메뉴 건너뛰기




Volumn 13, Issue 1, 1996, Pages 55-67

Absence of clinical, virological, and immunological signs of progression in HIV-1-infected patients receiving active anti-interferon-α immunization: A 30-month follow-up report

Author keywords

AIDS clinical trial; Anti IFN immunization; Anticytokine vaccination; HIV 1; Immunotherapy; Interferon

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERFERON ANTIBODY; RECOMBINANT ALPHA INTERFERON;

EID: 1542429111     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199609000-00009     Document Type: Article
Times cited : (42)

References (38)
  • 1
    • 0022629524 scopus 로고
    • Long-term cultures of HTLV-III-infected T cells: A model of cytopathology of T-cell depletion in AIDS
    • Zagury D, Bernard J, Leonard R, et al. Long-term cultures of HTLV-III-infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science 1986;231:850-3.
    • (1986) Science , vol.231 , pp. 850-853
    • Zagury, D.1    Bernard, J.2    Leonard, R.3
  • 2
    • 0027340164 scopus 로고
    • Th1 → Th2 switch is a critical step in the etiology of HIV infection
    • Clerici M, Shearer GA. Th1 → Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-10.
    • (1993) Immunol Today , vol.14 , pp. 107-110
    • Clerici, M.1    Shearer, G.A.2
  • 3
    • 0343100062 scopus 로고
    • Repairing the T cell defects in AIDS
    • Zagury D, Gagne I, Reveil B, et al. Repairing the T cell defects in AIDS. Lancet 1985;2:449.
    • (1985) Lancet , vol.2 , pp. 449
    • Zagury, D.1    Gagne, I.2    Reveil, B.3
  • 4
    • 0027332299 scopus 로고
    • Elevatd IFNγ and decreased 1L-2 gene expression are associated with HIV-1 infection
    • Fan J, Bass HZ, Fahey JL. Elevatd IFNγ and decreased 1L-2 gene expression are associated with HIV-1 infection. J Immunol 1993;152:5031-7.
    • (1993) J Immunol , vol.152 , pp. 5031-5037
    • Fan, J.1    Bass, H.Z.2    Fahey, J.L.3
  • 5
    • 0027743305 scopus 로고
    • Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro
    • Clerici M, Lucey DR, Berzofsky JA, et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-4.
    • (1993) Science , vol.262 , pp. 1721-1724
    • Clerici, M.1    Lucey, D.R.2    Berzofsky, J.A.3
  • 6
    • 0024416997 scopus 로고
    • Interferon and interferon inhibitor levels in patients infected with varicella-zoster virus, acquired immunodeficiency syndrome, acquired immunodeficiency syndrome-related complex, or Kaposi's sarcoma and in normal individuals
    • Ambrus JL, Poiesz BJ, Littie MA, Stadler I, Dibepard LA, Charda KC. Interferon and interferon inhibitor levels in patients infected with varicella-zoster virus, acquired immunodeficiency syndrome, acquired immunodeficiency syndrome-related complex, or Kaposi's sarcoma and in normal individuals. Am J Med 1989;87:405-7.
    • (1989) Am J Med , vol.87 , pp. 405-407
    • Ambrus, J.L.1    Poiesz, B.J.2    Littie, M.A.3    Stadler, I.4    Dibepard, L.A.5    Charda, K.C.6
  • 7
    • 0026534643 scopus 로고
    • Interferons in the persistance, pathogenesis and treatment of HIV infection
    • Francis ML, Meltzer MS, Gendelman HE. Interferons in the persistance, pathogenesis and treatment of HIV infection. AIDS Res Hum Retroviruses 1992;2:199-237.
    • (1992) AIDS Res Hum Retroviruses , vol.2 , pp. 199-237
    • Francis, M.L.1    Meltzer, M.S.2    Gendelman, H.E.3
  • 8
    • 0025909487 scopus 로고
    • Association of circulating receptor FcrRIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-β
    • Allen JB, Wong HL, Guyre PM, Simon GL, Wahl SM. Association of circulating receptor FcrRIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-β. J Clin Invest 1991;87;1773-9.
