active immunisation with IL-1 displayed on virus-like particles protects from autoimmune arthritis
    • Spohn G., Keller I., Beck M., Grest P., Jennings G.T., Bachmann M.F. Active immunisation with IL-1 displayed on virus-like particles protects from autoimmune arthritis. Eur. J. Immunol. 2008, 38:877-887.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 877-887
    • Spohn, G.1    Keller, I.2    Beck, M.3    Grest, P.4    Jennings, G.T.5    Bachmann, M.F.6
  • 145
    • 0032521450 scopus 로고    scopus 로고
    • Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations
    • Svenson M., Hansen M.B., Ross C., Diamant M., Rieneck K., Nielsen H., Bendtzen K. Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations. Blood 1998, 91:2054-2061.
    • (1998) Blood , vol.91 , pp. 2054-2061
    • Svenson, M.1    Hansen, M.B.2    Ross, C.3    Diamant, M.4    Rieneck, K.5    Nielsen, H.6    Bendtzen, K.7
  • 146
    • 34848850384 scopus 로고    scopus 로고
    • Active immunotherapy of allergic asthma with a recombinant human interleukin-5 protein as vaccine in a murine model
    • Tan G.H., Wang C.C., Huang F.Y., Wang H., Huang Y.H., Lin Y.Y. Active immunotherapy of allergic asthma with a recombinant human interleukin-5 protein as vaccine in a murine model. Chin. Med. J. 2007, 120:1517-1522.
    • (2007) Chin. Med. J. , vol.120 , pp. 1517-1522
    • Tan, G.H.1    Wang, C.C.2    Huang, F.Y.3    Wang, H.4    Huang, Y.H.5    Lin, Y.Y.6
  • 147
    • 0027535841 scopus 로고
    • The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): Prevention of disease and decrease of EAT-specific T cells
    • Tang H., Mignon-Godefroy K., Meroni P.L., Garotta G., Charreire J., Nicoletti F. The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): Prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol. 1993, 23:275-278.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 275-278
    • Tang, H.1    Mignon-Godefroy, K.2    Meroni, P.L.3    Garotta, G.4    Charreire, J.5    Nicoletti, F.6
  • 148
    • 0031418669 scopus 로고    scopus 로고
    • Prostate carcinoma response to cytotoxic therapy: In vivo resistance
    • Teicher B.A., Kakeji Y., Ara G., Herbst R.S., Northey D. Prostate carcinoma response to cytotoxic therapy: In vivo resistance. In Vivo 1997, 11:453-461.
    • (1997) In Vivo , vol.11 , pp. 453-461
    • Teicher, B.A.1    Kakeji, Y.2    Ara, G.3    Herbst, R.S.4    Northey, D.5
  • 149
    • 0028869486 scopus 로고
    • The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition
    • Theofilopoulos A.N. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol. Today 1995, 16:90-98.
    • (1995) Immunol. Today , vol.16 , pp. 90-98
    • Theofilopoulos, A.N.1
  • 152
    • 0027447123 scopus 로고
    • Trabecular cells express receptors that bind TGF-beta 1 and TGF-beta 2: A qualitative and quantitative characterization
    • Tripathi R.C., Borisuth N.S., Kolli S.P., Tripathi B.J. Trabecular cells express receptors that bind TGF-beta 1 and TGF-beta 2: A qualitative and quantitative characterization. Invest. Ophthalmol. Vis. Sci. 1993, 34:260-263.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 260-263
    • Tripathi, R.C.1    Borisuth, N.S.2    Kolli, S.P.3    Tripathi, B.J.4
  • 153
    • 33751243318 scopus 로고    scopus 로고
    • Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis
    • Uyttenhove C., Van Snick J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur. J. Immunol. 2006, 36:2868-2874.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 2868-2874
    • Uyttenhove, C.1    Van Snick, J.2
  • 154
    • 10944221275 scopus 로고    scopus 로고
    • Development of an anti-IL-12 p40 auto-vaccine: Protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection
    • Uyttenhove C., Arendse B., Stroobant V., Brombacher F., Van Snick J. Development of an anti-IL-12 p40 auto-vaccine: Protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection. Eur. J. Immunol. 2004, 34:3572-3581.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 3572-3581
    • Uyttenhove, C.1    Arendse, B.2    Stroobant, V.3    Brombacher, F.4    Van Snick, J.5
  • 156
    • 0025203676 scopus 로고
    • Characterization of the receptors for vascular endothelial growth factor
    • Vaisman N., Gospodarowicz D., Neufeld G. Characterization of the receptors for vascular endothelial growth factor. J. Biol. Chem. 1990, 265:19461-19466.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19461-19466
    • Vaisman, N.1    Gospodarowicz, D.2    Neufeld, G.3
  • 157
    • 77649168107 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: What are the important clinical markers to target?
