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Volumn 33, Issue 2-3, 2003, Pages 270-277

Production of lovastatin by Aspergillus terreus: Effects of the C:N ratio and the principal nutrients on growth and metabolite production

Author keywords

Lovastatin; Mevinolin fermentation

Indexed keywords

BIOMASS; CARBON; FRUCTOSE; GLYCEROL; NITROGEN; PRODUCTION; YEAST;

EID: 18844469113     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(03)00130-3     Document Type: Article
Times cited : (189)

References (19)
  • 1
    • 0018939225 scopus 로고
    • Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
    • Alberts A.W., Chen J., Kuron G., Hunt V., Huff J., Hoffman C.et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl- coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. U.S.A. 77:1980;3957-3961.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 3957-3961
    • Alberts, A.W.1    Chen, J.2    Kuron, G.3    Hunt, V.4    Huff, J.5    Hoffman, C.6
  • 2
    • 0025672856 scopus 로고
    • Lovastatin and simvastatin - Inhibitors of HMG CoA reductase and cholesterol-biosynthesis
    • Alberts A.W. Lovastatin and simvastatin - inhibitors of HMG CoA reductase and cholesterol-biosynthesis. Cardiology. 77:1990;14-21.
    • (1990) Cardiology , vol.77 , pp. 14-21
    • Alberts, A.W.1
  • 3
    • 0017055252 scopus 로고
    • ML-236 A, ML236 B and ML-236 C, new inhibitors of cholesterogenesis produced by Penicillium citrinum
    • Endo A., Kuroda M., Tsujita Y. ML-236 A, ML236 B and ML-236 C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29:1976;1346-1348.
    • (1976) J. Antibiot. , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 4
    • 0017043554 scopus 로고
    • Competitive inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase by ML-236 A and ML236 B fungal metabolites having hypocholesterolemic activity
    • Endo A., Kuroda M., Tanazawa K. Competitive inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase by ML-236 A and ML236 B fungal metabolites having hypocholesterolemic activity. FEBS Lett. 72:1976;323-326.
    • (1976) FEBS Lett. , vol.72 , pp. 323-326
    • Endo, A.1    Kuroda, M.2    Tanazawa, K.3
  • 5
    • 0029987019 scopus 로고    scopus 로고
    • Secondary metabolites of the fungus Monascus: A review
    • Juzlova P., Martinkova L., Kren V. Secondary metabolites of the fungus Monascus: a review. J. Ind. Microbiol. 16:1996;163-170.
    • (1996) J. Ind. Microbiol. , vol.16 , pp. 163-170
    • Juzlova, P.1    Martinkova, L.2    Kren, V.3
  • 6
    • 0030709314 scopus 로고    scopus 로고
    • Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process
    • Novak N., Gerdin S., Berovic M. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process. Biotechnol. Lett. 19:1997;947-948.
    • (1997) Biotechnol. Lett. , vol.19 , pp. 947-948
    • Novak, N.1    Gerdin, S.2    Berovic, M.3
  • 7
    • 0031850146 scopus 로고    scopus 로고
    • Production and purification of statins from Aspergillus terreus strains
    • Manzoni M., Rollini M., Bergomi S., Cavazzoni V. Production and purification of statins from Aspergillus terreus strains. Biotechnol. Tech. 12:1998;529-532.
    • (1998) Biotechnol. Tech. , vol.12 , pp. 529-532
    • Manzoni, M.1    Rollini, M.2    Bergomi, S.3    Cavazzoni, V.4
  • 9
    • 0031919558 scopus 로고    scopus 로고
    • Production of lovastatin by a wild strain of Aspergillus terreus
    • Szakács G., Morovján G., Tengerdy R.P. Production of lovastatin by a wild strain of Aspergillus terreus. Biotechnol. Lett. 20:1998;411-415.
    • (1998) Biotechnol. Lett. , vol.20 , pp. 411-415
    • Szakács, G.1    Morovján, G.2    Tengerdy, R.P.3
  • 11
    • 0035378199 scopus 로고    scopus 로고
    • Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium
    • Hajjaj H., Niederberger P., Duboc P. Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl. Environ. Microbiol. 67:2001;2596-2602.
