Collagen - Biomaterial for drug delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 45, Issue 2, 1998, Pages 113-136

  Friess, Wolfgang ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Biomaterials; Collagen; Crosslinking; Devices; Growth factors; Injectables; Ophthalmology; Sponges

Indexed keywords

BIOMATERIAL; COLLAGEN; GROWTH FACTOR;

CHEMICAL STRUCTURE; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; EXTRACTION; OPHTHALMOLOGY; PURIFICATION; REVIEW;

EID: 0031960548     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(98)00017-4     Document Type: Article

References (320)

1. M. Chvapil, R.L. Kronentahl, W. van Winkle, Jr., Medical and surgical applications of collagen, in: D.A. Hall, D.S. Jackson (Eds.), International Review of Connective Tissue Research, Academic Press, New York, 1973, pp. 1-61.
2. Chvapil M. Collagen sponge: theory and practice of medical applications. J. Biomed. Mater. Res. 11:1977;721-724.
3. Bloomfield S.E., Miyata T., Dunn M.W. Buese, Bueser N., Stenzel K.H., Rubin A.L. Soluble gentamicin ophthalmic inserts as a drug delivery system. Ophthalmol. 96:1978;885-887.
4. Nimni M.E., Cheung D., Strates B., Kodama M., Sheikh K. Chemically modified collagen: a natural biomaterial for tissue replacement. J. Biomed. Mat. Res. 21:1987;741-771.
5. Yannas I.V., Burke J.F. Design of an artificial skin. Part I. Basic design principles, J. Biomed. Mater. Res. 14:1980;65-81.
6. Yannas I.V., Burke J.F., Gordon P.L., Huang C., Rubenstein R.H. Design of an artificial skin. Part II. Control of chemical composition. J. Biomed. Mater. Res. 14:1980;107-131.
7. Pachence J.M., Berg R.A., Silver F.H. Collagen: its place in the medical device industry. Med. Device Diagn. Ind. 9:1987;49-55.
8. van Wachem P.B., van Luyn M.J.A., Ponte da Costa M.L. Myoblast seeding in a collagen matrix evaluated in vitro. J. Biomed. Mat. Res. 30:1996;353-360.
9. Sabolinski M.L., Alvarez O., Auletta M., Mulder G., Parenteau N.L. Cultured skin as a 'smart material' for healing wounds: experience in venous ulcers. Biomaterials. 17:1996;311-320.
10. Hubbell J.A. Biomaterials in tissue engineering. Biotechnology. 13:1995;565-576.
11. Pachence J.M. Collagen-based devices for soft tissue repair. J. Biomed. Mater. Res. 33:1996;35-40.
12. F. Berthiaume, M.L. Yarmush, Tissue engineering, in: J.D. Bronzino (Ed.), The Biomedical Engineering Handbook, CRC Press, Boca Raton, FL, 1995, pp. 1556-1566.
13. Othman M.O., Quassem W., Shahalam A.P. The mechanical properties of catgut in holding and bonding fractured bone. Med. Eng. Phys. 18:1996;584-590.
14. Guyuron B., Vaughan C.A. A comparison of absorbable and non-absorbable suture materials for skin repair. Plast. Reconst. Surg. 89:1992;234-236.
15. P.F. Nockemann, Die chirurgische Naht, Georg Thieme Verlag, Stuttgart, 1992, pp. 59-63.
16. K.A. Piez, Collagen, in: J.I. Kroschwitz (Ed.), Encyclopedia of Polymer Science and Engineering, Wiley, New York, 1985, pp. 699-727.
17. M.J. Barnes, The collagen-platelet interaction, in: J.B. Weiss, M.I.V. Jayson (Eds.), Collagen in Health and Disease, Churchill Livingstone, Edinburgh, 1982, pp. 179-197.
18. M.E. Nimni, R.D. Harkness, Molecular structures and functions of collagen, in: M.E. Nimni (Ed.), Collagen Vol. I - Biochemistry, CRC Press, Boca Raton, FL, 1988, pp. 1-79.
19. E.J. Kucharz, The Collagens: Biochemistry and Pathophysiology, Springer-Verlag, Berlin, 1992, pp. 7-29.
20. E.J. Miller, Collagen types: structure, distribution and functions, in: M.E. Nimni (Ed.), Collagen Vol. I - Biochemistry, CRC Press, Boca Raton, FL, 1988, pp. 139-157.
21. R. Timpl, Immunology of the collagens, in: K.A. Piez, A.H. Reddi (Eds.), Extracellular Matrix Biochemistry, Elsevier, New York, 1984, pp. 159-190.
22. E.J. Miller, Chemistry of collagens and their distribution, in: K.A. Piez, A.H. Reddi (Eds.), Extracellular Matrix Biochemistry, Elsevier, New York, 1984, pp. 41-82.
23. H.B. Lee, S.S. Kim, G. Khang, Polymeric biomaterials, in: J.D. Bronzino (Ed.), The Biomedical Engineering Handbook, CRC Press, Boca Raton, FL, 1995, pp. 581-597.
24. E.J. Kucharz, The Collagens: Biochemistry and Pathophysiology, Springer-Verlag, Berlin, 1992, pp. 34-39.
25. K.A. Piez, Molecular and aggregate structures of the collagens, in: K.A. Piez, A.H. Reddi (Eds.), Extracellular Matrix Biochemistry, Elsevier, New York, 1984, pp. 1-40.
26. Woessner J.F. Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93:1961;440-447.
27. B. Brodsky, S. Tanaka, E.F. Eikenberry, X-ray diffraction as a tool for studying collagen structure, in: M.E. Nimni (Ed.), Collagen Vol. I - Biochemistry, CRC Press, Boca Raton, FL, 1988, pp. 95-112.
28. C. Gunkel, Kollagenmikropartikel - Charakterisierungs und Herstellungsmethoden, Ph.D. Thesis, University of Marburg, Germany, 1994.
29. M. Yamauchi, G. Mechanic, Crosslinking of collagen, in: M.E. Nimni (Ed.), Collagen Vol. I - Biochemistry, CRC Press, Boca Raton, FL, 1988, pp. 157-172.
30. Reiser K., McCormick R.J., Rucker R.B. Enzymatic and non-enzymatic cross-linking of collagen and elastin. FASEB J. 6:1992;2439-2449.
31. Graham L., Gallop P.M. Covalent protein crosslinks: general detection, quantitation, and characterization via modification with diphenylborinic acid. Anal. Biochem. 217:1994;298-305.
32. Hanson D.A., Eyre D.R. Molecular site specificity of pyridinoline and pyrrole crosslinks in type I collagen of human bone. J. Biol. Chem. 271:1996;26508-26516.
33. Pratt D.A., Daniloff Y., Duncan A., Robins S.P. Automated analysis of the pyridinium crosslinks of collagen in tissue and urine using solid-phase extraction and reversed-phase high-performance liquid chromatography. Anal. Biochem. 207:1992;168-175.
34. Palokangas H., Kovanen V., Duncan A., Robins S.P. Age-related changes in the concentration of hydroxypyridinium crosslinks in functionally different skeletal muscles. Matrix. 12:1992;291-296.
35. T.E. Cawston, G. Murphy, Mammalian collagenases, in: L. Lorand (Ed.), Methods in Enzymology, Vol. 80, Proteolytic Enzymes, Academic Press, London, 1981, pp. 711-722.
36. G.P. Stricklin, M.S. Hibbs, Biochemistry and physiology of mammalian collagenases, in: M.E. Nimni (Ed.), Collagen Vol. I - Biochemistry, CRC Press, Boca Raton, FL, 1988, pp. 187-206.
37. Welgus H.G., Jeffrey J.J., Stricklin G.P., Roswit W.T., Eisen A.Z. Characteristics of the action of human skin fibroblast collagenase on fibrillar collagen. J. Biol. Chem. 255:1980;6806-6813.
38. D.E. Woolley, Mammalian collagenases, in K.A. Piez, A.H. Reddi (Eds.), Extracellular Matrix Biochemistry, Elsevier, New York, 1984, pp. 119-158.
39. E.J. Kucharz, The Collagens: Biochemistry and Pathophysiology, Springer-Verlag, Berlin, 1992, pp. 55-67.
40. McPherson J.M., Sawamura S., Armstrong R. An examination of the biologic response to injectable, glutaraldehyde cross-linked collagen implants. J. Biomed. Mater. Res. 20:1986;93-107.
