Dynamic compression of chondrocyte-seeded fibrin gels: Effects on matrix accumulation and mechanical stiffness

Osteoarthritis and Cartilage

Volumn 12, Issue 2, 2004, Pages 117-130

  Hunter, Christopher J ^a   Mouw, Janna K ^b   Levenston, Marc E ^b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Chondrocyte; Fibrin; Mechanical compression; Tissue engineering

Indexed keywords

COLLAGEN GEL; DISACCHARIDE; DNA; FIBRIN; GLYCOSAMINOGLYCAN POLYSULFATE; HYDROXYPROLINE; NITRITE; PROTEINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BIOMECHANICS; CARTILAGE CELL; CARTILAGE DEGENERATION; COLLAGEN SYNTHESIS; COMPRESSION; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; MECHANICAL STIMULATION; NONHUMAN; OSCILLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RIGIDITY; TISSUE ENGINEERING;

EID: 0842280651     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2003.08.009     Document Type: Article

References (51)

1. Mow VC, Ratcliffe A, Poole AR. Cartilage and diarthroidal joints as paradigms for heirarchical materials and structures. Biomaterials 1992;13:67-94.
2. Mow VC, Ratcliffe A. Structure and function of articular cartilage and meniscus. In: Mow VC, Hayes WC, Eds. Basic Orthopaedic Biomechanics. Philadelphia, PA: Lippincott-Raven Publishers 1997;113-77.
3. Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. AAOS Instructional Course Lectures 1998;47:487-504.
4. Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM. Principles of cartilage repair and regeneration. Clin Orthop 1997;0:254-69.
5. Homandberg GA, Wen C, Hui F. Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid. Osteoarthritis Cart 1998; 6:231-44.
6. Xie D, Hui F, Homandberg GA. Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitro. Arch Biochem Biophys 1993;307: 110-8.
7. Breinan HA, Minas T, Hsu HP, Nehrer S, Sledge CB, et al. Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg [Am] 1997;79:1439-51.
8. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.
9. Kreklau B, Sittinger M, Mensing MB, Voigt C, Berger G, Burmester GR, et al. Tissue engineering of biphasic joint cartilage transplants. Biomaterials 1999;20: 1743-9.
10. Kim YJ, Grodzinsky AJ, Plaas AH. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan. Arch Biochem Biophys 1996;328:331-40.
11. Quinn TM, Grodzinsky AJ, Buschmann MD, Kim YJ, Hunziker EB. Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants. J Cell Sci 1998; 111:573-83.
12. Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci 1995;108:1497-508.
13. Lee DA, Bader DL. Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res 1997; 15:181-8.
14. Ragan PM, Chin VI, Hung HH, Masuda K, Thonar EJ, Arner EC, et al. Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system. Arch Biochem Biophys 2000;383:256-64.
15. Hunter CJ, Imler SM, Malaviya P, Nerem RM, Levenston ME. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomaterials 2002;23:1249-59.
16. Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, et al. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res 1999;17:836-42.
17. Valhmu WB, Stazzone EJ, Bachrach NM, Saed-Nejad F, Fischer SG, Mow VC, et al. Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression. Arch Biochem Biophys 1998;353:29-36.
18. Sah RL, Kim YJ, Doong JY, Grodzinsky AJ, Plaas AH, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res 1989;7:619-36.
19. Staples AK, Ragan PM, Grodzinsky AJ, Tubo R, Binette F. Mechanical modulation of gene expression during differentiation of human articular chondrocytes (Abstract). Trans Orthop Res Soc 1999;0:697.
20. Mauck RL, Soltz MA, Wang CC, Wong DD, Chao PH, Valhmu WB, et al. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng 2000;122:252-60.
21. Fortier LA, Nixon AJ, Mohammed HO, Lust G. Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor beta-1. Am J Vet Res 1997;58:66-70.
22. Homminga GN, Buma P, Koot HW, van der Kraan PM, van den Berg WB. Chondrocyte behavior in fibrin glue in vitro. Acta Orthop Scand 1993;64:441-5.
23. Meinhart J, Fussenegger M, Hobling W. Stabilization of fibrin-chondrocyte constructs for cartilage reconstruction. Ann Plast Surg 1999;42:673-8.
