Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: Effects on ATPase activity, drug binding and transport

Biochemistry

Volumn 47, Issue 51, 2008, Pages 13686-13698

  Eckford, Paul D W ^a   Sharom, Frances J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATPASE ACTIVITIES; BI LAYERS; BROAD SPECTRUMS; CANCER.; CHEMOTHERAPEUTIC DRUGS; CHOLESTEROL CONTENTS; DRUG BINDINGS; DRUG TRANSPORTS; EFFLUX PUMPS; EXTRACTING REAGENTS; FLIPPASE; FUNCTIONAL ACTIVITIES; HYDROPHOBIC DRUGS; MULTIDRUG RESISTANCES; PHYSICO-CHEMICAL PROPERTIES; TUMOR CELLS; VIA EFFECTS;

BINDING ENERGY; CELL MEMBRANES; DRUG INTERACTIONS; FLOW INTERACTIONS; FUNCTIONS; GLYCOPROTEINS; LIPID BILAYERS; PHOSPHOLIPIDS; PROBABILITY DENSITY FUNCTION; PUMPS;

CHOLESTEROL;

ACRYLAMIDE; ADENOSINE TRIPHOSPHATASE; CHOLESTEROL; CYCLODEXTRIN; DAUNORUBICIN; FLIPPASE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; HOE 33342; PHOSPHOLIPID; TETRAMETHYLROSAMINE; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; LIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTEROL; CRICETINAE; DRUG RESISTANCE, MULTIPLE; LIPID BILAYERS; LIPIDS; MEMBRANE FLUIDITY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; WATER;

EID: 58149170576     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801409r     Document Type: Article

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