메뉴 건너뛰기




Volumn 48, Issue 3, 2012, Pages 111-120

Apoptosis-modulating drugs for improved cancer therapy

Author keywords

Apoptosis; Autophagy; Endoplasmic reticulum stress; Necroptosis; Unfolded protein response

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AEG 35156; ANTIBODY; AZD 8055; BORTEZOMIB; CONATUMUMAB; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DECOY RECEPTOR 2; DECOY RECEPTOR 3; DROZITUMAB; DULANERMIN; FAS ANTIGEN; FAS LIGAND; GATAPARSEN; GOSSYPOL; ISOSORBIDE; LEXATUMUMAB; MAPATUMUMAB; NAVITOCLAX; OBATOCLAX; OBLIMERSEN; PANOBINOSTAT; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; TANESPIMYCIN; TIGATUZUMAB; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84860168136     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000336875     Document Type: Review
Times cited : (76)

References (161)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA: Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0142029122 scopus 로고    scopus 로고
    • Resistance mechanisms of gastrointestinal cancers: Why does conventional chemotherapy fail?
    • DOI 10.1007/s00384-003-0496-x
    • Gieseler F, Rudolph P, Kloeppel G, Foelsch UR: Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail? Int J Colorectal Dis 2003; 18: 470-480. (Pubitemid 37265858)
    • (2003) International Journal of Colorectal Disease , vol.18 , Issue.6 , pp. 470-480
    • Gieseler, F.1    Rudolph, P.2    Kloeppel, G.3    Foelsch, U.R.4
  • 4
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • DOI 10.1002/path.1706
    • Longley DB, Johnston PG: Molecular mechanisms of drug resistance. J Pathol 2005; 205: 275-292. (Pubitemid 40227997)
    • (2005) Journal of Pathology , vol.205 , Issue.2 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 5
    • 80255138220 scopus 로고    scopus 로고
    • Targeted therapy for advanced renal cell cancer (RCC): A Cochrane systematic review of published randomised trials
    • Coppin C, Kollmannsberger C, Le L, Porzsolt F, Wilt TJ: Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials. BJU Int 2011; 108: 1556-1563.
    • (2011) BJU Int , vol.108 , pp. 1556-1563
    • Coppin, C.1    Kollmannsberger, C.2    Le, L.3    Porzsolt, F.4    Wilt, T.J.5
  • 6
    • 79958043820 scopus 로고    scopus 로고
    • Cetuximab in the treatment of patients with colorectal cancer
    • Garrett CR, Eng C: Cetuximab in the treatment of patients with colorectal cancer. Expert Opin Biol Ther 2011; 11: 937-949.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 937-949
    • Garrett, C.R.1    Eng, C.2
  • 11
    • 37549056216 scopus 로고    scopus 로고
    • The roles of therapy-induced autophagy and necrosis in cancer treatment
    • Amaravadi RK, Thompson CB: The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res 2007; 13: 7271-7279.
    • (2007) Clin Cancer Res , vol.13 , pp. 7271-7279
    • Amaravadi, R.K.1    Thompson, C.B.2
  • 12
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang Z, Klionsky DJ: Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814-822.
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 13
    • 57649167477 scopus 로고    scopus 로고
    • Necroptosis: A specialized pathway of programmed necrosis
    • Galluzzi L, Kroemer G: Necroptosis: a specialized pathway of programmed necrosis. Cell 2008; 135: 1161-1163.
    • (2008) Cell , vol.135 , pp. 1161-1163
    • Galluzzi, L.1    Kroemer, G.2
  • 14
    • 45449096100 scopus 로고    scopus 로고
    • Death through a tragedy: Mitotic catastrophe
    • DOI 10.1038/cdd.2008.47, PII CDD200847, Special Issue to celebrate Richard Lockshin's 70th Birthday
    • Vakifahmetoglu H, Olsson M, Zhivotovsky B: Death through a tragedy: mitotic catastrophe. Cell Death Differ 2008; 15: 1153-1162. (Pubitemid 351850968)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.7 , pp. 1153-1162
    • Vakifahmetoglu, H.1    Olsson, M.2    Zhivotovsky, B.3
  • 15
    • 2342635919 scopus 로고    scopus 로고
    • Cell death by mitotic catastrophe: A molecular definition
    • DOI 10.1038/sj.onc.1207528
    • Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G: Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004; 23: 2825-2837. (Pubitemid 38638845)
    • (2004) Oncogene , vol.23 , Issue.16 REV. ISS. 2 , pp. 2825-2837
    • Castedo, M.1    Perfettini, J.-L.2    Roumier, T.3    Andreau, K.4    Medema, R.5    Kroemer, G.6
  • 16
    • 0035834279 scopus 로고    scopus 로고
    • Molecular steps of death receptor and mitochondrial pathways of apoptosis
    • Gupta S: Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci 2001; 69: 2957-2964.