41. D.G. Wallace, J.M. McPherson, L. Ellingsworth, L. Cooperman, R. Armstrong, K.A. Piez, in: M.E. Nimni (Ed.), Collagen Vol. III - Biotechnology, CRC Press, Boca Raton, FL, 1988, pp. 117-144.
42. Gorham S.D., Hyland T.P., French D.A., Willins M.J. Cellular invasion and breakdown of three different collagen films in the lumbar muscle of the rat. Biomaterials. 11:1990;113-118.
43. Friess W., Zhou W., Groves M.J. In vivo activity of collagen matrices containing PS1, an anti-neoplastic glycan, against murine sarcoma cells. Pharm. Sci. 2:1996;1-4.
44. Boon M.E., Ruijgrok J.M., Vardaxis M.J. Collagen implants remain supple not allowing fibroblast ingrowth. Biomaterials. 16:1995;1089-1093.
45. Etherington D.J., Pugh D., Silver I.A. Collagen degradation in an experimental inflammatory lesion: studies on the role of the macrophage. Acta Biol. Med. Germ. 40:1981;1625-1636.
46. D.J. Etherington, R.A. Maciewicz, M.A.J. Taylor, R.J. Wardale, I.A. Silver, R.A. Murrills, D. Pugh, The role of collagen degrading cysteine proteinases in connective tissue metabolism, in: V. Turk (Ed.), Cystein Proteinases and Their Inhibitors, Walter de Gruyter, Berlin, pp. 269-282.
47. Hunt J.A., van der Laan J.S., Schakenraad J., Williams D.F. Quantitative in vivo assessment of the tissue response to dermal sheep collagen in abdominal wall defects. Biomaterials. 15:1993;378-382.
48. Dung S.-Z., Li Y., Dunipace A.J., Stookey G.K. Degradation of insoluble bovine collagen and human dentine collagen pretreated in vitro with lactic acid, pH 4.0 and 5.5. Archs. Oral Biol. 39:1994;901-905.
49. Romanos G.E., Hotz S.T.K., Schröter-Kermani C., Strub J.R. Extracellular matrix interactions during the in vivo degradation of collagen membranes in the rat skin: immunhistochemical distribution of collagen types IV, V, and VI. J. Biomed. Mater. Res. 29:1995;1121-1127.
50. van Wachem P.B., van Luyn M.J.A., Nieuwenhuis P., Koerten H.K., Olde Damink L., Ten Hoopen H., Feijen J. In vivo degradation of processed dermal sheep collagen evaluation with transmission electron microscopy. Biomaterials. 12:1991;215-223.
51. Oliver R.F., Barker H., Cooke A., Grant R.A. Dermal collagen implants. Biomaterials. 3:1982;38-40.
52. Diamond A.M., Gorham S.D., Etherington D.J., Robertson J.G., Light N.D. The effect of modification on the susceptibility of collagen to proteolysis: I. Chemical modification of amino acid side chains. Matrix. 11:1991;321-329.
53. Megerman J., Reddi E., L'Italien G.J., Warnock D.F., Abbott W.M. A laboratory model to quantitate the resistance of collagen vascular grafts to biodegradation. J. Biomed. Mater. Res. 25:1991;295-313.
54. Yannas I.V., Burke J.F., Huang C., Gordon P.L. Correlation of in vivo collagen degradation rate with in vitro measurements. J. Biomed. Mater. Res. 9:1975;623-628.
55. Okada T., Hayashi T., Ikada Y. Degradation of collagen suture in vitro and in vivo. Biomaterials. 13:1992;448-454.
56. Oliver R.F., Grant R.A., Cox R.W., Cooke A. Effect of aldehyde crosslinking on human dermal collagen implants in the rat. Br. J. Exp. Path. 61:1980;544-549.
57. Olmo N., Turnay J., Herrera J., Gavilanes J.G., Lizarbe A. Kinetics of in vivo degradation of sepiolite-collagen complexes: effect of glutaraldehyde treatment. J. Biomed. Mater. Res. 30:1996;77-84.
58. Olde Damink L.H.H., Dijkstra P.J., van Luyn M.J.A., van Wachem P.B., Nieuwenhuis P., Feijen J. In vitro degradation of dermal sheep collagen crosslinked using a water-soluble carbodiimide. Biomaterials. 17:1996;679-684.
59. Olde Damink L.H.H., Dijkstra P.J., van Luyn M.J.A., van Wachem P.B., Nieuwenhuis P., Feijen J. Changes in the mechanical properties of dermal sheep collagen during in vitro degradation. J. Biomed. Mater. Res. 29:1995;139-147.
60. L.H.H. Olde Daminck, Structure and properties of crosslinked dermal sheep collagen, Ph.D. Thesis, University of Twente, The Netherlands, 1992.
61. Anselme K., Petite H., Herbage D. Inhibition of calcification in vivo by acyl azide crosslinking of a collagen-glycosaminoglycan sponge. Matrix. 12:1992;264-273.
62. Kincl F.A., Ciaccio L.A. Suppression of immune responses by progesterone. Endocrinol. Exp. 14:1980;27-33.
63. T.F. Linsenmeyer, Immunology of purified collagens and their use in localization of collagen types in tissue, in: J.B. Weiss, M.I.V. Jayson (Eds.), Collagen in Health and Disease, Churchill Livingstone, Edinburgh, 1982, pp. 244-268.
64. Steffen C., Timpl R., Wolff I. Immunogenity and specificity of collagen. V. Demonstration of three different antigenic determinants on calf collagen. Immunology. 15:1968;135-144.
65. Ellingsworth L.R., DeLustro F., Brennan J.E., Sawamura S., McPherson J. The human response to reconstituted bovine collagen. J. Immunol. 136:1986;877-882.
66. Knapp T.R., Luck E., Daniels J.R. Behaviour of solubilised collagen as a bioimplant. J. Surg. Res. 23:1977;96-105.
67. DeLustro F., Condell R.A., Nguyen M.A., McPherson J.M. A comparative study of the biologic and immunlogic response to medical devices derived from dermal collagen. J. Biomed. Mater. Res. 20:1986;109-120.
68. Meade K.R., Silver F.H. Immunogenicity of collagenous implants. Biomaterials. 11:1990;176-180.
69. D.L. Gilbert, Collagen macromolecular drug delivery systems, Ph. D. Thesis, University of Utah, UT, 1988.
70. Cooperman L., Michaeli D. The immunogenicity of injectable collagen. I. A 1-year prospective study. J. Amer. Acad. Dermatol. 10:1984;638-644.
71. Cooperman L., Michaeli D. The immunogenicity of injectable collagen. II. A retrospective review of seventy-two tested and treated patients. J. Am. Acad. Dermatol. 10:1984;647-651.
72. Labow T.A., Silver D.N. Late reactions at Zyderm skin test sites. Cutis. 35:1985;154-158.
73. Takeda U., Odaki M., Yokata M. Acute and subacute toxicity studies on collagen wound dressing (CAS) in mice and rats, J. Toxicol. Sci. 7. Suppl. 2:1982;63-91.
74. S.D. Gorham, Collagen, in: D. Byrom (Ed.), Biomaterials, Stockton Press, New York, 1991, pp. 55-122.
75. Spira M., Liu B., Xu Z., Harrell R., Chahadeh H. Human amnion collagen for soft tissue augmentation - biochemical characterizations and animal observations. J. Biomed. Mater. Res. 28:1994;91-96.
76. H. Palefsky, B.B. Pharriss, G. Chu, Composition of low type III content human placental collagen, US Patent 5428022 (1992).
77. Kimura S., Takema Y., Kubota M. Octopus skin collagen. Isolation and characterization of collagen comprising two distinct α-chains. J. Biol. Chem. 256:1981;13230-13234.
78. R.A. Berg, Human collagen or pro-collagen production from milk produced by non-human mammal transformed with appropriate expression system provides homogeneous product for therapeutic use, PCT WO 94/16570 (1994).
79. D.P. DeVore, C.D. Kelman, S. Fagien, P. Casson, Autologen: autologous, injectable, dermal collagen, in: S. Bosniak (Ed.), Principles and Practice of Ophthalmic Plastic and Reconstructive Surgery, Chapter 65, W.B. Saunders, Philadelphia, PA, 1996, pp. 670-675.
