Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants

Toxicological Sciences

Volumn 94, Issue 2, 2006, Pages 240-255

  LoPachin, Richard M ^a   Barber, David S ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Neurotoxicity; Nitric oxide; Protein adduct; Redox signaling; S nitrosylation; Toxic neuropathy

Indexed keywords

4 HYDROXYNONENAL; ACROLEIN; ACRYLAMIDE; ACRYLONITRILE; ADENYLATE CYCLASE; CALCIUM CHANNEL; CARBON DISULFIDE; CHLORMETHINE; CREATINE KINASE; CYSTEINE; DOPAMINE TRANSPORTER; GLUTAMATE TRANSPORTER; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAVY METAL; HEMOGLOBIN; ISONIAZID; METABOTROPIC RECEPTOR; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; NICOTINIC RECEPTOR; NITRIC OXIDE; NORADRENALIN TRANSPORTER; PYRITHIONE SODIUM; SEROTONIN TRANSPORTER; SNARE PROTEIN; THIOL DERIVATIVE; UNINDEXED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CATALYSIS; ENVIRONMENTAL EXPOSURE; HUMAN; HYPOTHESIS; MOLECULAR INTERACTION; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NITROSYLATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARKINSONISM; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; BINDING SITES; CYSTEINE; NEUROTOXICITY SYNDROMES; NEUROTRANSMITTER AGENTS; NITRIC OXIDE; RATS; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; SYNAPSES; XENOBIOTICS;

EID: 33751429238     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl066     Document Type: Review

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