Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity

Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2003, Pages 702-715

  Hirokawa, Yoshimi ^a   Fujiwara, Iwao ^a   Suzuki, Kenji ^a   Harada, Hiroshi ^a   Yoshikawa, Takashi ^a   Yoshida, Naoyuki ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL] 2 METHOXYBENZAMIDE; 4 AMINO N (8 BENZYL 8 AZABICYCLO[3.2.1]OCTAN 3 YL) 5 CHLORO 2 METHOXYBENZAMIDE; 5 BROMO 2 METHOXY 6 METHYLAMINOPYRIDINE 3 CARBOXAMIDE; 5 BROMO N (1 ETHYL 4 METHYLHEXAHYDRO 1,4 DIAZEPIN 6 YL) 2 METHOXY 6 METHYLAMINONICOTINAMIDE; BRL 24682; CISAPRIDE; CISPLATIN; CLEBOPRIDE; DOMPERIDONE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; HALOPERIDOL; METOCLOPRAMIDE; MORPHINE; MOSAPRIDE CITRATE; N (1 ETHYL 4 METHYLHEXAHYDRO 1,4 DIAZEPIN 6 YL)PYRIDINE 3 CARBOXAMIDE DERIVATIVE; ONDANSETRON; PROKINETIC AGENT; PYRIDINE DERIVATIVE; RENZAPRIDE; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; UNCLASSIFIED DRUG; ZACOPRIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOG; DOSE RESPONSE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FERRET; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIEMETICS; AZEPINES; BRAIN; CRYSTALLOGRAPHY, X-RAY; DOGS; DOPAMINE ANTAGONISTS; FERRETS; MODELS, MOLECULAR; PYRIDINES; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037468411     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020270n     Document Type: Article

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