    • (2001) Life Sci , vol.69 , pp. 2957-2964
    • Gupta, S.1
  • 17
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z, El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther 2005; 4: 139-163. (Pubitemid 41351311)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.2 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 18
    • 0034641931 scopus 로고    scopus 로고
    • Corpse clearance defines the meaning of cell death
    • Savill J, Fadok V: Corpse clearance defines the meaning of cell death. Nature 2000; 407: 784-788.
    • (2000) Nature , vol.407 , pp. 784-788
    • Savill, J.1    Fadok, V.2
  • 20
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • DOI 10.1016/S0962-8924(01)02064-5, PII S0962892401020645
    • Baud V, Karin M: Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 2001; 11: 372-377. (Pubitemid 32900529)
    • (2001) Trends in Cell Biology , vol.11 , Issue.9 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 21
    • 79960913158 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis signaling pathway for cancer therapy
    • Sayers TJ: Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother 2011; 60: 1173-1180.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1173-1180
    • Sayers, T.J.1
  • 22
    • 0037276437 scopus 로고    scopus 로고
    • The CD95(Apo-1/ Fas) disc and beyond
    • Peter ME, Krammer PH: The CD95(Apo-1/ Fas) disc and beyond. Cell Death Differ 2003; 10: 26-35.
    • (2003) Cell Death Differ , vol.10 , pp. 26-35
    • Peter, M.E.1    Krammer, P.H.2
  • 24
    • 45749098451 scopus 로고    scopus 로고
    • To kill a tumor cell: The potential of proapoptotic receptor agonists
    • DOI 10.1172/JCI34359
    • Ashkenazi A, Herbst RS: To kill a tumor cell: the potential of proapoptotic receptor agonists. J Clin Invest 2008; 118: 1979-1990. (Pubitemid 351872316)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.6 , pp. 1979-1990
    • Ashkenazi, A.1    Herbst, R.S.2
  • 25
    • 0036716281 scopus 로고    scopus 로고
    • The BCL2 family: Regulators of the cellular life-or-death switch
    • DOI 10.1038/nrc883
    • Cory S, Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2: 647-656. (Pubitemid 37328916)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.9 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 26
    • 68149154728 scopus 로고    scopus 로고
    • BH3-only proteins and their roles in programmed cell death
    • Giam M, Huang DC, Bouillet P: BH3-only proteins and their roles in programmed cell death. Oncogene 2008; 27(suppl 1):S128-S136.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Giam, M.1    Huang, D.C.2    Bouillet, P.3
  • 27
    • 0035229427 scopus 로고    scopus 로고
    • The mitochondrion in apoptosis: How Pandora's box opens
    • DOI 10.1038/35048073
    • Zamzami N, Kroemer G: The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2001; 2: 67-71. (Pubitemid 33676964)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.1 , pp. 67-71
    • Zamzami, N.1    Kroemer, G.2
  • 28
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • DOI 10.1126/science.1099320
    • Green DR, Kroemer G: The pathophysiology of mitochondrial cell death. Science 2004; 305: 626-629. (Pubitemid 39006738)
    • (2004) Science , vol.305 , Issue.5684 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 29
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • DOI 10.1016/S0092-8674(00)80085-9
    • Liu X, Kim CN, Yang J, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: requirement for DATP and cytochrome c. Cell 1996; 86: 147-157. (Pubitemid 26256586)
    • (1996) Cell , vol.86 , Issue.1 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 30
    • 0033781027 scopus 로고    scopus 로고
    • The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
    • Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR: The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol 2000; 2: 156-162.
    • (2000) Nat Cell Biol , vol.2 , pp. 156-162
    • Goldstein, J.C.1    Waterhouse, N.J.2    Juin, P.3    Evan, G.I.4    Green, D.R.5
  • 31
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • DOI 10.1016/S0092-8674(00)80501-2
    • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X: Apaf-1, a human protein homologous to C. elegans ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405-413. (Pubitemid 27347231)
    • (1997) Cell , vol.90 , Issue.3 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 32
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and DATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489. (Pubitemid 27508237)
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 35
    • 12244288323 scopus 로고    scopus 로고
    • BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis
    • DOI 10.1016/S0169-328X(02)00582-X, PII S0169328X0200582X
    • Elyaman W, Terro F, Suen KC, Yardin C, Chang RC, Hugon J: Bad and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis. Brain Res Mol Brain Res 2002; 109: 233-238. (Pubitemid 36078390)
    • (2002) Molecular Brain Research , vol.109 , Issue.1-2 , pp. 233-238
    • Elyaman, W.1    Terro, F.2    Suen, K.-C.3    Yardin, C.4    Chang, R.C.-C.5    Hugon, J.6
  • 36
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri KF, Kroemer G: Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3:E255-E263.