    • Vaklavas C., Lenihan D., Kurzrock R., Tsimberidou A.M. Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: What are the important clinical markers to target?. Oncologist 2010, 15:130-141.
    • (2010) Oncologist , vol.15 , pp. 130-141
    • Vaklavas, C.1    Lenihan, D.2    Kurzrock, R.3    Tsimberidou, A.M.4
  • 158
    • 33846855387 scopus 로고    scopus 로고
    • Imaging and serum analysis of immune complex formation of radiolabelled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis
    • van der Laken C.J., Voskuyl A.E., Roos J.C., Stigter van Walsum M., de Groot E.R., Wolbink G., Dijkmans B.A., Aarden L.A. Imaging and serum analysis of immune complex formation of radiolabelled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis. Ann. Rheum. Dis. 2007, 66:253-256.
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 253-256
    • van der Laken, C.J.1    Voskuyl, A.E.2    Roos, J.C.3    Stigter van Walsum, M.4    de Groot, E.R.5    Wolbink, G.6    Dijkmans, B.A.7    Aarden, L.A.8
  • 161
    • 0025082315 scopus 로고
    • Mouse plasmacytoma growth in vivo: Enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against interleukin 6 or its receptor
    • Vink A., Coulie P., Warnier G., Renauld J.-C., Stevens M., Donckers D., VanSnick J. Mouse plasmacytoma growth in vivo: Enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against interleukin 6 or its receptor. J. Exp. Med. 1990, 172:997.
    • (1990) J. Exp. Med. , vol.172 , pp. 997
    • Vink, A.1    Coulie, P.2    Warnier, G.3    Renauld, J.-C.4    Stevens, M.5    Donckers, D.6    VanSnick, J.7
  • 162
    • 0024810651 scopus 로고
    • Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1
    • Viscidi R.P., Mayur K., Lederman H.M., Frankel A.D. Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1. Science 1989, 246:1606-1608.
    • (1989) Science , vol.246 , pp. 1606-1608
    • Viscidi, R.P.1    Mayur, K.2    Lederman, H.M.3    Frankel, A.D.4
  • 163
    • 1942437446 scopus 로고    scopus 로고
    • TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model
    • Waterston A.M., Salway F., Andreakos E., Butler D.M., Feldmann M., Coombes R.C. TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model. Br. J. Cancer 2004, 90:1279-1284.
    • (2004) Br. J. Cancer , vol.90 , pp. 1279-1284
    • Waterston, A.M.1    Salway, F.2    Andreakos, E.3    Butler, D.M.4    Feldmann, M.5    Coombes, R.C.6
  • 165
    • 0030947668 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis in the cotton top tamarin using antibody to tumour necrosis factor alpha
    • Watkins P.E., Warren B.F., Stephens S., Ward P., Foulkes R. Treatment of ulcerative colitis in the cotton top tamarin using antibody to tumour necrosis factor alpha. Gut 1997, 40:628-633.
