Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein

Biochemistry

Volumn 51, Issue 13, 2012, Pages 2852-2866

  Mandal, Debjani ^a   Moitra, Karobi ^a,c   Ghosh, Debabrata ^a   Xia, Di ^b   Dey, Saibal ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; ALLOSTERIC SITE; ATP HYDROLYSIS; ATPASE DOMAIN; COOH-TERMINAL; CYCLOSPORIN A; DRUG BINDING; DRUG MOLECULES; FUNCTIONAL DOMAINS; HIGHLY SENSITIVE; HOMOLOGY MODELING; INDEPENDENT MODE; MULTIDRUG TRANSPORTERS; P-GLYCOPROTEIN; POTENTIAL SITES; PROTEIN INTERFACES; RATIONAL DESIGN; SUBSTRATE BINDING; TRANSMEMBRANES; VERAPAMIL;

COMMUNICATION; GLYCOPROTEINS; LIPID BILAYERS; MODULATION; MODULATORS; PROTEINS;

BINDING SITES;

ADENOSINE TRIPHOSPHATASE; CARBOXYL GROUP; CYCLOSPORIN A; FLUPENTIXOL; GLYCOPROTEIN P; THIOXANTHENE; VERAPAMIL;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROLYSIS; LIPID BILAYER; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LIPID INTERACTION; PROTEIN TARGETING;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; BASE SEQUENCE; DNA PRIMERS; FLUPENTHIXOL; HUMANS; LIPIDS; MICE; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN;

BACTERIA (MICROORGANISMS);

EID: 84859396429     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201479k     Document Type: Article

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