메뉴 건너뛰기




Volumn 13, Issue 4-5, 2002, Pages 299-313

Cytokines and anti-cytokine biologicals in autoimmunity: Present and future

Author keywords

Autoimmunity; Cytokine; NF B; Rheumatoid arthritis; TNF

Indexed keywords

ADALIMUMAB; BETA1A INTERFERON; CYTOKINE; ETANERCEPT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERFERON BETA SERINE; LENERCEPT; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

EID: 0036695186     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(02)00018-7     Document Type: Review
Times cited : (144)

References (146)
  • 2
    • 0035555366 scopus 로고    scopus 로고
    • Autoimmune diseases: Genes, bugs and failed regulation
    • Ermann J, Fathman CG. Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol 2001;2(9):759-61.
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 759-761
    • Ermann, J.1    Fathman, C.G.2
  • 3
    • 0035555022 scopus 로고    scopus 로고
    • The genetics of complex autoimmune diseases: Non-MHC susceptibility genes
    • Wanstrat A, Wakeland E. The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol 2001;2(9):802-9.
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 802-809
    • Wanstrat, A.1    Wakeland, E.2
  • 4
    • 0035554904 scopus 로고    scopus 로고
    • Sex differences in autoimmune disease
    • Whitacre CC. Sex differences in autoimmune disease. Nat Immunol 2001;2(9):777-80.
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 777-780
    • Whitacre, C.C.1
  • 5
    • 0027375302 scopus 로고
    • Twin concordance rates for rheumatoid arthritis: Results from a nation-wide study
    • Silman AJ, MacGregor AJ, Thomson W, et al. Twin concordance rates for rheumatoid arthritis: results from a nation-wide study. Br J Rheumatol 1993;32(10):903-7.
    • (1993) Br J Rheumatol , vol.32 , Issue.10 , pp. 903-907
    • Silman, A.J.1    MacGregor, A.J.2    Thomson, W.3
  • 6
    • 0035555275 scopus 로고    scopus 로고
    • Pathogenesis of arthritis: Recent research progress
    • Feldmann M. Pathogenesis of arthritis: recent research progress. Nat Immunol 2001;2(9):771-3.
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 771-773
    • Feldmann, M.1
  • 7
    • 0035128996 scopus 로고    scopus 로고
    • Genetic models for CNS inflammation
    • Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nat Med 2001;7(2):161-6.
    • (2001) Nat Med , vol.7 , Issue.2 , pp. 161-166
    • Owens, T.1    Wekerle, H.2    Antel, J.3
  • 8
    • 0032754990 scopus 로고    scopus 로고
    • Cytokines that regulate autoimmune responses
    • Falcone M, Sarvetnick N. Cytokines that regulate autoimmune responses. Curr Opin Immunol 1999;11(6):670-6.
    • (1999) Curr Opin Immunol , vol.11 , Issue.6 , pp. 670-676
    • Falcone, M.1    Sarvetnick, N.2
  • 10
    • 0026091413 scopus 로고
    • Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis
    • Chu CQ, Field M, Feldmann M, Maini RN. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 1991;34(9):1125-32.
    • (1991) Arthritis Rheum , vol.34 , Issue.9 , pp. 1125-1132
    • Chu, C.Q.1    Field, M.2    Feldmann, M.3    Maini, R.N.4
  • 11
    • 0026568727 scopus 로고
    • In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis
    • Wood NC, Dickens E, Symons JA, Duff GW. In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis. Clin Immunol Immunopathol 1992;62(3):295-300.
    • (1992) Clin Immunol Immunopathol , vol.62 , Issue.3 , pp. 295-300
    • Wood, N.C.1    Dickens, E.2    Symons, J.A.3    Duff, G.W.4
  • 12
    • 0024678727 scopus 로고
    • Cytokine production in culture by cells isolated from the synovial membrane
    • Brennan FM, Chantry D, Jackson AM, Maini RN, Feldmann M. Cytokine production in culture by cells isolated from the synovial membrane. J Autoimmun 1989;2(Suppl):177-86.
    • (1989) J Autoimmun , vol.2 , Issue.SUPPL. , pp. 177-186
    • Brennan, F.M.1    Chantry, D.2    Jackson, A.M.3    Maini, R.N.4    Feldmann, M.5
  • 13
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001;19:163-96.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 14
    • 0024314554 scopus 로고
    • Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
    • Brennan FM, Chantry D, Jackson A, Maini R, Feldmann M. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 1989;2(8657):244-7.
    • (1989) Lancet , vol.2 , Issue.8657 , pp. 244-247
    • Brennan, F.M.1    Chantry, D.2    Jackson, A.3    Maini, R.4    Feldmann, M.5
  • 15
    • 0021069905 scopus 로고
    • An interleukin 1 like factor stimulates bone resorption in vitro
    • Gowen M, Wood DD, Ihrie EJ, McGuire MK, Russell RG. An interleukin 1 like factor stimulates bone resorption in vitro. Nature 1983;306(5941):378-80.
    • (1983) Nature , vol.306 , Issue.5941 , pp. 378-380
    • Gowen, M.1    Wood, D.D.2    Ihrie, E.J.3    McGuire, M.K.4    Russell, R.G.5
  • 16
    • 0022394427 scopus 로고
    • Pig interleukin 1: Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever
    • Saklatvala J, Sarsfield SJ, Townsend Y. Pig interleukin 1: purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever. J Exp Med 1985;162(4):1208-22.
    • (1985) J Exp Med , vol.162 , Issue.4 , pp. 1208-1222
    • Saklatvala, J.1    Sarsfield, S.J.2    Townsend, Y.3
  • 17
    • 0025707532 scopus 로고
    • IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1
    • Schindler R, Ghezzi P, Dinarello CA. IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1. J Immunol 1990;144(6):2216-22.
    • (1990) J Immunol , vol.144 , Issue.6 , pp. 2216-2222
    • Schindler, R.1    Ghezzi, P.2    Dinarello, C.A.3
  • 18
    • 0025221381 scopus 로고
    • Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes
    • Chantry D, Turner M, Brennan F, Kingsbury A, Feldmann M. Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. Cytokine 1990;2(1):60-7.
    • (1990) Cytokine , vol.2 , Issue.1 , pp. 60-67
    • Chantry, D.1    Turner, M.2    Brennan, F.3    Kingsbury, A.4    Feldmann, M.5
  • 19
    • 0023936157 scopus 로고
    • Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes
    • Burchett SK, Weaver WM, Westall JA, Larsen A, Kronheim S, Wilson CB. Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes. J Immunol 1988;140(10):3473-81.
