Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain

Critical Reviews in Toxicology

Volumn 42, Issue 5, 2012, Pages 443-464

  Riebeling, Christian ^a   Hayess, Katrin ^a   Peters, Annelieke K ^b,c   Steemans, Margino ^b   Spielmann, Horst ^a,d   Luch, Andreas ^a   Seiler, Andrea E M ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c Astellas Pharma Global Development   (Netherlands)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

alternatives to animal testing; applicability domain; embryonic stem cell test (EST); embryotoxicity; in vitro methods; Reproductive toxicology; teratogenicity

Indexed keywords

3 AMINOPROPIONITRILE; DINOSEB; DOXYLAMINE; FUROSEMIDE; METHYLAZOXYMETHANOL; METOCLOPRAMIDE; MEVINOLIN; NITROFEN; OCHRATOXIN; PAPAVERINE; PENICILLAMINE; PRAVASTATIN; WARFARIN;

ACCURACY; EMBRYONIC STEM CELL; EMBRYONIC STEM CELL TEST; EMBRYOTOXICITY; EUROPEAN UNION; HUMAN; IN VITRO STUDY; METHODOLOGY; NONHUMAN; PRACTICE GUIDELINE; REVIEW; TERATOGENICITY; VALIDATION STUDY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; EUROPE; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TERATOGENS; XENOBIOTICS;

ANIMALIA;

EID: 84859913639     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2012.674483     Document Type: Review

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