Scaffolds in tissue engineering bone and cartilage

Biomaterials

Volumn 21, Issue 24, 2000, Pages 2529-2543

  Hutmacher, Dietmar W ^a  

^a Lab for Biomedical Engineering   (Singapore)

Author keywords

Biodegradable and bioresorbable polymers; Design and fabrication of 3 D scaffold; Tissue engineering of bone and cartilage

Indexed keywords

BIODEGRADATION; BONE; CARTILAGE; CELL CULTURE; MECHANICAL PROPERTIES; METABOLISM; POLYMERS; POROUS MATERIALS; SURFACE CHEMISTRY;

TISSUE ENGINEERING;

BIOMATERIALS;

BIOMATERIAL; HYDROXYAPATITE; POLY(ORTHO ESTER); POLYANHYDRIDE; POLYCAPROLACTONE; POLYGLYCOLIDE; POLYMER;

BIODEGRADABLE IMPLANT; BIOENGINEERING; BONE; CARTILAGE; PRIORITY JOURNAL; REVIEW; THREE DIMENSIONAL IMAGING;

EID: 0034672872     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(00)00121-6     Document Type: Article

References (82)

1. Patrick C.W. Jr., Mikos A.G., McIntire Prospectus of tissue engineering. Patrick C.W. Jr., Mikos A.G., McIntire L.V. Frontiers in tissue engineering. 1998;3-14 Elsevier Science, New York, USA.
2. Naughton G.K.et al. Emerging developments in tissue engineering and cell technology. Tissue Eng. 1(2):1995;211-219.
3. Langer R., Vacanti J.P. Tissue engineering. Science. 260:1993;920-926.
4. Agrawal C., Niederauer G., Micallef D., Athanasiou K. The use of PLA-PGA polymers in orthopaedics. Encyclopedic handbook of biomaterials and bioengineering. 1995;2081-2115 Marcel Dekker, New York.
5. Bajpai P.K. Biodegradable scaffolds in orthopedic, oral and maxillofacial surgery. Rubin L.R. Biomaterials in reconstructive surgery. 1983;156 St. Louis, Mosby.
6. Chaignaud B.E., Langer R., Vacanti J.P. The history of tissue engineering using synthetic biodegradable polymer scaffolds and cells. Atala A., Mooney D.J. Synthetic biodegradable polymer scaffolds. 1997;1-14 Birkhauser, Boston.
7. Hollinger J.O., Chaudhari A. Bone regeneration materials for the mandibular and craniofacial complex. Cells Mater. 2:1992;143-151.
8. Hutmacher D., Hurzeler M., Schliephake H. A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants. 11:1996;667-678.
9. Hutmacher D., Kirsch A., Ackermann K.L., Huerzeler M.B. Matrix and carrier materials for bone growth factors - state of the art and future perspectives. Stark G.B., Horch R., Tancos E. Biological matrices and tissue reconstruction. 1998;197-206 Springer, Heidelberg, Germany.
10. Pachence J.M., Kohn J. Biodegradable polymers for tissue engineering. Lanza R.P., Langer R., Chick W.L. Principles of tissue engineering. 1997;273-293 R.G. Landes Co. Austin, Texas, USA.
11. West J.L., Hubbell J.A. Bioactive polymers. Atala A., Mooney D.J. Synthetic biodegradable polymer scaffolds. 1997;83-95 Birkhauser, Boston.
12. Wong W.H., Mooney D.J. Synthesis and properties of biodegradable polymers used as synthetic matrices for tissue engineering. Atala A., Mooney D.J. Synthetic biodegradable polymer scaffolds. 1997;51-82 Birkhauser, Boston.
13. Vert M., Li M.S., Spenlehauer G., Guerin P. Bioresorbability and biocompatibility of aliphatic polyesters. J Mater Sci. 3:1992;432-446.
14. Kronenthal R.L. Biodegradable polymers in medicine and surgery. Polym Sci Technol. 8:1975;119-137.
15. Agrawal C.M., Athanasiou K.A. Techniques to control pH in vicinity of biodegrading PLA-PGA implants. J Biomed Mater Res Appl Biomater. 38(2):1997;105-114.
16. Li S., Garreau H., Vert M. Structure-property relationships in the case of the degradation of massive aliphatic poly(α-hydroxy-acids) in aqueous media. Part 1: poly(D,L-lactic acid). J Mater Sci: Mater Med. 1:1990;123.