    • (1988) J Immunol , vol.140 , Issue.10 , pp. 3473-3481
    • Burchett, S.K.1    Weaver, W.M.2    Westall, J.A.3    Larsen, A.4    Kronheim, S.5    Wilson, C.B.6
  • 20
    • 0024549356 scopus 로고
    • Mechanism of immune complex-mediated damage: Induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha
    • Chantry D, Winearls CG, Maini RN, Feldmann M. Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol 1989;19(1):189-92.
    • (1989) Eur J Immunol , vol.19 , Issue.1 , pp. 189-192
    • Chantry, D.1    Winearls, C.G.2    Maini, R.N.3    Feldmann, M.4
  • 21
    • 0027465503 scopus 로고
    • Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: A possible role of CD69
    • Isler P, Vey E, Zhang JH, Dayer JM. Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: a possible role of CD69. Eur Cytokine Networks 1993;4(1):15-23.
    • (1993) Eur Cytokine Networks , vol.4 , Issue.1 , pp. 15-23
    • Isler, P.1    Vey, E.2    Zhang, J.H.3    Dayer, J.M.4
  • 22
    • 0029617952 scopus 로고
    • Modulation of pro-inflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti-TNF-alpha antibody with the interleukin-1 receptor antagonist
    • Butler DM, Maini RN, Feldmann M, Brennan FM. Modulation of pro-inflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti-TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur Cytokine Networks 1995;6(4):225-30.
    • (1995) Eur Cytokine Networks , vol.6 , Issue.4 , pp. 225-230
    • Butler, D.M.1    Maini, R.N.2    Feldmann, M.3    Brennan, F.M.4
  • 23
    • 0025939257 scopus 로고
    • Expression of granulocyte-macrophage colonystimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor-alpha
    • Haworth C, Brennan FM, Chantry D, Turner M, Maini RN, Feldmann M. Expression of granulocyte-macrophage colonystimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha. Eur J Immunol 1991;21(10):2575-9.
    • (1991) Eur J Immunol , vol.21 , Issue.10 , pp. 2575-2579
    • Haworth, C.1    Brennan, F.M.2    Chantry, D.3    Turner, M.4    Maini, R.N.5    Feldmann, M.6
  • 24
    • 0025847243 scopus 로고
    • Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha
    • Alvaro-Gracia JM, Zvaifler NJ, Brown CB, Kaushansky K, Firestein GS. Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha. J Immunol 1991;146(10):3365-71.
    • (1991) J Immunol , vol.146 , Issue.10 , pp. 3365-3371
    • Alvaro-Gracia, J.M.1    Zvaifler, N.J.2    Brown, C.B.3    Kaushansky, K.4    Firestein, G.S.5
  • 25
    • 0026656850 scopus 로고
    • Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice
    • Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA. Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc Natl Acad Sci USA 1992;89(16):7375-9.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.16 , pp. 7375-7379
    • Thorbecke, G.J.1    Shah, R.2    Leu, C.H.3    Kuruvilla, A.P.4    Hardison, A.M.5    Palladino, M.A.6
  • 26
    • 0026644298 scopus 로고
    • Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis
    • Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992;89(20):9784-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.20 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 27
    • 0026677361 scopus 로고
    • Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor
    • Piguet PF, Grau GE, Vesin C, Loetscher H, Gentz R, Lesslauer W. Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology 1992;77(4):510-4.
    • (1992) Immunology , vol.77 , Issue.4 , pp. 510-514
    • Piguet, P.F.1    Grau, G.E.2    Vesin, C.3    Loetscher, H.4    Gentz, R.5    Lesslauer, W.6
  • 28
    • 0027422060 scopus 로고
    • Influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice
    • Wooley PH, Dutcher J, Widmer MB, Gillis S. Influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice. J Immunol 1993;151(11):6602-7.
    • (1993) J Immunol , vol.151 , Issue.11 , pp. 6602-6607
    • Wooley, P.H.1    Dutcher, J.2    Widmer, M.B.3    Gillis, S.4
  • 29
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer J, Probert L, Cazlaris H, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10(13):4025-31.
    • (1991) EMBO J , vol.10 , Issue.13 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3
  • 30
    • 0029045458 scopus 로고
    • The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    • Probert L, Plows D, Kontogeorgos G, Kollias G. The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol 1995;25(6):1794-7.
    • (1995) Eur J Immunol , vol.25 , Issue.6 , pp. 1794-1797
    • Probert, L.1    Plows, D.2    Kontogeorgos, G.3    Kollias, G.4
  • 31
    • 0024822793 scopus 로고
    • Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia
    • Fong Y, Tracey KJ, Moldawer LL, et al. Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia. J Exp Med 1989;170(5):1627-33.
    • (1989) J Exp Med , vol.170 , Issue.5 , pp. 1627-1633
    • Fong, Y.1    Tracey, K.J.2    Moldawer, L.L.3
  • 32
  • 33
    • 0027959650 scopus 로고
    • Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes
    • Joyce DA, Gibbons DP, Green P, Steer JH, Feldmann M, Brennan FM. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur J Immunol 1994;24(11):2699-705.
    • (1994) Eur J Immunol , vol.24 , Issue.11 , pp. 2699-2705
    • Joyce, D.A.1    Gibbons, D.P.2    Green, P.3    Steer, J.H.4    Feldmann, M.5    Brennan, F.M.6
  • 34
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174(5):1209-20.
    • (1991) J Exp Med , vol.174 , Issue.5 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 35
    • 0031826987 scopus 로고    scopus 로고
    • Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis
    • Hermann JA, Hall MA, Maini RN, Feldmann M, Brennan FM. Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis. Arthritis Rheum 1998;41(8):1388-97.
    • (1998) Arthritis Rheum , vol.41 , Issue.8 , pp. 1388-1397
    • Hermann, J.A.1    Hall, M.A.2    Maini, R.N.3    Feldmann, M.4    Brennan, F.M.5
  • 36
    • 0026806992 scopus 로고
    • Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases
    • Cope AP, Aderka D, Doherty M, et al. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum 1992;35(10):1160-9.
    • (1992) Arthritis Rheum , vol.35 , Issue.10 , pp. 1160-1169
    • Cope, A.P.1    Aderka, D.2    Doherty, M.3
  • 37
    • 0026608722 scopus 로고
    • Inhibitors of interleukin 1 activity in synovial fluids and in cultured synovial fluid mononuclear cells
    • Roux-Lombard P, Modoux C, Vischer T, Grassi J, Dayer JM. Inhibitors of interleukin 1 activity in synovial fluids and in cultured synovial fluid mononuclear cells. J Rheumatol 1992;19(4):517-23.
    • (1992) J Rheumatol , vol.19 , Issue.4 , pp. 517-523
    • Roux-Lombard, P.1    Modoux, C.2    Vischer, T.3    Grassi, J.4    Dayer, J.M.5
  • 38
    • 0026721695 scopus 로고
    • IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium
    • Firestein GS, Berger AE, Tracey DE, et al. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J Immunol 1992;149(3):1054-62.