80. Benicewicz B.C., Hopper P.K. Polymers for absorbable surgical sutures - part I. J. Bioact. Compat. Polym. 5:1990;453-472.
81. A.M. Fielding, Preparation of neutral salt soluble collagen, in: D.A. Hall (Ed.), The Methodology of Connective Tissue Research, Joynson-Bruvvers, Oxford, 1976, pp. 9-12.
82. R.L. Trelstad, Immunology of collagens, in: H. Furthmayer (Ed.), Immunochemistry of the Extracellular Matrix, Vol. I Methods, CRC Press, Boca Raton, FL, 1982, pp. 32-39.
83. S. Bazin, A. Delaumay, Preparation of acid and citrate soluble collagen, in: D.A. Hall (Ed.), The Methodology of Connective Tissue Research, Joynson-Bruvvers, Oxford, 1976, pp. 13-18.
84. G. Cioca, Process for preparing macromolecular biologically active collagen, US Patent 4279812 (1981).
85. M. Roreger, Collagen preparation for the controlled release of active substances, PCT WO 95/28964 (1995).
86. S.-T. Li, Tissue-derived biomaterials (collagen), in: J.D. Bronzino (Ed.), The Biomedical Engineering Handbook, CRC Press, Boca Raton, FL, 1995, pp. 627-647.
87. Lee S.L. Optimal conditions for long-term storage of native collagens. Coll. Relat. Res. 3:1983;305-315.
88. Z. Deyl, M. Adam, Preparation of insoluble collagen, in: D.A. Hall (Ed.), The Methodology of Connective Tissue Research, Joynson-Bruvvers, Oxford, 1976, pp. 1-8.
89. Singh M.P., Stefko J., Lumpkin J.A., Rosenblatt J. The effect of electrostatic charge interactions on release rates of gentamicin from collagen matrices. Pharm. Res. 12:1995;1205-1210.
90. Srivastava S., Gorham S.D., Courtney J.M. The attachment and growth of an established cell line on collagen, chemically modified collagen, and collagen composite surfaces. Biomaterials. 11:1990;162-168.
91. Srivastava S., Gorham S.D., French D.A., Shivas A.A., Courtney J.M. In vivo evaluation and comparison of collagen, acetylated collagen and collagen/glycosaminoglycan composite films and sponges as candidate biomaterials. Biomaterials. 11:1990;155-161.
92. Wang C.L., Miyata T., Weksler B., Rubin A.L., Stenzel K.H. Collagen-induced platelet aggregation and release. I. Effects of side-chain modifications and role of arginyl residues. Biochem. Biophys. Acta. 544:1978;555-567.
93. Panduranga Rao K. Recent developments of collagen-based materials for medical applications and drug delivery systems. J. Biomater. Sci. Polymer Ed. 7:1995;623-645.
94. van Wachem P.B., van Luyn M.J.A., Olde Damink L.H.H., Dijkstra P.J., Feijen J., Nieuwenhuis P. Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall. Int. J. Artif. Organs. 17:1994;230-239.
95. T.J. Gao, T.S. Lindholm, Searching for a novel carrier for bioactive delivery of bone morphogenetic protein, in: T.S. Lindholm (Ed.), Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, R.G. Landes, Austin, TX, 1996, pp. 121-130.
96. E. Heidemann, The chemistry of tanning, in M.E. Nimni (Ed.), Collagen Vol. III - Biotechnology, CRC Press, Boca Raton, FL, 1988, pp. 39-61.
97. Gervais-Lugan M., Haran R., Lamure A., Lacabanne C. The effect of aluminum ions and sorbitol on collagen and skin: a thermally stimulated current spectroscopy study. J. Biomed. Mater. Res. 25:1991;1339-1346.
98. Khor E. Methods for the treatment of collagenous tissues for bioprostheses. Biomaterials. 18:1997;95-105.
99. W. Friess, R.J. Biron, S. Foskett, The effect of formaldehyde and ethylene oxide treatment on porous collagen systems, Pharm. Res. (1997) S-154.
100. Ruderman R.J., Wade C.W.R., Shepard W.D., Leonard F. Prolonged resorption of collagen sponges: vapor-phase treatment with formaldehyde. J. Biomed. Mater. Res. 7:1973;263-265.
101. British Pharmacopeia, Monography: Absorbable Gelatin Sponge, HMSO, Crown Copyright, London, 1993, pp. 1280-1281.
102. Jayakrishnan A., Jameel S.R. Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices. Biomaterials. 17:1996;471-484.
103. M.E. Nimni, D. Cheung, B. Strates, M. Kodama, K. Sheikh, Bioprosthesis derived from crosslinked and chemically modified collageneous tissue. in: M.E. Nimni (Ed.), Collagen Vol. III - Biotechnology, CRC Press, Boca Raton, FL, 1988, pp. 1-38.
104. Gratzer P.F., Pereira C.A., Lee J.M. Solvent environment modulates effects of glutaraldehyde crosslinking on tissue-derived biomaterials. J. Biomed. Mater. Res. 31:1996;533-543.
105. Rasmussen K.E., Albrechtsen J. Glutaraldehyde: influence of pH, temperature and buffering on the polymerization rate. Histochemistry. 38:1974;19-26.
106. Ruijgrok J.M., de Wijn J.R. Optimising glutaraldehyde crosslinking of collagen: effects of time, temperature and concentrations as measured by shrinkage temperature. J. Mater. Sci. Mater. Med. 5:1994;80-87.
107. Woodroof E.A. Use of glutaraldehyde and formaldehyde to process tissue heart valves. J. Bioeng. 2:1978;1-9.
108. Friess W., Lee G. Basic thermoanalytical studies on insoluble collagen implants. Biomaterials. 17:1996;2289-2294.
109. McPherson J.M., Ledger P.W., Sawamura S., Conti A., Wade S., Reihanian H., Wallace D.G. The preparation and physicochemical characterization of an injectable form of reconstituted, glutaraldehyde crosslinked, bovine corium collagen. J. Biomed. Mater. Res. 20:1986;79-92.
110. Simionescu A., Simionescu D., Deac R. Lysine-enhanced glutaraldehyde crosslinking of collagenous biomaterials. J. Biomed. Mater. Res. 25:1991;1495-1505.
111. Ruijgrok J.M., de Wijn J.R., Boon M.E. A model to determine microwave-stimulated crosslinking of collagen using diluted glutaraldehyde solutions. Scanning. 15:1993;110-114.
112. Visser C.E., Voute A.B.E., Oosting J., Boon M.E., Kok L.P. Microwave irradiation and crosslinking of collagen. Biomaterials. 13:1992;34-37.
113. Vardaxis N.J., Ruijgrok J.M., Rietveld D.C., Marres E.M., Boon M.E. Chemical and physical properties of collagen implants influence their fate in vivo as evaluated by light and confocal microscopy. J. Biomed. Mater. Res. 28:1994;1013-1025.
114. Golomb G., Schoen F.J., Smith M.S., Linden J., Dixon M., Levy R.J. The role of glutaraldehyde-induced crosslinks in calcification of bovine pericardium used in cardiac valve bioprostheses. Am. J. Pathol. 127:1987;122-130.
115. P.K. Bajpai, Immunological aspects of treated natural tissue prostheses, in: D.F. Williams (Ed.), Biocompatiblity of Tissue Analogues, CRC Press, Boca Raton, FL, 1985, pp. 5-25.
116. Huang-Lee L.L.H., Cheung D.T., Nimni M.E. Biochemical changes and cytotoxicity associated with degradation of polymeric glutaraldehyde derived crosslinks. J. Biomed. Mater. Res. 24:1990;1185-1202.
117. van Luyn M.J.A., van Wachem P.B., Olde Damink L., Dijkstra P.J., Feijen J., Nieuwenhuis P. Relations between in vitro cytotoxicity and crosslinked dermal sheep collagens. J. Biomed. Mater. Res. 26:1992;1091-1110.
118. van Luyn M.J.A., van Wachem P.B., Olde Damink L., Dijkstra P.J., Feijen J., Nieuwenhuis P. Secondary cytotoxicity of crosslinked dermal sheep collagens during repeated exposure to human fibroblasts. Biomaterials. 13:1992;1017-1024.
