Allosteric modulation of the human P-glycoprotein involves conformational changes mimicking catalytic transition intermediates

Archives of Biochemistry and Biophysics

Volumn 450, Issue 1, 2006, Pages 100-112

  Ghosh, Pratiti ^a   Moitra, Karobi ^a   Maki, Nazli ^a   Dey, Saibal ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

ABCB1; Flupentixol; N Benzoylarginine l p nitroanilide (BAPNA); Thioxanthene derivatives; Trypsin digestion; Vanadate trapping

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZOYLARGININE 4 NITROANILIDE; CIS TRANS ISOMERASE; CYCLOSPORIN A; FLUPENTIXOL; GLYCOPROTEIN P; MUTANT PROTEIN; POLYCLONAL ANTIBODY; THIOXANTHENE DERIVATIVE; TRYPSIN; VANADIC ACID; VINBLASTINE;

ALLOSTERISM; AMINE TRANSPORT; ARTICLE; CATALYSIS; CIS TRANS ISOMERISM; CONFORMATIONAL TRANSITION; DRUG TRANSPORT; HUMAN; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL TRANSPORT; FLUPENTHIXOL; HUMANS; MICE; NIH 3T3 CELLS; P-GLYCOPROTEIN; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; VINBLASTINE;

EID: 33646855552     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.02.025     Document Type: Article

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