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 37
    • 79952705597 scopus 로고    scopus 로고
    • Integrating stress signals at the endoplasmic reticulum: The Bcl-2 protein family rheostat
    • Rodriguez D, Rojas-Rivera D, Hetz C: Integrating stress signals at the endoplasmic reticulum: the Bcl-2 protein family rheostat. Biochim Biophys Acta 2011; 1813: 564-574.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 564-574
    • Rodriguez, D.1    Rojas-Rivera, D.2    Hetz, C.3
  • 38
    • 80052621140 scopus 로고    scopus 로고
    • Calcium and cell death mechanisms: A perspective from the cell death community
    • Zhivotovsky B, Orrenius S: Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium 2011; 50: 211-221.
    • (2011) Cell Calcium , vol.50 , pp. 211-221
    • Zhivotovsky, B.1    Orrenius, S.2
  • 39
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D: The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011; 334: 1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 40
    • 0032693671 scopus 로고    scopus 로고
    • Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    • Haze K, Yoshida H, Yanagi H, Yura T, Mori K: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 1999; 10: 3787-3799. (Pubitemid 29534025)
    • (1999) Molecular Biology of the Cell , vol.10 , Issue.11 , pp. 3787-3799
    • Haze, K.1    Yoshida, H.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 41
    • 0036069980 scopus 로고    scopus 로고
    • ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of golgi localization signals
    • DOI 10.1016/S1534-5807(02)00203-4
    • Shen J, Chen X, Hendershot L, Prywes R: ER stress regulation of ATF6 localization by dissociation of BIP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 2002; 3: 99-111. (Pubitemid 34778399)
    • (2002) Developmental Cell , vol.3 , Issue.1 , pp. 99-111
    • Shen, J.1    Chen, X.2    Hendershot, L.3    Prywes, R.4
  • 42
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-529. (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 43
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • DOI 10.1038/47513
    • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403: 98-103. (Pubitemid 30038529)
    • (2000) Nature , vol.403 , Issue.6765 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 44
    • 0033634641 scopus 로고    scopus 로고
    • Perk is essential for translational regulation and cell survival during the unfolded protein response
    • Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D: Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5: 897-904.
    • (2000) Mol Cell , vol.5 , pp. 897-904
    • Harding, H.P.1    Zhang, Y.2    Bertolotti, A.3    Zeng, H.4    Ron, D.5
  • 45
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • DOI 10.1126/science.287.5453.664
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-666. (Pubitemid 30070916)
    • (2000) Science , vol.287 , Issue.5453 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 46
    • 34247842740 scopus 로고    scopus 로고
    • The death domain superfamily in intracellular signaling of apoptosis and inflammation
    • DOI 10.1146/annurev.immunol.25.022106.141656
    • Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H: The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol 2007; 25: 561-586. (Pubitemid 46697917)
    • (2007) Annual Review of Immunology , vol.25 , pp. 561-586
    • Hyun, H.P.1    Lo, Y.-C.2    Lin, S.-C.3    Wang, L.4    Jin, K.Y.5    Wu, H.6
  • 47
    • 0032785181 scopus 로고    scopus 로고
    • Serial killers: Ordering caspase activation events in apoptosis
    • Slee EA, Adrain C, Martin SJ: Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ 1999; 6: 1067-1074.
    • (1999) Cell Death Differ , vol.6 , pp. 1067-1074
    • Slee, E.A.1    Adrain, C.2    Martin, S.J.3
  • 48
    • 0347601880 scopus 로고    scopus 로고
    • A decade of caspases
    • DOI 10.1038/sj.onc.1207107
    • Degterev A, Boyce M, Yuan J: A decade of caspases. Oncogene 2003; 22: 8543-8567. (Pubitemid 38028527)
    • (2003) Oncogene , vol.22 , Issue.53 REV. ISS. 7 , pp. 8543-8567
    • Degterev, A.1    Boyce, M.2    Yuan, J.3
  • 49
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu CJ, Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94: 491-501. (Pubitemid 28391865)
    • (1998) Cell , vol.94 , Issue.4 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.-J.3    Yuan, J.4
  • 50
    • 0033534446 scopus 로고    scopus 로고
    • Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
    • Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ: Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999; 274: 1156-1163.