    • (1991) J Clin Invest , vol.87 , pp. 1773-1779
    • Allen, J.B.1    Wong, H.L.2    Guyre, P.M.3    Simon, G.L.4    Wahl, S.M.5
  • 9
    • 0025059682 scopus 로고
    • Transforming growth factor β and non-cytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection
    • Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M. Transforming growth factor β and non-cytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 1990;87:8321-5.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8321-8325
    • Kekow, J.1    Wachsman, W.2    McCutchan, J.A.3    Cronin, M.4    Carson, D.A.5    Lotz, M.6
  • 10
    • 0025014780 scopus 로고
    • Infection with HIV is associated with elevated IL-6 levels and production
    • Breen EC, Rezai AR, Nakajima K, et al. Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 1990;144:480-4.
    • (1990) J Immunol , vol.144 , pp. 480-484
    • Breen, E.C.1    Rezai, A.R.2    Nakajima, K.3
  • 11
    • 0024351093 scopus 로고
    • Production of tumor necrosis factor α (TNFα) and interleukin-1 (IL-1) in patients with AIDS
    • Hober D, Haque A, Wattre P, Beaucaire G, Mouton Y, Capron A. Production of tumor necrosis factor α (TNFα) and interleukin-1 (IL-1) in patients with AIDS. Clin Exp Immunol 1989;78:329-33.
    • (1989) Clin Exp Immunol , vol.78 , pp. 329-333
    • Hober, D.1    Haque, A.2    Wattre, P.3    Beaucaire, G.4    Mouton, Y.5    Capron, A.6
  • 12
    • 0023696096 scopus 로고
    • Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
    • Lahdevirta J, Maury CPJ, Teppo AM, Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988;85:289-91.
    • (1988) Am J Med , vol.85 , pp. 289-291
    • Lahdevirta, J.1    Maury, C.P.J.2    Teppo, A.M.3    Repo, H.4
  • 13
    • 0023275975 scopus 로고
    • Idiopathic production of interleukin-1 in the acquired immunodeficiency syndrome
    • Lepe-Zuniga JL, Mansell PWA, Remwig L. Idiopathic production of interleukin-1 in the acquired immunodeficiency syndrome. J Clin Microbiol 1987;25:1695-700.
    • (1987) J Clin Microbiol , vol.25 , pp. 1695-1700
    • Lepe-Zuniga, J.L.1    Mansell, P.W.A.2    Remwig, L.3
  • 15
    • 0028912032 scopus 로고
    • + T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study
    • + T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study. N Engl J Med 1995;332:567-75.
    • (1995) N Engl J Med , vol.332 , pp. 567-575
    • Kovacs, J.A.1    Baseler, M.2    Dewar, R.J.3
  • 16
    • 0026684438 scopus 로고
    • One-year follow-up of vaccine therapy in HIV-infected immune deficient individuals: A new strategy
    • Zagury D, Bernard J, Halbreich A, et al. One-year follow-up of vaccine therapy in HIV-infected immune deficient individuals: a new strategy. J Acquire Immune Defic Syndr 1992;5:676-81.
    • (1992) J Acquire Immune Defic Syndr , vol.5 , pp. 676-681
    • Zagury, D.1    Bernard, J.2    Halbreich, A.3
  • 17
    • 0026681015 scopus 로고
    • Immunogenicity of combined anti-HIV and antiimmunosuppressive vaccine preparations
    • Carelli C, Halbreich A, Bernard J, et al. Immunogenicity of combined anti-HIV and antiimmunosuppressive vaccine preparations. Biomed Pharmacother 1992;46:149-53.
    • (1992) Biomed Pharmacother , vol.46 , pp. 149-153
    • Carelli, C.1    Halbreich, A.2    Bernard, J.3
  • 18
    • 0028170090 scopus 로고
    • A randomized, placebo-controlled, blind anti-AIDS clinical trial: Safety and immunogenicity of a specific anti-IFN alpha immunization