    • (2001) Appl. Environ. Microbiol. , vol.67 , pp. 2596-2602
    • Hajjaj, H.1    Niederberger, P.2    Duboc, P.3
  • 12
    • 85030954159 scopus 로고    scopus 로고
    • Enzymatic deacylation of simvastatin. British Patent GB2255974, 1992
    • Daborah RA, Lein J, Conder MJ, Tewalt GL. Enzymatic deacylation of simvastatin. British Patent GB2255974, 1992.
    • Daborah, R.A.1    Lein, J.2    Conder, M.J.3    Tewalt, G.L.4
  • 13
    • 0032993346 scopus 로고    scopus 로고
    • Fermentation optimization for the production of poly(β- hydroxybutyric acid) microbial thermoplastic
    • Grothe E., Moo-Young M., Chisti Y. Fermentation optimization for the production of poly(β-hydroxybutyric acid) microbial thermoplastic. Enzyme Microb. Technol. 25:1999;132-141.
    • (1999) Enzyme Microb. Technol. , vol.25 , pp. 132-141
    • Grothe, E.1    Moo-Young, M.2    Chisti, Y.3
  • 14
    • 0001682174 scopus 로고
    • Production of lovastatin, an inhibitor of cholesterol accumulation in humans
    • Demain AL, Somkuti GA, Hunter-Cevera JC, Rossmoore HW, editors. Amsterdam: Ellesmere
    • Buckland B, Gbewonyo K, Hallada T, Kaplan L, Masurekar P. Production of lovastatin, an inhibitor of cholesterol accumulation in humans. In: Demain AL, Somkuti GA, Hunter-Cevera JC, Rossmoore HW, editors. Novel microbial products for medicine and agriculture. Amsterdam: Ellesmere; 1989. p. 161-9.
    • (1989) Novel microbial products for medicine and agriculture , pp. 161-169
    • Buckland, B.1    Gbewonyo, K.2    Hallada, T.3    Kaplan, L.4    Masurekar, P.5
  • 15
    • 0034092485 scopus 로고    scopus 로고
    • Increased heterologous protein production in Aspergillus niger fermentation through extracellular proteases inhibition by pelleted growth
    • Xu J., Wang L., Ridgway D., Gu T., Moo-Young M. Increased heterologous protein production in Aspergillus niger fermentation through extracellular proteases inhibition by pelleted growth. Biotechnol. Progress. 16:2000;222-227.
    • (2000) Biotechnol. Progress , vol.16 , pp. 222-227
    • Xu, J.1    Wang, L.2    Ridgway, D.3    Gu, T.4    Moo-Young, M.5
  • 16
    • 0031588734 scopus 로고    scopus 로고
    • Monitoring of selected metabolites and biotransformation products from fermentation broths by high-performance liquid chromatography
    • Morovján G., Szakács G., Fekete J. Monitoring of selected metabolites and biotransformation products from fermentation broths by high-performance liquid chromatography. J. Chromatogr. A. 763:1997;165-172.
    • (1997) J. Chromatogr. A , vol.763 , pp. 165-172
    • Morovján, G.1    Szakács, G.2    Fekete, J.3
  • 17
    • 0029056468 scopus 로고
    • High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths
    • Friedrich J., Zuzek M., Bencina M., Cimerman A., Strancar A., Radez I. High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. J. Chromatogr. A. 704:1995;363-367.
    • (1995) J. Chromatogr. A , vol.704 , pp. 363-367
    • Friedrich, J.1    Zuzek, M.2    Bencina, M.3    Cimerman, A.4    Strancar, A.5    Radez, I.6
  • 18
    • 0029993963 scopus 로고    scopus 로고
    • Putative Diels-Alder-catalyzed cyclization during the biosynthesis of lovastatin
    • Witter D.J., Vederas J.C. Putative Diels-Alder-catalyzed cyclization during the biosynthesis of lovastatin. J. Org. Chem. 61:1996;2613-2623.
    • (1996) J. Org. Chem. , vol.61 , pp. 2613-2623
    • Witter, D.J.1    Vederas, J.C.2
  • 19
    • 0033591447 scopus 로고    scopus 로고
    • Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
    • Kennedy J., Auclair K., Kendrew S.G., Park C., Vederas J.C., Hutchinson C.R. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science. 284:1999;1368-1372.
    • (1999) Science , vol.284 , pp. 1368-1372
    • Kennedy, J.1    Auclair, K.2    Kendrew, S.G.3    Park, C.4    Vederas, J.C.5    Hutchinson, C.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.