    • (1999) J Biol Chem , vol.274 , pp. 1156-1163
    • Gross, A.1    Yin, X.M.2    Wang, K.3    Wei, M.C.4    Jockel, J.5    Milliman, C.6    Erdjument-Bromage, H.7    Tempst, P.8    Korsmeyer, S.J.9
  • 51
    • 0031455379 scopus 로고    scopus 로고
    • Apoptosis generates stable fragments of human type I keratins
    • DOI 10.1074/jbc.272.52.33197
    • Ku NO, Liao J, Omary MB: Apoptosis generates stable fragments of human type I keratins. J Biol Chem 1997; 272: 33197-33203. (Pubitemid 28023666)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.52 , pp. 33197-33203
    • Ku, N.-O.1    Liao, J.2    Omary, M.B.3
  • 52
    • 0030770449 scopus 로고    scopus 로고
    • Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
    • DOI 10.1083/jcb.138.6.1379
    • Caulin C, Salvesen GS, Oshima RG: Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997; 138: 1379-1394. (Pubitemid 27415063)
    • (1997) Journal of Cell Biology , vol.138 , Issue.6 , pp. 1379-1394
    • Caulin, C.1    Salvesen, G.S.2    Oshima, R.G.3
  • 53
    • 0035072953 scopus 로고    scopus 로고
    • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
    • DOI 10.1038/35070009
    • Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF: Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001; 3: 339-345. (Pubitemid 32288440)
    • (2001) Nature Cell Biology , vol.3 , Issue.4 , pp. 339-345
    • Coleman, M.L.1    Sahai, E.A.2    Yeo, M.3    Bosch, M.4    Dewar, A.5    Olson, M.F.6
  • 54
    • 0030462563 scopus 로고    scopus 로고
    • Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis
    • Janicke RU, Walker PA, Lin XY, Porter AG: Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J 1996; 15: 6969-6978. (Pubitemid 27023268)
    • (1996) EMBO Journal , vol.15 , Issue.24 , pp. 6969-6978
    • Janicke, R.U.1    Walker, P.A.2    Lin, X.Y.3    Porter, A.G.4
  • 55
    • 0032012062 scopus 로고    scopus 로고
    • Kip1 mediates apoptosis in endothelial cells through activation of cdk2: Role of a caspase cascade
    • Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM, Ross R: Cleavage of p21CIP1/WAF1 and p27KIP1 mediates apoptosis in endothelial cells through activation of CDK2: role of a caspase cascade. Mol Cell 1998; 1: 553-563. (Pubitemid 128374691)
    • (1998) Molecular Cell , vol.1 , Issue.4 , pp. 553-563
    • Levkau, B.1    Koyama, H.2    Raines, E.W.3    Clurman, B.E.4    Herren, B.5    Orth, K.6    Roberts, J.M.7    Ross, R.8
  • 56
    • 0032582539 scopus 로고    scopus 로고
    • Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis
    • DOI 10.1074/jbc.273.44.28549
    • Tang D, Kidd VJ: Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem 1998; 273: 28549-28552. (Pubitemid 28507533)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.44 , pp. 28549-28552
    • Tang, D.1    Kidd, V.J.2
  • 57
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • DOI 10.1038/34214
    • Sakahira H, Enari M, Nagata S: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391: 96-99. (Pubitemid 28079223)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 58
    • 77956680686 scopus 로고    scopus 로고
    • Survivin and IAP proteins in cell-death mechanisms
    • Altieri DC: Survivin and IAP proteins in cell-death mechanisms. Biochem J 2010; 430: 199-205.
    • (2010) Biochem J , vol.430 , pp. 199-205
    • Altieri, D.C.1
  • 59
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen M, Meier P: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010; 10: 561-574.
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 60
    • 42449152756 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins and apoptosis
    • DOI 10.1111/j.1745-7270.2008.00407.x
    • Wei Y, Fan T, Yu M: Inhibitor of apoptosis proteins and apoptosis. Acta Biochim Biophys Sin (Shanghai) 2008; 40: 278-288. (Pubitemid 351572108)
    • (2008) Acta Biochimica et Biophysica Sinica , vol.40 , Issue.4 , pp. 278-288
    • Wei, Y.1    Fan, T.2    Yu, M.3
  • 61
    • 0033215040 scopus 로고    scopus 로고
    • Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
    • DOI 10.1093/emboj/18.19.5242
    • Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC: Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 1999; 18: 5242-5251. (Pubitemid 29465575)
    • (1999) EMBO Journal , vol.18 , Issue.19 , pp. 5242-5251
    • Deveraux, Q.L.1    Leo, E.2    Stennicke, H.R.3    Welsh, K.4    Salvesen, G.S.5    Reed, J.C.6
  • 64
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • DOI 10.1016/j.ceb.2004.09.011, PII S0955067404001474
    • Edinger AL, Thompson CB: Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16: 663-669. (Pubitemid 39463117)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.6 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 65
    • 57649181391 scopus 로고    scopus 로고
    • Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    • Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J: Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008; 135: 1311-1323.
