Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of Diclectin (doxylamine-B6)

Canadian Journal of Clinical Pharmacology

Volumn 7, Issue 3, 2000, Pages 138-143

  Bishai, Raafat ^a   Mazzotta, Paul ^a   Atanackovic, Gordana ^a   Levichek, Zina ^a   Pole, Meena ^a   Magee, Laura A ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Doxylamine; Morning sickness; Nausea; Nausea and vomiting of pregnancy; Pregnancy; Pyridoxine; Vomiting

Indexed keywords

BENDECTIN; DEBENDOX; DOXYLAMINE; PYRIDOXINE;

ARTICLE; CLINICAL TRIAL; CONGENITAL MALFORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MOTION SICKNESS; NAUSEA; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; TERATOGENESIS; VOMITING;

EID: 0033696272     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. A prospective study of nausea and vomiting during pregnancy
2. Variables related to nausea and vomiting during pregnancy
3. Bendectin/Diclectin for morning sickness: A Canadian follow-up of an American tragedy
4. Measuring drug effectiveness by default: The case of Bendectin
5. Nausea and vomiting in pregnancy
6. Hyperemesis gravidarum. A review
7. Pregnancy nausea related to women's obstetrics and personal histories
8. Nausea and vomiting of pregnancy
9. The psychogenic etiology of the hyperemesis gravidarum
10. Vomiting and nausea in the first 12 weeks of pregnancy
11. The effect of periconceptional multivitamin-mineral supplementation on vertigo, nausea and vomiting in the first trimester of pregnancy
12. Vitamin B6 depletion in women with hyperemesis gravidarum
13. Gastric dysrhythmias and nausea of pregnancy
14. Antihistamines
15. H1-receptor antagonists
16. Biotransformation of doxylamine: Isolation, identification and synthesis of some metabolites
17. Identification in in vivo acetylation pathway for N-dealkylated metabolites of doxylamine in humans
18. Clearance of the antihistamine doxylamine - Reduced in elderly men but not in elderly women
19. Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives
20. The pharmacokinetics of doxylamine: Use of automated gas chromatography with nitrogen-phosphorus detection
21. Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon
22. Pharmacokinetics of doxylamine, a component of Bendectin, in the rhesus monkey
23. Vitamin B6: An overview
24. Bioavailability of vitamin B6
25. Vitamin B6 metabolism by human liver
26. Vitamin B6 requirements and recommendations
27. The utilization of intravenously infused pyridoxine in humans
28. Bendectin in the treatment of nausea and vomiting in pregnancy
29. 'Debendox' in pregnancy sickness
30. Treatment of pregnancy sickness
31. Variation in rates hospitalization for excessive vomiting in pregnancy by Bendectin/Diclectin use in Canada
32. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: A randomized, double-blind placebo-controlled study
33. Pyridoxine for nausea and vomiting of pregnancy: A randomized, double-blind, placebo-controlled trial
34. A method for meta-analysis of epidemiological studies
35. Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies
36. Bendectin: Review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogen-litigen