    • (1992) J Immunol , vol.149 , Issue.3 , pp. 1054-1062
    • Firestein, G.S.1    Berger, A.E.2    Tracey, D.E.3
  • 39
    • 0026545719 scopus 로고
    • Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage-pannus junction in rheumatoid arthritis
    • Deleuran BW, Chu CQ, Field M, et al. Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage-pannus junction in rheumatoid arthritis. Br J Rheumatol 1992;31(12):801-9.
    • (1992) Br J Rheumatol , vol.31 , Issue.12 , pp. 801-809
    • Deleuran, B.W.1    Chu, C.Q.2    Field, M.3
  • 40
    • 15844384253 scopus 로고    scopus 로고
    • Activation of the transcription factor nuclear factor-kappa B in human inflamed synovial tissue
    • Marok R, Winyard PG, Coumbe A, et al. Activation of the transcription factor nuclear factor-kappa B in human inflamed synovial tissue. Arthritis Rheum 1996;39(4):583-91.
    • (1996) Arthritis Rheum , vol.39 , Issue.4 , pp. 583-591
    • Marok, R.1    Winyard, P.G.2    Coumbe, A.3
  • 41
    • 0031744967 scopus 로고    scopus 로고
    • Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
    • Sioud M, Mellbye O, Forre O. Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin Exp Rheumatol 1998;16(2):125-34.
    • (1998) Clin Exp Rheumatol , vol.16 , Issue.2 , pp. 125-134
    • Sioud, M.1    Mellbye, O.2    Forre, O.3
  • 42
    • 0034748888 scopus 로고    scopus 로고
    • IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: Implications for autoimmune disease activity during these times
    • Elenkov IJ, Wilder RL, Bakalov VK, et al. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 2001;86(10):4933-8.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.10 , pp. 4933-4938
    • Elenkov, I.J.1    Wilder, R.L.2    Bakalov, V.K.3
  • 43
    • 0026552488 scopus 로고
    • Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
    • Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992;102(5):1620-7.
    • (1992) Gastroenterology , vol.102 , Issue.5 , pp. 1620-1627
    • Mullin, G.E.1    Lazenby, A.J.2    Harris, M.L.3    Bayless, T.M.4    James, S.P.5
  • 44
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112(4):1169-78.
    • (1997) Gastroenterology , vol.112 , Issue.4 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 45
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115(1):182-205.
    • (1998) Gastroenterology , vol.115 , Issue.1 , pp. 182-205
    • Fiocchi, C.1
  • 46
    • 0031853981 scopus 로고    scopus 로고
    • Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease
    • Noguchi M, Hiwatashi N, Liu Z, Toyota T. Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease. Gut 1998;43(2):203-9.
    • (1998) Gut , vol.43 , Issue.2 , pp. 203-209
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.3    Toyota, T.4
  • 47
    • 0031869524 scopus 로고    scopus 로고
    • In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease
    • Autschbach F, Braunstein J, Helmke B, et al. In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol 1998;153(1):121-30.
    • (1998) Am J Pathol , vol.153 , Issue.1 , pp. 121-130
    • Autschbach, F.1    Braunstein, J.2    Helmke, B.3
  • 48
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995;108(5):1434-44.
    • (1995) Gastroenterology , vol.108 , Issue.5 , pp. 1434-1444
    • Schreiber, S.1    Heinig, T.2    Thiele, H.G.3    Raedler, A.4
  • 49
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • van Dullemen HM, van Deventer SJ, Hommes DW, et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995;109(1):129-35.
    • (1995) Gastroenterology , vol.109 , Issue.1 , pp. 129-135
    • Van Dullemen, H.M.1    Van Deventer, S.J.2    Hommes, D.W.3
  • 50
    • 0032833517 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
    • Rutgeerts P, D'Haens G, Targan S, et al. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 1999;117(4):761-9.
    • (1999) Gastroenterology , vol.117 , Issue.4 , pp. 761-769
    • Rutgeerts, P.1    D'Haens, G.2    Targan, S.3
  • 51
    • 0024358808 scopus 로고
    • Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: Thyroid follicular cells produce interleukin-1 alpha and interleukin-6
    • Grubeck-Loebenstein B, Buchan G, Chantry D, et al. Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6. Clin Exp Immunol 1989;77(3):324-30.
    • (1989) Clin Exp Immunol , vol.77 , Issue.3 , pp. 324-330
    • Grubeck-Loebenstein, B.1    Buchan, G.2    Chantry, D.3
  • 52
    • 85009894618 scopus 로고    scopus 로고
    • The role of cytokines in thyroid health and disease
    • Brennan FM, Feldmann M, editors. London: R.G. Landes Company
    • Grubeck-Loebenstein B. The role of cytokines in thyroid health and disease. In: Brennan FM, Feldmann M, editors. Cytokines in autoimmunity. London: R.G. Landes Company, 1996. p. 101-20.
    • (1996) Cytokines in autoimmunity , pp. 101-120
    • Grubeck-Loebenstein, B.1
  • 53
    • 0028579773 scopus 로고
    • Autoimmune thyroid disease: Further developments in our understanding
    • Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocrinol Rev 1994;15(6):788-830.
    • (1994) Endocrinol Rev , vol.15 , Issue.6 , pp. 788-830
    • Weetman, A.P.1    McGregor, A.M.2
  • 54
    • 0002204890 scopus 로고    scopus 로고
    • Cytokines in sjogren's syndrome
    • Brennan FM, Feldmann M, editors. London: R.G. Landes Company
    • Skopouli FN, Moutsopoulos HM. Cytokines in sjogren's syndrome. In: Brennan FM, Feldmann M, editors. Cytokines in autoimmunity. London: R.G. Landes Company, 1996. p. 121-36.
    • (1996) Cytokines in autoimmunity , pp. 121-136
    • Skopouli, F.N.1    Moutsopoulos, H.M.2
  • 55
    • 0002576918 scopus 로고    scopus 로고
    • Cytokines in systemic lupus erythematosus
    • Brennan FM, Feldmann M, editors. London: R.G. Landes Company
    • Smolen JS, Graninger WB, Studnicka-Benke A, Steiner G. Cytokines in systemic lupus erythematosus. In: Brennan FM, Feldmann M, editors. Cytokines in autoimmunity. London: R.G. Landes Company, 1996. p. 137-52.
    • (1996) Cytokines in autoimmunity , pp. 137-152
    • Smolen, J.S.1    Graninger, W.B.2    Studnicka-Benke, A.3    Steiner, G.4
  • 56
    • 0032725836 scopus 로고    scopus 로고
    • Tumour necrosis factor and other cytokines in murine lupus
    • Theofilopoulos AN, Lawson BR. Tumour necrosis factor and other cytokines in murine lupus. Ann Rheum Dis 1999;58(Suppl 1):149-55.