    • (2008) Cell , vol.135 , pp. 1311-1323
    • Hitomi, J.1    Christofferson, D.E.2    Ng, A.3    Yao, J.4    Degterev, A.5    Xavier, R.J.6    Yuan, J.7
  • 68
    • 33644763298 scopus 로고    scopus 로고
    • Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis
    • DOI 10.1128/MCB.26.6.2215-2225.2006
    • Temkin V, Huang Q, Liu H, Osada H, Pope RM: Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 2006; 26: 2215-2225. (Pubitemid 43346922)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.6 , pp. 2215-2225
    • Temkin, V.1    Huang, Q.2    Liu, H.3    Osada, H.4    Pope, R.M.5
  • 69
    • 42449123761 scopus 로고    scopus 로고
    • Expansion and evolution of cell death programmes
    • DOI 10.1038/nrm2393, PII NRM2393
    • Degterev A, Yuan J: Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 2008; 9: 378-390. (Pubitemid 351574200)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.5 , pp. 378-390
    • Degterev, A.1    Yuan, J.2
  • 70
    • 80053580530 scopus 로고    scopus 로고
    • RIPK-dependent necrosis and its regulation by caspases: A mystery in five acts
    • Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS: RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell 2011; 44: 9-16.
    • (2011) Mol Cell , vol.44 , pp. 9-16
    • Green, D.R.1    Oberst, A.2    Dillon, C.P.3    Weinlich, R.4    Salvesen, G.S.5
  • 71
    • 34249037565 scopus 로고    scopus 로고
    • L-beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • DOI 10.1074/jbc.M700492200
    • Oberstein A, Jeffrey PD, Shi Y: Crystal structure of the BCL-XL-beclin 1 peptide complex: beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282: 13123-13132. (Pubitemid 47100641)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.17 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3
  • 72
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ: Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43: 67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 73
    • 48949098967 scopus 로고    scopus 로고
    • New insights into the mechanisms of macroautophagy in mammalian cells
    • Eskelinen EL: New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol 2008; 266: 207-247.
    • (2008) Int Rev Cell Mol Biol , vol.266 , pp. 207-247
    • Eskelinen, E.L.1
  • 74
    • 38049123578 scopus 로고    scopus 로고
    • Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress
    • Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z, Zong WX: Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ 2008; 15: 422-425.
    • (2008) Cell Death Differ , vol.15 , pp. 422-425
    • Ullman, E.1    Fan, Y.2    Stawowczyk, M.3    Chen, H.M.4    Yue, Z.5    Zong, W.X.6
  • 76
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke EH: Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 77
    • 43949123587 scopus 로고    scopus 로고
    • Fenretinide induces autophagic cell death in caspase-defective breast cancer cells
    • Fazi B, Bursch W, Fimia GM, Nardacci R, Piacentini M, Di Sano F, Piredda L: Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy 2008; 4: 435-441. (Pubitemid 351705140)
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 435-441
    • Fazi, B.1    Bursch, W.2    Fimia, G.M.3    Nardacci, R.4    Piacentini, M.5    Di, S.F.6    Piredda, L.7
  • 78
  • 80
    • 50249139559 scopus 로고    scopus 로고
    • Prognostic impact of Bcl-2 expression on advanced nasopharyngeal carcinoma
    • Chen MK, Lai JC, Chang CC, Chang JH, Chang YJ, Chen HC: Prognostic impact of Bcl-2 expression on advanced nasopharyngeal carcinoma. Head Neck 2008; 30: 1052-1057.
    • (2008) Head Neck , vol.30 , pp. 1052-1057
    • Chen, M.K.1    Lai, J.C.2    Chang, C.C.3    Chang, J.H.4    Chang, Y.J.5    Chen, H.C.6
  • 81
    • 45949097829 scopus 로고    scopus 로고
    • Meta-analysis confirms Bcl2 is an independent prognostic marker in breast cancer
    • Callagy GM, Webber MJ, Pharoah PD, Caldas C: Meta-analysis confirms Bcl2 is an independent prognostic marker in breast cancer. BMC Cancer 2008; 8: 153.
    • (2008) BMC Cancer , vol.8 , pp. 153
    • Callagy, G.M.1    Webber, M.J.2    Pharoah, P.D.3    Caldas, C.4
  • 83
    • 53849102946 scopus 로고    scopus 로고
    • Correlation between loss of Bcl-xL expression and improved prognosis in advanced esophageal cancer treated by preoperative chemoradiotherapy
    • Okumura M, Kajiyama Y, Takeda K, Okumura K, Tsurumaru M: Correlation between loss of Bcl-xL expression and improved prognosis in advanced esophageal cancer treated by preoperative chemoradiotherapy. Eur Surg Res 2008; 41: 260-266.
    • (2008) Eur Surg Res , vol.41 , pp. 260-266
    • Okumura, M.1    Kajiyama, Y.2    Takeda, K.3    Okumura, K.4    Tsurumaru, M.5
  • 85
    • 80855130595 scopus 로고    scopus 로고
    • Expression of apoptosis-related proteins and its clinical implication in surgically resected gastric carcinoma
    • Kim MA, Lee HE, Lee HS, Yang HK, Kim WH: Expression of apoptosis-related proteins and its clinical implication in surgically resected gastric carcinoma. Virchows Arch 2011; 459: 503-510.