119. Oliver R.F., Grant R.A., Cox R.W., Hulme M.J., Mudie A. Histological studies of subcutaneous and intraperitoneal implants of trypsin-prepared dermal collagen allografts in the rat. Clin. Orthop. Relat. Res. 115:1976;291-302.
120. Eybl E., Griesmacher A., Grimm M., Wolner E. Toxic effects of aldehydes released from fixed pericardium on bovine aortic endothelial cells. J. Biomed. Mater. Res. 23:1989;1355-1365.
121. Wiebe D., Megerman J., L'Italien G.J., Abbot W.M. Glutaraldehyde release from ascular prostheses of biologic origin. Surgery. 104:1988;26-33.
122. Chvapil M., Chvapil T.A., Owen J.A. Reaction of various skin wounds in the rat to collagen sponge dressing. J. Surg. Res. 41:1986;410-418.
123. Chvapil M., Speer D.P., Holubec H., Chvapil T.A., King D.H. Collagen fibers as a temporary scaffold for replacement of ACL in goats. J. Biomed. Mater. Res. 27:1993;313-325.
124. Olde Damink L.H.H., Dijkstra P.J., van Luyn M.J.A., van Wachem P.B., Nieuwenhuis P., Feijen J. Crosslinking of dermal sheep collagen using hexamethylene diisocyanate. J. Mater. Sci. Mater. Med. 2:1992;142-148.
125. Naimark W.A., Pereira C.A., Tsang K., Lee J.M. HMDC crosslinking of bovine pericardial tissue: a potential role of the solvent environment in the design of bioprosthetic materials. J. Mater. Sci. Mater. Med. 6:1995;235-241.
126. Chvapil M. Considerations on manufacturing principles of a synthetic burn dressing: a review. J. Biomed. Mater. Res. 16:1982;245-263.
127. Tu R., Lu C.-L., Thyagarajan K., Wang E., Nguyen H., Shen S., Hata C., Quijano R.C. Kinetic study of collagen fixation with polyepoxy fixatives. J. Biomed. Mater. Res. 27:1993;3-9.
128. Tu R., Quijano R.C., Lu C.L., Shen S., Wang E., Hata C., Lin D. A preliminary study of the fixation mechanism of collagen reaction with a polyepoxy fixative. Int. J. Artif. Organs. 16:1993;537-544.
129. Tu R., Shen S.-H., Lin D., Hata C., Thyagarajan K., Noishiki Y., Quijano R.C. Fixation of bioprosthetic tissues with monofunctional and multifunctional polyepoxy compound. J. Biomed. Mater. Res. 28:1994;677-684.
130. Sung H.-W., Hsu C.-S., Lee Y.-S., Lin D.-S. Crosslinking characteristics of an epoxy-fixed porcine tendon: effects of pH, temperature, and fixative concentration. J. Biomed. Mater. Res. 31:1996;511-518.
131. Sung H.-W., Shih J.-S., Hsu C.-S. Crosslinking characteristics of porcine tendons: effects of fixation with glutaraldehyde or epoxy. J. Biomed. Mater. Res. 30:1996;361-367.
132. Wang E., Thyagarajan K., Tu R., Lin D., Hata C., Shen S.H., Quijano R.C. Evaluation of collagen modification and surface properties of a bovine artery via polyepoxy compound fixation. Int. J. Artif. Organs. 16:1993;530-536.
133. Tang Z., Yue Y. Crosslinkage of collagen by polyglycidyl ethers. ASAIO J. 41:1995;72-78.
134. Lee J.M., Pereira C.A., Kan L.W.K. Effect of molecular structure of poly(glycidyl ether) reagents on crosslinking and mechanical properties of bovine pericardial xenograft materials. J. Biomed. Mater. Res. 28:1994;981-992.
135. Xi T., Ma J., Tian W., Lei X., Long S., Xi B. Prevention of tissue calcification on bioprosthetic heart valve by using epoxy compounds: a study of calcification test in vitro and in vivo. J. Biomed. Mater. Res. 26:1993;1241-1251.
136. Nishi C., Nakajima N., Ikada Y. In vitro evaluation of cytotoxicity of diepoxy compounds used for biomaterial modification. J. Biomed. Mater. Res. 29:1995;829-834.
137. Hassell J., Hand A.R. Tissue fixation with diimidoesters as an alternative to aldehydes. I. Comparison of crosslinking and ultrastructure obtained with dimethylsuberimidate and glutaraldehyde. J. Histochem. Cytochem. 22:1974;223-239.
138. Grabarek Z., Gergely J. Zero-length crosslinking procedure with the use of active esters. Anal. Biochem. 18:1990;131-135.
139. Petite H., Rault I., Huc A., Menasche P.H., Herbage D. Use of the acyl azide method for crosslinking collagen-rich tissues such as pericardium. J. Biomed. Mater. Res. 24:1990;179-187.
140. Petite H., Duval J.L., Frei V., Abdul-Malak N., Sigot-Luizard M.E., Herbage D. Cytocompatibilty of calf pericardium treated by glutaraldehyde and by the acyl azide methods in an organotypic culture model. Biomaterials. 16:1995;1003-1008.
141. Yannas I.V., Tobolksy A.V. Crosslinking of gelatin by dehydration. Nature. 215:1967;509-510.
142. Silver F.H., Yannas I.V., Salzman E.W. In vitro blood compatibility of glycosaminoglycan precipitated collagens. J. Biomed. Mater. Res. 13:1979;701-716.
143. Gorham S.D., Light N.D., Diamond A.M., Willins M.J., Bailey A.J., Wess T.J., Leslie M.J. Effect of chemical modifications on the susceptibility of collagen to proteolysis. II. Dehydrothermal crosslinking. Int. J. Biol. Macromol. 14:1992;129-138.
144. Wang M.-C., Pins G.D., Silver F.H. Collagen fibres with improved strength for the repair of soft tissue injuries. Biomaterials. 15:1994;507-512.
145. Koide M., Osaki K., Konishi J., Oyamada K., Katakura T., Takahashi A., Yoshizato K. A new type of biomaterial for artificial skin: dehydrothermally crosslinked composites of fibrillar and denatured collagens. J. Biomed. Mater. Res. 27:1993;79-87.
146. Weadock K., Olson R.M., Silver F.H. Evaluation of collagen crosslinking techniques. Biomater. Med. Dev. Artif. Organs. 11:1984;293-318.
147. Weadock K.S., Miller E.J., Bellincampi L.D., Zawadsky J.P., Dunn M.G. Physical crosslinking of collagen fibers: comparison of ultraviolet irradiation and dehydrothermal treatment. J. Biomed. Mater. Res. 29:1995;1373-1379.
148. Weadock K.S., Miller E.J., Keuffel E.L., Dunn M.G. Effect of physical crosslinking methods on collagen-fiber durability in proteolytic solutions. J. Biomed. Mater. Res. 32:1996;221-226.
149. R.R. Reich, D.J. Burgess, Ethylene oxide sterilization, in: J. Swarbrick, J.C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, Vol. 5, Marcel Dekker, New York, 1992, pp. 315-336.
150. Olde Damink L.H.H., Dijkstra P.J., van Luyn M.J.A., van Wachem P.B., Nieuwenhuis P., Feijen J. Influence of ethylene oxide gas treatment on the in vitro degradation behavior of dermal sheep collagen. J. Biomed. Mater. Res. 29:1995;149-155.
151. Vink P., Pleijsier K. Aeration of ethylene oxide sterilized polymers. Biomaterials. 7:1986;225-230.
152. United States Pharmacopeia 23, Sterilization by ionizing radiation, The United States Pharmacopeial Convention, Rockville, MD, 1995, p. 1978.
153. Cheung D.T., Perelman N., Tong D., Nimni M.E. The effect of γ-irradiation on collagen molecules, isolated α-chains, and crosslinked native fibers. J. Biomed. Mater. Res. 24:1990;581-589.
154. Miyata T., Sohde T., Rubin A.L., Stenzel K.H. Effects of ultraviolet irradiation on native and telopeptide-poor collagen. Biochim. Biophys. Acta. 229:1971;672-680.
155. M.-Y. Fu Lu, C. Thies, Collagen-based drug delivery devices, in: P. Tarche (Ed.), Polymers for Controlled Drug Delivery, CRC Press, Boca Raton, FL, 1991, pp. 149-161.
