Alcohol dehydrogenase as a critical mediator of retinoic acid synthesis from vitamin A in the mouse embryo

Journal of Nutrition

Volumn 128, Issue 2 SUPPL., 1998, Pages

  Duester, Gregg ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Alcohol dehydrogenase; Embryogenesis; Mice; Retinoic acid; Vitamin A

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; RETINOIC ACID; RETINOL;

CONFERENCE PAPER; EMBRYO DEVELOPMENT; ENZYME REGULATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIMITIVE STREAK; SIGNAL TRANSDUCTION; VITAMIN METABOLISM;

VERTEBRATA;

EID: 0031914505     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.2.459s     Document Type: Conference Paper

References (35)

1. Ang, H. L., Deltour, L., Hayamizu, T. F., Zgombic-Knight, M. & Duester, G. (1996) Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression. J. Biol. Chem. 271: 9526-9534.
2. Ang, H. L. & Duester, G. (1997) Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis, Dev. Dyn. 208: 536-543.
3. Boleda, M. D., Saubi, N., Farrés, J. & Parés, X. (1993) Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, omega-hydroxyfatty acids, and retinoids. Arch. Biochem. Biophys. 307: 85-90.
4. Chen, H., Namkung, M. J. & Juchau, M. R. (1995) Biotransformation of all-trans-retinol and all-trans-retinal to all-trans-retinoic acid in rat conceptal homogenates. Biochem. Pharmacol. 50: 1257-1264.
5. Connor, M. J. & Smit, M. H. (1987) Terminal-group oxidation of retinol by mouse epidermis: inhibition in vitro and in vivo. Biochem. J. 244: 489-492.
6. Danielsson, O. & Jörnvall, H. (1992) "Enzymogenesis": classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase line. Proc. Natl. Acad. Sci. U.S.A. 89: 9247-9251.
7. Deltour, L., Ang, H. L. & Duester, G. (1996) Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. FASEB J. 10: 1050-1057.
8. Dersch, H. & Zile, M. H. (1993) Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids. Dev. Biol. 160: 424-433.
9. Dockham, P. A., Lee, M.-O. & Sladek, N. E. (1992) Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Biochem. Pharmacol. 43: 2453-2469.
10. Duester, G. (1996) Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 35: 12221-12227.
11. Hogan, B.L.M., Thaller, C. & Eichele, G. (1992) Evidence that Hensen's node is a site of retinoic acid synthesis. Nature (Lond.) 359: 237-241.
12. Jones, K. L. & Smith, D. W. (1973) Recognition of the fetal alcohol syndrome in early infancy. Lancet 2: 999-1001.
13. Julià, P., Farrés, J. & Parés, X. (1986) Ocular alcohol dehydrogenase in the rat: regional distribution and kinetics of the ADH-1 isoenzyme with retinol and retinal. Exp. Eye Res. 42: 305-314.
14. Kastner, P., Chambon, P. & Leid, M. (1994) Role of nuclear retinoic acid receptors in the regulation of gene expression. In: Vitamin A in Health and Disease (Blomhoff, R., ed.), pp. 189-238. Marcel Dekker, New York, NY.
15. Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Hurley, T. D., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Edenberg, H. J. & Li, T.-K. (1995) Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes. J. Biol. Chem. 270: 3625-3630.
16. Koivusalo, M., Baumann, M. & Uotila, L. (1989) Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. FEBS Lett. 257: 105-109.
17. Kotch, L. E. & Sulik, K. K. (1992) Patterns of ethanol-induced cell death in the developing nervous system of mice; neural fold states through the time of anterior neural tube closure. Int. J. Dev. Neurosci. 10: 273-279.
18. Lee, M.-O., Manthey, C. L. & Sladek, N. E. (1991) Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid. Biochem. Pharmacol. 42: 1279-1285.
19. Lohnes, D., Mark, M., Mendelsohn, C., Dollé, P., Dierich, A., Gorry, P., Gansmuller, A. & Chambon, P. (1994) Function of the retinoic acid receptors (RARs) during development. (I) Craniofacial and skeletal abnormalities in RAR double mutants. Development 120: 2723-2748.
20. Luo, J. M., Sucov, H. M., Bader, J. A., Evans, R. M. & Giguère, V. (1996) Compound mutants for retinoic acid receptor (RAR) β and RARα 1 reveal developmental functions for multiple RARβ isoforms, Mech. Dev. 55: 33-44.
21. Maden, M., Gale, E., Kostetskii, I. & Zile, M. H. (1996) Vitamin A-deficient quail embryos have half a hindbrain and other neural defects. Curr. Biol. 6: 417-426.
22. McCaffery, P. & Dräger, U. C. (1994) Hot spots of retinoic acid synthesis in the developing spinal cord. Proc. Natl. Acad, Sci. U.S.A. 91: 7194-7197.
23. McCaffery, P., Posch, K. C., Napoli, J. L., Gudas, L. & Dräger, U. C. (1993) Changing patterns of the retinoic acid system in the developing retina. Dev. Biol. 158: 390-399.
24. Mendelsohn, C., Lohnes, D., Décimo, D., Lufkin, T., LeMeur, M., Chambon, P. & Mark, M. (1994) Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120: 2749-2771.
25. Mezey, E. & Holt, P. R. (1971) The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina. Exp. Mol. Pathol. 15: 148-156.
26. Moreno, A., Farrés, J., Parés, X., Jörnvall, H. & Persson, B. (1996) Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I). FEBS Lett. 395: 99-102.
27. Morriss-Kay, G. (1993) Retinoic acid and craniofacial development: molecules and morphogenesis. BioEssays 15: 9-15.
28. Niederreither, K., McCaffery, P., Dräger, U. C., Chambon, P. & Dollé, P. (1997) Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech. Dev. 62: 67-78.
29. Rossant, J., Zirngibl, R., Cado, D., Shago, M. & Giguère, V. (1991) Expression of a retinoic acid response element-hsplacZtransgene defines specific domains of transcriptional activity during mouse embryogenesis, Genes Dev. 5: 1333-1344.
30. Ruberte, E., Dolle, P., Chambon, P. & Morriss-Kay, G. (1991) Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111: 45-60.
31. Shimeld, S. M. (1996) Retinoic acid, HOX genes and the anterior-posterior axis in chordates. BioEssays 18: 613-616.
32. Soprano, D. R. & Blaner, W. S. (1994) Plasma retinol-binding protein. In: The Retinoids: Biology, Chemistry, and Medicine, 2nd ed. (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), pp. 257-281. Raven Press, New York, NY.
33. Thompson, J. N., Howell, J. M., Pitt, G.A.J. & McLaughlin, C. I. (1969) Biological activity of retinoic acid in the domestic fowl and the effects of vitamin A deficiency on the chick embryo. Br. J. Nutr. 23: 471-485.
34. Yang, Z.-N., Davis, G. J., Hurley, T. D., Stone, C. L., Li, T.-K. & Bosron, W. F. (1994) Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction. Alcohol. Clin. Exp. Res. 18: 587-591.
35. Zhao, D., McCaffery, P., Ivins, K. J., Neve, R. L., Hogan, P., Chin, W. W. & Dräger, U. C. (1996) Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Eur. J. Biochem. 240: 15-22.