    • (2011) Virchows Arch , vol.459 , pp. 503-510
    • Kim, M.A.1    Lee, H.E.2    Lee, H.S.3    Yang, H.K.4    Kim, W.H.5
  • 89
    • 77954158537 scopus 로고    scopus 로고
    • Prognostic significance of second mitochondria-derived activator of caspase (Smac/ DIABLO) expression in bladder cancer and target for therapy
    • Mizutani Y, Katsuoka Y, Bonavida B: Prognostic significance of second mitochondria-derived activator of caspase (Smac/ DIABLO) expression in bladder cancer and target for therapy. Int J Oncol 2010; 37: 503-508.
    • (2010) Int J Oncol , vol.37 , pp. 503-508
    • Mizutani, Y.1    Katsuoka, Y.2    Bonavida, B.3
  • 90
  • 93
    • 34447303334 scopus 로고    scopus 로고
    • CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme
    • DOI 10.1093/carcin/bgm014
    • Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, Esteller M: CPG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis 2007; 28: 1264-1268. (Pubitemid 47062686)
    • (2007) Carcinogenesis , vol.28 , Issue.6 , pp. 1264-1268
    • Martinez, R.1    Setien, F.2    Voelter, C.3    Casado, S.4    Quesada, M.P.5    Schackert, G.6    Esteller, M.7
  • 94
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME: Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241. (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 97
    • 0036160679 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Pro- and anti-apoptotic
    • DOI 10.1038/sj/cdd/4400978
    • Castedo M, Ferri KF, Kroemer G: Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic. Cell Death Differ 2002; 9: 99-100. (Pubitemid 34144768)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.2 , pp. 99-100
    • Castedo, M.1    Ferri, K.F.2    Kroemer, G.3
  • 98
    • 2542628931 scopus 로고    scopus 로고
    • Ras is involved in the negative control of autophagy through the class I PI3-kinase
    • DOI 10.1038/sj.onc.1207539
    • Furuta S, Hidaka E, Ogata A, Yokota S, Kamata T: Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 2004; 23: 3898-3904. (Pubitemid 38747918)
    • (2004) Oncogene , vol.23 , Issue.22 , pp. 3898-3904
    • Furuta, S.1    Hidaka, E.2    Ogata, A.3    Yokota, S.4    Kamata, T.5
  • 100
    • 77949670310 scopus 로고    scopus 로고
    • Death receptor agonists as a targeted therapy for cancer
    • Wiezorek J, Holland P, Graves J: Death receptor agonists as a targeted therapy for cancer. Clin Cancer Res 2010; 16: 1701-1708.
    • (2010) Clin Cancer Res , vol.16 , pp. 1701-1708
    • Wiezorek, J.1    Holland, P.2    Graves, J.3
  • 102
    • 44849120686 scopus 로고    scopus 로고
    • A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
    • DOI 10.1093/annonc/mdn015
    • Yada A, Yazawa M, Ishida S, Yoshida H, Ichikawa K, Kurakata S, Fujiwara K: A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. Ann Oncol 2008; 19: 1060-1067. (Pubitemid 351796330)
    • (2008) Annals of Oncology , vol.19 , Issue.6 , pp. 1060-1067
    • Yada, A.1    Yazawa, M.2    Ishida, S.3    Yoshida, H.4    Ichikawa, K.5    Kurakata, S.6    Fujiwara, K.7
  • 103
    • 34247145009 scopus 로고    scopus 로고
    • Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model
    • DOI 10.1016/j.canlet.2006.11.013, PII S0304383506006409
    • Zhang L, Zhang X, Barrisford GW, Olumi AF: Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DRr5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model. Cancer Lett 2007; 251: 146-157. (Pubitemid 46589773)
    • (2007) Cancer Letters , vol.251 , Issue.1 , pp. 146-157
    • Zhang, L.1    Zhang, X.2    Barrisford, G.W.3    Olumi, A.F.4
  • 110
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • DOI 10.1200/JCO.2006.08.8898
    • Tolcher AW, Mita M, Meropol NJ, von Mehren M, Patnaik A, Padavic K, Hill M, Mays T, McCoy T, Fox NL, Halpern W, Corey A, Cohen RB: Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 2007; 25: 1390-1395. (Pubitemid 46706887)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.11 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3    Von Mehren, M.4    Patnaik, A.5    Padavic, K.6    Hill, M.7    Mays, T.8    McCoy, T.9    Fox, N.L.10    Halpern, W.11    Corey, A.12    Cohen, R.B.13
  • 111
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
    • Greco FA, Bonomi P, Crawford J, Kelly K, Oh Y, Halpern W, Lo L, Gallant G, Klein J: Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008; 61: 82-90.
