FamClash: A method for ranking the activity of engineered enzymes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 12, 2004, Pages 4142-4147

  Saraf, Manish C ^b   Horswill, Alexander R ^a   Benkovic, Stephen J ^a   Maranas, Costas D ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b The Pennsylvania State University   (United States)

Author keywords

Computational hybrid prescreening; Dihydrofolate reductase; Incremental truncation; Protein engineering; Residue residue clash

Indexed keywords

AMINO ACID; DIHYDROFOLATE REDUCTASE; HYBRID PROTEIN; PEPTIDE LIBRARY; RECOMBINANT ENZYME;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; BACILLUS SUBTILIS; COMPUTER ANALYSIS; CROSSING OVER; ELECTRICITY; ENZYME ACTIVITY; ENZYME ENGINEERING; ESCHERICHIA COLI; EXPERIMENTATION; FAMCLASH; HYDROPHOBICITY; MODEL; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; PROTEIN FAMILY; REPRODUCIBILITY; SCREENING; SEQUENCE ALIGNMENT;

BACILLUS SUBTILIS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; PEPTIDE LIBRARY; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

BACILLUS SUBTILIS; ESCHERICHIA COLI;

EID: 1642529522     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400065101     Document Type: Article

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