TNFα kinoid vaccination-induced neutralizing antibodies to TNFα protect mice from autologous TNFα-driven chronic and acute inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 51, 2006, Pages 19442-19447

  Le Buanec, Hélène ^a   Delavallée, Laure ^b,c   Bessis, Natacha ^b,c   Paturance, Sébastien ^a   Bizzini, Bernard ^a   Gallo, Robert ^e   Zagury, Daniel ^a   Boissier, Marie Christophe ^b,d  

^a SORBONNE UNIVERSITÉ   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS 13   (France)

^d AVICENNE HOSPITAL   (France)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

Anticytokine vaccination; Rheumatoid arthritis; TNF therapeutic vaccination; TNF dependent shock

Indexed keywords

FREUND ADJUVANT; KEYHOLE LIMPET HEMOCYANIN; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA KINOID; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; HEMOCYANIN; KEYHOLE-LIMPET HEMOCYANIN;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CHRONIC DISEASE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CROHN DISEASE; DRUG EFFICACY; DRUG SAFETY; EXPERIMENTAL MODEL; FEMALE; IMMUNOPHARMACOLOGY; INFLAMMATION; JOINT DESTRUCTION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SEPTIC SHOCK; SHOCK; SYNOVITIS; T LYMPHOCYTE; VACCINATION; ANALYSIS OF VARIANCE; ANIMAL; ARTHROPATHY; BIOSYNTHESIS; COMPARATIVE STUDY; GEL CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOLOGY; IMMUNOTHERAPY; METHODOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, BLOCKING; CHROMATOGRAPHY, GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEMOCYANIN; IMMUNOBLOTTING; IMMUNOTHERAPY; INFLAMMATION; JOINT DISEASES; MICE; MICE, TRANSGENIC; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION;

EID: 33845879373     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604827103     Document Type: Article

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