Identification of diphenhydramine metabolites in human urine by capillary electrophoresis-ion trap-mass spectrometry

Electrophoresis

Volumn 25, Issue 10-11, 2004, Pages 1607-1614

  Baldacci, Andrea ^a   Prost, Francine ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Desmethyldiphenhydramine; Diphenhydramine N oxide; Diphenylmethoxyacetic acid glycine amide

Indexed keywords

ALKALINITY; AMIDES; AMINO ACIDS; BIOMOLECULES; BODY FLUIDS; CAPILLARY ELECTROPHORESIS; CHLORINE COMPOUNDS; ELECTROSPRAY IONIZATION; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CAPILLARY-ZONE ELECTROPHORESIS; DESMETHYLDIPHENHYDRAMINE; DIPHENHYDRAMINE; DIPHENHYDRAMINE-N-OXIDE; DIPHENYLMETHOXYACETIC ACID-GLYCINE AMIDE; GLYCINE AMIDE; HUMAN URINE; ION-TRAP MASS SPECTROMETRY; MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY; N-OXIDES;

METABOLITES;

ACETIC ACID; BUFFER; DESMETHYLDIPHENHYDRAMINE; DINORDIPHENHYDRAMINE; DIPHENHYDRAMINE; DIPHENHYDRAMINE DERIVATIVE; DIPHENHYDRAMINE N OXIDE; DIPHENYLMETHOXYACETIC ACID; DRUG METABOLITE; GLUTAMINE DERIVATIVE; GLYCINE DERIVATIVE; METHANOL DERIVATIVE; NORDIPHENHYDRAMINE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; COMPUTER PROGRAM; CONTROLLED STUDY; DEVICE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; HUMAN; ION TRAP MASS SPECTROMETRY; LIQUID; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; MIGRATION; PH; SOLID PHASE EXTRACTION; STANDARD;

EID: 3042815932     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.200305829     Document Type: Article

References (16)

1. Baselt, R. C., Cravey, R. H., Disposition of Toxic Drugs and Chemicals in Man, 4th Ed., Chemical Toxicology Institute, Foster City, CA 1995, pp. 264-267.
2. Herre, S., Pragst, F., J. Chromatogr. B 1997, 692, 111-126.
3. Schafroth, M., Thormann, W., Allemann, D., Electrophoresis 1994, 15, 72-78.
4. Steinmann, L., Thormann, W., J. Capil. Electrophor. 1995, 2, 81-88.
5. Adams, A. K., Essien, H., Binder, S. R., Ann. Biol. Clin. 1991, 49, 291-297.
6. Sadeg, N., François, G., Petit, B., Dutertre-Catella, H., Dumontet, M., Clin. Chem. 1997, 43, 498-504.
7. Zaugg, S., Thormann, W., J. Microcol. Sep. 2001, 13, 96-101.
8. Prost, F., Thormann, W., Electrophoresis 2001, 22, 3270-3280.
9. Prost, F., Thormann, W., Electrophoresis 2003, 24, 2598-2607.
10. Glazko, A. J., Dill, W. A., Young, R. M., Smith, T. C., Ogilvie, R. I., Clin. Pharmacol. Ther. 1974, 16, 1066-1076.
11. Chang, T., Okerholm, R. A., Glazko, A. J., Res. Commun. Chem. Pathol. Pharmacol. 1974, 9, 391-404.
12. Kumar, S., Rurak, D. W., Riggs, K. W., J. Mass Spectrom. 1998, 33, 1171-1181.
13. Liu, J., Cao, W., Yang, X., Wang, E., Talanta 2003, 59, 453-459.
14. Wey, A. B., Thormann, W., J. Chromatogr. B 2002, 770, 191-205.
15. Wernly, P., Thormann, W., Anal. Chem. 1992, 64, 2155-2159.
16. Cymerman Craig, J., Purushothaman, K. K., J. Org. Chem. 1970, 35, 1721-1722.