Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy

International Journal of Oncology

Volumn 37, Issue 2, 2010, Pages 503-508

  Yoichi, Mizutani ^a   Yoji, Katsuoka ^a   Benjamin, Bonavida ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adriamycin; Apoptosis; Bladder cancer; Cisplatin; Prognosis; Smac DIABLO

Indexed keywords

CISPLATIN; DOXORUBICIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUMOR MARKER; ANTINEOPLASTIC AGENT; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; SIGNAL PEPTIDE;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER GRADING; CANCER INVASION; CANCER RESISTANCE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTECTOMY; DIAGNOSTIC VALUE; FEMALE; FOLLOW UP; FROZEN SECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SUPERFICIAL CANCER; TRANSURETHRAL RESECTION; WESTERN BLOTTING; BLADDER TUMOR; CARCINOMA; DISEASE FREE SURVIVAL; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG RESISTANCE; EVALUATION; METABOLISM; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; PREDICTION AND FORECASTING; TUMOR CELL LINE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CARCINOMA; CELL LINE, TUMOR; DISEASE-FREE SURVIVAL; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 77954158537     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-0000699     Document Type: Article

References (31)

1. Sternberg CN, Yagoda A and Scher HI: Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol 133: 403-407, 1985. (Pubitemid 15129797)
2. Von der Maase H, Hansen SW and Roberts JT: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 17: 3068-3077, 2000.
3. Grossman HB, Soloway M and Messing E: Surveillance for recurrent bladder cancer using a point-of-care proteomic assay. JAMA 295: 299-305, 2007. (Pubitemid 43112958)
4. Bajorin DF, Dodd PM and Mazumdar M: Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy. J Clin Oncol 17: 3173-3181, 1999.
5. Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z and Alnemri ES: Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem 275: 36152-36157, 2000.
6. Du C, Fang M, Li Y, Li L and Wang X: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 33-42, 2000.
7. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ and Vaux DL: Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102: 43-53, 2000.
8. Fulda S, Wick W, Weller M and Debatin KM: Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 8: 808-815, 2002.
9. Ng CP and Bonavida B: X-linked inhibitor of apoptosis (XIAP) blocks Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: Sensitization by over-expression of second mitochondria-derived activator of caspase/ direct IAP-binding protein with low pl (Smac/DIABLO). Mol Cancer Ther 1: 1051-1058, 2002.
10. Mizutani Y, Matsubara H, Yamamoto K, Li YN, Mikami K, Okihara K, Kawauchi A, Bonavida B and Miki T: Prognostic significance of serum osteoprotegerin levels in patients with bladder cancer. Cancer 101: 1794-1802, 2004. (Pubitemid 39314742)
11. Mizutani Y, Wada H, Fukushima M, Yoshida O, Nakanishi H, Li YN and Miki T: Prognostic significance of orotate phosphoribosyltransferase activity in bladder cancer. Cancer 100: 723-731, 2004. (Pubitemid 38176849)
12. Mizutani Y, Nakanishi H, Li YN, Sato N, Kawauchi A and Miki T: Enhanced sensitivity of bladder cancer cells to cisplatin-mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522. J Urol 172: 1474-1479, 2004. (Pubitemid 39249752)
13. Mizutani Y, Yoshida O, Miki T and Bonavida B: Synergistic cytotoxicity and apoptosis by Apo-2 ligand and adriamycin against bladder cancer cells. Clin Cancer Res 5: 2605-2612, 1999. (Pubitemid 29437348)
14. Mizutani Y, Nakanishi H, Yamamoto K, Li YN, Matsubara H, Mikami K, Okihara K, Kawauchi A, Bonavida B and Miki T: Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance. J Clin Oncol 23: 448-454, 2005. (Pubitemid 46224220)
15. Mizutani Y, Kawauchi A, Benjamin B and Miki T: Smac/ DIABLO: A proapoptotic molecular target in renal cell cancer. In: Renal Cell Carcinoma: Molecular Targets and Clinical Application. Bukowski RM, Figlin RA and Motzer RJ (ed). The Humana Pres Inc., New Jersey, pp335-346, 2009.
16. Arnt CR, Chiorean MV, Heldebrant MP, Gores GJ and Kaufmann SH: Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. J Biol Chem 277: 44236-44243, 2002.
17. Yoo NJ, Kim HS, Kim SY, Park CH, Jeon HM, Jung ES, Lee JY and Lee SH: Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas. APMIS 111: 382-388, 2003. (Pubitemid 36560537)
18. Shibata T, Mahocka C, Wethkamp N, Heikaus S, Gabbert HE and Ramp U: Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas. Diagn Mol Pathol 16: 1-8, 2007.
19. Kempkensteffen C, Hinz S, Christoph F, Krause H, Magheli A, Schrader M, Schostak M, Miller K and Wreikert S: Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value. J Cancer Res Clin Oncol 134: 543-550, 2008.
20. Endo K, Kohnoe S, Watanabe A, Tashiro H, Sakata H, Morita M, Kakeji Y and Maehara Y: Clinical significance of Smac/ DIABLO expression in colorectal cancer. Oncol Rep 21: 351-355, 2009.
21. Sekimura A, Konishi A, Mizuno K, Kobayashi Y, Sasaki H, Yano M, Fukai I and Fujii Y: Expression of Smac/DIABLO is a novel prognostic marker in lung cancer. Oncol Rep 11: 797-802, 2004.
22. Bao ST, Gui SQ and Lin MS: Relationship between expression of Smac and Survivin and apoptosis of primary hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 5: 580-583, 2006.
23. Loehrer PJ, Einhorn LH and Elson PJ: A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol 10: 1066-1073, 1992.
24. Von der Maase H, Sengelov L and Roberts JT: Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol 23: 4602-4608, 2005.
25. Deveraux QL and Reed JC: IAP family proteins - suppressors of apoptosis. Genes Dev 13: 239-252, 1999.
26. Sasaki H, Sheng Y, Kotsuji F and Tsang BK: Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60: 5659-5666, 2000.
27. Goyal L: Cell death inhibition: Keeping caspases in check. Cell 104: 805-808, 2001.
28. Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fermandes-Alnemri T, Shi Y and Alnemri ES: A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410: 112-116, 2001.
29. Morizane Y, Honda R, Fukami K and Yasuda H: X-linked inhibitor of apoptosis function as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem 137: 125-132, 2005. (Pubitemid 40502388)
30. Hu S and Yang X: Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem 278: 10055-10060, 2003. (Pubitemid 36800260)
31. Fu J, Jin Y and Arend LJ: Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem 278: 52660-52672, 2003.