    • (1999) Ann Rheum Dis , vol.58 , Issue.SUPPL. 1 , pp. 149-155
    • Theofilopoulos, A.N.1    Lawson, B.R.2
  • 57
    • 0010515685 scopus 로고    scopus 로고
    • Cytokines in multiple sclerosis
    • Brennan FM, Feldmann M, editors. London: R.G. Landes Company
    • Baker D, Steinmann L, Gijbels K. Cytokines in multiple sclerosis. In: Brennan FM, Feldmann M, editors. Cytokines in autoimmunity. London: R.G. Landes Company, 1996. p. 77-100.
    • (1996) Cytokines in autoimmunity , pp. 77-100
    • Baker, D.1    Steinmann, L.2    Gijbels, K.3
  • 59
    • 0027361432 scopus 로고
    • Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
    • Knight DM, Trinh H, Le J, et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 1993;30(16):1443-53.
    • (1993) Mol Immunol , vol.30 , Issue.16 , pp. 1443-1453
    • Knight, D.M.1    Trinh, H.2    Le, J.3
  • 60
    • 0027438710 scopus 로고
    • Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
    • Elliott MJ, Maini RN, Feldmann M, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum 1993;36(12):1681-90.
    • (1993) Arthritis Rheum , vol.36 , Issue.12 , pp. 1681-1690
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 61
    • 0028143212 scopus 로고
    • Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis
    • Elliott MJ, Maini RN, Feldmann M, et al. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis. Lancet 1994;344(8930):1125-7.
    • (1994) Lancet , vol.344 , Issue.8930 , pp. 1125-1127
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 62
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised Phase III trial
    • ATTRACT Study Group
    • Maini R, St Clair EW, Breedveld F, et al. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised Phase III trial. ATTRACT Study Group. Lancet 1999;354(9194):1932-9.
    • (1999) Lancet , vol.354 , Issue.9194 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3
  • 63
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with Concomitant Therapy Study Group
    • Lipsky PE, van der Heijde DM, St Clair EW, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with Concomitant Therapy Study Group. N Engl J Med 2000;343(22):1594-602.
    • (2000) N Engl J Med , vol.343 , Issue.22 , pp. 1594-1602
    • Lipsky, P.E.1    Van der Heijde, D.M.2    St Clair, E.W.3
  • 64
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000;343(22):1586-93.
    • (2000) N Engl J Med , vol.343 , Issue.22 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 65
    • 0033768473 scopus 로고    scopus 로고
    • Update on D2E7: A fully human anti-tumour necrosis factor alpha monoclonal antibody
    • Kempeni J. Update on D2E7: a fully human anti-tumour necrosis factor alpha monoclonal antibody. Ann Rheum Dis 2000;59(Suppl 1):i44-5.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. 1
    • Kempeni, J.1
  • 66
    • 0028861236 scopus 로고
    • Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis
    • Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum 1995;38(2):151-60.
    • (1995) Arthritis Rheum , vol.38 , Issue.2 , pp. 151-160
    • Arend, W.P.1    Dayer, J.M.2
  • 67
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
    • Moreland LW, Baumgartner SW, Schiff MH, et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 1997;337(3):141-7.
    • (1997) N Engl J Med , vol.337 , Issue.3 , pp. 141-147
    • Moreland, L.W.1    Baumgartner, S.W.2    Schiff, M.H.3
  • 68
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor-Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD, et al. A trial of etanercept, a recombinant tumor necrosis factor receptor-Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999;340(4):253-9.
    • (1999) N Engl J Med , vol.340 , Issue.4 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 69
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis. A randomised, controlled trial
    • Moreland LW, Schiff MH, Baumgartner SW, et al. Etanercept therapy in rheumatoid arthritis. A randomised, controlled trial. Ann Intern Med 1999;130(6):478-86.
    • (1999) Ann Intern Med , vol.130 , Issue.6 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 70
    • 0033762622 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with PEGylated recombinant human soluble tumour necrosis factor receptor type I: A clinical update
    • Davis MW, Feige U, Bendele AM, Martin SW, Edwards III CK. Treatment of rheumatoid arthritis with PEGylated recombinant human soluble tumour necrosis factor receptor type I: a clinical update. Ann Rheum Dis 2000;59(Suppl 1):i41-3.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. 1
    • Davis, M.W.1    Feige, U.2    Bendele, A.M.3    Martin, S.W.4    Edwards C.K. III5
  • 71
    • 0000462090 scopus 로고    scopus 로고
    • Neutralization of TNF by Lenercept (TNFR55-IgG1, Ro 45-2081) in patients with rheumatoid arthritis treated for 3 months: Results of a European Phase II trial
    • Sander O, Rau R, van Riel P, et al. Neutralization of TNF by Lenercept (TNFR55-IgG1, Ro 45-2081) in patients with rheumatoid arthritis treated for 3 months: results of a European Phase II trial. Arthritis Rheum 1996;39(Suppl):S243.
    • (1996) Arthritis Rheum , vol.39 , Issue.SUPPL.
    • Sander, O.1    Rau, R.2    Van Riel, P.3
  • 72
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Gracia JM, Cobby M, et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998;41(12):2196-204.
    • (1998) Arthritis Rheum , vol.41 , Issue.12 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 73
    • 0034083128 scopus 로고    scopus 로고
    • A multicenter, double-blind, dose-ranging, randomised, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores
    • Jiang Y, Genant HK, Watt I, et al. A multicenter, double-blind, dose-ranging, randomised, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 2000;43(5):1001-9.
    • (2000) Arthritis Rheum , vol.43 , Issue.5 , pp. 1001-1009
    • Jiang, Y.1    Genant, H.K.2    Watt, I.3
  • 74
    • 0035305177 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis patients with interleukin-1 receptor antagonist: Radiologic assessment
    • Watt I, Cobby M. Treatment of rheumatoid arthritis patients with interleukin-1 receptor antagonist: radiologic assessment. Semin Arthritis Rheum (Suppl 2) 2001;30(5):21-5.
    • (2001) Semin Arthritis Rheum , vol.30 , Issue.5 SUPPL. 2 , pp. 21-25
    • Watt, I.1    Cobby, M.2
  • 76
    • 0033769803 scopus 로고    scopus 로고
    • Anti-interleukin-1 and anti-tumor necrosis factor-alpha synergistically inhibit adjuvant arthritis in Lewis rats
    • Feige U, Hu YL, Gasser J, Campagnuolo G, Munyakazi L, Bolon B. Anti-interleukin-1 and anti-tumor necrosis factor-alpha synergistically inhibit adjuvant arthritis in Lewis rats. Cell Mol Life Sci 2000;57(10):1457-70.