17. Li S., Garreau H., Vert M. Structure-property relationships in the case of the degradation of massive aliphatic poly(α-hydroxy-acids) in aqueous media. Part 2: degradation of lactide-glycolide PLA37.5 : GA25 and PLA75 : GA poly(D,L-lactic acid). J Mater Sci: Mater Med. 1:1990;131.
18. Li S., Garreau H., Vert M. Structure-property relationships in the case of the degradation of massive aliphatic poly(α-hydroxy-acids) in aqueous media. Part 3: influence of the morphology of poly(L-lactic acid). J Mater Sci: Mater Med. 1:1990;198.
19. Bergsma E.J., Brujn W., Rozema F.R., Bos R.M., Boering G. Late tissue response to poly(L-lactide) bone plates and screws. Biomaterials. 16(1):1995;25-31.
20. Bergsma E.J., Rozema F.R., Bos R.M., Brujn W. Foreign body reactions to resorbable poly(L-lactide) bone plates and screws used for the fixation of unstable zygomatic fractures. J Maxillofac Surg. 51:1993;666-670.
21. Böstmann O., Hirvensalo E., Mäkinen J., Rokkanen P. Foreign body reactions to fracture fixation implants of biodegradable synthetic polymers. J Bone Jt Surg. B72:1990;592.
22. Rehm K.E., Claes L., Helling H.J., Hutmacher D. Application of a polylactide pin. An open clinical prospective study. Leung K.S., Hung L.K., Leung P.C. Biodegradable implants in fracture fixation. 1994;54 World Scientific, Hong Kong.
23. Hutmacher DW, Kirsch A, Ackermann KL, Huerzeler MB. A tissue engineered cell occlusive device for hard tissue regeneration - a preliminary report. Int J Periodontics Restorative Dent, accepted for publication.
24. Shikinami Y., Okuno M. Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): part I. Basic characteristics. Biomaterials. 20:1998;859-877.
25. Freed L.E., Vunjak-Novakovic G. Tissue culture bioreactors. chondrogenesis as a model system Lanza R.P., Langer R., Chick W.L. Principles of tissue engineering. Austin. 1997;151-165 R.G. Landes Co, Texas, USA.
26. Young J.H., Teumer J., Kemp P.D., Parenteau N.L. Approaches to transplanting engineered cells and tissues. Lanza R.P., Langer R., Chick W.L. Principles of tissue engineering. Austin. 1997;297-307 R.G. Landes Co. Texas, USA.
27. Hillsley M.V., Frangos J.A. Review: bone tissue engineering: the role of interstitial fluid flow. Biotechnol Bioeng. 43:1994;573-581.
28. Thompson D.E., Agrawal C.M., Athanasiou K. The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic acid-polyglycolic acid. Tissue Eng. 2(1):1996;61-74.
29. Dunkelman N.S., Zimber M.P., LeBaron R.G., Pavelec R., Kwan M., Purchio A.F. Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system. Biotechnol Bioeng. 46:1995;299-305.
30. Freed L., Vunjak-Novakovic G., Biron R.J., Eagles D.B., Lesnoy D.C., Barlow S.K., Langer R. Biodegradable polymer scaffolds for tissue engineering. Biotechnology. 12:1994;689-693.
31. Grande D.A., Halberstadt C., Naughton G., Schwartz R., Manji R. Evaluation of matrix scaffolds for tissue engineering of cartilage grafts. J Biomed Mater Res. 34:1997;211-220.
32. Martin I., Padera R.F., Langer R., Vunjak-Novakovic G., Freed L.E. In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues. J Orthop Res. 16:1998;181-189.
33. Puelacher W.C., Vacanti J.P., Ferraro N.F., Schloo, Vacanti C.A. Femoral shaft reconstruction using tissue engineered growth of bone. Int J Oral Maxillofac Surg. 25:1996;223-228.
34. Ma P.X., Langer R. Morphology and mechanical function of long-term in vitro engineered cartilage. J Biomed Mater Res. 44:1999;217-221.
35. Freed L.E., Hollander A.P., Martin I., Barry J.R., Langer R., Vunjak-Novakovic G. Chondrogenesis in a cell-polymer-bioreactor system. Exp Cell Res. 240(1):1998;58-65.
36. Reddi A.H., Wientrob S., Muthukumaran N. Biological principles of bone induction. Orthopedic Clinics North America. 18:1987;207-212.
37. Brekke J.H. A rationale delivery of osteoconductive proteins (a review). Tissue Eng. 2(2):1996;97-114.
