Arterial aging: A journey into subclinical arterial disease

Current Opinion in Nephrology and Hypertension

Volumn 19, Issue 2, 2010, Pages 201-207

  Wang, Mingyi ^a   Monticone, Robert E ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Angiotensin II; Arterial aging; Arterial disease

Indexed keywords

ANGIOTENSIN II; REACTIVE OXYGEN METABOLITE;

AGE; ARTERY DISEASE; ARTERY WALL; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL INVASION; CELL PROLIFERATION; CELL SECRETION; ENDOTHELIAL DYSFUNCTION; FIBROBLAST; GLYCATION; HUMAN; HYPERTENSION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; VASCULAR SMOOTH MUSCLE;

AGING; ANGIOTENSIN II; ANIMALS; ARTERIES; ATHEROSCLEROSIS; HUMANS; SIGNAL TRANSDUCTION; VASCULAR DISEASES;

EID: 76749088438     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283361c0b     Document Type: Review

References (62)

1. Humes K. The population 65 years and older: aging in America. In: The book of the States:2005. Lexington: The Council of State Governments;2005. pp. 464-470.
2. Lakatta EG, Wang M, Najjar SS. Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am 2009; 93:583-604.
3. Lakatta EG. Central arterial aging and the epidemic of systolic hypertension and atherosclerosis. J Am Soc Hypertens 2007; 1:302-340.
4. Wang M, Lakatta EG. The salted artery and angiotensin II signaling: a deadly duo in arterial disease. J Hypertens 2009; 27:19-21.
5. Celermajer DS, Sorensen KE, Spiegelhalter DJ, et al. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994; 24:471-476.
6. Fu Z, Wang M, Gucek M, et al. Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion. Circ Res 2009; 104:1337-1346.
7. Li Z, Froehlich J, Galis ZS, et al. Increased expression of matrix met allopro-teinase-2 in the thickened intima of aged rats. Hypertension 1999; 33:116-123.
8. Wang M, Zhang J, Spinetti G, et al. Angiotensin II activates matrix met allo-proteinase type II and mimics age-associated carotid arterial remodeling in young rats. Am J Pathol 2005; 167:1429-1442.
9. Jiang L, Wang M, Zhang J, et al. Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. PLoS ONE 2008; 3:e2231.
10. Wang M, Takagi G, Asai K, et al. Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates. Hypertension 2003; 41:1308-1316.
11. Wang M, Zhang J, Jiang LQ, et al. Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension 2007; 50:219-227.
12. Wang M, Lakatta EG. Altered regulation of matrix met alloproteinase-2 in aortic remodeling during aging. Hypertension 2002; 39:865-873.
13. Wang M, Zhao D, Spinetti G, et al. Matrix met alloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. ArteriosclerThromb Vasc Biol 2006; 26:1503-1509.
14. Spinetti G, Wang M, Monticone R, et al. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol 2004; 24:1397-1402.
15. Wang M, Zhang J,deCaboR, et al. Calorie restriction reduces MMP-2 activity and retards age-associated aortic restructuring in rats. Circulation (Suppl II) 2006; 114:II-335.
16. Asai K, Kudej RK, Shen YT, et al. Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arterioscler Thromb Vasc Biol 2000; 20:1493-1499.
17. Csiszar A, Wang M, Lakatta EG, et al. Inflammation and endothelial dysfunc-tion during aging: role of NF-{kappa} B. J Appl Physiol 2008; 105:1333-1341.
18. Zhou X, Bohlen HG, Unthank JL, et al. Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived per oxide. Am J Physiol Heart Circ Physiol 2009.
19. Donato AJ, Eskurza I, Silver AE, et al. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium- dependent dilation and upregulation of nuclear factor-kappaB. Circ Res 2007; 100: 1659-1666.
20. Pierce GL, Lesniewski LA, Lawson BR, et al. Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 2009; 119:1284-1292.
21. Van der Loo B, Labugger R, Skepper JN, et al. Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 2000; 192:1731-1744.
22. Rauscher FM, Goldschmidt-Clermont PJ, Davis BH, et al. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 2003; 108:457-463.
23. Imanishi T, Hano T, Nishio I. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens 2005; 23:97-104.
24. Balestrieri ML, Schiano C, Felice F, et al. Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells. J Biochem 2008; 143:179-186.
25. Zhu G, Song M, Wang H, et al. Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: involvement of the phosphatidylinositol 3-kinase/Akt signaling pathway. Ann Vasc Surg 2009; 23:519-534.
26. Li Z, Cheng H, Lederer WJ, et al. Enhanced proliferation and migration and altered cytoskelet al proteins in early passage smooth muscle cells from young and old rat aortic explants. Exp Mol Pathol 1997; 64:1-11.
27. Hariri RJ, Hajjar DP, Coletti D, et al. Aging and arteriosclerosis. Cell cycle kinetics of young and old arterial smooth muscle cells. Am J Pathol 1988; 131:132-136.