    • (2000) Cell Mol Life Sci , vol.57 , Issue.10 , pp. 1457-1470
    • Feige, U.1    Hu, Y.L.2    Gasser, J.3    Campagnuolo, G.4    Munyakazi, L.5    Bolon, B.6
  • 77
    • 0027402917 scopus 로고
    • Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody
    • Wendling D, Racadot E, Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol 1993;20(2):259-62.
    • (1993) J Rheumatol , vol.20 , Issue.2 , pp. 259-262
    • Wendling, D.1    Racadot, E.2    Wijdenes, J.3
  • 78
    • 0031787640 scopus 로고    scopus 로고
    • Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanised anti-IL-6 receptor antibody
    • Yoshizaki K, Nishimoto N, Mihara M, Kishimoto T. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanised anti-IL-6 receptor antibody. Springer Semin Immunopathol 1998;20(1/2):247-59.
    • (1998) Springer Semin Immunopathol , vol.20 , Issue.1-2 , pp. 247-259
    • Yoshizaki, K.1    Nishimoto, N.2    Mihara, M.3    Kishimoto, T.4
  • 79
    • 0029671297 scopus 로고    scopus 로고
    • In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short-term cellular and molecular effects
    • Lorenz HM, Antoni C, Valerius T, et al. In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short-term cellular and molecular effects. J Immunol 1996;156(4):1646-53.
    • (1996) J Immunol , vol.156 , Issue.4 , pp. 1646-1653
    • Lorenz, H.M.1    Antoni, C.2    Valerius, T.3
  • 80
    • 0031810231 scopus 로고    scopus 로고
    • Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis
    • Paleolog EM, Young S, Stark AC, McCloskey RV, Feldmann M, Maini RN. Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. Arthritis Rheum 1998;41(7):1258-65.
    • (1998) Arthritis Rheum , vol.41 , Issue.7 , pp. 1258-1265
    • Paleolog, E.M.1    Young, S.2    Stark, A.C.3    McCloskey, R.V.4    Feldmann, M.5    Maini, R.N.6
  • 81
    • 0343674489 scopus 로고    scopus 로고
    • Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis
    • Taylor PC, Peters AM, Paleolog E, et al. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum 2000;43(1):38-47.
    • (2000) Arthritis Rheum , vol.43 , Issue.1 , pp. 38-47
    • Taylor, P.C.1    Peters, A.M.2    Paleolog, E.3
  • 82
    • 0033179534 scopus 로고    scopus 로고
    • Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis
    • Charles P, Elliott MJ, Davis D, et al. Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis. J Immunol 1999;163(3):1521-8.
    • (1999) J Immunol , vol.163 , Issue.3 , pp. 1521-1528
    • Charles, P.1    Elliott, M.J.2    Davis, D.3
  • 83
    • 0029896957 scopus 로고    scopus 로고
    • Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis
    • Tak PP, Taylor PC, Breedveld FC, et al. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum 1996;39(7):1077-81.
    • (1996) Arthritis Rheum , vol.39 , Issue.7 , pp. 1077-1081
    • Tak, P.P.1    Taylor, P.C.2    Breedveld, F.C.3
  • 84
    • 0035460227 scopus 로고    scopus 로고
    • Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis
    • Ballara S, Taylor PC, Reusch P, et al. Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum 2001;44(9):2055-64.
    • (2001) Arthritis Rheum , vol.44 , Issue.9 , pp. 2055-2064
    • Ballara, S.1    Taylor, P.C.2    Reusch, P.3
  • 85
    • 0030881463 scopus 로고    scopus 로고
    • Anaemia of chronic disease in rheumatoid arthritis: In vivo effects of tumour necrosis factor alpha blockade
    • Davis D, Charles PJ, Potter A, Feldmann M, Maini RN, Elliott MJ. Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade. Br J Rheumatol 1997;36(9):950-6.
    • (1997) Br J Rheumatol , vol.36 , Issue.9 , pp. 950-956
    • Davis, D.1    Charles, P.J.2    Potter, A.3    Feldmann, M.4    Maini, R.N.5    Elliott, M.J.6
  • 86
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
    • Crohn's Disease cA2 Study Group
    • Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997;337(15):1029-35.
    • (1997) N Engl J Med , vol.337 , Issue.15 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.3
  • 87
    • 0032913394 scopus 로고    scopus 로고
    • Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
    • D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 1999;116(5):1029-34.
    • (1999) Gastroenterology , vol.116 , Issue.5 , pp. 1029-1034
    • D'Haens, G.1    Van Deventer, S.2    Van Hogezand, R.3
  • 88
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • Baert FJ, D'Haens GR, Peeters M, et al. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999;116(1):22-8.
    • (1999) Gastroenterology , vol.116 , Issue.1 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3
  • 89
    • 0001311756 scopus 로고    scopus 로고
    • Retreatment with anti-TNFa chimeric antibody (cA2) effectively maintains cA2-induced remission in Crohn's disease
    • Rutgeerts P, D'Haens G, van Deventer SJ. Retreatment with anti-TNFa chimeric antibody (cA2) effectively maintains cA2-induced remission in Crohn's disease [abstr.]. Gastroenterology 1997;112:a1078.
    • (1997) Gastroenterology , vol.112
    • Rutgeerts, P.1    D'Haens, G.2    Van Deventer, S.J.3
  • 90
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999;340(18):1398-405.
    • (1999) N Engl J Med , vol.340 , Issue.18 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 91
    • 0034715977 scopus 로고    scopus 로고
    • Crohn's disease associated with spondyloarthropathy: Effect of TNF-alpha blockade with infliximab on articular symptoms
    • Van den Bosch F, Kruithof E, De Vos M, De Keyser F, Mielants H. Crohn's disease associated with spondyloarthropathy: effect of TNF-alpha blockade with infliximab on articular symptoms. Lancet 2000;356(9244):1821-2.
    • (2000) Lancet , vol.356 , Issue.9244 , pp. 1821-1822
    • Van den Bosch, F.1    Kruithof, E.2    De Vos, M.3    De Keyser, F.4    Mielants, H.5
  • 92
    • 0034130272 scopus 로고    scopus 로고
    • Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: An open pilot study
    • Van den Bosch F, Kruithof E, Baeten D, De Keyser F, Mielants H, Veys EM. Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study. Ann Rheum Dis 2000;59(6):428-33.
    • (2000) Ann Rheum Dis , vol.59 , Issue.6 , pp. 428-433
    • Van den Bosch, F.1    Kruithof, E.2    Baeten, D.3    De Keyser, F.4    Mielants, H.5    Veys, E.M.6
  • 93
    • 0034094123 scopus 로고    scopus 로고
    • Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab
    • Brandt J, Haibel H, Comely D, et al. Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab. Arthritis Rheum 2000;43(6):1346-52.