    • Gringeri A, Santagostino E, Mannucci PM, et al. A randomized, placebo-controlled, blind anti-AIDS clinical trial: safety and immunogenicity of a specific anti-IFN alpha immunization. J Acquir Immune Defic Syndr 1994;7:978-88.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 978-988
    • Gringeri, A.1    Santagostino, E.2    Mannucci, P.M.3
  • 19
    • 0029303388 scopus 로고
    • Anti-alpha interferon immunization: Safety and immunogenicity in symptomatic HIV positive patients at high risk of disease progression
    • Gringeri A, Santagostino E, Mannucci PM, et al. Anti-alpha interferon immunization: safety and immunogenicity in symptomatic HIV positive patients at high risk of disease progression. Cell Mol Biol 1995;41:381-7.
    • (1995) Cell Mol Biol , vol.41 , pp. 381-387
    • Gringeri, A.1    Santagostino, E.2    Mannucci, P.M.3
  • 20
    • 0016162148 scopus 로고
    • Immunosuppressive effect of an anti-interferon serum
    • Skurkovich S, et al. Immunosuppressive effect of an anti-interferon serum. Nature 1974;247:551-2.
    • (1974) Nature , vol.247 , pp. 551-552
    • Skurkovich, S.1
  • 21
    • 10144240440 scopus 로고
    • Preliminary clinical trial of anti-alpha IFN in patients with AIDS: A possible approach for immune enhancement
    • III International Conference on AIDS, Washington, 1987
    • Bellanti JA, Skurkovich SV, et al. preliminary clinical trial of anti-alpha IFN in patients with AIDS: a possible approach for immune enhancement. III International Conference on AIDS, Washington, 1987; Abstract book, 1987: MP 18.
    • (1987) Abstract Book
    • Bellanti, J.A.1    Skurkovich, S.V.2
  • 22
    • 0002852695 scopus 로고
    • Effects of interferons on cell growth and function
    • Taylor-Papadimitriu J. Effects of interferons on cell growth and function. Interferon 1980;2:13-46.
    • (1980) Interferon , vol.2 , pp. 13-46
    • Taylor-Papadimitriu, J.1
  • 23
    • 0020608920 scopus 로고
    • Ultrastructural markers in AIDS
    • Orenstein JM. Ultrastructural markers in AIDS. Lancet 1983;1:284-5.
    • (1983) Lancet , vol.1 , pp. 284-285
    • Orenstein, J.M.1
  • 24
    • 0021646281 scopus 로고
    • Role of interferon in AIDS
    • Preble, et al. Role of interferon in AIDS. Ann NY Acad Sci 1984;437:65.
    • (1984) Ann NY Acad Sci , vol.437 , pp. 65
    • Preble1
  • 25
    • 0022647288 scopus 로고
    • Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome
    • Vadhan-Raj S, et al. Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome. Cancer Res 1986;46: 417-25.
    • (1986) Cancer Res , vol.46 , pp. 417-425
    • Vadhan-Raj, S.1
  • 26
    • 0027220115 scopus 로고
    • Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells: Relationship to cytokine production pattern
    • Toth FD, Mosborg-Petersen P, Kiss J, et al. Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells: relationship to cytokine production pattern. J Virol 1993;67:5879-88.
    • (1993) J Virol , vol.67 , pp. 5879-5888
    • Toth, F.D.1    Mosborg-Petersen, P.2    Kiss, J.3
  • 27
    • 0027183936 scopus 로고
    • Identification of CD4 and MHC functional peptide sites and their homology with HIV-1 gp120 oligopeptides: Role in AIDS pathogenesis
    • Zagury JF, Bernard J, Achour A, et al. Identification of CD4 and MHC functional peptide sites and their homology with HIV-1 gp120 oligopeptides: role in AIDS pathogenesis. Proc Natl Acad Sci USA 1993;90:7573-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7573-7577
    • Zagury, J.F.1    Bernard, J.2    Achour, A.3
  • 28
    • 0027135736 scopus 로고
    • Coordinate induction of interferon α and γ by recombinant HIV-1 glycoprotein 120