156. D.P. DeVore, Collagen as an ophthalmic biomaterial, in: D.L. Wise, D.J. Trantolo, D.E. Altobelli, M.J. Yaszemski, J.D. Gresser, E.R. Schwartz (Eds.), Encyclopedic Handbook of Biomaterials and Bioengineering, Marcel Dekker, New York, 1995, pp. 1233-1260.
157. Rubin A.L., Stenzel K.H., Miyata T., White M.J., Dunn M. Collagen as a vehicle for drug delivery. J. Clin. Pharmacol. 17:1973;309-312.
158. Vasantha R., Sehgal P.K., Pandurango Rao K. Collagen ophthalmic inserts for pilocarpine drug delivery systems. Int. J. Pharm. 47:1988;95-102.
159. Punch P.I., Costa N.D., Edwards M.E., Wilcox G.E. The release of insoluble antibiotics from collagen ocular inserts in vitro and their insertion into the conjunctival sac of cattle. J. Vet. Pharmacol. Ther. 10:1987;37-42.
160. Poland D.E., Kaufman H.E. Clinical uses of collagen shields. J. Cataract Refractive Surg. 14:1988;489-491.
161. Robin J.B., Keys C.L., Kaminski L.A., Viana M.A. The effect of collagen shields on rabbit corneal reepithelialization after chemical debridement. Invest. Ophthalmol. Vis. Sci. 31:1990;1294-1300.
162. Shaker G.J., Ueda S., LoCascio J.A., Aquavella J.V. Effect of collagen shield on cat corneal epithelial wound healing. Invest. Ophthamol. Vis. Sci. 30:1989;1565-1568.
163. Marmer R.H. Therapeutic and protective properties of the corneal collagen shield. J. Cataract Refractive Surg. 14:1988;496-499.
164. Weissman B.A., Lee D.A. Oxygen transmissibility, thickness, and water content of three types of collagen shields. Arch. Ophthalmol. 106:1988;1706-1708.
165. Kaufman H.E. Collagen shield symposium. J. Cataract Refractive Surg. 14:1988;487-488.
166. Friedberg M.L., Pleyer U., Mondino B.J. Device drug delivery to the eye: collagen shields, iontophoresis, and pumps. Ophthamol. 98:1991;725-732.
167. Palmer R.M., McDonald M.B. A corneal lens/shield system to promote postoperative corneal epithelial healing. J. Cataract Refractive Surg. 21:1995;125-126.
168. Sintzel M.B., Bernatchez S.F., Tabatabay C., Gurny R. Biomaterials in ophthalmic drug delivery. Eur. J. Pharm. Biopharm. 42:1996;358-374.
169. Milani J.K., Verbukh I., Pleyer U., Sumner H., Adamu S.A., Halabi H.P., Chou H.J., Lee D.A., Mondino B.J. Collagen shields impregnated with gentamicin-dexamethasone as a potential drug delivery device. Am. J. Ophthalmol. 116:1993;622-627.
170. Baziuk N., Gremillion C.M. Jr., Peyman G.A., Cho H. Collagen shields and intraocular drug delivery: concentration of gentamicin in the aqueous and vitreous of a rabbit eye after lensectomy and vitrectomy. Int. Ophthalmol. 16:1992;101-107.
171. Phinney R.B., D Schwartz S., A Lee D., Mondino B.J. Collagen-shield delivery of gentamicin and vancomycin. Arch. Ophthalmol. 106:1988;1599-1604.
172. O'Brien T.P., Sawusch M.R., Dick J.D., Hamburg T.R., Gottsch J.D. Use of collagen corneal shields versus soft contact lenses to enhance penetration of topical tobramycin. J. Cataract Refractive Surg. 14:1988;505-507.
173. Unterman S.R., Rootman D.S., Hill J.M., Parelman J.J., Thompson H.W., Kaufman H.E. Collagen shield drug delivery: therapeutic concentrations of tobramycin in the rabbit cornea and aqueous humour. J. Cataract Refractive Surg. 14:1988;500-504.
174. Sawusch M.R., O'Brien T.P., Dick T.P., Gottsch J.D. Use of collagen corneal shields in the treatment of bacterial keratitis. Am. J. Ophthalmol. 106:1988;279-281.
175. Hobden J.A., Reidy J.J., O'Callaghan R.J., Hill J.M., Insler M.S., Rootman D.S. Treatment of experimental pseudomonas keratitis using collagen shields containing tobramycin. Arch. Ophthalmol. 106:1988;1605-1607.
176. Aquavella J.V., Ruffini J.J., LoCascio J.A. Use of collagen shields as a surgical adjunct. J. Cataract Refractive Surg. 14:1988;492-495.
177. Assil K.K., Zarnegar S.R., Fouraker S.R., Schanzlin D.J. Efficacy of tobramycin-soaked collagen shields vs. tobramycin eyedrop loaden dose for sustained experimental pseudomonas aeruginosa-induced keratitis in rabbits. Am. J. Ophthalmol. 113:1992;418-423.
178. Dorigo M.T., De Natale R., Miglioli P.A. Collagen shields delivery of netilmicin: a study of ocular pharmacokinetics. Chemotherapy. 41:1995;1-4.
179. Mendicute J., Ondarra A., Eder F., Ostolaza J.I., Salaberria M., Lamsfus J.M. The use of collagen shields impregnated with amphotericin B to treat aspergillus keratomycosis. CLAO J. 21:1995;252-255.
180. Schwartz S.D., Harrison S.A., Engstrom R.E. Jr., Bawdon R.E., Lee D.A., Mondino B.J. Collagen shield delivery of amphotericin B. Am. J. Ophthalmol. 109:1990;701-704.
181. Sawusch M.R., O'Brien T.P., Updegraff S.A. Collagen corneal shields enhance penetration of topical prednisolone acetate. J. Cataract Refractive Surg. 14:1988;625-628.
182. Hwang D.G., Stern W.H., Hwang P.H., MacGowan-Smith L.A. Collagen shield enhancement of topical dexamethasone penetration. Arch. Ophthalmol. 107:1989;1375-1380.
183. Pleyer U., Elkins B., Rückert D., Lutz S., Grammer J., Chou J., Schmidt K.H., Mondino B.J. Ocular absorption of cyclosporine A from liposomes incorporated into collagen shields. Curr. Eye Res. 13:1994;177-181.
184. Grammer J.B., Kortüm F.A., Wolburg H., Lüdtke R., Schmidt K.-H., Thiel H.-J., Pleyer U. Impregnation of collagen corneal shields with liposomes: uptake and release of hydrophilic and lipophilic marker substances. Curr. Eye Res. 15:1996;815-823.
185. Finkelstein I., Trope G.E., Meno I.A., Rootsman D., Basu P.K. Potential value of collagen shields as a subconjunctival depot release system. Curr. Eye Res. 90:1990;653-659.
186. Hasty B., Heuer D.K., Minckler D.S. Primate trabeculectomies with 5-fluorouracil collagen implants. Am. J. Ophthalmol. 109:1990;721-725.
187. Ros R.E., Tijl J.W., Faber J.A.J. Bandage lenses: collagen shield vs. hydrogel lens. CLAO J. 17:1991;187-190.
188. Gebhardt B.M., Kaufman H.E. Collagen as a delivery system for hydrophobic drugs: studies with cyclosporine. J. Ocul. Pharmacol. Ther. 11:1995;319-327.
189. Gebhardt B.M., Varnell E.D., Kaufman H.E. Cyclosporine in collagen particles: corneal penetration and suppression of allograft rejection. J. Ocul. Pharmacol. Ther. 11:1995;509-517.
190. H.E. Kaufman, Ophthalmic drug delivery system containing bioreodible polymers, US Patent 4865846 (1989).
191. C.-C.R. Fu, E. Shek, J.S. Fleitman, M.C. de Leung, Collagen containing ophthalmic formulation, Eur. Patent 90119626.1 (1990).
192. Remacle M., Dujardin J.-M. G Lawson, Treatment of vocal fold immobility by glutaraldehyde-crosslinked collagen injection: long-term results. Ann. Otol. Rhinol. Laryngol. 104:1995;437-441.
193. Shortliffe L.M.D., Freiha F.S., Kessler R., A Stamey T., E Constantinou C. Treatment of urinary incontinence by the periurethral implantation of glutaraldehyde crosslinked collagen. J. Urol. 141:1989;538-541.