    • (2000) Arthritis Rheum , vol.43 , Issue.6 , pp. 1346-1352
    • Brandt, J.1    Haibel, H.2    Comely, D.3
  • 94
    • 0034780921 scopus 로고    scopus 로고
    • Treatment of active spondyloarthropathy with infliximab, the chimeric monoclonal antibody to tumour necrosis factor a
    • Van ben Bosch F, Beaten D, Kruithof F, De Keyser F, Mielants H, Veys EM. Treatment of active spondyloarthropathy with infliximab, the chimeric monoclonal antibody to tumour necrosis factor a. Ann Rheum Dis 2001;60(Suppl):iii33-6.
    • (2001) Ann Rheum Dis , vol.60 , Issue.SUPPL.
    • Van ben Bosch, F.1    Beaten, D.2    Kruithof, F.3    De Keyser, F.4    Mielants, H.5    Veys, E.M.6
  • 95
    • 0035150659 scopus 로고    scopus 로고
    • Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: Histologic findings in eight patients from an open-label pilot study
    • Baeten D, Kruithof E, Van den Bosch F, et al. Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. Arthritis Rheum 2001;44(1):186-95.
    • (2001) Arthritis Rheum , vol.44 , Issue.1 , pp. 186-195
    • Baeten, D.1    Kruithof, E.2    Van den Bosch, F.3
  • 96
    • 0000998464 scopus 로고    scopus 로고
    • Etanercept in the treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled study
    • Gorman JD, Sack KE, Davis JC. Etanercept in the treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled study [abstr.]. Arthritis Rheum 2000;43(Suppl):S403.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Gorman, J.D.1    Sack, K.E.2    Davis, J.C.3
  • 97
    • 0034673697 scopus 로고    scopus 로고
    • Etanercept in children with polyarticular juvenile rheumatoid arthritis: Pediatric Rheumatology Collaborative Study Group
    • Lovell DJ, Giannini EH, Reiff A, et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis: Pediatric Rheumatology Collaborative Study Group. N Engl J Med 2000;342(11):763-9.
    • (2000) N Engl J Med , vol.342 , Issue.11 , pp. 763-769
    • Lovell, D.J.1    Giannini, E.H.2    Reiff, A.3
  • 98
    • 0034729950 scopus 로고    scopus 로고
    • Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial
    • Mease PJ, Goffe BS, Metz J, VanderStoep A, Finck B, Burge DJ. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 2000;356(9227):385-90.
    • (2000) Lancet , vol.356 , Issue.9227 , pp. 385-390
    • Mease, P.J.1    Goffe, B.S.2    Metz, J.3    VanderStoep, A.4    Finck, B.5    Burge, D.J.6
  • 99
    • 0000134946 scopus 로고    scopus 로고
    • Etanercept in Wegener's granulomatosis: A 6 months open-label trial evaluate safety
    • Stone J, Uhlfelder M, Hellmann D, Crook S, Bedocs N, Hoffman G. Etanercept in Wegener's granulomatosis: a 6 months open-label trial evaluate safety [abstr.]. Arhtritis Rheum 2000;43(Suppl):S404.
    • (2000) Arhtritis Rheum , vol.43 , Issue.SUPPL.
    • Stone, J.1    Uhlfelder, M.2    Hellmann, D.3    Crook, S.4    Bedocs, N.5    Hoffman, G.6
  • 101
    • 0000657962 scopus 로고    scopus 로고
    • Anti-TNF blockade with infliximab (Remicade®) in polymyositis and dermatomyositis
    • Hengstman G, van den Hoogen F, ven Engelen B, et al. Anti-TNF blockade with infliximab (Remicade®) in polymyositis and dermatomyositis [abstr.]. Arhtritis Rheum 2000;43(Suppl):S193.
    • (2000) Arhtritis Rheum , vol.43 , Issue.SUPPL.
    • Hengstman, G.1    Van den Hoogen, F.2    Ven Engelen, B.3
  • 102
    • 0001540374 scopus 로고    scopus 로고
    • Etanercept as treatment for diffuse scleroderma: A pilot study
    • Ellman MH, MacDonald PA, Hayes FA. Etanercept as treatment for diffuse scleroderma: a pilot study [abstr.]. Arhtritis Rheum 2000;43(Suppl):S392.
    • (2000) Arhtritis Rheum , vol.43 , Issue.SUPPL.
    • Ellman, M.H.1    MacDonald, P.A.2    Hayes, F.A.3
  • 103
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomised, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • Anonymous. TNF neutralization in MS: results of a randomised, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 1999;53(3):457-65.
    • (1999) Neurology , vol.53 , Issue.3 , pp. 457-465
  • 104
    • 0029751983 scopus 로고    scopus 로고
    • Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
    • van Oosten BW, Barkhof F, Truyen L, et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 1996;47(6):1531-4.
    • (1996) Neurology , vol.47 , Issue.6 , pp. 1531-1534
    • Van Oosten, B.W.1    Barkhof, F.2    Truyen, L.3
  • 105
    • 0030911341 scopus 로고    scopus 로고
    • Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signalling
    • Cope AP, Liblau RS, Yang XD, et al. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signalling. J Exp Med 1997;185(9):1573-84.
    • (1997) J Exp Med , vol.185 , Issue.9 , pp. 1573-1584
    • Cope, A.P.1    Liblau, R.S.2    Yang, X.D.3
  • 106
    • 0027978457 scopus 로고
    • Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cel receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis
    • Cope AP, Londei M, Chu NR, et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cel receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest 1994;94(2):749-60.
    • (1994) J Clin Invest , vol.94 , Issue.2 , pp. 749-760
    • Cope, A.P.1    Londei, M.2    Chu, N.R.3
  • 107
    • 0000428990 scopus 로고    scopus 로고
    • The rhuIL-10 in subjects with active rheumatoid arthritis (RA): A Phase I and cytokine response study
    • Maini RN, Paulus H, Breedveld FC, et al. The rhuIL-10 in subjects with active rheumatoid arthritis (RA): a Phase I and cytokine response study [abstr.]. Arhtritis Rheum 1997;40:S224.
    • (1997) Arhtritis Rheum , vol.40
    • Maini, R.N.1    Paulus, H.2    Breedveld, F.C.3
  • 108
    • 4243711659 scopus 로고    scopus 로고
    • Phase I/II study evaluating the safety and potential efficacy of recombinant interleukin-11 in patients with refractory rheumatoid arthritis
    • Moreland LW, Chase W, Fife R, et al. Phase I/II study evaluating the safety and potential efficacy of recombinant interleukin-11 in patients with refractory rheumatoid arthritis. Arthritis Rheum 1999;42(Suppl):224.
    • (1999) Arthritis Rheum , vol.42 , Issue.SUPPL. , pp. 224
    • Moreland, L.W.1    Chase, W.2    Fife, R.3
  • 109
    • 17844403234 scopus 로고    scopus 로고
    • Results of a Phase I/II randomised, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis
    • Moreland L, Gugliotti R, King K, et al. Results of a Phase I/II randomised, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis. Arthritis Res 2001;3(4):247-52.