    • (2008) Lung Cancer , vol.61 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3    Kelly, K.4    Oh, Y.5    Halpern, W.6    Lo, L.7    Gallant, G.8    Klein, J.9
  • 114
    • 76349085626 scopus 로고    scopus 로고
    • Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
    • Trarbach T, Moehler M, Heinemann V, Kohne CH, Przyborek M, Schulz C, Sneller V, Gallant G, Kanzler S: Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br J Cancer 2010; 102: 506-512.
    • (2010) Br J Cancer , vol.102 , pp. 506-512
    • Trarbach, T.1    Moehler, M.2    Heinemann, V.3    Kohne, C.H.4    Przyborek, M.5    Schulz, C.6    Sneller, V.7    Gallant, G.8    Kanzler, S.9
  • 118
    • 34250332128 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells
    • DOI 10.1158/0008-5472.CAN-06-4274
    • Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY: The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Res 2007; 67: 4981-4988. (Pubitemid 46910207)
    • (2007) Cancer Research , vol.67 , Issue.10 , pp. 4981-4988
    • Liu, X.1    Yue, P.2    Chen, S.3    Hu, L.4    Lonial, S.5    Khuri, F.R.6    Sun, S.-Y.7
  • 119
    • 38749133727 scopus 로고    scopus 로고
    • Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis
    • DOI 10.1002/pros.20706
    • Thorpe JA, Christian PA, Schwarze SR: Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis. Prostate 2008; 68: 200-209. (Pubitemid 351186232)
    • (2008) Prostate , vol.68 , Issue.2 , pp. 200-209
    • Thorpe, J.A.1    Christian, P.A.2    Schwarze, S.R.3
  • 120
    • 49849089793 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 (Velcade) induces stabilization of the TRAIL receptor DR5 mRNA through the 3′-untranslated region
    • Kandasamy K, Kraft AS: Proteasome inhibitor PS-341 (Velcade) induces stabilization of the TRAIL receptor DR5 mRNA through the 3′-untranslated region. Mol Cancer Ther 2008; 7: 1091-1100.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1091-1100
    • Kandasamy, K.1    Kraft, A.S.2
  • 123
    • 68149112387 scopus 로고    scopus 로고
    • Mimicking the BH3 domain to kill cancer cells
    • Chonghaile TN, Letai A: Mimicking the BH3 domain to kill cancer cells. Oncogene 2008; 27(suppl 1):S149-S157.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Chonghaile, T.N.1    Letai, A.2
  • 124
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
    • Kang MH, Reynolds CP: Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009; 15: 1126-1132.
    • (2009) Clin Cancer Res , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 126
    • 1642618055 scopus 로고    scopus 로고
    • Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin
    • Lopes de Menezes DE, Hudon N, McIntosh N, Mayer LD: Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin. Clin Cancer Res 2000; 6: 2891-2902. (Pubitemid 30482132)
    • (2000) Clinical Cancer Research , vol.6 , Issue.7 , pp. 2891-2902
    • Lopes, D.M.D.E.1    Hudon, N.2    McIntosh, N.3    Mayer, L.D.4
  • 128
    • 0034794290 scopus 로고    scopus 로고
    • Preliminary phase I results of G3139 (Bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer
    • Tolcher AW: Preliminary phase I results of G3139 (Bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer. Semin Oncol 2001; 28: 67-70.
    • (2001) Semin Oncol , vol.28 , pp. 67-70
    • Tolcher, A.W.1
  • 129
    • 34047217206 scopus 로고    scopus 로고
    • Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
    • DOI 10.1200/JCO.2006.07.1191
    • O'Brien S, Moore JO, Boyd TE, Larratt LM, Skotnicki A, Koziner B, Chanan-Khan AA, Seymour JF, Bociek RG, Pavletic S, Rai KR: Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 2007; 25: 1114-1120. (Pubitemid 46596764)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.9 , pp. 1114-1120
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3    Larratt, L.M.4    Skotnicki, A.5    Koziner, B.6    Chanan-Khan, A.A.7    Seymour, J.F.8    Bociek, R.G.9    Pavletic, S.10    Rai, K.R.11
  • 130
    • 70449723145 scopus 로고    scopus 로고
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
    • O'Brien S, Moore JO, Boyd TE, Larratt LM, Skotnicki AB, Koziner B, Chanan-Khan AA, Seymour JF, Gribben J, Itri LM, Rai KR: 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. J Clin Oncol 2009; 27: 5208-5212.
    • (2009) J Clin Oncol , vol.27 , pp. 5208-5212
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3    Larratt, L.M.4    Skotnicki, A.B.5    Koziner, B.6    Chanan-Khan, A.A.7    Seymour, J.F.8    Gribben, J.9    Itri, L.M.10    Rai, K.R.11
  • 132
    • 84862493119 scopus 로고    scopus 로고
    • The therapeutic potential of RNA interference: Novel approaches for cancer treatment
    • E-pub ahead of print
    • Okamoto K, Murawaki Y: The therapeutic potential of RNA interference: novel approaches for cancer treatment. Curr Pharm Biotechnol 2011, E-pub ahead of print.