194. Cendron M., DeVore D.P., Connolly R., Sant G.R., Ucci A., Calahan R., Klauber G.T. The biological behavior of autologous collagen injected into the rabbit bladder. J. Urol. 154:1995;808-811.
195. Wallace D.G., Rhee W., Weiss B. Shear creep of injectable collagen biomaterials. J. Biomed. Mater. Res. 21:1987;861-880.
196. Wallace D.G., Rhee W., Reihanian H., Ksander G., Lee R., Braun W.B., Weiss B.A., Pharriss B.B. Injectable crosslinked collagen with improved flow properties. J. Biomed. Mater. Res. 23:1989;931-945.
197. D.G. Wallace, H. Reihanian, B.B. Pharriss, W.G. Braun, Injectable implant composition having improved intrudability, Eur. Patent 87305651.9 (1988).
198. Rosenblatt J., Devereux B., Wallace D.G. Injectable collagen as a pH-sensitive hydrogel. Biomaterials. 12:1994;985-995.
199. Sutton R., Yu N., Luck E., Brown D., Conley F. Reduction of vinblastine neurotoxicity in mice utilizing a collagen matrix carrier. Sel. Cancer Ther. 6:1990;35-49.
200. Davidson B.S., Izzo F., Cromeens D.M., Stephens L.C., Siddik Z.H., Curley S.A. Collagen matrix cisplatin prevents local tumor growth after margin-positive resection. J. Surg. Res. 58:1995;618-624.
201. Ning S., Trisler K., Brown D.M., Yu N.Y., Kanekal S., Lundsten M.J., Knox S.J. Intratumoral radioimmunotherapy of a human colon cancer xenograft using a sustained-release gel. Radiother. Oncol. 39:1996;179-189.
202. 195mPt-cisplatin in murine tumors with a novel injectable sustained-release drug delivery system, Pharm. Res. 12 (1995) S-228.
203. 14C-fluorouracil in murine fibrosarcomas, Pharm. Res. 12 (1995) S-227.
204. Yu N.Y., Orenberg E.K., Luck E., Brown D., Conley F. Antitumor effect of intratumoral administration of fluorouracil/epinephrin injectable gel in C3H mice. Cancer Chemother. Pharmacol. 36:1995;27-34.
205. Horakova Z., Krajicek M., Chvapil M., Boissier J. Prolongation by collagenous substances of several pharmacologic actions. Therapie. 22:1967;1455-1460.
206. Rosenblatt J., Rhee W., Wallace D. The effect of collagen fiber size distribution on the release rate of proteins from collagen matrices by diffusion. J. Control. Release. 9:1989;195-203.
207. Singh M., Lumpkin J.A., Rosenblatt J. Diffusion and desorption controlled polypeptide release from collagen matrices. Proc. Int. Symp. Control. Release Bioact. Mater. 21:1994;300-301.
208. Singh M., Rosenblatt J. Polypeptide delivery from collagen: electrostatic effects. Proc. Int. Symp. Control. Release Bioact. Mater. 20:1993;107-108.
209. M.A. Singh, Fundamental study of electrostatic effects on release of polypeptides from collagen hydrogels, Ph. D. Thesis, University of Maryland, Baltimore, MD, 1994.
210. J.S. Rosenblatt, R.A. Berg, Collagen-based injectable drug delivery system and its use, Eur. Patent 95101589.0 (1995).
211. Vijaya Ramesh D., Sehgal P.K., Dhar S.C. In vitro interaction of bleomycin with collagen - equilibrium dialysis technique. Indian J. Biochem. Biophys. 26:1989;196-198.
212. Slavin J., Nash J.R., Kingsnorth A.N. Effect of transforming growth factor beta and basic fibroblast growth factor on steroid impaired healing intestinal wound. Br. J. Surg. 79:1992;69-72.
213. Marchand R., Woerly S., Bertrand L., Valdes N. Evaluation of two crosslinked collagen gels implanted in the transected spinal cord. Brain Res. Bull. 30:1993;415-422.
214. Docherty R., Forrester J.V., Lackie J.M., Gregory D.W. Glycosaminoglycans facilitate the movement of fibroblasts through three-dimensional collagen matrices. J. Cell Sci. 92:1989;263-270.
215. Joosten E.A.J., Bär P.R., Gispen W.H. Collagen implants and cortico-spinal axonal growth after mid-thoracic spinal cord lesion in the adult rat. J. Neurosci. Res. 41:1995;481-490.
216. Saltzman W.M., Parkhurst M.R., Parsons-Wingerter P., Zhu W.H. Three-dimensional cell sultures mimic tissues. Ann. N.Y. Acad. Sci. 665:1992;259-273.
217. Parkhurst M.R., Saltzman W.M. Leukocytes migrate through three-dimensional gels of midcycle cervical mucus. Cell Immunol. 156:1994;77-94.
218. Parkhurst M.R., Saltzman W.M. Quantification of human neutrophil motility in three-dimensional collagen gels. Effect of collagen concentration. Biophys. J. 61:1992;306-315.
219. Baldwin S.P., Krewson C.E., Saltzman W.M. PC12 cell aggregation and neurite growth in gels of collagen, laminin and fibronectin. Int. J. Dev. Neurosci. 14:1996;351-364.
220. Weiner A.L., Carpenter-Green S.S., Soehngen E.C., Lenk R.P., Popescu M.C. Liposome-collagen gel matrix: a novel sustained drug delivery system. J. Pharm. Sci. 74:1985;922-925.
221. Pajean M., Herbage D. Effect of collagen on liposome permeability. Int. J. Pharm. 91:1993;209-216.
222. Takenaka H., Fujioka K., Takada Y. New formulations of bioactive materials. Pharm. Tech. Japan. 2:1986;1083-1091.
223. Y. Yamahira, K. Fujioka, S. Sato, N. Yoshido, Sustained-release injections. Eur. Patent 84112313.6 (1991).
224. Burke J.F., Yannas I.V., Quinby W.C., Bondoc C.C., Jung W.K. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann. Surg. 194:1981;413-428.
225. Yannas I.V. Biologically active analogues of the extracellular matrix: artificial skin and nerves. Angew. Chem. Int. Ed. 29:1990;20-35.
226. Lefebvre F., Gorecki S., Bareille R., Amedee J., Bordenave L., Rabaud M. New artificial connective matrix-like structure made of elastin solubilized peptides and collagens: elaboration, biochemical and structural properties. Biomaterials. 13:1992;28-33.
227. Lefebvre F., Pilet P., Bonzon N., Daculsi G., Rabaud M. New preparation and microstructure of the EndoPatch elastin-collagen containing glycosaminoglycans. Biomaterials. 17:1996;1813-1818.
228. Doillon C.J., Silver F.H. Collagen-based wound dressing: effects of hyaluronic acid and fibronectin on wound healing. Biomaterials. 7:1986;3-8.
229. Ellis D.L., Yannas I.V. Recent advances in tissue synthesis in vivo by use of collagen-glycosaminoglycan copolymers. Biomaterials. 17:1996;291-299.
230. Dagalakis N., Flink J., Stasikelis P. .Bur, Burke J.F., Yannas I.V. Design of an artificial skin. Part III. Control of pore structure. J. Biomed. Mater. Res. 14:1980;511-528.
231. Matsuda K., Suzuki S., Isshiki N., Yoshioka K., Wada R., Hyon S.H., Ikada Y. Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic. Biomaterials. 13:1992;119-122.
232. Doillon C.J., Whyne C.F., Brandwein S., Silver F.H. Collagen-based wound dressings: control of pore structure and morphology. J. Biomed. Mater. Res. 20:1986;1219-1228.
233. Anselme K., Bacques C., Charriere G., Hartmann D.J., Herbage D., Garrone R. Tissue reaction to subcutaneous implantation of a collagen sponge. A histological, ultrastructural, and immunological study. J. Biomed. Mater. Res. 24:1990;689-703.
234. Chen C.S., Yannas I.V., Spector M. Pore strain behaviour of collagen-glycoaminoglycan analogues of extracellular matrix. Biomaterials. 16:1995;777-783.
235. Geesin J.C., Brown L.J., Liu Z., Berg R.A. Development of a skin model based on insoluble fibrillar collagen. J. Biomed. Mater. Res. 33:1996;1-8.