    • (2001) Arthritis Res , vol.3 , Issue.4 , pp. 247-252
    • Moreland, L.1    Gugliotti, R.2    King, K.3
  • 110
    • 0345251966 scopus 로고    scopus 로고
    • Interleukin 10 treatment of psoriasis: Clinical results of a Phase II trial
    • Asadullah K, Docke WD, Ebeling M, et al. Interleukin 10 treatment of psoriasis: clinical results of a Phase II trial. Arch Dermatol 1999;135(2):187-92.
    • (1999) Arch Dermatol , vol.135 , Issue.2 , pp. 187-192
    • Asadullah, K.1    Docke, W.D.2    Ebeling, M.3
  • 111
    • 0345251966 scopus 로고    scopus 로고
    • Interleukin 10 treatment of psoriasis: Clinical results of a Phase II trial
    • Asadullah K, Docke WD, Ebeling M, et al. Interleukin 10 treatment of psoriasis: clinical results of a Phase II trial. Arch Dermatol 1999;135(2):187-92.
    • (1999) Arch Dermatol , vol.135 , Issue.2 , pp. 187-192
    • Asadullah, K.1    Docke, W.D.2    Ebeling, M.3
  • 112
    • 0035478652 scopus 로고    scopus 로고
    • IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis
    • McInnes IB, Illei GG, Danning CL, et al. IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis. J Immunol 2001;167(7):4075-82.
    • (2001) J Immunol , vol.167 , Issue.7 , pp. 4075-4082
    • McInnes, I.B.1    Illei, G.G.2    Danning, C.L.3
  • 113
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomised, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • Anonymous. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomised, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology 1993;43:655-61.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 114
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomised controlled trial
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • Anonymous. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomised controlled trial. The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 1995;45(7):1277-85.
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1277-1285
  • 115
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomised, double-blind placebo-controlled trial
    • Paty DW, Li DK. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomised, double-blind placebo-controlled trial. Neurology 1993;43(4):662-7.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 116
    • 0028988737 scopus 로고
    • The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis
    • Stone LA, Frank JA, Albert PS, et al. The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann Neurol 1995;37(5):611-9.
    • (1995) Ann Neurol , vol.37 , Issue.5 , pp. 611-619
    • Stone, L.A.1    Frank, J.A.2    Albert, P.S.3
  • 117
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on Interferon Beta-1b in Secondary Progressive MS
    • Anonymous. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. European Study Group on Interferon Beta-1b in Secondary Progressive MS. Lancet 1998;352:1491-7.
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 119
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996;39(3):285-94.
    • (1996) Ann Neurol , vol.39 , Issue.3 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 120
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • Prevention of Relapses and Disability by Interferon Beta-1a Subcutaneously in Multiple Sclerosis (PRISMS) Study Group
    • Anonymous. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Prevention of Relapses and Disability by Interferon Beta-1a Subcutaneously in Multiple Sclerosis (PRISMS) Study Group. Lancet 1998;352:1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 121
    • 0035849494 scopus 로고    scopus 로고
    • Randomised controlled trial of interferon-beta-1a in secondary progressive MS: MRI results
    • Li DK, Zhao GJ, Paty DW. Randomised controlled trial of interferon-beta-1a in secondary progressive MS: MRI results. Neurology 2001;56(11):1505-13.
    • (2001) Neurology , vol.56 , Issue.11 , pp. 1505-1513
    • Li, D.K.1    Zhao, G.J.2    Paty, D.W.3
  • 122
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • Maini RN, Breedveld FC, Kalden JR, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41(9):1552-63.
    • (1998) Arthritis Rheum , vol.41 , Issue.9 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 123
    • 0028226982 scopus 로고
    • Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis
    • Williams RO, Mason LJ, Feldmann M, Maini RN. Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. Proc Natl Acad Sci USA 1994;91(7):2762-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.7 , pp. 2762-2766
    • Williams, R.O.1    Mason, L.J.2    Feldmann, M.3    Maini, R.N.4
  • 124
    • 0031851205 scopus 로고    scopus 로고
    • Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: Comparison of low-dose cyclosporin and parenteral gold
    • Zeidler HK, Kvien TK, Hannonen P, et al. Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: comparison of low-dose cyclosporin and parenteral gold. Br J Rheumatol 1998;37(8):874-82.
    • (1998) Br J Rheumatol , vol.37 , Issue.8 , pp. 874-882
    • Zeidler, H.K.1    Kvien, T.K.2    Hannonen, P.3
  • 125
    • 0034123087 scopus 로고    scopus 로고
    • Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomised controlled trials of leflunomide in patients with active rheumatoid arthritis
    • Leflunomide Rheumatoid Arthritis Investigators Group
    • Sharp JT, Strand V, Leung H, Hurley F, Loew-Friedrich I. Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomised controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. Arthritis Rheum 2000;43(3):495-505.
    • (2000) Arthritis Rheum , vol.43 , Issue.3 , pp. 495-505
    • Sharp, J.T.1    Strand, V.2    Leung, H.3    Hurley, F.4    Loew-Friedrich, I.5
  • 126
    • 0033758415 scopus 로고    scopus 로고
    • Future prospects for anti-cytokine treatment
    • Feldmann M, Miotla J, Paleolog E, et al. Future prospects for anti-cytokine treatment. Ann Rheum Dis 2000;59(Suppl 1):i119-22.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. 1
    • Feldmann, M.1    Miotla, J.2    Paleolog, E.3
  • 127
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralising agent
    • Keane J, Gershon S, Wise RP, et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralising agent. N Engl J Med 2001;345(15):1098-104.
    • (2001) N Engl J Med , vol.345 , Issue.15 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3
  • 128
    • 0032493278 scopus 로고    scopus 로고
    • Efficient adenoviral infection with I-kappa B alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappa B dependent
    • Foxwell B, Browne K, Bondeson J, et al. Efficient adenoviral infection with I-kappa B alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappa B dependent. Proc Natl Acad Sci USA 1998;95(14):8211-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.14 , pp. 8211-8215
    • Foxwell, B.1    Browne, K.2    Bondeson, J.3
  • 129
    • 0033545863 scopus 로고    scopus 로고
    • Defining therapeutic targets by using adenovirus: Blocking NF-kappa B inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
    • Bondeson J, Foxwell B, Brennan F, Feldmann M. Defining therapeutic targets by using adenovirus: blocking NF-kappa B inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Proc Natl Acad Sci USA 1999;96(10):5668-73.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.10 , pp. 5668-5673
    • Bondeson, J.1    Foxwell, B.2    Brennan, F.3    Feldmann, M.4
  • 130
    • 0033104615 scopus 로고    scopus 로고
    • Selective regulation of cytokine induction by adenoviral gene transfer of I-kappa B alpha into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, pro-inflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappa B independent
    • Bondeson J, Browne KA, Brennan FM, Foxwell BM, Feldmann M. Selective regulation of cytokine induction by adenoviral gene transfer of I-kappa B alpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, pro-inflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappa B independent. J Immunol 1999;162(5):2939-45.