    • Capobianchi MR, Ameglio F, Fei PC, et al. Coordinate induction of interferon α and γ by recombinant HIV-1 glycoprotein 120. AIDS Res Hum Retovir 1993;10:437-43.
    • (1993) AIDS Res Hum Retovir , vol.10 , pp. 437-443
    • Capobianchi, M.R.1    Ameglio, F.2    Fei, P.C.3
  • 29
    • 0025049877 scopus 로고
    • Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFNα 2b and human IFNγ in healthy blood donors
    • Ross C, Hansen MB, Shyberg T, Berg K. Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFNα 2b and human IFNγ in healthy blood donors. Clin Exp Immunol 1990;82:57-62.
    • (1990) Clin Exp Immunol , vol.82 , pp. 57-62
    • Ross, C.1    Hansen, M.B.2    Shyberg, T.3    Berg, K.4
  • 30
    • 0029300707 scopus 로고
    • "Kinoids": The basis for anticytokine immunization and their use in HIV infection
    • Bizzini B, Achour A. "Kinoids": the basis for anticytokine immunization and their use in HIV infection. Cell Mol Biol 1995;41:351-6.
    • (1995) Cell Mol Biol , vol.41 , pp. 351-356
    • Bizzini, B.1    Achour, A.2
  • 31
    • 1542438862 scopus 로고
    • Structure, composition and principles of detoxification of diphteria and tetanus toxin
    • Manclark CD, ed. Bethesda, MD: Department of Health and Human Services, US Public Health Service, DHHC Public (FDA)
    • Bizzini B. Structure, composition and principles of detoxification of diphteria and tetanus toxin. In: Manclark CD, ed. Proceedings of an Informal Consultation on the WHO Requirements for Diphtheria, Pertussis and Combined Vaccines. Bethesda, MD: Department of Health and Human Services, US Public Health Service, DHHC Public (FDA) 1991;1174:252.
    • (1991) Proceedings of An Informal Consultation on the WHO Requirements for Diphtheria, Pertussis and Combined Vaccines , vol.1174 , pp. 252
    • Bizzini, B.1
  • 33
    • 0029297491 scopus 로고
    • Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection
    • Fall LS, Chams V, Le Coq H, et al. Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection. Cell Mol Biol 1995;41:409-16.
    • (1995) Cell Mol Biol , vol.41 , pp. 409-416
    • Fall, L.S.1    Chams, V.2    Le Coq, H.3
  • 34
    • 0028327705 scopus 로고
    • Multi-target PCR analysis by capillary electrophoresis and laser-induced fluorescence
    • Lu W, Han DS, Yuan J, Andrieu JM. Multi-target PCR analysis by capillary electrophoresis and laser-induced fluorescence. Nature 1994;368:269-71.
    • (1994) Nature , vol.368 , pp. 269-271
    • Lu, W.1    Han, D.S.2    Yuan, J.3    Andrieu, J.M.4
  • 35
    • 0029009027 scopus 로고
    • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection
    • Margolick JB, Munoz A. Donnenberg AD, et al., for the Multicenter AIDS Cohort Study. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. Nature Med 1995; 1:674-80.
    • (1995) Nature Med , vol.1 , pp. 674-680
    • Margolick, J.B.1    Munoz, A.2    Donnenberg, A.D.3
  • 36
    • 0029163872 scopus 로고
    • Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis? a model for HIV-1-induced immunopathogenesis
    • Zagury JF, Chams V, Lachgar A, et al. Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis? A model for HIV-1-induced immunopathogenesis. Cell Death Differen 1995;2:23-32.
    • (1995) Cell Death Differen , vol.2 , pp. 23-32
    • Zagury, J.F.1    Chams, V.2    Lachgar, A.3
  • 38
    • 0029081506 scopus 로고
    • Natural history of HIV-1 cell-free viremia
    • Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-8.
    • (1995) JAMA , vol.274 , pp. 554-558
    • Henrard, D.R.1    Phillips, J.F.2    Muenz, L.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.