236. Royce P.M., Kato T., Ohsaki K., Miura A. The enhancement of cellular infiltration and vascularisation of a collagenous dermal implant in the rat by platelet-derived growth factor BB. J. Dermatol. Sci. 10:1995;42-52.
237. Lepisto J., Kujari H., Niinikoski J., Laato M. Effects of heterodimeric isoform of platelet-derived growth factor PDGF-AB on wound healing in the rat. Eur. Surg. Res. 26:1995;267-272.
238. A Ksander G., Ogawa Y., Chu G.H., McMullin H., Rosenblatt J.S., McPherson J.M. Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strength in guinea pig dermal wounds healing by secondary intent. Ann. Surg. 211:1990;288-294.
239. Marks M.G., Doillon C., Silver F.H. Effects of fibroblasts and basic fibroblast growth factor on facilitation of dermal wound healing by type I collagen matrices. J. Biomed. Mater. Res. 25:1991;683-696.
240. Tweden K.S., Spadone D.P., Terranova V.P. Neovascularization of surface demineralized dentin. J. Periodontol. 60:1989;460-466.
241. S.-Z. Song, A. Morawiecki, Collagen-containing sponges as drug delivery for proteins, PCT WO 93/21908 (1993).
242. M.R. Urist, Bone morpogenetic protein in biology and medicine, in: T.S. Lindholm (Ed.), Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, R.G. Landes, Austin, TX, 1996, pp. 7-27.
243. Kenley R.A., Yim K., Abrams J., Ron E., Turek T., Marden L.J., Hollinger J.O. Biotechnology and bone graft substitutes. Pharm. Res. 10:1993;1393-1401.
244. L. Jortikka, Target cells and receptors for bone morphogenetic protein, in: T.S. Lindholm (Ed.), Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, R.G. Landes, Austin, TX, 1996, pp. 65-74.
245. U. Ripamonti, The generation of bone in primates by bone morphogenetic proteins, in: T.S. Lindholm (Ed.), Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, R.G. Landes, Austin, TX, 1996, pp. 131-145.
246. Deatherage J.R., Miller E.J. Packaging and delivery of bone induction factors in a collagenous implant. Coll. Relat. Res. 7:1987;225-231.
247. Fujimura K., Bessho K., Kusumoto K., Ogawa Y., Iizuka T. Experimental studies on bone inducing activity of composites of atelopeptide type I collagen as a carrier for ectopic induction by rhBMP-2. Biochem. Biophys. Res. Commun. 208:1995;316-322.
248. Horisaka Y., Okamoto Y., Matsumoto N., Yoshimura Y., Hirano A., Nishida M., Kawada J., Yamashita K., Takagi T. Histological changes of implanted collagen material during bone induction. J. Biomed. Mater. Res. 28:1994;97-103.
249. S.D. Cook, G.C. Baffes, M.W. Wolfe, T. Kuber Sampath, D.C. Rueger, T.S. Whitecloud, The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects, J. Bone Joint Surg. 76-A (1994) 827-838.
250. S.D. Cook, M.W. Wolfe, S.L. Salkeld, D.C. Rueger, Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates, J. Bone Joint Surg. 77-A (1995) 734-750.
251. Ripamonti U., van den Heever B., Sampath T.K., Tucker M.M., Rueger D.C., Reddi A.H. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors. 123:1996;273-289.
252. Schimandle J.H., Boden S.D., Hutton W.C. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine. 20:1995;1326-1337.
253. Boden S.D., Moskovitz P.A., Morone M.A., Toribitake Y. Video-assisted lateral intertransverse process arthrodesis. Validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and non-human primate (rhesus) monkey. Spine. 15:1996;2689-2697.
254. Nakashima M. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J. Dent. Res. 73:1994;1515-1522.
255. Nakashima M. Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix. Arch. Oral Biol. 39:1994;1085-1089.
256. Gao T.J., Lindholm T.S., Kommonen B., Ragni P., Paronzini A., Lindholm T.C., Jämsä T., Jalovaara P. Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and type IV collagen. J. Biomed. Mater. Res. 32:1996;505-512.
257. H. Uludag, G. Timony, D. D'Augusta, C. Blake, R. Palmer, K. Hammerstone, J. Wozney, In vivo delivery of rhBMP-2 using collagen sponges, Proc. Control. Release Soc., Baltimore, MD, 1996, pp. 51-52.
258. W. Friess, H. Uludag, R.J. Biron, M. Townsend, Recombinant human bone morphogenetic protein-2/collagen sponge combinations - in vitro and pharmacokinetic performance, Pharm. Res. 14 (1997) S-155.
259. Toolan B.C., Frenkel S.R., Pachence J.M., Yalowitz L., Alexander H. Effects of growth-factor-enhanced culture on a chondrocyte-collagen implant for cartilage repair. J. Biomed. Mater. Res. 31:1996;273-280.
260. Fujisato T., Sajiki T., Liu Q., Ikada Y. Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials. 17:1996;155-162.
261. Paino C.L., Fernandez-Valle C., Bates M.L., Bunge M.B. Regrowth of axons in lesioned adult rat spinal cord: promotion by implants of cultured Schwann cells. J. Neurocytol. 23:1994;433-452.
262. Boyce S.T., Christianson D.J., Hansbrough J.F. Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. J. Biomed. Mater. Res. 22:1988;939-957.
263. Bell E., Ehrlich P., Buttle D.J., Nakatsuji T. Living tissue formed in vitro and accepted as skin-equivalent of full-thickness. Science. 221:1981;1052-1054.
264. Hancock K., Leigh I.M. Cultured keratinocytes and keratinocyte grafts. Br. Med. J. 299:1989;1179-1180.
265. E.W. Taylor, Surgical infection: current concerns. Eur. J. Surg. 163 Suppl. 578 (1997) 5-9.
266. Calhoun J.H., Mader J.T. Antibiotic beads in the management of surgical infections. Am. J. Surg. 157:1989;443-449.
267. Gerhart T.N., Roux R.D., Horowitz G., Miller R.L., Hanff P., Hayes W.C. Antibiotic release from an experimental biodegradable bone cement. J. Orthop. Res. 6:1988;585-592.
268. Wahlig H., Dingeldein E. Antibiotics and bone cements: experimental and clinical long-term observations. Acta Orthop. Scand. 51:1980;49-56.
269. Becker P.L., Smith R.A., Williams R.S., Dutkowsky J.P. Comparison of antibiotic release from polymethylmethacrylate beads and sponge collagen. J. Orthop. Res. 12:1994;737-741.
270. A. Stemberger, H. Grimm, F. Bader, H.D. Rahn, R. Ascherl, Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge, Eur. J. Surg. 163 Suppl. 578 (1997) 17-26.
271. N. Rushton, Applications of local antibiotic therapy, Eur. J. Surg. 163 Suppl. 578 (1997) 27-30.
272. Firsov A.A., Nazarov A.D., Fomina I.P. Biodegradable implants containing gentamicin: drug release and pharmacokinetics. Drug Dev. Ind. Pharm. 13:1987;1651-1674.
273. F. Scaglione, Pharmacotherapy - the facts and fantasies of prophylaxis and combined therapies, Eur. J. Surg. 163 Suppl. 578 (1997) 11-16.
274. Jorgensen L., Sorensen T., Lorentzen J. Clinical and pharmacokinetic evaluation of gentamicin coating collagen in groin wound infections after vascular reconstruction. Eur. J. Vasc. Surg. 5:1991;87-91.
275. C. von Hasselbach, The management of infected THP revisions using gnetamicin loaded collagen-sponges, 26th World Cong. Int. Coll. Surg., Milan, 1988.
276. von Hasselbach C. Klinik und Pharmakokinetik von Kollagen-Gentamicin als adjuvante Lokaltherapie knöcherner Infektionen. Unfallchirurgie. 29:1989;459-470.
277. H. Wahlig, E. Dingeldein, A new flavonoidic gentamicin salt providing a controlled sustained release of the antibiotic from biomaterials, Proc. Eur. Cong. Biomater., Bologna, Italy, 1986, p. 196.