    • (1997) Gut , vol.40 , pp. 628-633
    • Watkins, P.E.1    Warren, B.F.2    Stephens, S.3    Ward, P.4    Foulkes, R.5
  • 166
    • 0033779762 scopus 로고    scopus 로고
    • The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
    • Weiner G.J. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J. Leukoc. Biol. 2000, 68:455-463.
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 455-463
    • Weiner, G.J.1
  • 167
    • 0026644298 scopus 로고
    • Anti-TNF ameliorates joint disease in murine collagen-induced arthritis
    • Williams R.O., Feldmann M., Maini R.N. Anti-TNF ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. USA 1992, 89:9784-9788.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 168
    • 0031435653 scopus 로고    scopus 로고
    • Reversal of tumor-induced immunosuppression: A new approach to cancer therapy
    • Wojtowicz-Praga S. Reversal of tumor-induced immunosuppression: A new approach to cancer therapy. J. Immunother. 1997, 20:165-177.
    • (1997) J. Immunother. , vol.20 , pp. 165-177
    • Wojtowicz-Praga, S.1
  • 170
    • 36448931232 scopus 로고    scopus 로고
    • IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    • Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 2007, 9:R96.
    • (2007) Arthritis Res. Ther. , vol.9
    • Yago, T.1    Nanke, Y.2    Kawamoto, M.3    Furuya, T.4    Kobashigawa, T.5    Kamatani, N.6    Kotake, S.7
  • 171
    • 0025764726 scopus 로고
    • Anti-HIV cellular immunotherapy in AIDS
    • Zagury D. Anti-HIV cellular immunotherapy in AIDS. Lancet 1991, 338:694-695.
    • (1991) Lancet , vol.338 , pp. 694-695
    • Zagury, D.1
  • 173
    • 0034940764 scopus 로고    scopus 로고
    • Toward a new generation of vaccines: The anti-cytokine therapeutic vaccines
    • Zagury D., Burny A., Gallo R.C. Toward a new generation of vaccines: The anti-cytokine therapeutic vaccines. Proc. Natl. Acad. Sci. USA 2001, 98:8024-8029.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8024-8029
    • Zagury, D.1    Burny, A.2    Gallo, R.C.3
  • 174
    • 0037379605 scopus 로고    scopus 로고
    • Active versus passive anti-cytokine antibody therapy against cytokine-associated chronic diseases
    • Review
    • Zagury D., Le Buanec H., Bizzini B., Burny A., Lewis G., Gallo R.C. Active versus passive anti-cytokine antibody therapy against cytokine-associated chronic diseases. Cytokine Growth Factor Rev. 2003, 14:123-137. Review.
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 123-137
    • Zagury, D.1    Le Buanec, H.2    Bizzini, B.3    Burny, A.4    Lewis, G.5    Gallo, R.C.6
  • 176
    • 0027096251 scopus 로고
    • Tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: A potential mechanism for human immunodeficiency virus-1-induced hematopoietic suppression
    • Zauli G., Davis B.R., Re M.C., Visani G., Furlini G., La Placa M. tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: A potential mechanism for human immunodeficiency virus-1-induced hematopoietic suppression. Blood 1992, 80:3036-3043.
    • (1992) Blood , vol.80 , pp. 3036-3043
    • Zauli, G.1    Davis, B.R.2    Re, M.C.3    Visani, G.4    Furlini, G.5    La Placa, M.6
  • 177
    • 0030240562 scopus 로고    scopus 로고
    • Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes
    • Zauli G., Gibellini D., Celeghini C., Mischiati C., Bassini A., La Placa M., Capitani S. Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes. J. Immunol. 1996, 157:2216-2224.
    • (1996) J. Immunol. , vol.157 , pp. 2216-2224
    • Zauli, G.1    Gibellini, D.2    Celeghini, C.3    Mischiati, C.4    Bassini, A.5    La Placa, M.6    Capitani, S.7
  • 179
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 2005, 5:263-274.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 181


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.