28. Gennaro G, Menard C, Giasson E, et al. Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation. Arterioscler Thromb Vasc Biol 2003; 23:204-210.
29. Pauly RR, Passaniti A, Crow M, et al. Experimental models that mimic the differentiation and dedifferentiation of vascular cells. Circulation 1992; 86 (Suppl):III68-III73.
30. Yang D, McCrann DJ, Nguyen H, et al. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell 2007; 6:257-260.
31. McCrann DJ, Yang D, Chen H, et al. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle 2009; 8:902-908.
32. Kunieda T, Minamino T, Nishi J, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006; 114:953-960.
33. Rodier F, Coppe JP, Patil CK, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11:973-979.
34. Coppe J, Patil CK, Rodier K, et al. Senescence-associated secretory phe-notypes reveal cell-nonautonomous functions. Plos Biol 2008; 6:e301.
35. Mahmoudi M, Gorenne I, Mercer J, et al. Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ Res 2008; 103:717-725.
36. Costopoulos C, Liew TV, Bennett M. Ageing and atherosclerosis: mechanisms and therapeutic options. Biochem Pharmacol 2008; 75:1251-1261.
37. Burton DG, Giles PJ, Sheerin AN, et al. Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification. Exp Gerontol 2009; 44:659-665.
38. Susic D, Varagic J, Ahn J, et al. Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats. Am J Hypertens 2004; 17:328-333.
39. Kass DA, Shapiro EP, Kawaguchi M, et al. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 2001; 104:1464-1470.
40. VaitkeviciusPV, Lane M,Spurgeon H, et al. A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci USA 2001; 98:1171-1175.
41. Taddei S, Virdis A, Mattei P, et al. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997; 29:736-743.
42. Scuteri A, Najjar SS, Muller DC, et al. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol 2004; 43:1388-1395.
43. Franklin SS, Larson MG, Khan SA, et al. Does the relationship of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation 2001; 103:1245-1249.
44. Scuteri A, Chen CH, Yin FC, et al. Functional correlates of central arterial geometric phenotypes. Hypertension 2001; 38:1471-1475.
45. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104:191-196.
46. Rudner XL, Berkowitz DE, Booth JV, et al. Subtype specific regulation of human vascular alpha (1)-adrenergic receptors by vessel bed and age. Circulation 1999; 100:2336-2343.
47. Michel JB, Heudes D, Michel O, et al. Effect of chronic ANGI-converting enzyme inhibition on aging processes: II: large arteries. Am J Physiol 1994; 267:R124-R135.
48. Basso N, Cini R, Pietrelli A, et al. Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol 2007; 293:H1351-H1358.
49. Uddin M, Yang H, Shi M, et al. Elevation of oxidative stress in the aorta of genetically hypertensive mice. Mech Ageing Dev 2003; 124:811-817.
50. Wu R, Millette E, Wu L, et al. Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. J Hypertens 2001; 19:741-748.
51. Sarzani R, Arnaldi G, Takasaki I, et al. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Hypertension 1991; 18 (5 Suppl):III93-III99.
52. Benigni A, Corna D, Zoja C, et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest 2009; 119:524-530.
53. Linz W, Heitsch H, Scholkens BA, et al. Long-term angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats. Hypertension 2000; 35:908-913.
54. Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol 1991; 139:1119-1129.
55. Fenton M, Huang HL, Hong Y, et al. Early atherogenesis in senescence-accelerated mice. Experiment Gerontol 2004; 39:115-122.
56. Spagnoli LG, Orlandi A, Mauriello A, et al. Aging and atherosclerosis in the rabbit. 1. Distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis 1991; 89:11-24.
57. Clarkson TB, Adams MR, Weingand KW, et al. Effect of age on atherosclerosis progression in nonhuman primates. In: Bates SR, Ganghoff EC, editors. Atherogenesis and aging. New York: Springer-Verlag; 1987 pp. 57-71.
58. Bagnato C, Thumar J, Mayya V, et al. Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics 2007; 6:1088-1102.
59. Eto H, Miyata M, Shirasawa T, et al. The long-term effect of angiotensin II type 1a receptor deficiency on hypercholesterolemia-induced atherosclerosis. Hypertens Res 2008; 31:1631-1642.
60. Gareus R, Kotsaki E, Xanthoulea S, et al. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 2008; 8:372-383.
61. Collins AR, Lyon CJ, Xia X, et al. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 2009; 104:e42-e54.
62. Smith BJ, Lightfoot SA, Lerner MR, et al. Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation. Cardiovasc Pathol 2009; 18:1-10.