38. Chen CS, Milan Mrksich, Sui Huang, Whitesides GM, Ingber D. Geometric control of cell life and death. Science 1997;276:1425-8.
39. Ingber D.E. Tensegrity: the architectural basis of cellular mechanotransduction. Ann Rev Physiol. 59:1997;575-599.
40. Freed L.E., Hollander A.P., Martin I., Barry J.R., Langer R., Vunjak-Novakovic G. Chondrogenesis in a cell-polymer-bioreactor system. Exp Cell Res. 240(1):1998;58-65.
41. Reece G.P., Patrick C.W. Jr. Tissue engineered construct design principles. Patrick C.W. Jr., Mikos A.G., McIntire L.V. Frontiers in tissue engineering. 1998;166-196 Elsevier Science, New York, USA.
42. Vander AJ, Shermann JH, Luciano DS. Human physiology. New York: McGraw-Hill, 1985. p. 341-66.
43. Lu L., Mikos A.G. The importance of new processing techniques in tissue engineering. MRS Bull. 11:1996;28-32.
44. Thomson R.C., Yaszemski M.J., Mikos A.G. Polymer scaffold processing. Lanza R.P., Langer R., Chick W.L. Principles of tissue engineering. 1997;263-272 R.G. Landes Co. Austin, TX, USA.
45. Widmer M.S., Mikos A.G. Fabrication of biodegradable polymer scaffolds for tissue engineering. Patrick C.W. Jr., Mikos A.G., McIntire L.V. Frontiers in tissue engineering. 1998;107-120 Elsevier Science, New York, USA.
46. Mikos A.G., Thorsen A.J., Czerwonka L.A., Bao Y., Langer R., Winslow D.N., Vacanti J.P. Preparation and characterization of poly(L-lactic acid) foams. Polymer. 35(5):1994;1068-1077.
47. Mikos A.G., Sarakinos G., Leite S.M., Vacanti J.P., Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials. 14:1993;323-330.
48. Widmer M.S., Gupta P.K., Lu L., Meszlenyi R.K., Evans G.R.D., Brandt K., Savel T., Gurlek A., Patrick C.W., Mikos A.G. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials. 19:1998;1945-1955.
49. Vieth W.R. Diffusion in and through polymers. principles and applications:1991;Carl Hanser Verlag, München.
50. Tom J.W., Debenedetti P.G. Particle formation with supercritical fluids - a review. J Aerosol Sci. 22(5):1991;555-584.
51. Michaeli W, Seibt S. Molding of resorbable polymers at low temperatures. ANTEC 1995. p. 3397-9.
52. Mooney D.J., Baldwin D.F., Suh N.P., Vacanti J.P., Langer R. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials. 17:1996;1417-1422.
53. Harris L.D., Kim B.S., Mooney D.J. Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res. 42:1998;396-402.
54. Whang K., Thomas C.H., Healy K.E., Nuber G. A novel method to fabricate bioabsorbable scaffolds. Polymers. 36:1995;837-842.
55. Whang K., Tsai D.C., Nam E.K., Aitken M., Sprague S.M., Patel P.K., Healy K.E. Ectopic bone formation via rhBMP-2 delivery from porous bioresorbable polymer scaffolds. J Biomed Mater Res. 42:1998;491-499.
56. Whang K., Healy K.E., Elenz D.R., Nam E.K., Tsai D.C., Thomas C.H., Nuber M.D., Glorieux F.H., Travers R., Sprague S.M. Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. Tissue Eng. 5(1):1999;35-51.
57. Nam S.Y., Park T.G. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J Biomed Mater Res. 47(1):1999;8-16.
58. Zhang R., Ma P.X. Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res. 44(4):1999;446-455.
59. Schugens C., Maguet V., Grandfils C., Jerome R., Teyssie P. Polylactide macroporous biodegradable implants for cell transplantation. 2. Preparation of polylactide foams by liquid-liquid phase separation. J Biomed Mater Res. 30:1996;449-461.
60. Lo H., Ponticiello M.S., Leong K.W. Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng. 1:1995;15-28.
61. Hutmacher DW, Teoh SH, Feng SS, Ramakrishna S, Zein I. Tissue engineering research - the engineer's role. Medical Dev J, accepted for publication.