278. R. Gericke, H. Wahlig. E. Dingeldein, Flavanone derivatives, US Patent 4938257 (1990).
279. A. Stemberger, M. Unkauf, D.E. Arnold, G. Blümel, Drug carrier systems based on resorbable polyester collagen and/or biomaterial combinations. in: C.G. Gebelein, T.C. Cheng, C.C.-M. Yang (Eds.), Cosmetic and Pharmaceutical Applications of Polymers, Plenum Press, New York, 1990, pp. 263-268.
280. Matsuda K., Suzuki S., Isshiki N., Yoshioka K., Okada T., Hyon S.H., Ikada Y. A bilayer artificial skin capable of sustained release of an antibiotic. Brit. J. Plastic. Surg. 44:1991;142-146.
281. P. Fleckenstein, H. Wahlig, E. Dingeldein, Wirkstoff-Depot. Dt. Off., German Patent Application 3429038 (1986).
282. Wachol-Drewek Z., Pfeiffer M., Scholl E. Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentamicin. Biomaterials. 17:1996;1733-1738.
283. Peng Y.M., Alberts D.S., Graham V., Surwit E.A., Weiner S., Meyskens F.L. Cervical tissue uptake of all-trans-retinoic acid delivered via a collagen sponge-cervical cap delivery device in patients with cervical dyplasia. Invest. New Drugs. 4:1986;245-249.
284. Dorr R., Surwit E.A., Droegemueller W., Alberts D.S., Meyskens F.L., Chvapil M. In vitro retinoid binding and release from a collagen sponge material in a simulated intravaginal environment. J. Biomed. Mater. Res. 16:1982;839-850.
285. Bradley W.G., Wilkes G.L. Some mechanical property considerations of reconstituted collagen for drug release supports. Biomater. Med. Dev. Artif. Organs. 5:1977;159-175.
286. Cascone M.C., Sim B., Downes S. Blends of synthetic and natural polymers as drug delivery systems for growth hormone. Biomaterials. 16:1995;569-574.
287. Friess W., Lee G., Groves M.J. Insoluble collagen matrices for prolonged delivery of proteins. Pharm. Develop. Tech. 1:1996;185-193.
288. Minabe M., Uematsu A., Nishijima K. momat, Tomomatsu E., Tamura T., Hori T., Umemoto T., Hino T. Application of a local drug delivery system to periodontal therapy: I. Development of collagen preparations with immobilized tetracycline. J. Periodontol. 60:1989;113-117.
289. Minabe M., Takeuchi K., Tamura K., Hori T., Umemoto T. Subgingival administration of tetracycline on a collagen film. J. Periodontol. 60:1989;552-556.
290. W. Steffan, A. Stemberger, K.H. Sorg, Collagen insert containing an active ingredient for introduction into bones or soft parts, Eur. Patent 82105341.0 (1985).
291. Greenwald R.A., Golub L.M., Lavietes B., Ramamurthy N.S., Gruber B., Laskin R.S., McNamara T.F. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J. Rheumatol. 14:1987;28-32.
292. T.F. McNamara, N.S. Ramamurthy, L.M. Golub, Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same, US Patent 4935412 (1990).
293. S.-Z. Song, A. Morawiecki, G.F. Pierce, C.G. Pitt, Collagen film for sustained delivery of proteins, Eur. Patent 92305467.3 (1992).
294. Takeuchi K. Application of local drug delivery systems to periodontal therapy. Nihon-shishubyo-gakkai-kaishi. 34:1992;741-758.
295. Matsuoka J., Sakagami K., Shiozaki S., Uchida S., Fujiwara T., Gohchi A., Orita K. Development of an interleukin-2 slow delivery system. Trans. Am. Soc. Artif. Intern. Organs. 34:1988;729-731.
296. Fujioka K., Takada Y., Sato S., Miyata T. Novel delivery system for proteins using collagen as a carrier material: the minipellet. J. Control. Release. 33:1995;307-315.
297. Fujioka Y., Takada Y. Collagen-based drug delivery system - development of minipellet system. Pharm. Tech. Japan. 7:1991;402-409.
298. Y. Yamahira, K. Fujioka, S. Sato, N. Yoshido, Prolonged sustained-release preparations, Eur. Patent 84112310.2 (1985).
299. Öner L., Groves M.J. Optimization of conditions for preparing 2- to 5-micron-range gelatin microparticles by using chilled dehydration agents. Pharm. Res. 10:1993;621-626.
300. Nastruzzi C., Pastesini C., Cortesi R., Esposito E., Gambari R., Menegatti E. Production and in vitro evaluation of gelatin microspheres containing an antitumour tetra-amidine. J. Microencapsulation. 11:1994;249-260.
301. Ratcliffe J.H., Hunneyball I.M., Smith A., Wilson C.G., Davis S.S. Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs. J. Pharm. Pharmacol. 36:1984;431-436.
302. Tabata Y., Ikeda Y. Synthesis of gelatin microspheres containing interferon. Pharm. Res. 6:1989;422-427.
303. Altankov G., Brodvarova I., Rashkov I. Synthesis of protein-coated gelatin microspheres and their use as microcarriers for cell culture. Part I. Derivatization with native collagen. J. Biomater. Sci. Polymer Ed. 2:1991;81-89.
304. J. Kreuter, D. Scherer, W. Müller, M. Roreger, Verfahren zur Herstellung von Kollagenpartikeln und ihre Verwendung als Wirkstoffträger., German Patent Application Dt. Off. 4038887 (1990).
305. Rössler B., Kreuter J., Scherer D. Collagen microparticles: preparation and properties. J. Microencapsulation. 12:1995;49-57.
306. Rössler B., Kreuter J., Ross G. Effect of collagen microparticles on the stability of retinol and its absorption into hairless mouse skin in vitro. Pharmazie. 49:1994;175-179.
307. B. Rössler, Entwicklung und Untersuchung von Kollagenmikropartikeln als Wirkstoffträger in Hydrogelen am Beispiel all-trans Retinol. Ph. D. Thesis, University of Frankfurt, Germany, 1993.
308. A. Berthold, K. Cremer, J. Kreuter, Collagen microparticles: carriers for glucocorticosteroids, Eur. J. Pharm. Biopharm. 45 (1998) 23-29.
309. Maffia G.J. Control of pore size and morphology in collagen microspheres. Mater. Res. Soc. Symp. Proc. 331:1994;53-58.
310. R.A. Berg, F.H. Silver, J.M. Pachence, Collagen matrix beads for soft tissue repair, US Patent 4837285 (1989).
311. Jefferies S.R., Richards R., Bernath F.R. Preliminary studies with L-asparaginase bound to implantable bovine collagen heterografts: a potential long-term, sustained dosage, anti-tumor enzyme therapy system. Biomater. Med. Dev. Artif. Organs. 5:1977;337-354.
312. Raghunath K., Pandurango Rao K., Joseph K.T. Polymeric drugs: some studies on collagen-kanamycin conjugates. J. Macromol. Sci. Chem. A22:1985;1735-1751.
313. Boyce S.T., Stompro B.E., Hansbrough J.F. Biotinylation of implantable collagen for drug delivery. J. Biomed. Mater. Res. 26:1992;547-553.
314. Stompro B.E., Hansbrough J.F., Boyce S.T. Attachment of peptide growth factors to implantable collagen. J. Surg. Res. 46:1989;413-421.
315. R. Bhatnagar, A.R. Ray, Composites of collagen with synthetic polymers for biomedical applications, in: M. Szycher (Ed.), High Performance Biomaterials, Technomic Publishing, Lancaster, OH, 1991, pp. 179-184.
316. Guidance for Industry - The sourcing and processing of gelatin to reduce the potential risk posed by bovine spongiform encephalopathy (BSE) in FDA-regulated products for human use, issued by US Department of Health and Human Services, FDA, September 1997
317. Note for guidance for minimizing the risk of transmitting agents causing spongiform encephalopathy via medicinal products, issued by the Commission of the European Communities, December 11, 1992, EC-Document No. III/3298/91-EN.
318. Gelatin from BSE countries may be used in oral and topical products, FDC Reports, October 13, 1997, pp. 5-6.
319. Bekanntmachung der Sicherheitsanforderungen an Arzneimittel aus Körperbestandteilen von Rind, Schaf oder Ziege zur Vermeidung des Risikos einer Übertragung von BSE bzw, Scrapie, issued by the Bundesgesundheitsamt, Bundesanzeiger No. 40, February 26, 1994, p. 46.
320. ®. Biologicals. 24:1996;103-111.