    • (2011) Curr Pharm Biotechnol
    • Okamoto, K.1    Murawaki, Y.2
  • 133
    • 23944502266 scopus 로고    scopus 로고
    • Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer
    • DOI 10.1136/gut.2004.056192
    • Ocker M, Neureiter D, Lueders M, Zopf S, Ganslmayer M, Hahn EG, Herold C, Schuppan D: Variants of Bcl-2 specific siRNA for silencing antiapoptotic Bcl-2 in pancreatic cancer. Gut 2005; 54: 1298-1308. (Pubitemid 41192493)
    • (2005) Gut , vol.54 , Issue.9 , pp. 1298-1308
    • Ocker, M.1    Neureiter, D.2    Lueders, M.3    Zopf, S.4    Ganslmayer, M.5    Hahn, E.G.6    Herold, C.7    Schuppan, D.8
  • 135
  • 140
    • 79953025265 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer
    • Ready N, Karaseva NA, Orlov SV, Luft AV, Popovych O, Holmlund JT, Wood BA, Leopold L: Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. J Thorac Oncol 2011; 6: 781-785.
    • (2011) J Thorac Oncol , vol.6 , pp. 781-785
    • Ready, N.1    Karaseva, N.A.2    Orlov, S.V.3    Luft, A.V.4    Popovych, O.5    Holmlund, J.T.6    Wood, B.A.7    Leopold, L.8
  • 145
    • 84862493120 scopus 로고    scopus 로고
    • ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein
    • E-pub ahead of print
    • Wang G, Zhan Y, Wang H, Li W: ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic
    • (2011) Cancer Chemother Pharmacol
    • Wang, G.1    Zhan, Y.2    Wang, H.3    Li, W.4
  • 147
    • 29244470510 scopus 로고    scopus 로고
    • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
    • DOI 10.1158/0008-5472.CAN-05-2394
    • Nawrocki ST, Carew JS, Dunner K Jr, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, Mc-Conkey DJ: Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res 2005; 65: 11510-11519. (Pubitemid 41821709)
    • (2005) Cancer Research , vol.65 , Issue.24 , pp. 11510-11519
    • Nawrocki, S.T.1    Carew, J.S.2    Dunner Jr., K.3    Boise, L.H.4    Chiao, P.J.5    Huang, P.6    Abbruzzese, J.L.7    McConkey, D.J.8
  • 148
    • 65649113298 scopus 로고    scopus 로고
    • Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma
    • Taiyab A, Sreedhar AS, Rao ChM: Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. Biochem Pharmacol 2009; 78: 142-152.
    • (2009) Biochem Pharmacol , vol.78 , pp. 142-152
    • Taiyab, A.1    Sreedhar, A.S.2    Rao, Ch.M.3
  • 149
    • 84862504031 scopus 로고    scopus 로고
    • New drugs, old fashioned ways: ER stress induced cell death
    • E-pub ahead of print
    • Di Fazio P, Ocker M, Montalbano R: New drugs, old fashioned ways: ER stress induced cell death. Curr Pharm Biotechnol 2011, E-pub ahead of print.
    • (2011) Curr Pharm Biotechnol
    • Di Fazio, P.1    Ocker, M.2    Montalbano, R.3
  • 151
    • 79959337199 scopus 로고    scopus 로고
    • Deacetylase inhibitors - Focus on non-histone targets and effects
    • Ocker M: Deacetylase inhibitors - focus on non-histone targets and effects. World J Biol Chem 2010; 1: 55-61.
    • (2010) World J Biol Chem , vol.1 , pp. 55-61
    • Ocker, M.1
  • 152
  • 153
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: Therapeutic implications
    • Yang ZJ, Chee CE, Huang S, Sinicrope FA: The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011; 10: 1533-1541.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.A.4
  • 157
    • 70349329714 scopus 로고    scopus 로고
    • Smac mimetics as new cancer therapeutics
    • Chen DJ, Huerta S: Smac mimetics as new cancer therapeutics. Anticancer Drugs 2009; 20: 646-658.
    • (2009) Anticancer Drugs , vol.20 , pp. 646-658
    • Chen, D.J.1    Huerta, S.2
  • 161
    • 79953655787 scopus 로고    scopus 로고
    • Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
    • Kelly RJ, Lopez-Chavez A, Citrin D, Janik JE, Morris JC: Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin. Mol Cancer 2011; 10: 35.
    • (2011) Mol Cancer , vol.10 , pp. 35
    • Kelly, R.J.1    Lopez-Chavez, A.2    Citrin, D.3    Janik, J.E.4    Morris, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.