24. Hendrickson DA, Nixon AJ, Grande DA, Todhunter RJ, Minor RM, Erb H, et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res 1994;12:485-97.
25. Perka C, Arnold U, Spitzer RS, Lindenhayn K. The use of fibrin beads for tissue engineering and subsequential transplantation. Tiss Eng 2001;7:359-61.
26. Silverman RP, Passaretti D, Huang W, Randolph MA, Yaremchuk MJ. Injectable tissue-engineered cartilage using a fibrin glue polymer. Plast Reconstr Surg 1999;103:1809-18.
27. Nerem RM, Seliktar D. Vascular Tissue Engineering. Annual Review of Biomedical Engineering 2001; 3:225-43.
28. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-7.
29. Creemers LB, Jansen DC, van Veen-Reurings A, van den Bos T, Everts V. Microassay for the assessment of low levels of hydroxyproline. Biotechniques 1997; 22:656-8.
30. Woessner JJ. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961; 93:440-7.
31. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988;174:168-76.
32. Calabro A, Hascall VC, Midura RJ. Adaptation of FACE methodology for microanalysis of total hyaluronan and chondroitin sulfate composition from cartilage. Glycobiology 2000;10:283-93.
33. Jackson P. Fluorophore-assisted carbohydrate electrophoresis: a new technology for the analysis of glycans. Biochem Soc Trans 1993;21:121-5.
34. Mouw JK, Case ND, Guldberg RE, Plaas AH, Levenston ME. Evaluation of glycosaminoglycan composition in tissue engineered cartilage constructs using fluorophore-assisted carbohydrate electrophoresis (Abstract). Trans Orthop Res Soc 2001;0:613.
35. Choi NS, Kim SH. Two fibrin zymography methods for analysis of plasminogen activators on gels. Anal Biochem 2000;281:236-8.
36. Kim SH, Choi NS, Lee WY. Fibrin zymography: a direct analysis of fibrinolytic enzymes on gels. Anal Biochem 1998;263:115-6.
37. Steinmeyer J, Knue S. The proteoglycan metabolism of mature bovine articular cartilage explants superimposed to continuously applied cyclic mechanical loading. Biochem Biophys Res Commun 1997;240:216-21.
38. Hunter CJ, Levenston ME, Nerem RM. Engineered/native cartilage adhesion varies with scaffold selection (Abstract). Ann Biomed Eng 2001;29:S150.
39. Turner CH. Three rules for bone adaptation to mechanical stimuli. Bone 1998;23:399-407.
40. Studer R, Jaffurs D, Stefanovic-Racic M, Robbins PD, Evans CH. Nitric oxide in osteoarthritis. Osteoarthritis Cart 1999;7:377-9.
41. Loening AM, James IE, Levenston ME, Badger AM, Frank EH, Kurz B, et al. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys 2000; 381:205-12.
42. Chowdhury TT, Bader DL, Lee DA. Dynamic compression inhibits the synthesis of nitric oxide and pge(2) by il-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun 2001;285:1168-74.
43. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993; 178:749-54.
44. Lee DA, Frean SP, Lees P, Bader DL. Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. Biochem Biophys Res Commun 1998;251:580-5.
45. Gailit J, Clarke C, Newman D, Tonnesen MG, Mosesson MW, Clark RA. Human fibroblasts bind directly to fibrinogen at RGD sites through integrin alpha(v)beta3. Exp Cell Res 1997;232:118-26.
46. Loeser RF. Chondrocyte integrin expression and function. Biorheology 2000;37:109-16.
47. Cao L, Lee V, Adams ME, Kiani C, Zhang Y, Hu W, et al. beta-Integrin-collagen interaction reduces chondrocyte apoptosis. Matrix Biol 1999;18:343-55.
48. Salter DM, Millward-Sadler SJ, Nuki G, Wright MO. Integrin-interleukin-4 mechanotransduction pathways in human chondrocytes. Clin Orthop 2001;0:S49-60.
49. Millward-Sadler SJ, Wright MO, Lee H, Nishida K, Caldwell H, Nuki G, et al. Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes. J Cell Biol 1999;145:183-9.
50. Millward-Sadler SJ, Wright MO, Davies LW, Nuki G, Salter DM. Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arth Rheum 2000;43:2091-9.
51. Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Salter DM. Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and beta-catenin in human articular chondrocytes after mechanical stimulation. J Bone Miner Res 2000;15:1501-9.