IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 47, 2011, Pages 18995-19000

  Buanec, Hélène Le ^a,b,c   Gougeon, Marie Lise ^c   Mathian, Alexis ^d,e   Lebon, Pierre ^b,f   Dupont, Jean Michel ^g   Peltre, Gabriel ^h   Hemon, Patrice ^a,b   Schmid, Michel ⁱ   Bizzini, Bernard ^j   Künding, Thomas ^k   Burny, Arsène ^l   Bensussan, Armand ^a,b   Amoura, Zahir ^d,e   Gallo, Robert C ^m   Zagury, Daniel ^j  

^a SAINT LOUIS HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT PASTEUR   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f HÔPITAL SAINT VINCENT DE PAUL   (France)

^g Medecine et Innovation   (France)

^h CNRS   (France)

ⁱ UNIVERSITÉ PARIS DIDEROT   (France)

^j Neovacs SA   (France)

^k UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^l JULES BORDET INSTITUTE   (Belgium)

^m UNIVERSITY OF MARYLAND   (United States)

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Author keywords

Anti IFN immune therapy; Autoimmunity; Inflammation driven regulatory T cell regulation; Lupus pathogenesis; Regulatory T cell functional diversity

Indexed keywords

ALPHA INTERFERON; COMPLEMENT COMPONENT C3B; INTERLEUKIN 10; MEMBRANE COFACTOR PROTEIN;

ADULT; AGED; ARTICLE; CELL CONTACT; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOSTIMULATION; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD46; CELL DIFFERENTIATION; COMPLEMENT ACTIVATION; COMPLEMENT C3B; DNA PRIMERS; FLOW CYTOMETRY; HUMANS; IMMUNOTHERAPY; INTERFERON-ALPHA; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; LUPUS ERYTHEMATOSUS, SYSTEMIC; REAL-TIME POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY;

EID: 82755187763     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113301108     Document Type: Article

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