62. Rotter N., Aigner J., Naumann A., Planck H., Hammer C., Burmester G., Sittinger M. Cartilage reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage. J Biomed Mater Res. 42:1998;347-356.
63. Sittinger M., Reitzel D., Dauner M., Hierlemann H., Hammer C., Kastenbauer E., Planck H. Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. J Biomed Mater Res Appl Biomater. 33(2):1996;57-63.
64. Puelacher W.C., Vacanti J.P., Ferraro N.F., Schloo, Vacanti C.A. Femoral shaft reconstruction using tissue engineered growth of bone. Int J Oral Maxillofac Surg. 25:1996;223-228.
65. Freed L.E., Vunjak-Novakovic G. Culture of organized cell communities. Adv Drug Deliver Rev. 33(1-2):1998;15-30.
66. Hutmacher DW, Burdet E, Schantz TJ, Robotic micro-assembly fabrication of three-dimensional bioresorbable scaffolds for tissue engineering, in press.
67. Beaman J.J. Backround and definitions. Beamann J.J., Barlow J.W., Bourell D.L., Crawford R.H., Marcus H.L., McAlea K.P. Solid freeform fabrication. a new direction in manufacturing:1997;1-20 Kluwer Academic Publishers, Boston, USA.
68. Sachs E., Cima M., Williams P., Brancazio D., Cornie J. Three-dimensional printing. rapid tooling and prototypes directly from a CAD model J Eng Industry. 114:1992;481-488.
69. Cima L.G., Vacanti J.P., Vacanti C., Ingber D., Mooney D., Langer R. Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng. 113:1991;143-151.
70. Park A., Wu B., Griffith L.G. Integration of surface modification and 3-D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion. J Biomater Sci Polym Ed. 9(2):1998;89-110.
71. Wu B.M., Borland S.W., Giordano R.A., Cima L.G., Sachs E.M., Cima M.J. Solid free-form fabrication of drug delivery devices. J Contr Rel. 40:1996;77-87.
72. Giordano R.A., Wu B.M., Borland S.W., Cima L.G., Sachs E.M., Cima M.J. Mechanical properties of dense polylactic acid structures fabricated by three-dimensional printing. J Biomater Sci Polym Ed. 8(1):1996;63-75.
73. Agarwala M.K., Jamalabad V.R., Langrana N.A., Safari A., Whalen P.J., Danforth S.C. Structural quality of parts processed by fused deposition. Rapid Prototyping J. 2(4):1996;4-19.
74. Gray IV R.W., Baird D.G., Bohn J.H. Effects of processing conditions on short TCLP fiber reinforced FDM parts. Rapid Prototyping J. 1(4):1998;14-25.
75. Buckwalter JA, Mankin, HJ, Articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and transplantation. J Bone Jt Surg 1997;A79(4):612-32.
76. Newman A.P. Articular cartilage repair. Amer J Sports Med. 26(2):1998;309-324.
77. Glowacki J., Yates K., Little G., Mizuno S. Induced chondroblastic differentiation of human fibroblasts by three-dimensional culture with demineralized bone matrix. Mater Sci Eng. C6:1998;199-203.
78. de Chalain T., Phillips J.H., Hinek A. Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and κ-elastin. J Biomed Mater Res. 44:1999;280-288.
79. Lee E.H., Chen F., Chan J.W.K., Bose K. Treatment of growth arrest by transfer of cultured chondrocytes into physeal defects. J Paediatric Orthoped. 18(2):1998;155-160.
80. ten Koppel P.G., van Osch G.J., Verwoerd C.D., Verwoerd-Verhoef H.L. Efficacy of perichondrium and a trabecular demineralized bone matrix for generating cartilage. Plast Reconstruct Surg. 102(6):1998;2012-2020.
81. Bruns J., Kahrs J., Kampen J., Behrens P., Plitz W. Autologous perichondral tissue for meniscal replacement. J Bone Jt Surg - British Volume. 80(5):1998;918-923.
82. Hutmacher DW, Zein I, Teoh SH, Ng KW, Schantz JT, Leahy JC. Design and fabrication of a 3D scaffold for tissue engineering bone. In: Agrawal CM, Parr JE, Lin ST, editors. Synthetic bioabsorbable polymers for implants, STP 1396. American Society for Testing and Materials, West Conshohocken, PA, 2000. p. 52-67.