    • (1999) J Immunol , vol.162 , Issue.5 , pp. 2939-2945
    • Bondeson, J.1    Browne, K.A.2    Brennan, F.M.3    Foxwell, B.M.4    Feldmann, M.5
  • 131
    • 0030898796 scopus 로고    scopus 로고
    • The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction
    • Knauper V, Cowell S, Smith B, et al. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J Biol Chem 1997;272(12):7608-16.
    • (1997) J Biol Chem , vol.272 , Issue.12 , pp. 7608-7616
    • Knauper, V.1    Cowell, S.2    Smith, B.3
  • 132
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodeling
    • Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 1990;6(4):121-5.
    • (1990) Trends Genet , vol.6 , Issue.4 , pp. 121-125
    • Matrisian, L.M.1
  • 133
    • 0032522576 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3
    • Cowell S, Knauper V, Stewart ML, et al. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3. Biochem J 1998;331(Pt 2):453-8.
    • (1998) Biochem J , vol.331 , Issue.PART 2 , pp. 453-458
    • Cowell, S.1    Knauper, V.2    Stewart, M.L.3
  • 134
    • 0032505870 scopus 로고    scopus 로고
    • NF-kappa B activation provides the potential link between inflammation and hyperplasia in the arthritic joint
    • Miagkov AV, Kovalenko DV, Brown CE, et al. NF-kappa B activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA 1998;95(23):13859-64.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.23 , pp. 13859-13864
    • Miagkov, A.V.1    Kovalenko, D.V.2    Brown, C.E.3
  • 135
    • 13044316560 scopus 로고    scopus 로고
    • Role of the proteasome and NF-kappa B in streptococcal cell wall-induced polyarthritis
    • Palombella VJ, Conner EM, Fuseler JW, et al. Role of the proteasome and NF-kappa B in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci USA 1998;95(26):15671-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.26 , pp. 15671-15676
    • Palombella, V.J.1    Conner, E.M.2    Fuseler, J.W.3
  • 136
    • 0033596126 scopus 로고    scopus 로고
    • Diverse agents act at multiple levels to inhibit the Rel/NF-kappa B signal transduction pathway
    • Epinat JC, Gilmore TD. Diverse agents act at multiple levels to inhibit the Rel/NF-kappa B signal transduction pathway. Oncogene 1999;18(49):6896-909.
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6896-6909
    • Epinat, J.C.1    Gilmore, T.D.2
  • 137
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000;97(17):9561-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.17 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3
  • 138
    • 0035889229 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase is dispensable for activation of NF-kappa B in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappa B in primary human fibroblasts
    • Smith C, Andreakos E, Crawley JB, Brennan FM, Feldmann M, Foxwell BM. NF-kappa B-inducing kinase is dispensable for activation of NF-kappa B in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappa B in primary human fibroblasts. J Immunol 2001;167(10):5895-903.
    • (2001) J Immunol , vol.167 , Issue.10 , pp. 5895-5903
    • Smith, C.1    Andreakos, E.2    Crawley, J.B.3    Brennan, F.M.4    Feldmann, M.5    Foxwell, B.M.6
  • 139
    • 0036525596 scopus 로고    scopus 로고
    • Nuclear factor-κB activation in alveolar macrophages requires IκB kinase β, but not nuclear factor-κB inducing kinase
    • Conron M, Andreakos E, Pantelidis P, et al. Nuclear factor-KB activation in alveolar macrophages requires IκB kinase β, but not nuclear factor-κB inducing kinase. Am J Respir Crit Care Med 2002;165(7):996-1004.
    • (2002) Am J Respir Crit Care Med , vol.165 , Issue.7 , pp. 996-1004
    • Conron, M.1    Andreakos, E.2    Pantelidis, P.3
  • 140
    • 0030881742 scopus 로고    scopus 로고
    • Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: Glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK
    • Swantek JL, Cobb MH, Geppert TD. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol Cell Biol 1997;17(11):6274-82.
    • (1997) Mol Cell Biol , vol.17 , Issue.11 , pp. 6274-6282
    • Swantek, J.L.1    Cobb, M.H.2    Geppert, T.D.3
  • 141
    • 0031985903 scopus 로고    scopus 로고
    • Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: Role of the p38 and p42/44 mitogen-activated protein kinases
    • Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BM, Brennan FM. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 1998;160(2):920-8.
    • (1998) J Immunol , vol.160 , Issue.2 , pp. 920-928
    • Foey, A.D.1    Parry, S.L.2    Williams, L.M.3    Feldmann, M.4    Foxwell, B.M.5    Brennan, F.M.6
  • 142
    • 0035794225 scopus 로고    scopus 로고
    • Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts
    • Rutault K, Hazzalin CA, Mahadevan LC. Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts. J Biol Chem 2001;276(9):6666-74.
    • (2001) J Biol Chem , vol.276 , Issue.9 , pp. 6666-6674
    • Rutault, K.1    Hazzalin, C.A.2    Mahadevan, L.C.3
  • 143
    • 0032951716 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
    • Dean JL, Brook M, Clark AR, Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem 1999;274(1):264-9.
    • (1999) J Biol Chem , vol.274 , Issue.1 , pp. 264-269
    • Dean, J.L.1    Brook, M.2    Clark, A.R.3    Saklatvala, J.4
  • 144
    • 0032515186 scopus 로고    scopus 로고
    • A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
    • Ridley SH, Dean JL, Sarsfield SJ, Brook M, Clark AR, Saklatvala J. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett 1998;439(1/2):75-80.
    • (1998) FEBS Lett , vol.439 , Issue.1-2 , pp. 75-80
    • Ridley, S.H.1    Dean, J.L.2    Sarsfield, S.J.3    Brook, M.4    Clark, A.R.5    Saklatvala, J.6
  • 145
    • 0035086636 scopus 로고    scopus 로고
    • The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
    • McLay LM, Halley F, Souness JE, et al. The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy. Bioorg Med Chem 2001;9(2):537-54.
    • (2001) Bioorg Med Chem , vol.9 , Issue.2 , pp. 537-554
    • McLay, L.M.1    Halley, F.2    Souness, J.E.3
  • 146
    • 0034931503 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle DL, Chang L, et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001;108(1):73-81.
    • (2001) J Clin Invest , vol.108 , Issue.1 , pp. 73-81
    • Han, Z.1    Boyle, D.L.2    Chang, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.