Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccine

Vaccine

Volumn 26, Issue 23, 2008, Pages 2873-2881

  Xue, Xiaochang ^a,b   Feng, Guodong ^a   Li, Meng ^a,b   Qin, Xin ^a,b   Wu, Shouzhen ^a,b   Zhang, Cun ^a,b   You, Yanjie ^a,b   Wang, Weihua ^a,b   Jiang, Changli ^a,b   Liu, Yan ^a,b   Zhu, Wenhua ^a,b   Ran, Yonggang ^a,b   Zhang, Zhen ^a,b   Yan, Zhen ^a,b   Han, Wei ^a,b   Zhang, Yingqi ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b State Key Laboratory of Cancer Biology   (China)

Author keywords

Autovaccine; B lymphocyte stimulator; Experimental autoimmune encephalomyelitis; Tetanus toxoid T helper epitope

Indexed keywords

B CELL ACTIVATING FACTOR; NEUTRALIZING ANTIBODY; TETANUS TOXOID;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HELPER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; B-CELL ACTIVATING FACTOR; BEHAVIOR, ANIMAL; CEREBELLUM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NEUTRALIZATION TESTS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; VACCINES; VACCINES, SYNTHETIC;

EID: 43249129316     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.03.043     Document Type: Article

References (25)

1. Hsu B.L., Harless S.M., Lindsley R.C., Hilbert D.M., and Cancro M.P. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 168 (2002) 5993-5996
2. Schiemann B., Gommerman J.L., Vora K., Cachero T.G., Shulga-Morskaya S., Dobles M., et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293 (2001) 2111-2114
3. Kolln J., Ren H.M., Da R.R., Zhang Y., Spillner E., Olek M., et al. Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol 177 (2006) 5652-5658
4. Hohlfeld R., and Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci USA 101 Suppl. 2 (2004) 14599-14606
5. Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest 109 1 (2002) 59-68
6. Zhang J., Roschke V., Baker K.P., Wang Z., Alarcón G.S., Fessler B.J., et al. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol 166 (2001) 6-10
7. Cheema G.S., Roschke V., Hilbert D.M., and Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 44 (2001) 1313-1319
8. Krumbholz M., Theil D., Derfuss T., Rosenwald A., Schrader F., Monoranu C.M., et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 201 (2005) 195-200
9. Hauser S.L., and Oksenberg J.R. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52 (2006) 61-76
10. Magliozzi R., Howell O., Vora A., Serafini B., Nicholas R., Puopolo M., et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130 (2007) 1089-1104
11. Owens G.P., Bennett J.L., Gilden D.H., and Burgoon M.P. The B cell response in multiple sclerosis. Neurol Res 28 (2006) 236-244
12. Keegan M., Konig F., McClelland R., Bruck W., Morales Y., Bitsch A., et al. Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet 366 (2005) 579-582
13. Magliozzi R., Columba-Cabezas S., Serafini B., and Aloisi F. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 148 (2004) 11-23
14. Huntington N.D., Tomioka R., Clavarino C., Chow A.M., Linares D., Mana P., et al. A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int Immunol 18 (2006) 1473-1485
15. Ruiz PJ, Garren H, Ruiz IU, Hirschberg DL, Nguyen LV, Karpuj MV, et al. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol 199;162:3336-41.
16. Dalum I., Jensen M.R., Hindersson P., Elsner H.I., and Mouritsen S. Breaking of B cell tolerance toward a highly conserved self-protein. J Immunol 157 (1996) 4796-4804
17. Birnbaum G., Kotilinek L., Schlievert P., Clark H.B., Trotter J., Horvath E., et al. Heat shock proteins and experimental autoimmune encephalomyelitis (EAE). I. Immunization with a peptide of the myelin protein 2′,3′ cyclic nucleotide 3′ phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE. J Neurosci Res 44 (1996) 381-396
18. Xue X.C., Wang Z.L., Yan Z., Shi J.H., Han W., and Zhang Y.Q. Production and purification of recombinant human BLyS mutant from inclusion bodies. Protein Expr Purif 42 (2005) 194-199
19. Kovarik J., Chabannes D., and Borel J.F. Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat. Int J Immunopharmacol 17 (1995) 255-263
20. Kalyvas A., and David S. Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease. Neuron 41 (2004) 323-335
21. Lucchinetti C., Bruck W., and Noseworthy J. Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr Opin Neurol 14 (2001) 259-269
22. Calabresi P.A. Diagnosis and management of multiple sclerosis. Am Fam Physician 70 (2004) 1935-1944
23. Li M., Yan Z., Han W., and Zhang Y.Q. Mimotope vaccination for epitope-specific induction of anti-CD20 antibodies. Cell Immunol 239 (2006) 136-143
24. Dalum I., Butler D.M., Jensen M.R., Hindersson P., Steinaa L., Waterston A.M., et al. Therapeutic antibodies elicited by immunization against TNF-alpha. Nat Biotechnol 17 (1999) 666-669
25. Buddeberg B.S., Kerschensteiner M., Merkler D., Stadelmann C., and Schwab M.E. Behavioral testing strategies in a localized animal model of multiple sclerosis. J Neuroimmunol 153 1-2 (2004) 158-170